LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Domain of unknown function (DUF3336)/Patatin-like phospholipase - putative
Species:
Leishmania infantum
UniProt:
A4IAC8_LEIIN
TriTrypDb:
LINF_340043600
Length:
570

Annotations

Annotations by Jardim et al.

Lipid Metabolism, Patatin-like phospholipase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4IAC8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC8

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0008152 metabolic process 1 12
GO:0044238 primary metabolic process 2 12
GO:0071704 organic substance metabolic process 2 12
GO:0009056 catabolic process 2 1
GO:0016042 lipid catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004806 triglyceride lipase activity 5 11
GO:0016298 lipase activity 4 11
GO:0016787 hydrolase activity 2 12
GO:0016788 hydrolase activity, acting on ester bonds 3 11
GO:0052689 carboxylic ester hydrolase activity 4 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 74 78 PF00656 0.463
CLV_MEL_PAP_1 156 162 PF00089 0.267
CLV_NRD_NRD_1 133 135 PF00675 0.244
CLV_NRD_NRD_1 168 170 PF00675 0.325
CLV_NRD_NRD_1 322 324 PF00675 0.325
CLV_PCSK_FUR_1 266 270 PF00082 0.297
CLV_PCSK_KEX2_1 133 135 PF00082 0.343
CLV_PCSK_KEX2_1 168 170 PF00082 0.311
CLV_PCSK_KEX2_1 268 270 PF00082 0.250
CLV_PCSK_KEX2_1 322 324 PF00082 0.283
CLV_PCSK_KEX2_1 564 566 PF00082 0.368
CLV_PCSK_PC1ET2_1 268 270 PF00082 0.319
CLV_PCSK_PC1ET2_1 564 566 PF00082 0.368
CLV_PCSK_SKI1_1 175 179 PF00082 0.338
CLV_PCSK_SKI1_1 375 379 PF00082 0.353
CLV_PCSK_SKI1_1 419 423 PF00082 0.279
DEG_APCC_DBOX_1 174 182 PF00400 0.543
DEG_APCC_DBOX_1 434 442 PF00400 0.511
DEG_Nend_UBRbox_2 1 3 PF02207 0.353
DEG_SIAH_1 351 359 PF03145 0.530
DEG_SPOP_SBC_1 358 362 PF00917 0.618
DOC_CKS1_1 258 263 PF01111 0.373
DOC_CYCLIN_RxL_1 372 381 PF00134 0.506
DOC_CYCLIN_yCln2_LP_2 214 217 PF00134 0.297
DOC_MAPK_gen_1 304 313 PF00069 0.419
DOC_MAPK_gen_1 322 329 PF00069 0.450
DOC_MAPK_gen_1 417 426 PF00069 0.558
DOC_MAPK_MEF2A_6 304 313 PF00069 0.502
DOC_MAPK_MEF2A_6 322 331 PF00069 0.395
DOC_MAPK_RevD_3 309 323 PF00069 0.416
DOC_PP1_RVXF_1 476 483 PF00149 0.534
DOC_PP2B_LxvP_1 214 217 PF13499 0.277
DOC_PP2B_LxvP_1 309 312 PF13499 0.504
DOC_PP2B_LxvP_1 41 44 PF13499 0.588
DOC_SPAK_OSR1_1 425 429 PF12202 0.531
DOC_USP7_MATH_1 312 316 PF00917 0.502
DOC_USP7_MATH_1 358 362 PF00917 0.703
DOC_USP7_MATH_1 512 516 PF00917 0.510
DOC_USP7_MATH_1 68 72 PF00917 0.511
DOC_USP7_UBL2_3 139 143 PF12436 0.401
DOC_WW_Pin1_4 257 262 PF00397 0.394
DOC_WW_Pin1_4 314 319 PF00397 0.412
DOC_WW_Pin1_4 334 339 PF00397 0.483
DOC_WW_Pin1_4 489 494 PF00397 0.565
DOC_WW_Pin1_4 522 527 PF00397 0.510
LIG_14-3-3_CanoR_1 380 390 PF00244 0.644
LIG_14-3-3_CanoR_1 462 466 PF00244 0.610
LIG_14-3-3_CanoR_1 550 556 PF00244 0.541
LIG_Actin_WH2_2 93 109 PF00022 0.416
LIG_BRCT_BRCA1_1 199 203 PF00533 0.373
LIG_BRCT_BRCA1_1 27 31 PF00533 0.290
LIG_BRCT_BRCA1_1 87 91 PF00533 0.504
LIG_deltaCOP1_diTrp_1 264 270 PF00928 0.465
LIG_deltaCOP1_diTrp_1 459 465 PF00928 0.536
LIG_eIF4E_1 185 191 PF01652 0.421
LIG_FHA_1 140 146 PF00498 0.402
LIG_FHA_1 17 23 PF00498 0.223
LIG_FHA_1 172 178 PF00498 0.535
LIG_FHA_1 186 192 PF00498 0.399
LIG_FHA_1 274 280 PF00498 0.473
LIG_FHA_1 303 309 PF00498 0.421
LIG_FHA_1 351 357 PF00498 0.514
LIG_FHA_1 372 378 PF00498 0.609
LIG_FHA_1 382 388 PF00498 0.519
LIG_FHA_1 462 468 PF00498 0.598
LIG_FHA_2 295 301 PF00498 0.423
LIG_FHA_2 334 340 PF00498 0.497
LIG_FHA_2 496 502 PF00498 0.692
LIG_FHA_2 59 65 PF00498 0.424
LIG_FHA_2 70 76 PF00498 0.504
LIG_FHA_2 97 103 PF00498 0.504
LIG_GBD_Chelix_1 22 30 PF00786 0.290
LIG_LIR_Gen_1 148 157 PF02991 0.411
LIG_LIR_Gen_1 494 504 PF02991 0.500
LIG_LIR_Gen_1 514 524 PF02991 0.564
LIG_LIR_Nem_3 148 152 PF02991 0.411
LIG_LIR_Nem_3 19 24 PF02991 0.376
LIG_LIR_Nem_3 264 270 PF02991 0.494
LIG_LIR_Nem_3 459 463 PF02991 0.520
LIG_LIR_Nem_3 494 500 PF02991 0.516
LIG_LIR_Nem_3 514 520 PF02991 0.560
LIG_LIR_Nem_3 64 69 PF02991 0.408
LIG_LIR_Nem_3 88 93 PF02991 0.423
LIG_MLH1_MIPbox_1 87 91 PF16413 0.504
LIG_NRBOX 437 443 PF00104 0.505
LIG_Pex14_2 298 302 PF04695 0.554
LIG_Pex14_2 422 426 PF04695 0.542
LIG_PTB_Apo_2 307 314 PF02174 0.417
LIG_SH2_CRK 149 153 PF00017 0.445
LIG_SH2_CRK 27 31 PF00017 0.290
LIG_SH2_CRK 485 489 PF00017 0.557
LIG_SH2_CRK 50 54 PF00017 0.504
LIG_SH2_NCK_1 485 489 PF00017 0.557
LIG_SH2_SRC 390 393 PF00017 0.519
LIG_SH2_STAP1 27 31 PF00017 0.290
LIG_SH2_STAP1 399 403 PF00017 0.585
LIG_SH2_STAP1 463 467 PF00017 0.497
LIG_SH2_STAP1 485 489 PF00017 0.528
LIG_SH2_STAP1 63 67 PF00017 0.432
LIG_SH2_STAT3 437 440 PF00017 0.471
LIG_SH2_STAT5 136 139 PF00017 0.432
LIG_SH2_STAT5 21 24 PF00017 0.373
LIG_SH2_STAT5 334 337 PF00017 0.434
LIG_SH2_STAT5 437 440 PF00017 0.513
LIG_SH2_STAT5 463 466 PF00017 0.525
LIG_SH2_STAT5 519 522 PF00017 0.580
LIG_SH2_STAT5 90 93 PF00017 0.504
LIG_SH3_2 318 323 PF14604 0.416
LIG_SH3_3 276 282 PF00018 0.497
LIG_SH3_3 315 321 PF00018 0.416
LIG_SH3_3 408 414 PF00018 0.536
LIG_SUMO_SIM_par_1 101 108 PF11976 0.459
LIG_SUMO_SIM_par_1 281 287 PF11976 0.430
LIG_SUMO_SIM_par_1 39 46 PF11976 0.552
LIG_SUMO_SIM_par_1 532 537 PF11976 0.467
LIG_TRAF2_1 62 65 PF00917 0.463
LIG_TRAF2_1 99 102 PF00917 0.485
LIG_TYR_ITIM 25 30 PF00017 0.290
LIG_TYR_ITIM 407 412 PF00017 0.563
LIG_UBA3_1 115 121 PF00899 0.473
LIG_WRC_WIRS_1 496 501 PF05994 0.572
LIG_WRC_WIRS_1 90 95 PF05994 0.504
MOD_CK1_1 108 114 PF00069 0.526
MOD_CK1_1 148 154 PF00069 0.476
MOD_CK1_1 179 185 PF00069 0.466
MOD_CK1_1 245 251 PF00069 0.460
MOD_CK1_1 360 366 PF00069 0.643
MOD_CK1_1 430 436 PF00069 0.463
MOD_CK1_1 492 498 PF00069 0.673
MOD_CK1_1 515 521 PF00069 0.580
MOD_CK1_1 525 531 PF00069 0.625
MOD_CK2_1 247 253 PF00069 0.556
MOD_CK2_1 294 300 PF00069 0.410
MOD_CK2_1 495 501 PF00069 0.666
MOD_CK2_1 58 64 PF00069 0.431
MOD_CK2_1 96 102 PF00069 0.485
MOD_GlcNHglycan 110 113 PF01048 0.239
MOD_GlcNHglycan 199 202 PF01048 0.359
MOD_GlcNHglycan 2 5 PF01048 0.550
MOD_GlcNHglycan 221 224 PF01048 0.351
MOD_GlcNHglycan 245 248 PF01048 0.258
MOD_GlcNHglycan 314 317 PF01048 0.241
MOD_GlcNHglycan 343 346 PF01048 0.234
MOD_GlcNHglycan 384 387 PF01048 0.329
MOD_GSK3_1 137 144 PF00069 0.496
MOD_GSK3_1 233 240 PF00069 0.302
MOD_GSK3_1 241 248 PF00069 0.548
MOD_GSK3_1 378 385 PF00069 0.491
MOD_GSK3_1 395 402 PF00069 0.592
MOD_GSK3_1 491 498 PF00069 0.700
MOD_GSK3_1 511 518 PF00069 0.423
MOD_GSK3_1 81 88 PF00069 0.506
MOD_NEK2_1 137 142 PF00069 0.473
MOD_NEK2_1 197 202 PF00069 0.384
MOD_NEK2_1 227 232 PF00069 0.460
MOD_NEK2_1 241 246 PF00069 0.435
MOD_NEK2_1 289 294 PF00069 0.468
MOD_NEK2_1 302 307 PF00069 0.491
MOD_NEK2_1 341 346 PF00069 0.434
MOD_NEK2_1 378 383 PF00069 0.522
MOD_NEK2_1 442 447 PF00069 0.539
MOD_NEK2_1 549 554 PF00069 0.507
MOD_PKA_2 381 387 PF00069 0.571
MOD_PKA_2 461 467 PF00069 0.610
MOD_PKA_2 549 555 PF00069 0.529
MOD_PKB_1 380 388 PF00069 0.494
MOD_Plk_1 179 185 PF00069 0.533
MOD_Plk_1 294 300 PF00069 0.418
MOD_Plk_1 430 436 PF00069 0.469
MOD_Plk_1 85 91 PF00069 0.504
MOD_Plk_4 11 17 PF00069 0.402
MOD_Plk_4 141 147 PF00069 0.430
MOD_Plk_4 148 154 PF00069 0.400
MOD_Plk_4 227 233 PF00069 0.386
MOD_Plk_4 237 243 PF00069 0.511
MOD_Plk_4 442 448 PF00069 0.478
MOD_Plk_4 492 498 PF00069 0.640
MOD_Plk_4 512 518 PF00069 0.575
MOD_Plk_4 86 92 PF00069 0.504
MOD_ProDKin_1 257 263 PF00069 0.394
MOD_ProDKin_1 314 320 PF00069 0.412
MOD_ProDKin_1 334 340 PF00069 0.483
MOD_ProDKin_1 489 495 PF00069 0.562
MOD_ProDKin_1 522 528 PF00069 0.512
TRG_DiLeu_BaEn_1 253 258 PF01217 0.401
TRG_DiLeu_BaEn_4 101 107 PF01217 0.504
TRG_DiLeu_BaLyEn_6 269 274 PF01217 0.504
TRG_DiLeu_BaLyEn_6 475 480 PF01217 0.527
TRG_ENDOCYTIC_2 149 152 PF00928 0.425
TRG_ENDOCYTIC_2 27 30 PF00928 0.290
TRG_ENDOCYTIC_2 409 412 PF00928 0.586
TRG_ENDOCYTIC_2 485 488 PF00928 0.611
TRG_ENDOCYTIC_2 50 53 PF00928 0.577
TRG_ENDOCYTIC_2 519 522 PF00928 0.583
TRG_ENDOCYTIC_2 90 93 PF00928 0.440
TRG_ER_diArg_1 133 135 PF00400 0.444
TRG_ER_diArg_1 168 170 PF00400 0.608
TRG_ER_diArg_1 172 175 PF00400 0.566
TRG_ER_diArg_1 321 323 PF00400 0.521
TRG_ER_diArg_1 380 383 PF00400 0.558
TRG_ER_diArg_1 451 454 PF00400 0.606
TRG_NES_CRM1_1 416 431 PF08389 0.469
TRG_Pf-PMV_PEXEL_1 291 295 PF00026 0.334
TRG_Pf-PMV_PEXEL_1 98 102 PF00026 0.268

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9M9 Leptomonas seymouri 61% 99%
A0A0S4JME6 Bodo saltans 30% 100%
A0A0S4JR20 Bodo saltans 27% 100%
A0A1X0PA17 Trypanosomatidae 33% 100%
A0A3Q8INR2 Leishmania donovani 99% 100%
A0A422N5R5 Trypanosoma rangeli 34% 100%
A1CRG6 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 28% 80%
A4HB80 Leishmania braziliensis 85% 100%
A4HIE6 Leishmania braziliensis 29% 75%
A4R8V2 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 24% 72%
A5DIR3 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 27% 79%
A5DUA8 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 25% 70%
E9B5F1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O14115 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 90%
P0CT18 Magnaporthe oryzae (strain Y34) 24% 72%
Q2HA54 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 25% 67%
Q4Q2I2 Leishmania major 94% 100%
Q4Q779 Leishmania major 28% 70%
Q6BXC8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 25% 72%
Q9LZA6 Arabidopsis thaliana 24% 69%
Q9M1I6 Arabidopsis thaliana 25% 71%
Q9Y7P3 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
V5BW64 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS