LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAB4_LEIIN
TriTrypDb:
LINF_340041700
Length:
237

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9

Expansion

Sequence features

A4IAB4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAB4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 52 56 PF00656 0.406
CLV_NRD_NRD_1 16 18 PF00675 0.534
CLV_NRD_NRD_1 216 218 PF00675 0.403
CLV_NRD_NRD_1 48 50 PF00675 0.328
CLV_PCSK_KEX2_1 16 18 PF00082 0.525
CLV_PCSK_KEX2_1 216 218 PF00082 0.405
CLV_PCSK_KEX2_1 48 50 PF00082 0.328
CLV_PCSK_PC7_1 12 18 PF00082 0.508
CLV_PCSK_SKI1_1 12 16 PF00082 0.516
CLV_PCSK_SKI1_1 192 196 PF00082 0.342
CLV_PCSK_SKI1_1 96 100 PF00082 0.473
DOC_CYCLIN_RxL_1 114 124 PF00134 0.427
DOC_CYCLIN_RxL_1 9 18 PF00134 0.521
DOC_MAPK_MEF2A_6 128 136 PF00069 0.310
DOC_PP1_RVXF_1 115 122 PF00149 0.415
DOC_PP1_RVXF_1 126 132 PF00149 0.294
DOC_USP7_MATH_1 103 107 PF00917 0.455
DOC_USP7_MATH_1 233 237 PF00917 0.671
DOC_USP7_MATH_1 37 41 PF00917 0.481
DOC_USP7_MATH_1 65 69 PF00917 0.529
DOC_WW_Pin1_4 194 199 PF00397 0.407
DOC_WW_Pin1_4 227 232 PF00397 0.524
DOC_WW_Pin1_4 35 40 PF00397 0.435
LIG_14-3-3_CanoR_1 16 26 PF00244 0.492
LIG_14-3-3_CanoR_1 192 198 PF00244 0.460
LIG_14-3-3_CanoR_1 66 70 PF00244 0.566
LIG_14-3-3_CanoR_1 96 101 PF00244 0.438
LIG_Actin_WH2_2 38 56 PF00022 0.343
LIG_BRCT_BRCA1_1 19 23 PF00533 0.426
LIG_CSL_BTD_1 130 133 PF09270 0.364
LIG_FHA_1 213 219 PF00498 0.431
LIG_FHA_1 9 15 PF00498 0.590
LIG_FHA_2 1 7 PF00498 0.625
LIG_FHA_2 135 141 PF00498 0.409
LIG_GBD_Chelix_1 158 166 PF00786 0.391
LIG_LIR_Gen_1 40 51 PF02991 0.416
LIG_LIR_Gen_1 73 81 PF02991 0.343
LIG_LIR_Nem_3 20 26 PF02991 0.440
LIG_LIR_Nem_3 40 46 PF02991 0.461
LIG_LIR_Nem_3 73 78 PF02991 0.399
LIG_LIR_Nem_3 87 93 PF02991 0.331
LIG_NRBOX 157 163 PF00104 0.309
LIG_Pex14_1 131 135 PF04695 0.359
LIG_SH2_CRK 43 47 PF00017 0.368
LIG_SH2_CRK 97 101 PF00017 0.348
LIG_SH2_NCK_1 97 101 PF00017 0.348
LIG_SH2_PTP2 50 53 PF00017 0.390
LIG_SH2_STAP1 43 47 PF00017 0.412
LIG_SH2_STAT5 125 128 PF00017 0.370
LIG_SH2_STAT5 50 53 PF00017 0.447
LIG_SH2_STAT5 75 78 PF00017 0.356
LIG_SH2_STAT5 90 93 PF00017 0.388
LIG_SH3_3 36 42 PF00018 0.470
LIG_SUMO_SIM_anti_2 155 163 PF11976 0.408
LIG_SUMO_SIM_par_1 23 29 PF11976 0.511
LIG_TRAF2_1 2 5 PF00917 0.679
LIG_TYR_ITIM 41 46 PF00017 0.420
LIG_UBA3_1 190 195 PF00899 0.336
MOD_CK1_1 148 154 PF00069 0.309
MOD_CK1_1 196 202 PF00069 0.407
MOD_GlcNHglycan 105 108 PF01048 0.447
MOD_GlcNHglycan 176 180 PF01048 0.398
MOD_GlcNHglycan 207 210 PF01048 0.328
MOD_GlcNHglycan 61 64 PF01048 0.554
MOD_GSK3_1 143 150 PF00069 0.396
MOD_GSK3_1 194 201 PF00069 0.400
MOD_GSK3_1 229 236 PF00069 0.602
MOD_GSK3_1 31 38 PF00069 0.503
MOD_NEK2_1 143 148 PF00069 0.396
MOD_NEK2_1 15 20 PF00069 0.490
MOD_NEK2_1 162 167 PF00069 0.255
MOD_NEK2_1 175 180 PF00069 0.490
MOD_NEK2_1 193 198 PF00069 0.234
MOD_PIKK_1 148 154 PF00454 0.324
MOD_PIKK_1 198 204 PF00454 0.408
MOD_PKA_2 15 21 PF00069 0.488
MOD_PKA_2 65 71 PF00069 0.556
MOD_Plk_4 121 127 PF00069 0.410
MOD_Plk_4 71 77 PF00069 0.493
MOD_ProDKin_1 194 200 PF00069 0.402
MOD_ProDKin_1 227 233 PF00069 0.531
MOD_ProDKin_1 35 41 PF00069 0.418
TRG_DiLeu_BaLyEn_6 21 26 PF01217 0.521
TRG_DiLeu_BaLyEn_6 9 14 PF01217 0.514
TRG_ENDOCYTIC_2 43 46 PF00928 0.455
TRG_ENDOCYTIC_2 50 53 PF00928 0.440
TRG_ENDOCYTIC_2 75 78 PF00928 0.385
TRG_ENDOCYTIC_2 97 100 PF00928 0.394
TRG_ER_diArg_1 15 17 PF00400 0.532
TRG_ER_diArg_1 216 218 PF00400 0.378
TRG_ER_diArg_1 47 49 PF00400 0.385

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P9Z0 Trypanosomatidae 31% 100%
A0A3S7X8B4 Leishmania donovani 100% 100%
A4HB66 Leishmania braziliensis 75% 100%
C9ZLY2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B5D7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2J6 Leishmania major 92% 100%
V5BQJ6 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2026 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS