LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/Ankyrin repeat/Ankyrin repeats (many copies) - putative
Species:
Leishmania infantum
UniProt:
A4IAC2_LEIIN
TriTrypDb:
LINF_340043000
Length:
341

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 11
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAC2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAC2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 235 237 PF00675 0.562
CLV_NRD_NRD_1 262 264 PF00675 0.557
CLV_NRD_NRD_1 90 92 PF00675 0.424
CLV_PCSK_KEX2_1 234 236 PF00082 0.552
CLV_PCSK_KEX2_1 262 264 PF00082 0.557
CLV_PCSK_SKI1_1 16 20 PF00082 0.447
CLV_PCSK_SKI1_1 196 200 PF00082 0.502
DEG_COP1_1 250 259 PF00400 0.635
DOC_CKS1_1 136 141 PF01111 0.396
DOC_MAPK_gen_1 132 142 PF00069 0.298
DOC_MAPK_gen_1 179 188 PF00069 0.262
DOC_MAPK_MEF2A_6 148 156 PF00069 0.396
DOC_MAPK_MEF2A_6 179 188 PF00069 0.262
DOC_MAPK_MEF2A_6 247 256 PF00069 0.502
DOC_USP7_MATH_1 212 216 PF00917 0.488
DOC_USP7_MATH_1 274 278 PF00917 0.507
DOC_WW_Pin1_4 135 140 PF00397 0.249
DOC_WW_Pin1_4 168 173 PF00397 0.328
DOC_WW_Pin1_4 282 287 PF00397 0.633
DOC_WW_Pin1_4 45 50 PF00397 0.335
DOC_WW_Pin1_4 68 73 PF00397 0.328
LIG_14-3-3_CanoR_1 234 239 PF00244 0.564
LIG_Actin_WH2_2 180 198 PF00022 0.375
LIG_BIR_II_1 1 5 PF00653 0.483
LIG_FHA_1 149 155 PF00498 0.425
LIG_FHA_1 305 311 PF00498 0.669
LIG_FHA_2 311 317 PF00498 0.574
LIG_FHA_2 65 71 PF00498 0.412
LIG_LIR_Apic_2 280 286 PF02991 0.468
LIG_LIR_Apic_2 334 339 PF02991 0.537
LIG_LIR_Gen_1 150 160 PF02991 0.353
LIG_LIR_Gen_1 2 8 PF02991 0.303
LIG_LIR_Gen_1 71 82 PF02991 0.396
LIG_LIR_Nem_3 150 156 PF02991 0.318
LIG_LIR_Nem_3 178 184 PF02991 0.418
LIG_LIR_Nem_3 2 6 PF02991 0.287
LIG_LIR_Nem_3 33 38 PF02991 0.310
LIG_LIR_Nem_3 71 77 PF02991 0.396
LIG_NRBOX 118 124 PF00104 0.344
LIG_SH2_CRK 283 287 PF00017 0.564
LIG_SH2_CRK 336 340 PF00017 0.631
LIG_SH2_NCK_1 283 287 PF00017 0.504
LIG_SH2_NCK_1 336 340 PF00017 0.504
LIG_SH2_PTP2 35 38 PF00017 0.319
LIG_SH2_PTP2 74 77 PF00017 0.396
LIG_SH2_SRC 336 339 PF00017 0.552
LIG_SH2_SRC 87 90 PF00017 0.288
LIG_SH2_STAT5 141 144 PF00017 0.314
LIG_SH2_STAT5 153 156 PF00017 0.323
LIG_SH2_STAT5 35 38 PF00017 0.305
LIG_SH2_STAT5 39 42 PF00017 0.297
LIG_SH2_STAT5 74 77 PF00017 0.257
LIG_SH2_STAT5 87 90 PF00017 0.230
LIG_SH3_3 253 259 PF00018 0.542
LIG_SH3_3 284 290 PF00018 0.482
LIG_SH3_3 95 101 PF00018 0.288
LIG_TRAF2_1 134 137 PF00917 0.385
LIG_TRAF2_1 277 280 PF00917 0.484
LIG_WRC_WIRS_1 118 123 PF05994 0.198
MOD_CK2_1 174 180 PF00069 0.468
MOD_CK2_1 274 280 PF00069 0.499
MOD_CK2_1 310 316 PF00069 0.690
MOD_CK2_1 64 70 PF00069 0.344
MOD_GlcNHglycan 123 126 PF01048 0.385
MOD_GlcNHglycan 32 35 PF01048 0.295
MOD_GSK3_1 117 124 PF00069 0.417
MOD_GSK3_1 197 204 PF00069 0.551
MOD_GSK3_1 64 71 PF00069 0.367
MOD_N-GLC_1 30 35 PF02516 0.372
MOD_NEK2_1 121 126 PF00069 0.410
MOD_NEK2_1 73 78 PF00069 0.389
MOD_PK_1 324 330 PF00069 0.540
MOD_PKA_1 234 240 PF00069 0.500
MOD_PKA_2 102 108 PF00069 0.458
MOD_PKA_2 234 240 PF00069 0.585
MOD_PKA_2 299 305 PF00069 0.601
MOD_PKA_2 64 70 PF00069 0.255
MOD_Plk_4 117 123 PF00069 0.369
MOD_Plk_4 148 154 PF00069 0.422
MOD_Plk_4 305 311 PF00069 0.599
MOD_ProDKin_1 135 141 PF00069 0.249
MOD_ProDKin_1 168 174 PF00069 0.328
MOD_ProDKin_1 282 288 PF00069 0.637
MOD_ProDKin_1 45 51 PF00069 0.335
MOD_ProDKin_1 68 74 PF00069 0.328
MOD_SUMO_rev_2 167 172 PF00179 0.264
MOD_SUMO_rev_2 177 184 PF00179 0.266
MOD_SUMO_rev_2 250 257 PF00179 0.580
TRG_ENDOCYTIC_2 153 156 PF00928 0.290
TRG_ENDOCYTIC_2 181 184 PF00928 0.304
TRG_ENDOCYTIC_2 35 38 PF00928 0.310
TRG_ENDOCYTIC_2 74 77 PF00928 0.396
TRG_ER_diArg_1 206 209 PF00400 0.535
TRG_ER_diArg_1 233 236 PF00400 0.522
TRG_ER_diArg_1 261 263 PF00400 0.553
TRG_Pf-PMV_PEXEL_1 276 280 PF00026 0.518

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB55 Leptomonas seymouri 67% 100%
A0A0S4IZ37 Bodo saltans 25% 93%
A0A1X0PAB8 Trypanosomatidae 47% 100%
A0A3Q8IFT3 Leishmania donovani 100% 100%
A0A3R7RA24 Trypanosoma rangeli 43% 100%
A4HB74 Leishmania braziliensis 86% 100%
C9ZLX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9B1A1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 83%
E9B5E5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q2I8 Leishmania major 93% 100%
V5B6C0 Trypanosoma cruzi 48% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS