Abhydrolase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAC4_LEIIN

TriTrypDb:

LINF_340043200

Length:

870

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4IAC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.666
CLV_NRD_NRD_1	244	246	PF00675	0.516
CLV_NRD_NRD_1	732	734	PF00675	0.540
CLV_NRD_NRD_1	783	785	PF00675	0.497
CLV_NRD_NRD_1	795	797	PF00675	0.490
CLV_PCSK_KEX2_1	732	734	PF00082	0.540
CLV_PCSK_KEX2_1	785	787	PF00082	0.526
CLV_PCSK_KEX2_1	795	797	PF00082	0.502
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.531
CLV_PCSK_SKI1_1	10	14	PF00082	0.516
CLV_PCSK_SKI1_1	263	267	PF00082	0.436
CLV_PCSK_SKI1_1	343	347	PF00082	0.381
CLV_PCSK_SKI1_1	376	380	PF00082	0.611
CLV_PCSK_SKI1_1	556	560	PF00082	0.537
CLV_PCSK_SKI1_1	796	800	PF00082	0.586
CLV_Separin_Metazoa	21	25	PF03568	0.582
DEG_APCC_DBOX_1	631	639	PF00400	0.371
DEG_COP1_1	749	758	PF00400	0.567
DEG_MDM2_SWIB_1	468	475	PF02201	0.638
DEG_SCF_FBW7_1	550	557	PF00400	0.523
DEG_SCF_FBW7_1	614	621	PF00400	0.540
DEG_SPOP_SBC_1	112	116	PF00917	0.567
DOC_CDC14_PxL_1	773	781	PF14671	0.533
DOC_CKS1_1	551	556	PF01111	0.519
DOC_CKS1_1	811	816	PF01111	0.528
DOC_CYCLIN_RxL_1	729	740	PF00134	0.546
DOC_CYCLIN_yClb1_LxF_4	731	736	PF00134	0.364
DOC_MAPK_MEF2A_6	394	402	PF00069	0.564
DOC_MAPK_MEF2A_6	508	517	PF00069	0.443
DOC_MAPK_MEF2A_6	556	564	PF00069	0.541
DOC_PP1_RVXF_1	641	648	PF00149	0.503
DOC_PP1_RVXF_1	730	737	PF00149	0.354
DOC_PP1_RVXF_1	8	14	PF00149	0.503
DOC_PP2B_LxvP_1	513	516	PF13499	0.599
DOC_PP2B_LxvP_1	605	608	PF13499	0.446
DOC_PP2B_LxvP_1	809	812	PF13499	0.655
DOC_PP2B_LxvP_1	863	866	PF13499	0.681
DOC_PP4_FxxP_1	195	198	PF00568	0.412
DOC_USP7_MATH_1	113	117	PF00917	0.701
DOC_USP7_MATH_1	118	122	PF00917	0.628
DOC_USP7_MATH_1	366	370	PF00917	0.553
DOC_USP7_MATH_1	422	426	PF00917	0.656
DOC_USP7_MATH_1	489	493	PF00917	0.536
DOC_USP7_MATH_1	554	558	PF00917	0.515
DOC_USP7_MATH_1	618	622	PF00917	0.602
DOC_USP7_MATH_1	625	629	PF00917	0.576
DOC_USP7_MATH_1	692	696	PF00917	0.704
DOC_USP7_MATH_1	737	741	PF00917	0.509
DOC_USP7_MATH_1	80	84	PF00917	0.737
DOC_USP7_MATH_2	2	8	PF00917	0.513
DOC_WW_Pin1_4	301	306	PF00397	0.629
DOC_WW_Pin1_4	446	451	PF00397	0.672
DOC_WW_Pin1_4	550	555	PF00397	0.418
DOC_WW_Pin1_4	592	597	PF00397	0.501
DOC_WW_Pin1_4	614	619	PF00397	0.519
DOC_WW_Pin1_4	759	764	PF00397	0.659
DOC_WW_Pin1_4	810	815	PF00397	0.707
LIG_14-3-3_CanoR_1	145	155	PF00244	0.404
LIG_14-3-3_CanoR_1	252	258	PF00244	0.479
LIG_14-3-3_CanoR_1	27	35	PF00244	0.475
LIG_14-3-3_CanoR_1	343	352	PF00244	0.364
LIG_14-3-3_CanoR_1	376	381	PF00244	0.637
LIG_14-3-3_CanoR_1	486	492	PF00244	0.580
LIG_14-3-3_CanoR_1	556	561	PF00244	0.537
LIG_14-3-3_CanoR_1	60	64	PF00244	0.473
LIG_14-3-3_CanoR_1	632	641	PF00244	0.500
LIG_14-3-3_CanoR_1	723	731	PF00244	0.537
LIG_14-3-3_CanoR_1	795	803	PF00244	0.577
LIG_14-3-3_CanoR_1	85	90	PF00244	0.686
LIG_14-3-3_CanoR_1	95	99	PF00244	0.549
LIG_Actin_WH2_2	350	365	PF00022	0.413
LIG_Actin_WH2_2	8	26	PF00022	0.531
LIG_ActinCP_TwfCPI_2	195	202	PF01115	0.385
LIG_APCC_ABBA_1	330	335	PF00400	0.485
LIG_BIR_III_2	264	268	PF00653	0.439
LIG_BRCT_BRCA1_1	128	132	PF00533	0.519
LIG_BRCT_BRCA1_1	430	434	PF00533	0.704
LIG_BRCT_BRCA1_1	83	87	PF00533	0.703
LIG_BRCT_BRCA1_1	99	103	PF00533	0.487
LIG_CaM_NSCaTE_8	33	40	PF13499	0.512
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.516
LIG_deltaCOP1_diTrp_1	4	13	PF00928	0.416
LIG_EH1_1	229	237	PF00400	0.512
LIG_EVH1_1	817	821	PF00568	0.717
LIG_FHA_1	183	189	PF00498	0.517
LIG_FHA_1	236	242	PF00498	0.468
LIG_FHA_1	273	279	PF00498	0.503
LIG_FHA_1	317	323	PF00498	0.462
LIG_FHA_1	327	333	PF00498	0.480
LIG_FHA_1	344	350	PF00498	0.379
LIG_FHA_1	557	563	PF00498	0.507
LIG_FHA_1	593	599	PF00498	0.504
LIG_FHA_1	609	615	PF00498	0.414
LIG_FHA_1	684	690	PF00498	0.533
LIG_FHA_1	704	710	PF00498	0.390
LIG_FHA_1	795	801	PF00498	0.593
LIG_FHA_2	437	443	PF00498	0.620
LIG_FHA_2	535	541	PF00498	0.581
LIG_FHA_2	778	784	PF00498	0.489
LIG_LIR_Apic_2	194	198	PF02991	0.454
LIG_LIR_Apic_2	764	769	PF02991	0.505
LIG_LIR_Gen_1	133	142	PF02991	0.371
LIG_LIR_Gen_1	149	157	PF02991	0.351
LIG_LIR_Gen_1	31	40	PF02991	0.477
LIG_LIR_Gen_1	315	326	PF02991	0.466
LIG_LIR_Gen_1	374	385	PF02991	0.495
LIG_LIR_Gen_1	470	476	PF02991	0.635
LIG_LIR_Gen_1	671	680	PF02991	0.596
LIG_LIR_Gen_1	704	713	PF02991	0.394
LIG_LIR_Gen_1	767	778	PF02991	0.542
LIG_LIR_Gen_1	840	851	PF02991	0.646
LIG_LIR_Nem_3	129	135	PF02991	0.388
LIG_LIR_Nem_3	149	155	PF02991	0.246
LIG_LIR_Nem_3	255	261	PF02991	0.401
LIG_LIR_Nem_3	264	269	PF02991	0.351
LIG_LIR_Nem_3	31	36	PF02991	0.433
LIG_LIR_Nem_3	315	321	PF02991	0.477
LIG_LIR_Nem_3	374	380	PF02991	0.501
LIG_LIR_Nem_3	47	53	PF02991	0.342
LIG_LIR_Nem_3	470	475	PF02991	0.638
LIG_LIR_Nem_3	553	558	PF02991	0.578
LIG_LIR_Nem_3	6	12	PF02991	0.399
LIG_LIR_Nem_3	667	672	PF02991	0.522
LIG_LIR_Nem_3	704	708	PF02991	0.407
LIG_LIR_Nem_3	767	773	PF02991	0.557
LIG_LIR_Nem_3	840	846	PF02991	0.658
LIG_LYPXL_S_1	387	391	PF13949	0.613
LIG_LYPXL_yS_3	388	391	PF13949	0.608
LIG_PAM2_1	657	669	PF00658	0.523
LIG_Pex14_1	9	13	PF04695	0.376
LIG_Pex14_2	195	199	PF04695	0.489
LIG_Pex14_2	468	472	PF04695	0.640
LIG_Pex14_2	741	745	PF04695	0.447
LIG_RPA_C_Fungi	483	495	PF08784	0.507
LIG_SH2_CRK	377	381	PF00017	0.504
LIG_SH2_CRK	766	770	PF00017	0.557
LIG_SH2_NCK_1	190	194	PF00017	0.330
LIG_SH2_NCK_1	247	251	PF00017	0.448
LIG_SH2_NCK_1	377	381	PF00017	0.592
LIG_SH2_NCK_1	766	770	PF00017	0.557
LIG_SH2_STAP1	333	337	PF00017	0.521
LIG_SH2_STAT3	339	342	PF00017	0.445
LIG_SH2_STAT3	652	655	PF00017	0.446
LIG_SH2_STAT5	190	193	PF00017	0.379
LIG_SH2_STAT5	372	375	PF00017	0.629
LIG_SH2_STAT5	778	781	PF00017	0.573
LIG_SH3_2	728	733	PF14604	0.543
LIG_SH3_3	308	314	PF00018	0.591
LIG_SH3_3	334	340	PF00018	0.537
LIG_SH3_3	414	420	PF00018	0.696
LIG_SH3_3	512	518	PF00018	0.502
LIG_SH3_3	597	603	PF00018	0.456
LIG_SH3_3	725	731	PF00018	0.432
LIG_SH3_3	812	818	PF00018	0.631
LIG_SH3_3	863	869	PF00018	0.505
LIG_SUMO_SIM_par_1	323	329	PF11976	0.386
LIG_SUMO_SIM_par_1	50	55	PF11976	0.512
LIG_UBA3_1	240	246	PF00899	0.488
LIG_WRC_WIRS_1	349	354	PF05994	0.477
LIG_WRC_WIRS_1	693	698	PF05994	0.634
LIG_WRC_WIRS_1	702	707	PF05994	0.372
LIG_WW_2	818	821	PF00397	0.666
LIG_WW_3	601	605	PF00397	0.449
MOD_CDK_SPxK_1	550	556	PF00069	0.512
MOD_CDK_SPxK_1	614	620	PF00069	0.418
MOD_CK1_1	312	318	PF00069	0.505
MOD_CK1_1	446	452	PF00069	0.663
MOD_CK1_1	487	493	PF00069	0.580
MOD_CK1_1	678	684	PF00069	0.691
MOD_CK1_1	694	700	PF00069	0.593
MOD_CK1_1	740	746	PF00069	0.531
MOD_CK1_1	81	87	PF00069	0.769
MOD_CK1_1	90	96	PF00069	0.564
MOD_CK1_1	97	103	PF00069	0.485
MOD_CK2_1	15	21	PF00069	0.415
MOD_CK2_1	348	354	PF00069	0.437
MOD_CK2_1	436	442	PF00069	0.621
MOD_CK2_1	470	476	PF00069	0.646
MOD_CK2_1	59	65	PF00069	0.552
MOD_CK2_1	692	698	PF00069	0.630
MOD_CK2_1	777	783	PF00069	0.587
MOD_CK2_1	799	805	PF00069	0.589
MOD_GlcNHglycan	105	108	PF01048	0.709
MOD_GlcNHglycan	121	124	PF01048	0.483
MOD_GlcNHglycan	132	135	PF01048	0.291
MOD_GlcNHglycan	168	171	PF01048	0.586
MOD_GlcNHglycan	176	179	PF01048	0.448
MOD_GlcNHglycan	38	41	PF01048	0.428
MOD_GlcNHglycan	577	580	PF01048	0.630
MOD_GlcNHglycan	620	623	PF01048	0.679
MOD_GlcNHglycan	627	630	PF01048	0.670
MOD_GlcNHglycan	635	638	PF01048	0.376
MOD_GlcNHglycan	746	749	PF01048	0.650
MOD_GSK3_1	103	110	PF00069	0.732
MOD_GSK3_1	126	133	PF00069	0.489
MOD_GSK3_1	146	153	PF00069	0.221
MOD_GSK3_1	184	191	PF00069	0.413
MOD_GSK3_1	312	319	PF00069	0.472
MOD_GSK3_1	429	436	PF00069	0.695
MOD_GSK3_1	463	470	PF00069	0.660
MOD_GSK3_1	550	557	PF00069	0.489
MOD_GSK3_1	575	582	PF00069	0.639
MOD_GSK3_1	608	615	PF00069	0.546
MOD_GSK3_1	736	743	PF00069	0.532
MOD_GSK3_1	744	751	PF00069	0.598
MOD_GSK3_1	81	88	PF00069	0.732
MOD_GSK3_1	90	97	PF00069	0.727
MOD_N-GLC_1	107	112	PF02516	0.760
MOD_N-GLC_1	410	415	PF02516	0.532
MOD_N-GLC_1	684	689	PF02516	0.760
MOD_N-GLC_2	478	480	PF02516	0.552
MOD_NEK2_1	103	108	PF00069	0.733
MOD_NEK2_1	184	189	PF00069	0.412
MOD_NEK2_1	235	240	PF00069	0.459
MOD_NEK2_1	299	304	PF00069	0.531
MOD_NEK2_1	326	331	PF00069	0.457
MOD_NEK2_1	36	41	PF00069	0.396
MOD_NEK2_1	484	489	PF00069	0.686
MOD_NEK2_1	612	617	PF00069	0.566
MOD_NEK2_1	676	681	PF00069	0.570
MOD_NEK2_1	736	741	PF00069	0.567
MOD_NEK2_1	799	804	PF00069	0.601
MOD_NEK2_1	87	92	PF00069	0.689
MOD_NEK2_2	463	468	PF00069	0.540
MOD_NEK2_2	608	613	PF00069	0.454
MOD_PIKK_1	146	152	PF00454	0.388
MOD_PIKK_1	206	212	PF00454	0.492
MOD_PIKK_1	577	583	PF00454	0.761
MOD_PIKK_1	612	618	PF00454	0.576
MOD_PIKK_1	829	835	PF00454	0.561
MOD_PKA_1	786	792	PF00069	0.540
MOD_PKA_2	118	124	PF00069	0.688
MOD_PKA_2	150	156	PF00069	0.434
MOD_PKA_2	174	180	PF00069	0.501
MOD_PKA_2	251	257	PF00069	0.453
MOD_PKA_2	26	32	PF00069	0.442
MOD_PKA_2	487	493	PF00069	0.555
MOD_PKA_2	59	65	PF00069	0.472
MOD_PKA_2	631	637	PF00069	0.385
MOD_PKA_2	722	728	PF00069	0.549
MOD_PKA_2	794	800	PF00069	0.568
MOD_PKA_2	94	100	PF00069	0.574
MOD_PKB_1	784	792	PF00069	0.467
MOD_Plk_1	4	10	PF00069	0.555
MOD_Plk_1	436	442	PF00069	0.665
MOD_Plk_1	443	449	PF00069	0.663
MOD_Plk_1	470	476	PF00069	0.642
MOD_Plk_1	684	690	PF00069	0.644
MOD_Plk_4	191	197	PF00069	0.417
MOD_Plk_4	306	312	PF00069	0.599
MOD_Plk_4	326	332	PF00069	0.189
MOD_Plk_4	429	435	PF00069	0.640
MOD_Plk_4	463	469	PF00069	0.554
MOD_Plk_4	522	528	PF00069	0.543
MOD_Plk_4	608	614	PF00069	0.439
MOD_Plk_4	711	717	PF00069	0.351
MOD_Plk_4	838	844	PF00069	0.644
MOD_Plk_4	94	100	PF00069	0.631
MOD_ProDKin_1	301	307	PF00069	0.622
MOD_ProDKin_1	446	452	PF00069	0.669
MOD_ProDKin_1	550	556	PF00069	0.425
MOD_ProDKin_1	592	598	PF00069	0.496
MOD_ProDKin_1	614	620	PF00069	0.529
MOD_ProDKin_1	759	765	PF00069	0.655
MOD_ProDKin_1	810	816	PF00069	0.713
TRG_DiLeu_BaEn_1	179	184	PF01217	0.593
TRG_DiLeu_BaEn_1	698	703	PF01217	0.410
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.549
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.515
TRG_ENDOCYTIC_2	258	261	PF00928	0.473
TRG_ENDOCYTIC_2	377	380	PF00928	0.496
TRG_ENDOCYTIC_2	388	391	PF00928	0.510
TRG_ENDOCYTIC_2	669	672	PF00928	0.517
TRG_ENDOCYTIC_2	770	773	PF00928	0.628
TRG_ER_diArg_1	731	733	PF00400	0.550
TRG_NES_CRM1_1	137	150	PF08389	0.476
TRG_NES_CRM1_1	320	336	PF08389	0.476
TRG_NES_CRM1_1	707	719	PF08389	0.460
TRG_NLS_MonoExtN_4	784	789	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W8	Leptomonas seymouri	44%	99%
A0A1X0PA03	Trypanosomatidae	28%	100%
A0A3R7K2U6	Trypanosoma rangeli	27%	100%
A0A3S5H7X7	Leishmania donovani	99%	100%
A4HB76	Leishmania braziliensis	75%	100%
C9ZLW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B5E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2I6	Leishmania major	91%	100%
V5BW70	Trypanosoma cruzi	26%	100%