D-aminoacyl-tRNA deacylase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-Tyr-tRNA(Tyr) deacylase - putative

Species:

Leishmania infantum

UniProt:

A4IAA2_LEIIN

TriTrypDb:

LINF_340040600

Length:

211

Annotations

Annotations by Jardim et al.

Amino acid metabolism, D-Tyr-tRNA(Tyr) deacylase, putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAA2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006399	tRNA metabolic process	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0051499	D-aminoacyl-tRNA deacylase activity	6	11
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.472
CLV_C14_Caspase3-7	63	67	PF00656	0.468
CLV_PCSK_SKI1_1	29	33	PF00082	0.227
CLV_PCSK_SKI1_1	86	90	PF00082	0.242
DEG_APCC_DBOX_1	28	36	PF00400	0.293
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DOC_MAPK_gen_1	122	130	PF00069	0.434
DOC_MAPK_gen_1	18	28	PF00069	0.497
DOC_MAPK_gen_1	47	57	PF00069	0.496
DOC_MAPK_MEF2A_6	21	30	PF00069	0.441
DOC_MAPK_MEF2A_6	50	59	PF00069	0.441
DOC_MAPK_MEF2A_6	76	83	PF00069	0.500
DOC_PP1_RVXF_1	124	131	PF00149	0.432
DOC_PP2B_LxvP_1	112	115	PF13499	0.409
DOC_USP7_MATH_1	115	119	PF00917	0.470
DOC_WW_Pin1_4	89	94	PF00397	0.498
LIG_BIR_III_4	162	166	PF00653	0.451
LIG_BRCT_BRCA1_1	126	130	PF00533	0.500
LIG_BRCT_BRCA1_1	187	191	PF00533	0.496
LIG_EH1_1	76	84	PF00400	0.468
LIG_FHA_1	25	31	PF00498	0.350
LIG_LIR_Gen_1	127	138	PF02991	0.500
LIG_LIR_Gen_1	144	153	PF02991	0.439
LIG_LIR_Gen_1	202	211	PF02991	0.444
LIG_LIR_Gen_1	85	96	PF02991	0.500
LIG_LIR_Nem_3	127	133	PF02991	0.500
LIG_LIR_Nem_3	144	149	PF02991	0.439
LIG_LIR_Nem_3	177	182	PF02991	0.501
LIG_LIR_Nem_3	85	91	PF02991	0.500
LIG_PCNA_PIPBox_1	84	93	PF02747	0.454
LIG_PDZ_Class_2	206	211	PF00595	0.420
LIG_Pex14_2	205	209	PF04695	0.496
LIG_SH2_CRK	16	20	PF00017	0.485
LIG_SH2_STAT5	48	51	PF00017	0.427
LIG_SH2_STAT5	58	61	PF00017	0.409
LIG_SH3_3	4	10	PF00018	0.387
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.420
LIG_TRAF2_1	102	105	PF00917	0.467
LIG_TYR_ITIM	14	19	PF00017	0.448
MOD_CDC14_SPxK_1	92	95	PF00782	0.500
MOD_CDK_SPxK_1	89	95	PF00069	0.498
MOD_CK2_1	99	105	PF00069	0.455
MOD_GlcNHglycan	187	190	PF01048	0.265
MOD_GlcNHglycan	66	69	PF01048	0.332
MOD_GSK3_1	181	188	PF00069	0.499
MOD_GSK3_1	60	67	PF00069	0.529
MOD_GSK3_1	82	89	PF00069	0.457
MOD_NEK2_1	82	87	PF00069	0.500
MOD_PK_1	124	130	PF00069	0.500
MOD_PKA_2	64	70	PF00069	0.468
MOD_Plk_1	156	162	PF00069	0.444
MOD_ProDKin_1	89	95	PF00069	0.498
MOD_SUMO_for_1	174	177	PF00179	0.490
TRG_DiLeu_BaEn_1	108	113	PF01217	0.523
TRG_ENDOCYTIC_2	143	146	PF00928	0.434
TRG_ENDOCYTIC_2	16	19	PF00928	0.488
TRG_ENDOCYTIC_2	58	61	PF00928	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW6	Leptomonas seymouri	78%	100%
A0A0S4JLF2	Bodo saltans	38%	100%
A0A1X0P9Y0	Trypanosomatidae	51%	100%
A0A3S7X8A0	Leishmania donovani	100%	100%
A0A422NEP7	Trypanosoma rangeli	50%	100%
A4HB55	Leishmania braziliensis	79%	100%
C9ZLZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E1C762	Gallus gallus	32%	100%
E9B5C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P84066	Leishmania major	97%	100%
Q4Q2K8	Leishmania major	96%	100%
Q68EL2	Danio rerio	30%	100%
Q8BHA3	Mus musculus	30%	100%
Q96FN9	Homo sapiens	31%	100%