SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAB7_LEIIN

TriTrypDb:

LINF_340042000

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAB7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.666
CLV_C14_Caspase3-7	165	169	PF00656	0.621
CLV_NRD_NRD_1	12	14	PF00675	0.467
CLV_NRD_NRD_1	209	211	PF00675	0.433
CLV_NRD_NRD_1	290	292	PF00675	0.504
CLV_NRD_NRD_1	46	48	PF00675	0.487
CLV_NRD_NRD_1	99	101	PF00675	0.663
CLV_PCSK_KEX2_1	12	14	PF00082	0.465
CLV_PCSK_KEX2_1	209	211	PF00082	0.419
CLV_PCSK_KEX2_1	290	292	PF00082	0.497
CLV_PCSK_KEX2_1	46	48	PF00082	0.515
CLV_PCSK_SKI1_1	290	294	PF00082	0.502
CLV_PCSK_SKI1_1	306	310	PF00082	0.424
DEG_APCC_DBOX_1	129	137	PF00400	0.426
DEG_Nend_Nbox_1	1	3	PF02207	0.584
DOC_CYCLIN_RxL_1	286	297	PF00134	0.469
DOC_MAPK_gen_1	290	301	PF00069	0.464
DOC_PP1_RVXF_1	196	202	PF00149	0.429
DOC_PP1_RVXF_1	270	277	PF00149	0.602
DOC_USP7_MATH_1	172	176	PF00917	0.665
DOC_USP7_MATH_1	219	223	PF00917	0.410
DOC_USP7_MATH_1	277	281	PF00917	0.574
DOC_WW_Pin1_4	124	129	PF00397	0.519
DOC_WW_Pin1_4	59	64	PF00397	0.651
DOC_WW_Pin1_4	93	98	PF00397	0.578
LIG_14-3-3_CanoR_1	107	114	PF00244	0.495
LIG_14-3-3_CanoR_1	306	316	PF00244	0.460
LIG_14-3-3_CanoR_1	81	87	PF00244	0.392
LIG_Actin_WH2_2	280	296	PF00022	0.523
LIG_BIR_III_4	238	242	PF00653	0.503
LIG_deltaCOP1_diTrp_1	315	321	PF00928	0.382
LIG_eIF4E_1	24	30	PF01652	0.496
LIG_FHA_1	142	148	PF00498	0.651
LIG_FHA_1	287	293	PF00498	0.435
LIG_FHA_1	72	78	PF00498	0.429
LIG_FHA_2	308	314	PF00498	0.469
LIG_LIR_Apic_2	21	27	PF02991	0.502
LIG_LIR_Gen_1	112	122	PF02991	0.536
LIG_LIR_Gen_1	19	30	PF02991	0.454
LIG_LIR_Gen_1	200	207	PF02991	0.421
LIG_LIR_Gen_1	258	268	PF02991	0.595
LIG_LIR_Nem_3	112	117	PF02991	0.504
LIG_LIR_Nem_3	19	25	PF02991	0.414
LIG_LIR_Nem_3	200	204	PF02991	0.423
LIG_LIR_Nem_3	243	248	PF02991	0.403
LIG_LIR_Nem_3	258	263	PF02991	0.419
LIG_LYPXL_S_1	244	248	PF13949	0.374
LIG_LYPXL_yS_3	245	248	PF13949	0.375
LIG_Pex14_1	26	30	PF04695	0.417
LIG_Pex14_1	317	321	PF04695	0.505
LIG_SH2_NCK_1	157	161	PF00017	0.582
LIG_SH2_PTP2	260	263	PF00017	0.566
LIG_SH2_STAP1	157	161	PF00017	0.562
LIG_SH2_STAT3	323	326	PF00017	0.405
LIG_SH2_STAT5	132	135	PF00017	0.406
LIG_SH2_STAT5	22	25	PF00017	0.423
LIG_SH2_STAT5	260	263	PF00017	0.566
LIG_SH2_STAT5	28	31	PF00017	0.362
LIG_SH2_STAT5	323	326	PF00017	0.448
LIG_SH2_STAT5	70	73	PF00017	0.502
LIG_SH3_2	125	130	PF14604	0.552
LIG_SH3_3	122	128	PF00018	0.517
LIG_SH3_3	70	76	PF00018	0.498
LIG_SH3_3	91	97	PF00018	0.551
MOD_CDC14_SPxK_1	127	130	PF00782	0.504
MOD_CDK_SPxK_1	124	130	PF00069	0.521
MOD_CDK_SPxxK_3	93	100	PF00069	0.553
MOD_CK1_1	93	99	PF00069	0.574
MOD_CK2_1	106	112	PF00069	0.524
MOD_CK2_1	139	145	PF00069	0.511
MOD_CK2_1	276	282	PF00069	0.609
MOD_CK2_1	92	98	PF00069	0.479
MOD_GlcNHglycan	108	111	PF01048	0.503
MOD_GlcNHglycan	141	144	PF01048	0.561
MOD_GlcNHglycan	193	196	PF01048	0.532
MOD_GlcNHglycan	256	260	PF01048	0.418
MOD_GlcNHglycan	278	282	PF01048	0.595
MOD_GSK3_1	141	148	PF00069	0.605
MOD_GSK3_1	225	232	PF00069	0.383
MOD_GSK3_1	251	258	PF00069	0.381
MOD_GSK3_1	4	11	PF00069	0.603
MOD_GSK3_1	88	95	PF00069	0.470
MOD_GSK3_1	96	103	PF00069	0.516
MOD_NEK2_1	139	144	PF00069	0.526
MOD_NEK2_1	229	234	PF00069	0.453
MOD_NEK2_1	4	9	PF00069	0.597
MOD_NEK2_1	71	76	PF00069	0.431
MOD_NEK2_1	90	95	PF00069	0.453
MOD_PIKK_1	193	199	PF00454	0.413
MOD_PKA_1	100	106	PF00069	0.647
MOD_PKA_2	106	112	PF00069	0.482
MOD_PKA_2	8	14	PF00069	0.492
MOD_Plk_1	18	24	PF00069	0.497
MOD_Plk_4	100	106	PF00069	0.586
MOD_Plk_4	18	24	PF00069	0.503
MOD_Plk_4	240	246	PF00069	0.430
MOD_ProDKin_1	124	130	PF00069	0.521
MOD_ProDKin_1	59	65	PF00069	0.648
MOD_ProDKin_1	93	99	PF00069	0.587
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.444
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.476
TRG_ENDOCYTIC_2	108	111	PF00928	0.480
TRG_ENDOCYTIC_2	132	135	PF00928	0.393
TRG_ENDOCYTIC_2	22	25	PF00928	0.416
TRG_ENDOCYTIC_2	245	248	PF00928	0.366
TRG_ENDOCYTIC_2	260	263	PF00928	0.428
TRG_ENDOCYTIC_2	70	73	PF00928	0.502
TRG_ER_diArg_1	12	14	PF00400	0.454
TRG_ER_diArg_1	209	211	PF00400	0.463
TRG_ER_diArg_1	290	292	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T7	Leptomonas seymouri	72%	97%
A0A0S4KKV6	Bodo saltans	33%	95%
A0A1X0PAA6	Trypanosomatidae	43%	100%
A0A3S5IR23	Trypanosoma rangeli	49%	100%
A0A3S7X8A6	Leishmania donovani	99%	100%
A4HB69	Leishmania braziliensis	86%	100%
C9ZLX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9B5E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2J3	Leishmania major	95%	100%
V5BV68	Trypanosoma cruzi	49%	95%