Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAC9_LEIIN

TriTrypDb:

LINF_340043700

Length:

511

Annotations

Annotations by Jardim et al.

Hydrolase, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 14, no: 2
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

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Expansion

Sequence features

A4IAC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC9

Function

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Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0004564	beta-fructofuranosidase activity	5	1
GO:0016787	hydrolase activity	2	14
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	399	401	PF00675	0.540
CLV_NRD_NRD_1	507	509	PF00675	0.479
CLV_PCSK_KEX2_1	230	232	PF00082	0.522
CLV_PCSK_KEX2_1	249	251	PF00082	0.395
CLV_PCSK_KEX2_1	392	394	PF00082	0.592
CLV_PCSK_KEX2_1	507	509	PF00082	0.479
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.542
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.542
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.530
CLV_PCSK_PC7_1	226	232	PF00082	0.542

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	53%	100%
A0A0S4JMD5	Bodo saltans	28%	100%
A0A0S4JQJ5	Bodo saltans	32%	90%
A0A1X0PA11	Trypanosomatidae	28%	100%
A0A1X0PAC3	Trypanosomatidae	34%	98%
A0A3Q8IHH9	Leishmania donovani	99%	100%
A0A3R7K6I9	Trypanosoma rangeli	31%	100%
A0A3R7KT12	Trypanosoma rangeli	26%	99%
A4HB81	Leishmania braziliensis	64%	100%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%

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