LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Metallo-beta-lactamase superfamily - putative
Species:
Leishmania infantum
UniProt:
A4IAA8_LEIIN
TriTrypDb:
LINF_340041100
Length:
515

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAA8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAA8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0004416 hydroxyacylglutathione hydrolase activity 5 3
GO:0016787 hydrolase activity 2 4
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0016790 thiolester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 421 425 PF00656 0.570
CLV_C14_Caspase3-7 431 435 PF00656 0.588
CLV_NRD_NRD_1 508 510 PF00675 0.357
CLV_PCSK_KEX2_1 507 509 PF00082 0.333
CLV_PCSK_SKI1_1 123 127 PF00082 0.610
DOC_CYCLIN_yClb3_PxF_3 63 71 PF00134 0.596
DOC_CYCLIN_yCln2_LP_2 203 209 PF00134 0.492
DOC_MAPK_DCC_7 155 164 PF00069 0.464
DOC_MAPK_gen_1 448 455 PF00069 0.682
DOC_MAPK_MEF2A_6 155 164 PF00069 0.448
DOC_MAPK_MEF2A_6 200 209 PF00069 0.492
DOC_MAPK_MEF2A_6 448 455 PF00069 0.664
DOC_MAPK_MEF2A_6 468 476 PF00069 0.420
DOC_PP1_RVXF_1 256 262 PF00149 0.434
DOC_PP2B_LxvP_1 203 206 PF13499 0.492
DOC_USP7_MATH_1 492 496 PF00917 0.601
DOC_USP7_MATH_2 340 346 PF00917 0.550
DOC_USP7_UBL2_3 485 489 PF12436 0.545
DOC_WW_Pin1_4 115 120 PF00397 0.363
DOC_WW_Pin1_4 277 282 PF00397 0.492
DOC_WW_Pin1_4 317 322 PF00397 0.584
DOC_WW_Pin1_4 403 408 PF00397 0.579
LIG_14-3-3_CanoR_1 353 357 PF00244 0.502
LIG_14-3-3_CanoR_1 361 366 PF00244 0.496
LIG_14-3-3_CanoR_1 399 407 PF00244 0.630
LIG_Actin_WH2_2 107 125 PF00022 0.375
LIG_Actin_WH2_2 469 487 PF00022 0.498
LIG_APCC_ABBA_1 162 167 PF00400 0.522
LIG_APCC_ABBA_1 238 243 PF00400 0.412
LIG_BIR_II_1 1 5 PF00653 0.595
LIG_BIR_III_2 278 282 PF00653 0.480
LIG_BRCT_BRCA1_1 279 283 PF00533 0.495
LIG_BRCT_BRCA1_1 303 307 PF00533 0.396
LIG_BRCT_BRCA1_1 66 70 PF00533 0.584
LIG_BRCT_BRCA1_1 71 75 PF00533 0.567
LIG_Clathr_ClatBox_1 473 477 PF01394 0.528
LIG_EH_1 61 65 PF12763 0.550
LIG_FHA_1 148 154 PF00498 0.534
LIG_FHA_1 176 182 PF00498 0.451
LIG_FHA_1 208 214 PF00498 0.415
LIG_FHA_1 341 347 PF00498 0.507
LIG_FHA_1 384 390 PF00498 0.472
LIG_FHA_2 353 359 PF00498 0.482
LIG_FHA_2 366 372 PF00498 0.590
LIG_FHA_2 404 410 PF00498 0.640
LIG_FHA_2 429 435 PF00498 0.609
LIG_FHA_2 473 479 PF00498 0.527
LIG_LIR_Apic_2 35 40 PF02991 0.407
LIG_LIR_Apic_2 6 10 PF02991 0.480
LIG_LIR_Gen_1 167 176 PF02991 0.397
LIG_LIR_Gen_1 280 290 PF02991 0.480
LIG_LIR_Nem_3 167 172 PF02991 0.432
LIG_LIR_Nem_3 43 49 PF02991 0.321
LIG_LIR_Nem_3 72 78 PF02991 0.431
LIG_LIR_Nem_3 86 92 PF02991 0.204
LIG_MYND_1 253 257 PF01753 0.480
LIG_Pex14_2 132 136 PF04695 0.348
LIG_Pex14_2 64 68 PF04695 0.543
LIG_SH2_CRK 169 173 PF00017 0.439
LIG_SH2_CRK 46 50 PF00017 0.355
LIG_SH2_CRK 89 93 PF00017 0.314
LIG_SH2_NCK_1 137 141 PF00017 0.357
LIG_SH2_SRC 171 174 PF00017 0.489
LIG_SH2_SRC 19 22 PF00017 0.357
LIG_SH2_STAP1 169 173 PF00017 0.405
LIG_SH2_STAP1 19 23 PF00017 0.327
LIG_SH2_STAP1 385 389 PF00017 0.449
LIG_SH2_STAT5 171 174 PF00017 0.396
LIG_SH2_STAT5 380 383 PF00017 0.427
LIG_SH2_STAT5 385 388 PF00017 0.451
LIG_SH2_STAT5 415 418 PF00017 0.507
LIG_SH2_STAT5 46 49 PF00017 0.316
LIG_SH2_STAT5 503 506 PF00017 0.485
LIG_SH2_STAT5 82 85 PF00017 0.295
LIG_SH3_1 234 240 PF00018 0.498
LIG_SH3_3 157 163 PF00018 0.424
LIG_SH3_3 183 189 PF00018 0.401
LIG_SH3_3 233 239 PF00018 0.470
LIG_SH3_3 247 253 PF00018 0.384
LIG_SH3_3 404 410 PF00018 0.612
LIG_SH3_3 450 456 PF00018 0.628
LIG_SH3_3 466 472 PF00018 0.346
LIG_SH3_3 57 63 PF00018 0.531
LIG_SH3_3 88 94 PF00018 0.476
LIG_SH3_3 97 103 PF00018 0.348
LIG_SH3_5 103 107 PF00018 0.233
LIG_SUMO_SIM_anti_2 392 398 PF11976 0.544
LIG_SUMO_SIM_par_1 392 398 PF11976 0.544
LIG_SUMO_SIM_par_1 472 479 PF11976 0.486
LIG_TRAF2_1 240 243 PF00917 0.434
LIG_TRAF2_1 311 314 PF00917 0.564
LIG_TRAF2_1 368 371 PF00917 0.591
LIG_TYR_ITIM 44 49 PF00017 0.357
LIG_TYR_ITIM 87 92 PF00017 0.347
LIG_UBA3_1 172 180 PF00899 0.492
LIG_UBA3_1 227 234 PF00899 0.439
LIG_UBA3_1 74 80 PF00899 0.375
LIG_WRC_WIRS_1 65 70 PF05994 0.586
MOD_CDC14_SPxK_1 118 121 PF00782 0.403
MOD_CDK_SPxK_1 115 121 PF00069 0.396
MOD_CDK_SPxK_1 317 323 PF00069 0.574
MOD_CK1_1 175 181 PF00069 0.396
MOD_CK1_1 277 283 PF00069 0.355
MOD_CK2_1 229 235 PF00069 0.449
MOD_CK2_1 308 314 PF00069 0.480
MOD_CK2_1 352 358 PF00069 0.473
MOD_CK2_1 365 371 PF00069 0.605
MOD_DYRK1A_RPxSP_1 403 407 PF00069 0.589
MOD_GlcNHglycan 26 29 PF01048 0.562
MOD_GlcNHglycan 310 313 PF01048 0.271
MOD_GlcNHglycan 32 35 PF01048 0.592
MOD_GlcNHglycan 512 515 PF01048 0.492
MOD_GlcNHglycan 55 58 PF01048 0.299
MOD_GSK3_1 207 214 PF00069 0.398
MOD_GSK3_1 361 368 PF00069 0.525
MOD_GSK3_1 395 402 PF00069 0.579
MOD_GSK3_1 430 437 PF00069 0.605
MOD_GSK3_1 456 463 PF00069 0.467
MOD_GSK3_1 9 16 PF00069 0.289
MOD_NEK2_1 172 177 PF00069 0.407
MOD_NEK2_1 227 232 PF00069 0.413
MOD_NEK2_1 81 86 PF00069 0.239
MOD_NEK2_2 40 45 PF00069 0.433
MOD_PIKK_1 361 367 PF00454 0.611
MOD_PKA_2 352 358 PF00069 0.545
MOD_PKA_2 398 404 PF00069 0.593
MOD_PKB_1 403 411 PF00069 0.542
MOD_Plk_4 149 155 PF00069 0.497
MOD_Plk_4 188 194 PF00069 0.389
MOD_Plk_4 3 9 PF00069 0.545
MOD_Plk_4 301 307 PF00069 0.402
MOD_Plk_4 328 334 PF00069 0.511
MOD_Plk_4 352 358 PF00069 0.545
MOD_Plk_4 392 398 PF00069 0.542
MOD_Plk_4 64 70 PF00069 0.601
MOD_ProDKin_1 115 121 PF00069 0.370
MOD_ProDKin_1 277 283 PF00069 0.492
MOD_ProDKin_1 317 323 PF00069 0.575
MOD_ProDKin_1 403 409 PF00069 0.570
TRG_DiLeu_BaEn_1 374 379 PF01217 0.519
TRG_DiLeu_BaEn_1 392 397 PF01217 0.587
TRG_DiLeu_BaEn_4 265 271 PF01217 0.423
TRG_DiLeu_BaEn_4 374 380 PF01217 0.509
TRG_DiLeu_BaLyEn_6 250 255 PF01217 0.480
TRG_DiLeu_BaLyEn_6 385 390 PF01217 0.500
TRG_DiLeu_BaLyEn_6 469 474 PF01217 0.446
TRG_DiLeu_BaLyEn_6 73 78 PF01217 0.492
TRG_ENDOCYTIC_2 169 172 PF00928 0.439
TRG_ENDOCYTIC_2 46 49 PF00928 0.375
TRG_ENDOCYTIC_2 89 92 PF00928 0.335
TRG_ER_diArg_1 360 363 PF00400 0.564
TRG_ER_diArg_1 507 509 PF00400 0.506
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.311

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PD83 Leptomonas seymouri 67% 99%
A0A0S4IM37 Bodo saltans 35% 100%
A0A1X0PA00 Trypanosomatidae 37% 100%
A0A3R7K9K9 Trypanosoma rangeli 41% 100%
A0A3S7X8A7 Leishmania donovani 100% 100%
A4HB60 Leishmania braziliensis 83% 100%
C9ZLY8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9B5D1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2K2 Leishmania major 92% 100%
Q8N490 Homo sapiens 29% 100%
V5B5D7 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS