LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
TPR repeat/Tetratricopeptide repeat - putative
Species:
Leishmania infantum
UniProt:
A4IAB5_LEIIN
TriTrypDb:
LINF_340041800
Length:
425

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IAB5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAB5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 132 136 PF00656 0.417
CLV_C14_Caspase3-7 61 65 PF00656 0.668
CLV_NRD_NRD_1 137 139 PF00675 0.334
CLV_NRD_NRD_1 278 280 PF00675 0.344
CLV_PCSK_KEX2_1 194 196 PF00082 0.532
CLV_PCSK_KEX2_1 235 237 PF00082 0.415
CLV_PCSK_KEX2_1 278 280 PF00082 0.397
CLV_PCSK_KEX2_1 403 405 PF00082 0.358
CLV_PCSK_PC1ET2_1 194 196 PF00082 0.532
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.503
CLV_PCSK_PC1ET2_1 403 405 PF00082 0.217
CLV_PCSK_SKI1_1 138 142 PF00082 0.372
CLV_PCSK_SKI1_1 182 186 PF00082 0.477
CLV_PCSK_SKI1_1 199 203 PF00082 0.267
CLV_PCSK_SKI1_1 205 209 PF00082 0.325
CLV_PCSK_SKI1_1 308 312 PF00082 0.274
CLV_PCSK_SKI1_1 418 422 PF00082 0.522
DEG_APCC_DBOX_1 24 32 PF00400 0.606
DEG_Nend_Nbox_1 1 3 PF02207 0.608
DOC_ANK_TNKS_1 366 373 PF00023 0.427
DOC_CKS1_1 111 116 PF01111 0.571
DOC_MAPK_gen_1 199 209 PF00069 0.335
DOC_MAPK_MEF2A_6 202 210 PF00069 0.335
DOC_PP1_RVXF_1 2 8 PF00149 0.534
DOC_PP2B_LxvP_1 35 38 PF13499 0.533
DOC_USP7_MATH_1 16 20 PF00917 0.684
DOC_USP7_MATH_1 374 378 PF00917 0.448
DOC_USP7_MATH_1 44 48 PF00917 0.620
DOC_USP7_UBL2_3 414 418 PF12436 0.461
DOC_WW_Pin1_4 110 115 PF00397 0.516
DOC_WW_Pin1_4 281 286 PF00397 0.413
DOC_WW_Pin1_4 404 409 PF00397 0.417
LIG_14-3-3_CanoR_1 49 56 PF00244 0.606
LIG_APCC_ABBA_1 175 180 PF00400 0.480
LIG_BIR_III_4 338 342 PF00653 0.334
LIG_eIF4E_1 305 311 PF01652 0.417
LIG_FHA_1 325 331 PF00498 0.232
LIG_FHA_1 67 73 PF00498 0.707
LIG_FHA_1 7 13 PF00498 0.678
LIG_FHA_2 288 294 PF00498 0.289
LIG_LIR_Gen_1 101 107 PF02991 0.444
LIG_LIR_Gen_1 331 339 PF02991 0.275
LIG_LIR_Nem_3 101 106 PF02991 0.463
LIG_LIR_Nem_3 228 234 PF02991 0.497
LIG_LIR_Nem_3 331 336 PF02991 0.275
LIG_SH2_CRK 161 165 PF00017 0.336
LIG_SH2_PTP2 333 336 PF00017 0.417
LIG_SH2_SRC 231 234 PF00017 0.432
LIG_SH2_SRC 353 356 PF00017 0.417
LIG_SH2_STAT3 273 276 PF00017 0.298
LIG_SH2_STAT5 333 336 PF00017 0.289
LIG_SH2_STAT5 353 356 PF00017 0.145
LIG_SH2_STAT5 382 385 PF00017 0.346
LIG_SH3_1 279 285 PF00018 0.417
LIG_SH3_3 111 117 PF00018 0.570
LIG_SH3_3 279 285 PF00018 0.417
LIG_SH3_3 405 411 PF00018 0.417
LIG_Sin3_3 391 398 PF02671 0.417
LIG_SUMO_SIM_anti_2 396 403 PF11976 0.217
LIG_SUMO_SIM_par_1 290 296 PF11976 0.311
LIG_TRAF2_1 171 174 PF00917 0.351
LIG_TRAF2_1 274 277 PF00917 0.350
MOD_CK1_1 39 45 PF00069 0.645
MOD_CK1_1 66 72 PF00069 0.690
MOD_CK2_1 271 277 PF00069 0.417
MOD_CK2_1 287 293 PF00069 0.188
MOD_CK2_1 73 79 PF00069 0.442
MOD_CK2_1 95 101 PF00069 0.477
MOD_GlcNHglycan 376 379 PF01048 0.443
MOD_GlcNHglycan 41 44 PF01048 0.652
MOD_GlcNHglycan 97 100 PF01048 0.491
MOD_GSK3_1 106 113 PF00069 0.454
MOD_GSK3_1 58 65 PF00069 0.668
MOD_N-GLC_1 404 409 PF02516 0.368
MOD_N-GLC_1 58 63 PF02516 0.724
MOD_NEK2_1 133 138 PF00069 0.371
MOD_NEK2_1 185 190 PF00069 0.418
MOD_NEK2_1 287 292 PF00069 0.343
MOD_NEK2_1 329 334 PF00069 0.289
MOD_PIKK_1 324 330 PF00454 0.259
MOD_PIKK_1 345 351 PF00454 0.217
MOD_PIKK_1 44 50 PF00454 0.661
MOD_Plk_1 185 191 PF00069 0.471
MOD_Plk_4 115 121 PF00069 0.445
MOD_Plk_4 287 293 PF00069 0.289
MOD_Plk_4 329 335 PF00069 0.374
MOD_Plk_4 36 42 PF00069 0.650
MOD_Plk_4 397 403 PF00069 0.469
MOD_ProDKin_1 110 116 PF00069 0.505
MOD_ProDKin_1 281 287 PF00069 0.405
MOD_ProDKin_1 404 410 PF00069 0.417
MOD_SUMO_for_1 171 174 PF00179 0.458
MOD_SUMO_rev_2 174 184 PF00179 0.427
TRG_ENDOCYTIC_2 130 133 PF00928 0.309
TRG_ENDOCYTIC_2 161 164 PF00928 0.331
TRG_ENDOCYTIC_2 178 181 PF00928 0.303
TRG_ENDOCYTIC_2 231 234 PF00928 0.432
TRG_ENDOCYTIC_2 333 336 PF00928 0.289
TRG_ER_diArg_1 25 28 PF00400 0.586
TRG_ER_diArg_1 278 280 PF00400 0.462
TRG_ER_diArg_1 361 364 PF00400 0.383
TRG_NES_CRM1_1 132 144 PF08389 0.339
TRG_NES_CRM1_1 180 193 PF08389 0.346
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.417
TRG_Pf-PMV_PEXEL_1 182 186 PF00026 0.368
TRG_Pf-PMV_PEXEL_1 308 312 PF00026 0.289
TRG_Pf-PMV_PEXEL_1 78 82 PF00026 0.533

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCA8 Leptomonas seymouri 74% 96%
A0A0S4IIG6 Bodo saltans 39% 100%
A0A1X0PAU4 Trypanosomatidae 58% 100%
A0A3R7KCS2 Trypanosoma rangeli 55% 100%
A0A3S7X8G8 Leishmania donovani 100% 100%
A4HB67 Leishmania braziliensis 84% 100%
C9ZLY1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B5D8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q2J5 Leishmania major 94% 100%
V5DM07 Trypanosoma cruzi 60% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS