Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAD0_LEIIN

TriTrypDb:

LINF_340043800

Length:

162

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	yes	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 7
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Phosphorylation

Promastigote: 109

Expansion

Sequence features

A4IAD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.572
CLV_NRD_NRD_1	4	6	PF00675	0.542
CLV_NRD_NRD_1	95	97	PF00675	0.572
CLV_PCSK_KEX2_1	102	104	PF00082	0.572
CLV_PCSK_KEX2_1	95	97	PF00082	0.572
DEG_SCF_FBW7_2	85	92	PF00400	0.761
DEG_SPOP_SBC_1	23	27	PF00917	0.568
DOC_MAPK_gen_1	65	73	PF00069	0.694
DOC_PP1_RVXF_1	73	79	PF00149	0.731
DOC_USP7_MATH_1	138	142	PF00917	0.795
DOC_WW_Pin1_4	85	90	PF00397	0.767
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_CtBP_PxDLS_1	33	37	PF00389	0.520
LIG_eIF4E_1	57	63	PF01652	0.652
LIG_FHA_1	40	46	PF00498	0.458
LIG_GBD_Chelix_1	51	59	PF00786	0.490
LIG_LIR_Gen_1	70	78	PF02991	0.741
LIG_LIR_Nem_3	58	63	PF02991	0.566
LIG_LIR_Nem_3	70	76	PF02991	0.692
LIG_SH2_STAT5	57	60	PF00017	0.608
LIG_SH3_3	121	127	PF00018	0.703
LIG_SH3_3	154	160	PF00018	0.785
LIG_SUMO_SIM_anti_2	42	48	PF11976	0.466
MOD_CDK_SPK_2	85	90	PF00069	0.737
MOD_CDK_SPxK_1	85	91	PF00069	0.693
MOD_CK2_1	71	77	PF00069	0.638
MOD_GlcNHglycan	108	111	PF01048	0.859
MOD_GlcNHglycan	67	70	PF01048	0.774
MOD_GSK3_1	151	158	PF00069	0.769
MOD_GSK3_1	65	72	PF00069	0.754
MOD_N-GLC_1	85	90	PF02516	0.689
MOD_NEK2_1	47	52	PF00069	0.424
MOD_NEK2_1	55	60	PF00069	0.449
MOD_NEK2_1	71	76	PF00069	0.673
MOD_PIKK_1	122	128	PF00454	0.693
MOD_PIKK_1	138	144	PF00454	0.606
MOD_Plk_1	151	157	PF00069	0.773
MOD_Plk_1	69	75	PF00069	0.647
MOD_Plk_4	47	53	PF00069	0.497
MOD_Plk_4	55	61	PF00069	0.455
MOD_ProDKin_1	85	91	PF00069	0.693
MOD_SUMO_for_1	89	92	PF00179	0.787
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.590
TRG_ER_diArg_1	64	67	PF00400	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA23	Leptomonas seymouri	46%	88%
A0A3Q8ILG5	Leishmania donovani	76%	100%
A0A3S7X8E8	Leishmania donovani	99%	100%
A4HB82	Leishmania braziliensis	67%	70%
A4IAD1	Leishmania infantum	68%	93%
E9B5F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B5F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2I0	Leishmania major	86%	100%