LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAA5_LEIIN
TriTrypDb:
LINF_340040900
Length:
729

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAA5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAA5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 572 576 PF00656 0.741
CLV_C14_Caspase3-7 61 65 PF00656 0.483
CLV_NRD_NRD_1 241 243 PF00675 0.752
CLV_NRD_NRD_1 523 525 PF00675 0.485
CLV_NRD_NRD_1 653 655 PF00675 0.631
CLV_NRD_NRD_1 71 73 PF00675 0.591
CLV_PCSK_KEX2_1 118 120 PF00082 0.502
CLV_PCSK_KEX2_1 241 243 PF00082 0.752
CLV_PCSK_KEX2_1 29 31 PF00082 0.576
CLV_PCSK_KEX2_1 525 527 PF00082 0.529
CLV_PCSK_KEX2_1 652 654 PF00082 0.683
CLV_PCSK_KEX2_1 71 73 PF00082 0.591
CLV_PCSK_PC1ET2_1 118 120 PF00082 0.502
CLV_PCSK_PC1ET2_1 29 31 PF00082 0.576
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.509
CLV_PCSK_PC7_1 649 655 PF00082 0.674
CLV_PCSK_SKI1_1 138 142 PF00082 0.457
CLV_PCSK_SKI1_1 202 206 PF00082 0.614
CLV_PCSK_SKI1_1 307 311 PF00082 0.543
CLV_PCSK_SKI1_1 35 39 PF00082 0.551
CLV_PCSK_SKI1_1 42 46 PF00082 0.523
CLV_PCSK_SKI1_1 584 588 PF00082 0.617
CLV_PCSK_SKI1_1 642 646 PF00082 0.615
CLV_Separin_Metazoa 39 43 PF03568 0.651
CLV_Separin_Metazoa 608 612 PF03568 0.715
DEG_APCC_DBOX_1 34 42 PF00400 0.543
DEG_APCC_DBOX_1 651 659 PF00400 0.675
DEG_APCC_KENBOX_2 335 339 PF00400 0.653
DEG_Nend_Nbox_1 1 3 PF02207 0.598
DEG_SCF_FBW7_1 372 378 PF00400 0.706
DEG_SCF_FBW7_2 685 691 PF00400 0.664
DEG_SPOP_SBC_1 700 704 PF00917 0.571
DOC_CKS1_1 372 377 PF01111 0.700
DOC_CKS1_1 408 413 PF01111 0.684
DOC_CKS1_1 682 687 PF01111 0.656
DOC_CYCLIN_RxL_1 135 144 PF00134 0.504
DOC_CYCLIN_yCln2_LP_2 692 698 PF00134 0.589
DOC_MAPK_gen_1 642 650 PF00069 0.639
DOC_MAPK_gen_1 652 660 PF00069 0.520
DOC_MAPK_HePTP_8 650 662 PF00069 0.684
DOC_MAPK_MEF2A_6 653 662 PF00069 0.590
DOC_PP1_RVXF_1 482 489 PF00149 0.536
DOC_PP2B_LxvP_1 409 412 PF13499 0.614
DOC_PP2B_LxvP_1 692 695 PF13499 0.634
DOC_PP2B_LxvP_1 720 723 PF13499 0.699
DOC_PP2B_PxIxI_1 264 270 PF00149 0.569
DOC_PP4_FxxP_1 488 491 PF00568 0.495
DOC_PP4_FxxP_1 84 87 PF00568 0.434
DOC_USP7_MATH_1 173 177 PF00917 0.599
DOC_USP7_MATH_1 273 277 PF00917 0.737
DOC_USP7_MATH_1 31 35 PF00917 0.526
DOC_USP7_MATH_1 375 379 PF00917 0.720
DOC_USP7_MATH_1 535 539 PF00917 0.606
DOC_USP7_MATH_1 630 634 PF00917 0.672
DOC_USP7_MATH_1 65 69 PF00917 0.541
DOC_USP7_MATH_1 700 704 PF00917 0.707
DOC_USP7_MATH_1 723 727 PF00917 0.672
DOC_WW_Pin1_4 103 108 PF00397 0.463
DOC_WW_Pin1_4 152 157 PF00397 0.475
DOC_WW_Pin1_4 246 251 PF00397 0.768
DOC_WW_Pin1_4 296 301 PF00397 0.635
DOC_WW_Pin1_4 312 317 PF00397 0.352
DOC_WW_Pin1_4 371 376 PF00397 0.760
DOC_WW_Pin1_4 407 412 PF00397 0.667
DOC_WW_Pin1_4 602 607 PF00397 0.724
DOC_WW_Pin1_4 681 686 PF00397 0.746
DOC_WW_Pin1_4 701 706 PF00397 0.777
DOC_WW_Pin1_4 709 714 PF00397 0.694
LIG_14-3-3_CanoR_1 223 228 PF00244 0.608
LIG_14-3-3_CanoR_1 30 38 PF00244 0.539
LIG_14-3-3_CanoR_1 555 560 PF00244 0.576
LIG_14-3-3_CanoR_1 611 617 PF00244 0.749
LIG_APCC_ABBA_1 207 212 PF00400 0.430
LIG_APCC_ABBAyCdc20_2 291 297 PF00400 0.656
LIG_Clathr_ClatBox_1 195 199 PF01394 0.570
LIG_Clathr_ClatBox_1 207 211 PF01394 0.411
LIG_deltaCOP1_diTrp_1 674 680 PF00928 0.800
LIG_eIF4E_1 110 116 PF01652 0.418
LIG_FAT_LD_1 15 23 PF03623 0.503
LIG_FHA_1 153 159 PF00498 0.557
LIG_FHA_1 184 190 PF00498 0.440
LIG_FHA_1 199 205 PF00498 0.515
LIG_FHA_1 264 270 PF00498 0.736
LIG_FHA_1 508 514 PF00498 0.613
LIG_FHA_1 549 555 PF00498 0.752
LIG_FHA_1 594 600 PF00498 0.619
LIG_FHA_1 617 623 PF00498 0.703
LIG_FHA_1 715 721 PF00498 0.698
LIG_FHA_2 273 279 PF00498 0.778
LIG_FHA_2 437 443 PF00498 0.666
LIG_FHA_2 450 456 PF00498 0.607
LIG_FHA_2 475 481 PF00498 0.557
LIG_FHA_2 568 574 PF00498 0.571
LIG_Integrin_isoDGR_2 338 340 PF01839 0.657
LIG_Integrin_isoDGR_2 502 504 PF01839 0.537
LIG_IRF3_LxIS_1 137 144 PF10401 0.452
LIG_LIR_Apic_2 186 190 PF02991 0.539
LIG_LIR_Gen_1 111 120 PF02991 0.480
LIG_LIR_Gen_1 131 142 PF02991 0.374
LIG_LIR_Gen_1 177 188 PF02991 0.469
LIG_LIR_Gen_1 283 292 PF02991 0.636
LIG_LIR_Gen_1 494 501 PF02991 0.520
LIG_LIR_Gen_1 646 655 PF02991 0.670
LIG_LIR_Gen_1 679 688 PF02991 0.783
LIG_LIR_Nem_3 131 137 PF02991 0.488
LIG_LIR_Nem_3 152 157 PF02991 0.577
LIG_LIR_Nem_3 177 183 PF02991 0.487
LIG_LIR_Nem_3 283 288 PF02991 0.649
LIG_LIR_Nem_3 302 308 PF02991 0.293
LIG_LIR_Nem_3 494 500 PF02991 0.513
LIG_LIR_Nem_3 565 571 PF02991 0.710
LIG_LIR_Nem_3 646 650 PF02991 0.669
LIG_LIR_Nem_3 679 683 PF02991 0.794
LIG_NRBOX 14 20 PF00104 0.504
LIG_NRBOX 226 232 PF00104 0.544
LIG_PCNA_yPIPBox_3 359 367 PF02747 0.514
LIG_PDZ_Class_2 724 729 PF00595 0.744
LIG_Pex14_1 617 621 PF04695 0.647
LIG_Pex14_2 324 328 PF04695 0.511
LIG_Pex14_2 9 13 PF04695 0.533
LIG_PTB_Apo_2 148 155 PF02174 0.485
LIG_PTB_Phospho_1 148 154 PF10480 0.587
LIG_RPA_C_Fungi 649 661 PF08784 0.681
LIG_SH2_CRK 120 124 PF00017 0.584
LIG_SH2_CRK 134 138 PF00017 0.346
LIG_SH2_CRK 154 158 PF00017 0.215
LIG_SH2_CRK 187 191 PF00017 0.545
LIG_SH2_CRK 497 501 PF00017 0.504
LIG_SH2_GRB2like 366 369 PF00017 0.512
LIG_SH2_GRB2like 629 632 PF00017 0.651
LIG_SH2_NCK_1 187 191 PF00017 0.545
LIG_SH2_NCK_1 497 501 PF00017 0.504
LIG_SH2_NCK_1 629 633 PF00017 0.733
LIG_SH2_SRC 629 632 PF00017 0.651
LIG_SH2_STAP1 55 59 PF00017 0.531
LIG_SH2_STAT5 154 157 PF00017 0.548
LIG_SH2_STAT5 2 5 PF00017 0.665
LIG_SH2_STAT5 216 219 PF00017 0.477
LIG_SH2_STAT5 308 311 PF00017 0.493
LIG_SH2_STAT5 366 369 PF00017 0.534
LIG_SH2_STAT5 519 522 PF00017 0.606
LIG_SH2_STAT5 647 650 PF00017 0.545
LIG_SH2_STAT5 83 86 PF00017 0.440
LIG_SH3_3 197 203 PF00018 0.601
LIG_SH3_3 391 397 PF00018 0.772
LIG_SH3_3 417 423 PF00018 0.842
LIG_SH3_3 635 641 PF00018 0.685
LIG_SH3_3 666 672 PF00018 0.765
LIG_SH3_3 679 685 PF00018 0.467
LIG_SUMO_SIM_anti_2 556 561 PF11976 0.569
LIG_SUMO_SIM_par_1 265 272 PF11976 0.646
LIG_SUMO_SIM_par_1 585 591 PF11976 0.677
LIG_TRAF2_1 275 278 PF00917 0.699
LIG_TRAF2_1 570 573 PF00917 0.570
LIG_TRAF2_1 605 608 PF00917 0.563
LIG_TRAF2_2 316 321 PF00917 0.542
LIG_TRFH_1 497 501 PF08558 0.504
LIG_WRC_WIRS_1 10 15 PF05994 0.589
LIG_WRC_WIRS_1 59 64 PF05994 0.482
LIG_WW_3 423 427 PF00397 0.757
MOD_CDC14_SPxK_1 254 257 PF00782 0.615
MOD_CDK_SPxK_1 251 257 PF00069 0.613
MOD_CK1_1 152 158 PF00069 0.570
MOD_CK1_1 229 235 PF00069 0.695
MOD_CK1_1 249 255 PF00069 0.452
MOD_CK1_1 272 278 PF00069 0.697
MOD_CK1_1 378 384 PF00069 0.755
MOD_CK1_1 602 608 PF00069 0.720
MOD_CK2_1 272 278 PF00069 0.782
MOD_CK2_1 296 302 PF00069 0.522
MOD_CK2_1 436 442 PF00069 0.603
MOD_CK2_1 460 466 PF00069 0.623
MOD_CK2_1 474 480 PF00069 0.469
MOD_CK2_1 567 573 PF00069 0.572
MOD_CK2_1 602 608 PF00069 0.655
MOD_CK2_1 700 706 PF00069 0.710
MOD_GlcNHglycan 143 146 PF01048 0.535
MOD_GlcNHglycan 251 254 PF01048 0.685
MOD_GlcNHglycan 261 264 PF01048 0.671
MOD_GlcNHglycan 271 274 PF01048 0.619
MOD_GlcNHglycan 389 393 PF01048 0.761
MOD_GlcNHglycan 433 436 PF01048 0.698
MOD_GlcNHglycan 530 533 PF01048 0.639
MOD_GlcNHglycan 536 540 PF01048 0.616
MOD_GlcNHglycan 545 548 PF01048 0.515
MOD_GSK3_1 198 205 PF00069 0.577
MOD_GSK3_1 225 232 PF00069 0.639
MOD_GSK3_1 259 266 PF00069 0.674
MOD_GSK3_1 268 275 PF00069 0.646
MOD_GSK3_1 371 378 PF00069 0.675
MOD_GSK3_1 427 434 PF00069 0.728
MOD_GSK3_1 456 463 PF00069 0.645
MOD_GSK3_1 5 12 PF00069 0.517
MOD_GSK3_1 543 550 PF00069 0.686
MOD_GSK3_1 588 595 PF00069 0.599
MOD_GSK3_1 616 623 PF00069 0.705
MOD_N-GLC_1 150 155 PF02516 0.597
MOD_N-GLC_1 378 383 PF02516 0.720
MOD_N-GLC_1 5 10 PF02516 0.514
MOD_N-GLC_1 630 635 PF02516 0.676
MOD_NEK2_1 149 154 PF00069 0.580
MOD_NEK2_1 183 188 PF00069 0.544
MOD_NEK2_1 230 235 PF00069 0.601
MOD_NEK2_1 599 604 PF00069 0.623
MOD_NEK2_1 9 14 PF00069 0.490
MOD_NEK2_2 449 454 PF00069 0.615
MOD_NEK2_2 55 60 PF00069 0.537
MOD_PIKK_1 126 132 PF00454 0.620
MOD_PIKK_1 167 173 PF00454 0.599
MOD_PIKK_1 314 320 PF00454 0.639
MOD_PIKK_1 404 410 PF00454 0.662
MOD_PIKK_1 436 442 PF00454 0.603
MOD_PIKK_1 44 50 PF00454 0.563
MOD_PIKK_1 466 472 PF00454 0.648
MOD_PIKK_1 610 616 PF00454 0.745
MOD_PIKK_1 721 727 PF00454 0.714
MOD_PK_1 555 561 PF00069 0.572
MOD_PK_1 654 660 PF00069 0.679
MOD_PKA_2 474 480 PF00069 0.571
MOD_PKA_2 610 616 PF00069 0.709
MOD_PKB_1 223 231 PF00069 0.506
MOD_PKB_1 652 660 PF00069 0.680
MOD_Plk_1 150 156 PF00069 0.589
MOD_Plk_1 320 326 PF00069 0.642
MOD_Plk_1 456 462 PF00069 0.622
MOD_Plk_1 5 11 PF00069 0.563
MOD_Plk_2-3 588 594 PF00069 0.707
MOD_Plk_4 14 20 PF00069 0.406
MOD_Plk_4 175 181 PF00069 0.596
MOD_Plk_4 226 232 PF00069 0.646
MOD_Plk_4 456 462 PF00069 0.676
MOD_Plk_4 5 11 PF00069 0.576
MOD_Plk_4 555 561 PF00069 0.572
MOD_Plk_4 643 649 PF00069 0.597
MOD_ProDKin_1 103 109 PF00069 0.458
MOD_ProDKin_1 152 158 PF00069 0.468
MOD_ProDKin_1 246 252 PF00069 0.770
MOD_ProDKin_1 296 302 PF00069 0.623
MOD_ProDKin_1 312 318 PF00069 0.355
MOD_ProDKin_1 371 377 PF00069 0.767
MOD_ProDKin_1 407 413 PF00069 0.668
MOD_ProDKin_1 602 608 PF00069 0.720
MOD_ProDKin_1 681 687 PF00069 0.746
MOD_ProDKin_1 701 707 PF00069 0.780
MOD_ProDKin_1 709 715 PF00069 0.692
MOD_SUMO_rev_2 521 527 PF00179 0.540
TRG_DiLeu_BaEn_2 336 342 PF01217 0.667
TRG_DiLeu_BaLyEn_6 646 651 PF01217 0.667
TRG_ENDOCYTIC_2 110 113 PF00928 0.465
TRG_ENDOCYTIC_2 120 123 PF00928 0.485
TRG_ENDOCYTIC_2 134 137 PF00928 0.376
TRG_ENDOCYTIC_2 154 157 PF00928 0.218
TRG_ENDOCYTIC_2 216 219 PF00928 0.477
TRG_ENDOCYTIC_2 497 500 PF00928 0.486
TRG_ENDOCYTIC_2 568 571 PF00928 0.671
TRG_ENDOCYTIC_2 647 650 PF00928 0.566
TRG_ENDOCYTIC_2 83 86 PF00928 0.440
TRG_ER_diArg_1 240 242 PF00400 0.725
TRG_ER_diArg_1 310 313 PF00400 0.519
TRG_ER_diArg_1 524 527 PF00400 0.486
TRG_ER_diArg_1 651 654 PF00400 0.677
TRG_Pf-PMV_PEXEL_1 365 369 PF00026 0.562
TRG_Pf-PMV_PEXEL_1 462 466 PF00026 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I561 Leptomonas seymouri 45% 99%
A0A3S7X8F7 Leishmania donovani 100% 100%
A4HB58 Leishmania braziliensis 80% 100%
E9B5C8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q2K5 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS