LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAC9_LEIIN
TriTrypDb:
LINF_340043700
Length:
511

Annotations

Annotations by Jardim et al.

Hydrolase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 14, no: 2
NetGPI no yes: 0, no: 16
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
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Expansion

Sequence features

A4IAC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC9

Function

Biological processes
TermNameLevelCount
GO:0008152 metabolic process 1 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 14
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 1
GO:0004564 beta-fructofuranosidase activity 5 1
GO:0016787 hydrolase activity 2 14
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 399 401 PF00675 0.540
CLV_NRD_NRD_1 507 509 PF00675 0.479
CLV_PCSK_KEX2_1 230 232 PF00082 0.522
CLV_PCSK_KEX2_1 249 251 PF00082 0.395
CLV_PCSK_KEX2_1 392 394 PF00082 0.592
CLV_PCSK_KEX2_1 507 509 PF00082 0.479
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.542
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.542
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.530
CLV_PCSK_PC7_1 226 232 PF00082 0.542
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HYJ4 Leptomonas seymouri 53% 100%
A0A0S4JMD5 Bodo saltans 28% 100%
A0A0S4JQJ5 Bodo saltans 32% 90%
A0A1X0PA11 Trypanosomatidae 28% 100%
A0A1X0PAC3 Trypanosomatidae 34% 98%
A0A3Q8IHH9 Leishmania donovani 99% 100%
A0A3R7K6I9 Trypanosoma rangeli 31% 100%
A0A3R7KT12 Trypanosoma rangeli 26% 99%
A4HB81 Leishmania braziliensis 64% 100%
C9ZLW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS