Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IA96_LEIIN

TriTrypDb:

LINF_340039900

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.489
CLV_C14_Caspase3-7	58	62	PF00656	0.411
CLV_NRD_NRD_1	166	168	PF00675	0.623
CLV_NRD_NRD_1	22	24	PF00675	0.656
CLV_NRD_NRD_1	387	389	PF00675	0.360
CLV_PCSK_KEX2_1	166	168	PF00082	0.586
CLV_PCSK_KEX2_1	21	23	PF00082	0.688
CLV_PCSK_KEX2_1	470	472	PF00082	0.529
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.529
CLV_PCSK_SKI1_1	109	113	PF00082	0.602
CLV_PCSK_SKI1_1	124	128	PF00082	0.526
CLV_PCSK_SKI1_1	167	171	PF00082	0.591
CLV_PCSK_SKI1_1	180	184	PF00082	0.611
CLV_PCSK_SKI1_1	257	261	PF00082	0.579
DEG_APCC_DBOX_1	179	187	PF00400	0.462
DEG_SPOP_SBC_1	405	409	PF00917	0.634
DOC_ANK_TNKS_1	324	331	PF00023	0.396
DOC_CYCLIN_yCln2_LP_2	182	185	PF00134	0.369
DOC_MAPK_DCC_7	180	188	PF00069	0.432
DOC_MAPK_MEF2A_6	12	20	PF00069	0.431
DOC_MAPK_MEF2A_6	180	188	PF00069	0.432
DOC_PP1_RVXF_1	234	241	PF00149	0.468
DOC_PP1_RVXF_1	263	270	PF00149	0.431
DOC_PP1_RVXF_1	361	367	PF00149	0.436
DOC_PP2B_LxvP_1	127	130	PF13499	0.403
DOC_PP2B_LxvP_1	182	185	PF13499	0.369
DOC_PP2B_LxvP_1	473	476	PF13499	0.686
DOC_USP7_MATH_1	156	160	PF00917	0.404
DOC_USP7_MATH_1	296	300	PF00917	0.366
DOC_USP7_MATH_1	41	45	PF00917	0.401
DOC_USP7_MATH_1	415	419	PF00917	0.688
DOC_USP7_MATH_1	56	60	PF00917	0.387
DOC_USP7_MATH_1	88	92	PF00917	0.549
DOC_WW_Pin1_4	174	179	PF00397	0.432
DOC_WW_Pin1_4	84	89	PF00397	0.510
LIG_14-3-3_CanoR_1	201	208	PF00244	0.428
LIG_14-3-3_CanoR_1	291	296	PF00244	0.358
LIG_14-3-3_CanoR_1	325	329	PF00244	0.350
LIG_14-3-3_CanoR_1	363	369	PF00244	0.366
LIG_14-3-3_CanoR_1	37	45	PF00244	0.422
LIG_14-3-3_CanoR_1	388	397	PF00244	0.638
LIG_14-3-3_CanoR_1	77	81	PF00244	0.372
LIG_Actin_WH2_2	252	267	PF00022	0.376
LIG_Actin_WH2_2	383	400	PF00022	0.631
LIG_AP2alpha_1	307	311	PF02296	0.403
LIG_BRCT_BRCA1_1	307	311	PF00533	0.467
LIG_Clathr_ClatBox_1	111	115	PF01394	0.411
LIG_CtBP_PxDLS_1	439	443	PF00389	0.641
LIG_deltaCOP1_diTrp_1	105	110	PF00928	0.345
LIG_FHA_1	254	260	PF00498	0.369
LIG_FHA_1	26	32	PF00498	0.490
LIG_FHA_1	350	356	PF00498	0.420
LIG_FHA_1	375	381	PF00498	0.296
LIG_FHA_1	426	432	PF00498	0.639
LIG_FHA_1	447	453	PF00498	0.595
LIG_FHA_2	422	428	PF00498	0.693
LIG_FHA_2	50	56	PF00498	0.460
LIG_LIR_Gen_1	191	198	PF02991	0.440
LIG_LIR_Gen_1	200	208	PF02991	0.429
LIG_LIR_Gen_1	234	244	PF02991	0.382
LIG_LIR_Gen_1	305	315	PF02991	0.350
LIG_LIR_Gen_1	367	376	PF02991	0.383
LIG_LIR_Gen_1	427	438	PF02991	0.669
LIG_LIR_Gen_1	44	51	PF02991	0.372
LIG_LIR_Nem_3	191	195	PF02991	0.436
LIG_LIR_Nem_3	200	205	PF02991	0.409
LIG_LIR_Nem_3	234	240	PF02991	0.419
LIG_LIR_Nem_3	305	310	PF02991	0.425
LIG_LIR_Nem_3	367	371	PF02991	0.371
LIG_LIR_Nem_3	427	433	PF02991	0.674
LIG_LIR_Nem_3	44	48	PF02991	0.361
LIG_MLH1_MIPbox_1	307	311	PF16413	0.470
LIG_MYND_3	380	384	PF01753	0.622
LIG_Pex14_1	454	458	PF04695	0.585
LIG_Pex14_2	195	199	PF04695	0.358
LIG_Pex14_2	307	311	PF04695	0.403
LIG_REV1ctd_RIR_1	158	167	PF16727	0.365
LIG_SH2_STAP1	45	49	PF00017	0.450
LIG_SH2_STAT5	237	240	PF00017	0.341
LIG_SH2_STAT5	45	48	PF00017	0.457
LIG_SH3_3	375	381	PF00018	0.383
LIG_SUMO_SIM_par_1	115	123	PF11976	0.419
LIG_SUMO_SIM_par_1	27	32	PF11976	0.479
LIG_TRAF2_1	424	427	PF00917	0.704
LIG_TRAF2_1	62	65	PF00917	0.428
LIG_UBA3_1	260	265	PF00899	0.378
LIG_UBA3_1	38	47	PF00899	0.427
LIG_WRC_WIRS_1	157	162	PF05994	0.404
MOD_CDK_SPxK_1	174	180	PF00069	0.438
MOD_CK1_1	200	206	PF00069	0.417
MOD_CK1_1	263	269	PF00069	0.359
MOD_CK1_1	305	311	PF00069	0.444
MOD_CK1_1	91	97	PF00069	0.553
MOD_CK2_1	419	425	PF00069	0.713
MOD_CK2_1	438	444	PF00069	0.487
MOD_CK2_1	49	55	PF00069	0.463
MOD_CMANNOS	107	110	PF00535	0.539
MOD_CMANNOS	365	368	PF00535	0.436
MOD_GlcNHglycan	139	142	PF01048	0.714
MOD_GlcNHglycan	146	149	PF01048	0.627
MOD_GlcNHglycan	225	228	PF01048	0.672
MOD_GlcNHglycan	314	318	PF01048	0.593
MOD_GlcNHglycan	39	42	PF01048	0.660
MOD_GlcNHglycan	392	395	PF01048	0.382
MOD_GlcNHglycan	416	420	PF01048	0.545
MOD_GlcNHglycan	446	449	PF01048	0.404
MOD_GlcNHglycan	57	61	PF01048	0.571
MOD_GlcNHglycan	93	96	PF01048	0.765
MOD_GSK3_1	167	174	PF00069	0.423
MOD_GSK3_1	298	305	PF00069	0.426
MOD_GSK3_1	345	352	PF00069	0.328
MOD_GSK3_1	37	44	PF00069	0.434
MOD_GSK3_1	370	377	PF00069	0.288
MOD_GSK3_1	400	407	PF00069	0.634
MOD_GSK3_1	415	422	PF00069	0.752
MOD_GSK3_1	440	447	PF00069	0.632
MOD_GSK3_1	84	91	PF00069	0.526
MOD_N-GLC_1	302	307	PF02516	0.644
MOD_NEK2_1	188	193	PF00069	0.344
MOD_NEK2_1	260	265	PF00069	0.431
MOD_NEK2_1	364	369	PF00069	0.503
MOD_NEK2_1	383	388	PF00069	0.464
MOD_NEK2_1	390	395	PF00069	0.568
MOD_NEK2_2	156	161	PF00069	0.401
MOD_PIKK_1	113	119	PF00454	0.378
MOD_PIKK_1	298	304	PF00454	0.419
MOD_PIKK_1	345	351	PF00454	0.325
MOD_PKA_2	200	206	PF00069	0.399
MOD_PKA_2	324	330	PF00069	0.359
MOD_PKA_2	345	351	PF00069	0.382
MOD_PKA_2	76	82	PF00069	0.371
MOD_Plk_1	16	22	PF00069	0.513
MOD_Plk_1	302	308	PF00069	0.448
MOD_Plk_1	383	389	PF00069	0.623
MOD_Plk_2-3	27	33	PF00069	0.434
MOD_Plk_4	156	162	PF00069	0.385
MOD_Plk_4	374	380	PF00069	0.323
MOD_Plk_4	425	431	PF00069	0.641
MOD_Plk_4	67	73	PF00069	0.367
MOD_Plk_4	76	82	PF00069	0.383
MOD_ProDKin_1	174	180	PF00069	0.438
MOD_ProDKin_1	84	90	PF00069	0.512
TRG_DiLeu_BaEn_1	469	474	PF01217	0.667
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.422
TRG_ENDOCYTIC_2	192	195	PF00928	0.390
TRG_ENDOCYTIC_2	237	240	PF00928	0.352
TRG_ENDOCYTIC_2	45	48	PF00928	0.364
TRG_ER_diArg_1	20	23	PF00400	0.484
TRG_ER_diArg_1	290	293	PF00400	0.344
TRG_NES_CRM1_1	322	336	PF08389	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P448	Leptomonas seymouri	33%	96%
A0A3S7X8E6	Leishmania donovani	99%	100%
A4HB48	Leishmania braziliensis	69%	100%
E9B5B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2L5	Leishmania major	88%	100%