LeishMANIAdb
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OmpA-like domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
OmpA-like domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAC3_LEIIN
TriTrypDb:
LINF_340043100
Length:
940

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAC3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 102 106 PF00656 0.653
CLV_C14_Caspase3-7 504 508 PF00656 0.459
CLV_C14_Caspase3-7 511 515 PF00656 0.447
CLV_C14_Caspase3-7 550 554 PF00656 0.424
CLV_MEL_PAP_1 472 478 PF00089 0.498
CLV_NRD_NRD_1 133 135 PF00675 0.580
CLV_NRD_NRD_1 144 146 PF00675 0.537
CLV_NRD_NRD_1 352 354 PF00675 0.559
CLV_NRD_NRD_1 377 379 PF00675 0.517
CLV_NRD_NRD_1 382 384 PF00675 0.551
CLV_NRD_NRD_1 398 400 PF00675 0.474
CLV_NRD_NRD_1 403 405 PF00675 0.426
CLV_NRD_NRD_1 438 440 PF00675 0.507
CLV_NRD_NRD_1 848 850 PF00675 0.658
CLV_NRD_NRD_1 922 924 PF00675 0.699
CLV_PCSK_KEX2_1 133 135 PF00082 0.580
CLV_PCSK_KEX2_1 144 146 PF00082 0.537
CLV_PCSK_KEX2_1 262 264 PF00082 0.609
CLV_PCSK_KEX2_1 352 354 PF00082 0.548
CLV_PCSK_KEX2_1 377 379 PF00082 0.517
CLV_PCSK_KEX2_1 382 384 PF00082 0.551
CLV_PCSK_KEX2_1 388 390 PF00082 0.488
CLV_PCSK_KEX2_1 398 400 PF00082 0.447
CLV_PCSK_KEX2_1 438 440 PF00082 0.518
CLV_PCSK_KEX2_1 691 693 PF00082 0.566
CLV_PCSK_KEX2_1 848 850 PF00082 0.658
CLV_PCSK_KEX2_1 921 923 PF00082 0.715
CLV_PCSK_PC1ET2_1 262 264 PF00082 0.609
CLV_PCSK_PC1ET2_1 388 390 PF00082 0.488
CLV_PCSK_PC1ET2_1 691 693 PF00082 0.537
CLV_PCSK_PC7_1 140 146 PF00082 0.538
CLV_PCSK_PC7_1 378 384 PF00082 0.504
CLV_PCSK_SKI1_1 13 17 PF00082 0.531
CLV_PCSK_SKI1_1 405 409 PF00082 0.504
CLV_PCSK_SKI1_1 545 549 PF00082 0.474
DEG_SCF_FBW7_1 594 600 PF00400 0.563
DEG_SPOP_SBC_1 234 238 PF00917 0.612
DEG_SPOP_SBC_1 624 628 PF00917 0.655
DEG_SPOP_SBC_1 866 870 PF00917 0.601
DOC_CKS1_1 594 599 PF01111 0.565
DOC_CKS1_1 871 876 PF01111 0.653
DOC_CYCLIN_yCln2_LP_2 61 67 PF00134 0.662
DOC_MAPK_gen_1 310 316 PF00069 0.518
DOC_MAPK_gen_1 689 696 PF00069 0.567
DOC_MAPK_gen_1 79 87 PF00069 0.700
DOC_MAPK_MEF2A_6 17 25 PF00069 0.424
DOC_MAPK_MEF2A_6 81 89 PF00069 0.729
DOC_MAPK_MEF2A_6 876 884 PF00069 0.591
DOC_PP1_RVXF_1 413 419 PF00149 0.434
DOC_PP2B_LxvP_1 222 225 PF13499 0.628
DOC_PP2B_LxvP_1 61 64 PF13499 0.665
DOC_PP2B_LxvP_1 836 839 PF13499 0.617
DOC_PP2B_LxvP_1 891 894 PF13499 0.604
DOC_PP4_FxxP_1 898 901 PF00568 0.618
DOC_PP4_MxPP_1 749 752 PF00568 0.530
DOC_USP7_MATH_1 123 127 PF00917 0.608
DOC_USP7_MATH_1 183 187 PF00917 0.639
DOC_USP7_MATH_1 197 201 PF00917 0.636
DOC_USP7_MATH_1 204 208 PF00917 0.622
DOC_USP7_MATH_1 225 229 PF00917 0.631
DOC_USP7_MATH_1 234 238 PF00917 0.558
DOC_USP7_MATH_1 288 292 PF00917 0.687
DOC_USP7_MATH_1 512 516 PF00917 0.522
DOC_USP7_MATH_1 565 569 PF00917 0.428
DOC_USP7_MATH_1 631 635 PF00917 0.637
DOC_USP7_MATH_1 648 652 PF00917 0.539
DOC_USP7_MATH_1 804 808 PF00917 0.672
DOC_USP7_MATH_2 610 616 PF00917 0.613
DOC_USP7_UBL2_3 384 388 PF12436 0.439
DOC_USP7_UBL2_3 449 453 PF12436 0.433
DOC_WW_Pin1_4 155 160 PF00397 0.499
DOC_WW_Pin1_4 29 34 PF00397 0.723
DOC_WW_Pin1_4 593 598 PF00397 0.682
DOC_WW_Pin1_4 629 634 PF00397 0.638
DOC_WW_Pin1_4 641 646 PF00397 0.585
DOC_WW_Pin1_4 659 664 PF00397 0.530
DOC_WW_Pin1_4 731 736 PF00397 0.768
DOC_WW_Pin1_4 743 748 PF00397 0.637
DOC_WW_Pin1_4 762 767 PF00397 0.555
DOC_WW_Pin1_4 800 805 PF00397 0.651
DOC_WW_Pin1_4 819 824 PF00397 0.521
DOC_WW_Pin1_4 851 856 PF00397 0.622
DOC_WW_Pin1_4 867 872 PF00397 0.562
DOC_WW_Pin1_4 882 887 PF00397 0.560
DOC_WW_Pin1_4 900 905 PF00397 0.568
DOC_WW_Pin1_4 912 917 PF00397 0.599
LIG_14-3-3_CanoR_1 398 408 PF00244 0.465
LIG_14-3-3_CanoR_1 417 426 PF00244 0.375
LIG_14-3-3_CanoR_1 441 451 PF00244 0.419
LIG_14-3-3_CanoR_1 467 473 PF00244 0.483
LIG_14-3-3_CterR_2 938 940 PF00244 0.594
LIG_BIR_III_2 832 836 PF00653 0.664
LIG_BRCT_BRCA1_1 201 205 PF00533 0.664
LIG_CaM_IQ_9 302 317 PF13499 0.524
LIG_EH_1 932 936 PF12763 0.642
LIG_FHA_1 185 191 PF00498 0.608
LIG_FHA_1 238 244 PF00498 0.544
LIG_FHA_1 300 306 PF00498 0.544
LIG_FHA_1 594 600 PF00498 0.639
LIG_FHA_1 697 703 PF00498 0.575
LIG_FHA_1 732 738 PF00498 0.650
LIG_FHA_1 822 828 PF00498 0.617
LIG_FHA_1 852 858 PF00498 0.652
LIG_FHA_2 130 136 PF00498 0.526
LIG_FHA_2 150 156 PF00498 0.526
LIG_FHA_2 35 41 PF00498 0.689
LIG_FHA_2 425 431 PF00498 0.475
LIG_FHA_2 531 537 PF00498 0.491
LIG_FHA_2 548 554 PF00498 0.392
LIG_FHA_2 575 581 PF00498 0.569
LIG_FHA_2 727 733 PF00498 0.678
LIG_GBD_Chelix_1 443 451 PF00786 0.536
LIG_LIR_Apic_2 69 73 PF02991 0.552
LIG_LIR_Nem_3 674 680 PF02991 0.573
LIG_MYND_1 597 601 PF01753 0.585
LIG_NRBOX 20 26 PF00104 0.615
LIG_Pex14_2 935 939 PF04695 0.624
LIG_PTAP_UEV_1 632 637 PF05743 0.657
LIG_SH2_PTP2 70 73 PF00017 0.573
LIG_SH2_SRC 70 73 PF00017 0.617
LIG_SH2_STAT5 70 73 PF00017 0.680
LIG_SH3_1 70 76 PF00018 0.568
LIG_SH3_2 871 876 PF14604 0.653
LIG_SH3_3 581 587 PF00018 0.665
LIG_SH3_3 595 601 PF00018 0.554
LIG_SH3_3 604 610 PF00018 0.601
LIG_SH3_3 611 617 PF00018 0.572
LIG_SH3_3 630 636 PF00018 0.541
LIG_SH3_3 639 645 PF00018 0.604
LIG_SH3_3 70 76 PF00018 0.643
LIG_SH3_3 838 844 PF00018 0.675
LIG_SH3_3 86 92 PF00018 0.527
LIG_SH3_3 860 866 PF00018 0.636
LIG_SH3_3 868 874 PF00018 0.597
LIG_SH3_3 898 904 PF00018 0.664
LIG_SH3_CIN85_PxpxPR_1 636 641 PF14604 0.614
LIG_SUMO_SIM_anti_2 536 542 PF11976 0.489
LIG_SUMO_SIM_anti_2 699 704 PF11976 0.548
LIG_SUMO_SIM_par_1 612 619 PF11976 0.616
LIG_SUMO_SIM_par_1 698 704 PF11976 0.494
LIG_SUMO_SIM_par_1 82 88 PF11976 0.682
LIG_TRAF2_1 159 162 PF00917 0.524
LIG_TRAF2_1 178 181 PF00917 0.529
LIG_TRAF2_1 191 194 PF00917 0.589
LIG_TRAF2_1 292 295 PF00917 0.565
LIG_TRAF2_1 372 375 PF00917 0.528
LIG_TRAF2_1 427 430 PF00917 0.477
LIG_TRAF2_1 609 612 PF00917 0.657
LIG_TRAF2_1 814 817 PF00917 0.629
MOD_CDK_SPK_2 641 646 PF00069 0.669
MOD_CDK_SPxK_1 870 876 PF00069 0.655
MOD_CDK_SPxxK_3 659 666 PF00069 0.626
MOD_CDK_SPxxK_3 821 828 PF00069 0.642
MOD_CDK_SPxxK_3 882 889 PF00069 0.647
MOD_CK1_1 235 241 PF00069 0.651
MOD_CK1_1 28 34 PF00069 0.601
MOD_CK1_1 483 489 PF00069 0.524
MOD_CK1_1 615 621 PF00069 0.661
MOD_CK1_1 673 679 PF00069 0.651
MOD_CK1_1 743 749 PF00069 0.680
MOD_CK1_1 765 771 PF00069 0.712
MOD_CK1_1 805 811 PF00069 0.697
MOD_CK1_1 870 876 PF00069 0.692
MOD_CK2_1 149 155 PF00069 0.562
MOD_CK2_1 188 194 PF00069 0.710
MOD_CK2_1 225 231 PF00069 0.613
MOD_CK2_1 288 294 PF00069 0.650
MOD_CK2_1 424 430 PF00069 0.467
MOD_CK2_1 505 511 PF00069 0.465
MOD_CK2_1 530 536 PF00069 0.490
MOD_CK2_1 574 580 PF00069 0.551
MOD_CK2_1 672 678 PF00069 0.665
MOD_CK2_1 785 791 PF00069 0.799
MOD_CK2_1 872 878 PF00069 0.658
MOD_DYRK1A_RPxSP_1 641 645 PF00069 0.626
MOD_GlcNHglycan 190 193 PF01048 0.675
MOD_GlcNHglycan 199 202 PF01048 0.608
MOD_GlcNHglycan 289 293 PF01048 0.587
MOD_GlcNHglycan 434 437 PF01048 0.516
MOD_GlcNHglycan 476 479 PF01048 0.449
MOD_GlcNHglycan 633 636 PF01048 0.688
MOD_GlcNHglycan 716 719 PF01048 0.606
MOD_GlcNHglycan 753 756 PF01048 0.672
MOD_GlcNHglycan 791 794 PF01048 0.703
MOD_GlcNHglycan 804 807 PF01048 0.600
MOD_GlcNHglycan 906 909 PF01048 0.651
MOD_GSK3_1 184 191 PF00069 0.645
MOD_GSK3_1 233 240 PF00069 0.667
MOD_GSK3_1 242 249 PF00069 0.621
MOD_GSK3_1 25 32 PF00069 0.594
MOD_GSK3_1 420 427 PF00069 0.475
MOD_GSK3_1 479 486 PF00069 0.492
MOD_GSK3_1 593 600 PF00069 0.678
MOD_GSK3_1 625 632 PF00069 0.635
MOD_GSK3_1 701 708 PF00069 0.492
MOD_GSK3_1 727 734 PF00069 0.650
MOD_GSK3_1 739 746 PF00069 0.626
MOD_GSK3_1 747 754 PF00069 0.569
MOD_GSK3_1 762 769 PF00069 0.570
MOD_GSK3_1 785 792 PF00069 0.677
MOD_GSK3_1 796 803 PF00069 0.606
MOD_GSK3_1 866 873 PF00069 0.623
MOD_GSK3_1 880 887 PF00069 0.572
MOD_GSK3_1 900 907 PF00069 0.562
MOD_GSK3_1 908 915 PF00069 0.587
MOD_NEK2_1 25 30 PF00069 0.582
MOD_NEK2_1 299 304 PF00069 0.616
MOD_NEK2_1 479 484 PF00069 0.532
MOD_NEK2_1 880 885 PF00069 0.630
MOD_PIKK_1 168 174 PF00454 0.519
MOD_PIKK_1 305 311 PF00454 0.474
MOD_PIKK_1 424 430 PF00454 0.467
MOD_PIKK_1 483 489 PF00454 0.501
MOD_PIKK_1 565 571 PF00454 0.423
MOD_PIKK_1 796 802 PF00454 0.703
MOD_PIKK_1 884 890 PF00454 0.580
MOD_PKA_1 921 927 PF00069 0.583
MOD_PKA_2 188 194 PF00069 0.804
MOD_PKA_2 466 472 PF00069 0.489
MOD_PKA_2 474 480 PF00069 0.437
MOD_PKA_2 739 745 PF00069 0.603
MOD_PKA_2 921 927 PF00069 0.583
MOD_PKB_1 415 423 PF00069 0.455
MOD_Plk_1 123 129 PF00069 0.528
MOD_Plk_1 579 585 PF00069 0.531
MOD_Plk_1 673 679 PF00069 0.679
MOD_Plk_1 740 746 PF00069 0.638
MOD_Plk_1 85 91 PF00069 0.691
MOD_Plk_2-3 727 733 PF00069 0.636
MOD_Plk_4 225 231 PF00069 0.621
MOD_Plk_4 31 37 PF00069 0.718
MOD_Plk_4 696 702 PF00069 0.558
MOD_ProDKin_1 155 161 PF00069 0.501
MOD_ProDKin_1 29 35 PF00069 0.732
MOD_ProDKin_1 593 599 PF00069 0.683
MOD_ProDKin_1 629 635 PF00069 0.638
MOD_ProDKin_1 641 647 PF00069 0.584
MOD_ProDKin_1 659 665 PF00069 0.531
MOD_ProDKin_1 731 737 PF00069 0.766
MOD_ProDKin_1 743 749 PF00069 0.638
MOD_ProDKin_1 762 768 PF00069 0.557
MOD_ProDKin_1 800 806 PF00069 0.650
MOD_ProDKin_1 819 825 PF00069 0.520
MOD_ProDKin_1 851 857 PF00069 0.624
MOD_ProDKin_1 867 873 PF00069 0.563
MOD_ProDKin_1 882 888 PF00069 0.559
MOD_ProDKin_1 900 906 PF00069 0.572
MOD_ProDKin_1 912 918 PF00069 0.598
MOD_SUMO_rev_2 259 264 PF00179 0.518
MOD_SUMO_rev_2 289 299 PF00179 0.644
MOD_SUMO_rev_2 446 455 PF00179 0.468
TRG_DiLeu_BaEn_1 536 541 PF01217 0.444
TRG_DiLeu_BaEn_4 141 147 PF01217 0.461
TRG_DiLeu_BaEn_4 294 300 PF01217 0.621
TRG_DiLeu_BaEn_4 816 822 PF01217 0.615
TRG_ER_diArg_1 144 146 PF00400 0.537
TRG_ER_diArg_1 398 400 PF00400 0.426
TRG_ER_diArg_1 415 418 PF00400 0.442
TRG_ER_diArg_1 472 475 PF00400 0.464
TRG_ER_diArg_1 770 773 PF00400 0.595
TRG_ER_diArg_1 848 850 PF00400 0.655
TRG_ER_diArg_1 921 923 PF00400 0.639
TRG_Pf-PMV_PEXEL_1 115 119 PF00026 0.515
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.517
TRG_Pf-PMV_PEXEL_1 297 301 PF00026 0.618
TRG_Pf-PMV_PEXEL_1 398 403 PF00026 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X8C0 Leishmania donovani 99% 100%
A4HB75 Leishmania braziliensis 46% 100%
E9B5E6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
Q4Q2I7 Leishmania major 82% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS