LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAC9_LEIIN
TriTrypDb:
LINF_340043700
Length:
511

Annotations

Annotations by Jardim et al.

Hydrolase, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 14, no: 2
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13

Expansion

Sequence features

A4IAC9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC9

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 14
GO:0016787 hydrolase activity 2 14
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 1
GO:0004564 beta-fructofuranosidase activity 5 1
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 399 401 PF00675 0.540
CLV_NRD_NRD_1 507 509 PF00675 0.479
CLV_PCSK_KEX2_1 230 232 PF00082 0.522
CLV_PCSK_KEX2_1 249 251 PF00082 0.395
CLV_PCSK_KEX2_1 392 394 PF00082 0.592
CLV_PCSK_KEX2_1 507 509 PF00082 0.479
CLV_PCSK_PC1ET2_1 230 232 PF00082 0.542
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.542
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.530
CLV_PCSK_PC7_1 226 232 PF00082 0.542
CLV_PCSK_SKI1_1 277 281 PF00082 0.552
CLV_PCSK_SKI1_1 292 296 PF00082 0.552
CLV_PCSK_SKI1_1 351 355 PF00082 0.575
CLV_PCSK_SKI1_1 382 386 PF00082 0.524
CLV_PCSK_SKI1_1 44 48 PF00082 0.560
DEG_APCC_DBOX_1 218 226 PF00400 0.286
DEG_Nend_UBRbox_1 1 4 PF02207 0.571
DOC_CKS1_1 495 500 PF01111 0.583
DOC_MAPK_gen_1 274 284 PF00069 0.336
DOC_MAPK_gen_1 400 411 PF00069 0.322
DOC_MAPK_MEF2A_6 277 284 PF00069 0.327
DOC_MAPK_MEF2A_6 298 306 PF00069 0.361
DOC_PP2B_LxvP_1 200 203 PF13499 0.309
DOC_PP2B_LxvP_1 294 297 PF13499 0.363
DOC_USP7_MATH_1 168 172 PF00917 0.344
DOC_USP7_MATH_1 203 207 PF00917 0.273
DOC_USP7_MATH_1 433 437 PF00917 0.420
DOC_USP7_MATH_1 73 77 PF00917 0.341
DOC_USP7_MATH_1 95 99 PF00917 0.358
DOC_WW_Pin1_4 307 312 PF00397 0.278
DOC_WW_Pin1_4 494 499 PF00397 0.704
DOC_WW_Pin1_4 50 55 PF00397 0.264
LIG_14-3-3_CanoR_1 367 373 PF00244 0.353
LIG_14-3-3_CanoR_1 382 387 PF00244 0.348
LIG_14-3-3_CanoR_1 440 444 PF00244 0.312
LIG_14-3-3_CanoR_1 468 476 PF00244 0.658
LIG_14-3-3_CanoR_1 507 511 PF00244 0.695
LIG_BRCT_BRCA1_1 108 112 PF00533 0.335
LIG_BRCT_BRCA1_1 309 313 PF00533 0.383
LIG_BRCT_BRCA1_1 393 397 PF00533 0.304
LIG_deltaCOP1_diTrp_1 377 387 PF00928 0.321
LIG_deltaCOP1_diTrp_1 88 94 PF00928 0.323
LIG_FHA_1 18 24 PF00498 0.575
LIG_FHA_1 242 248 PF00498 0.276
LIG_FHA_1 325 331 PF00498 0.283
LIG_FHA_1 444 450 PF00498 0.226
LIG_FHA_1 494 500 PF00498 0.741
LIG_FHA_2 144 150 PF00498 0.260
LIG_FHA_2 336 342 PF00498 0.372
LIG_FHA_2 376 382 PF00498 0.335
LIG_FHA_2 69 75 PF00498 0.286
LIG_LIR_Gen_1 109 117 PF02991 0.299
LIG_LIR_Gen_1 244 252 PF02991 0.324
LIG_LIR_Gen_1 266 276 PF02991 0.273
LIG_LIR_Gen_1 377 387 PF02991 0.330
LIG_LIR_Gen_1 473 483 PF02991 0.600
LIG_LIR_LC3C_4 278 282 PF02991 0.286
LIG_LIR_Nem_3 109 115 PF02991 0.297
LIG_LIR_Nem_3 138 143 PF02991 0.319
LIG_LIR_Nem_3 244 248 PF02991 0.307
LIG_LIR_Nem_3 266 272 PF02991 0.236
LIG_LIR_Nem_3 275 279 PF02991 0.229
LIG_LIR_Nem_3 288 294 PF02991 0.288
LIG_LIR_Nem_3 33 39 PF02991 0.298
LIG_LIR_Nem_3 377 383 PF02991 0.299
LIG_NRBOX 190 196 PF00104 0.307
LIG_PDZ_Class_1 506 511 PF00595 0.658
LIG_Pex14_1 261 265 PF04695 0.243
LIG_Pex14_2 324 328 PF04695 0.383
LIG_Pex14_2 383 387 PF04695 0.358
LIG_PTB_Apo_2 172 179 PF02174 0.331
LIG_PTB_Phospho_1 172 178 PF10480 0.331
LIG_SH2_CRK 245 249 PF00017 0.318
LIG_SH2_CRK 269 273 PF00017 0.295
LIG_SH2_CRK 36 40 PF00017 0.260
LIG_SH2_CRK 429 433 PF00017 0.422
LIG_SH2_PTP2 408 411 PF00017 0.347
LIG_SH2_SRC 408 411 PF00017 0.205
LIG_SH2_STAP1 179 183 PF00017 0.314
LIG_SH2_STAP1 265 269 PF00017 0.337
LIG_SH2_STAT3 56 59 PF00017 0.260
LIG_SH2_STAT5 179 182 PF00017 0.273
LIG_SH2_STAT5 319 322 PF00017 0.253
LIG_SH2_STAT5 337 340 PF00017 0.223
LIG_SH2_STAT5 408 411 PF00017 0.330
LIG_SH2_STAT5 421 424 PF00017 0.330
LIG_SH2_STAT5 85 88 PF00017 0.314
LIG_SH3_3 199 205 PF00018 0.287
LIG_SUMO_SIM_anti_2 278 283 PF11976 0.355
LIG_SUMO_SIM_anti_2 368 375 PF11976 0.289
LIG_SUMO_SIM_par_1 187 193 PF11976 0.239
LIG_SUMO_SIM_par_1 463 469 PF11976 0.542
LIG_TRAF2_1 148 151 PF00917 0.330
LIG_TRFH_1 429 433 PF08558 0.346
LIG_TYR_ITIM 34 39 PF00017 0.286
LIG_WW_2 202 205 PF00397 0.221
MOD_CK1_1 206 212 PF00069 0.263
MOD_CK1_1 335 341 PF00069 0.378
MOD_CK1_1 346 352 PF00069 0.330
MOD_CK1_1 368 374 PF00069 0.309
MOD_CK1_1 436 442 PF00069 0.475
MOD_CK1_1 469 475 PF00069 0.599
MOD_CK1_1 487 493 PF00069 0.695
MOD_CK1_1 494 500 PF00069 0.711
MOD_CK1_1 50 56 PF00069 0.264
MOD_CK2_1 143 149 PF00069 0.336
MOD_CK2_1 163 169 PF00069 0.190
MOD_CK2_1 335 341 PF00069 0.375
MOD_CK2_1 346 352 PF00069 0.375
MOD_CK2_1 410 416 PF00069 0.332
MOD_GlcNHglycan 126 129 PF01048 0.536
MOD_GlcNHglycan 253 256 PF01048 0.533
MOD_GlcNHglycan 345 348 PF01048 0.577
MOD_GlcNHglycan 367 370 PF01048 0.422
MOD_GlcNHglycan 468 471 PF01048 0.397
MOD_GlcNHglycan 480 483 PF01048 0.463
MOD_GlcNHglycan 74 78 PF01048 0.520
MOD_GSK3_1 113 120 PF00069 0.294
MOD_GSK3_1 139 146 PF00069 0.268
MOD_GSK3_1 213 220 PF00069 0.344
MOD_GSK3_1 368 375 PF00069 0.293
MOD_GSK3_1 439 446 PF00069 0.445
MOD_GSK3_1 46 53 PF00069 0.303
MOD_GSK3_1 466 473 PF00069 0.615
MOD_GSK3_1 474 481 PF00069 0.667
MOD_GSK3_1 487 494 PF00069 0.581
MOD_N-GLC_1 113 118 PF02516 0.409
MOD_N-GLC_1 206 211 PF02516 0.492
MOD_N-GLC_1 322 327 PF02516 0.574
MOD_N-GLC_1 375 380 PF02516 0.432
MOD_N-GLC_1 417 422 PF02516 0.567
MOD_N-GLC_1 427 432 PF02516 0.616
MOD_N-GLC_1 95 100 PF02516 0.510
MOD_NEK2_1 143 148 PF00069 0.277
MOD_NEK2_1 182 187 PF00069 0.278
MOD_NEK2_1 285 290 PF00069 0.285
MOD_NEK2_1 39 44 PF00069 0.343
MOD_NEK2_1 457 462 PF00069 0.361
MOD_NEK2_1 466 471 PF00069 0.569
MOD_NEK2_1 474 479 PF00069 0.633
MOD_NEK2_1 68 73 PF00069 0.235
MOD_NEK2_1 94 99 PF00069 0.300
MOD_PIKK_1 391 397 PF00454 0.243
MOD_PIKK_1 433 439 PF00454 0.414
MOD_PIKK_1 491 497 PF00454 0.585
MOD_PKA_2 335 341 PF00069 0.387
MOD_PKA_2 439 445 PF00069 0.451
MOD_Plk_1 113 119 PF00069 0.242
MOD_Plk_1 143 149 PF00069 0.281
MOD_Plk_1 168 174 PF00069 0.298
MOD_Plk_1 265 271 PF00069 0.325
MOD_Plk_1 375 381 PF00069 0.400
MOD_Plk_1 417 423 PF00069 0.349
MOD_Plk_1 427 433 PF00069 0.407
MOD_Plk_1 61 67 PF00069 0.328
MOD_Plk_1 95 101 PF00069 0.277
MOD_Plk_2-3 145 151 PF00069 0.194
MOD_Plk_4 168 174 PF00069 0.352
MOD_Plk_4 190 196 PF00069 0.246
MOD_Plk_4 268 274 PF00069 0.285
MOD_Plk_4 315 321 PF00069 0.231
MOD_Plk_4 375 381 PF00069 0.358
MOD_Plk_4 382 388 PF00069 0.311
MOD_Plk_4 410 416 PF00069 0.264
MOD_Plk_4 417 423 PF00069 0.278
MOD_Plk_4 427 433 PF00069 0.286
MOD_Plk_4 439 445 PF00069 0.376
MOD_Plk_4 484 490 PF00069 0.716
MOD_Plk_4 78 84 PF00069 0.299
MOD_ProDKin_1 307 313 PF00069 0.284
MOD_ProDKin_1 494 500 PF00069 0.705
MOD_ProDKin_1 50 56 PF00069 0.264
MOD_SUMO_rev_2 271 279 PF00179 0.335
TRG_DiLeu_BaEn_1 275 280 PF01217 0.339
TRG_ENDOCYTIC_2 140 143 PF00928 0.310
TRG_ENDOCYTIC_2 179 182 PF00928 0.250
TRG_ENDOCYTIC_2 245 248 PF00928 0.288
TRG_ENDOCYTIC_2 269 272 PF00928 0.252
TRG_ENDOCYTIC_2 276 279 PF00928 0.246
TRG_ENDOCYTIC_2 36 39 PF00928 0.268
TRG_ENDOCYTIC_2 408 411 PF00928 0.338
TRG_ENDOCYTIC_2 429 432 PF00928 0.362
TRG_NES_CRM1_1 107 118 PF08389 0.329
TRG_Pf-PMV_PEXEL_1 70 74 PF00026 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYJ4 Leptomonas seymouri 53% 100%
A0A0S4JMD5 Bodo saltans 28% 100%
A0A0S4JQJ5 Bodo saltans 32% 90%
A0A1X0PA11 Trypanosomatidae 28% 100%
A0A1X0PAC3 Trypanosomatidae 34% 98%
A0A3Q8IHH9 Leishmania donovani 99% 100%
A0A3R7K6I9 Trypanosoma rangeli 31% 100%
A0A3R7KT12 Trypanosoma rangeli 26% 99%
A4HB81 Leishmania braziliensis 64% 100%
C9ZLW4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZLW5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AHU3 Leishmania infantum 36% 100%
E9B5F2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
P17405 Homo sapiens 22% 81%
P58242 Mus musculus 22% 100%
P70158 Mus musculus 23% 100%
Q04519 Mus musculus 22% 81%
Q4Q2I1 Leishmania major 91% 100%
Q55C09 Dictyostelium discoideum 24% 88%
Q641Z7 Rattus norvegicus 22% 100%
Q92484 Homo sapiens 22% 100%
V5DMV6 Trypanosoma cruzi 27% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS