LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

UBP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
UBP-type domain-containing protein
Gene product:
Zn-finger in ubiquitin-hydrolases and other protein - putative
Species:
Leishmania infantum
UniProt:
A4IA95_LEIIN
TriTrypDb:
LINF_340039800 *
Length:
587

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IA95
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA95

Function

Biological processes
Term Name Level Count
GO:0006807 nitrogen compound metabolic process 2 1
GO:0007165 signal transduction 2 1
GO:0007264 small GTPase mediated signal transduction 4 1
GO:0007265 Ras protein signal transduction 5 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0008270 zinc ion binding 6 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12
GO:0046914 transition metal ion binding 5 12
GO:0003824 catalytic activity 1 2
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061630 ubiquitin protein ligase activity 5 1
GO:0061659 ubiquitin-like protein ligase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 115 119 PF00656 0.289
CLV_C14_Caspase3-7 175 179 PF00656 0.515
CLV_C14_Caspase3-7 395 399 PF00656 0.531
CLV_C14_Caspase3-7 75 79 PF00656 0.634
CLV_NRD_NRD_1 235 237 PF00675 0.489
CLV_NRD_NRD_1 36 38 PF00675 0.307
CLV_NRD_NRD_1 465 467 PF00675 0.604
CLV_NRD_NRD_1 539 541 PF00675 0.562
CLV_NRD_NRD_1 574 576 PF00675 0.719
CLV_PCSK_KEX2_1 235 237 PF00082 0.489
CLV_PCSK_KEX2_1 400 402 PF00082 0.471
CLV_PCSK_KEX2_1 464 466 PF00082 0.574
CLV_PCSK_KEX2_1 539 541 PF00082 0.594
CLV_PCSK_KEX2_1 574 576 PF00082 0.725
CLV_PCSK_PC1ET2_1 400 402 PF00082 0.514
CLV_PCSK_PC1ET2_1 464 466 PF00082 0.606
CLV_PCSK_SKI1_1 38 42 PF00082 0.331
CLV_PCSK_SKI1_1 380 384 PF00082 0.597
CLV_PCSK_SKI1_1 400 404 PF00082 0.247
CLV_PCSK_SKI1_1 476 480 PF00082 0.564
CLV_PCSK_SKI1_1 500 504 PF00082 0.530
CLV_PCSK_SKI1_1 522 526 PF00082 0.568
CLV_PCSK_SKI1_1 552 556 PF00082 0.696
DEG_Nend_Nbox_1 1 3 PF02207 0.293
DEG_SPOP_SBC_1 157 161 PF00917 0.449
DEG_SPOP_SBC_1 72 76 PF00917 0.611
DOC_CKS1_1 45 50 PF01111 0.511
DOC_CYCLIN_yClb5_NLxxxL_5 476 482 PF00134 0.550
DOC_MAPK_gen_1 8 17 PF00069 0.491
DOC_MAPK_MEF2A_6 266 274 PF00069 0.513
DOC_PP4_FxxP_1 45 48 PF00568 0.378
DOC_USP7_MATH_1 120 124 PF00917 0.445
DOC_USP7_MATH_1 133 137 PF00917 0.450
DOC_USP7_MATH_1 253 257 PF00917 0.513
DOC_USP7_MATH_1 350 354 PF00917 0.698
DOC_USP7_MATH_1 453 457 PF00917 0.611
DOC_USP7_MATH_1 48 52 PF00917 0.451
DOC_USP7_MATH_1 502 506 PF00917 0.575
DOC_USP7_MATH_1 72 76 PF00917 0.670
DOC_USP7_MATH_1 79 83 PF00917 0.700
DOC_USP7_MATH_1 89 93 PF00917 0.327
DOC_USP7_UBL2_3 368 372 PF12436 0.558
DOC_USP7_UBL2_3 377 381 PF12436 0.459
DOC_USP7_UBL2_3 38 42 PF12436 0.341
DOC_WW_Pin1_4 206 211 PF00397 0.484
DOC_WW_Pin1_4 360 365 PF00397 0.706
DOC_WW_Pin1_4 44 49 PF00397 0.512
LIG_14-3-3_CanoR_1 158 163 PF00244 0.459
LIG_14-3-3_CanoR_1 429 439 PF00244 0.670
LIG_14-3-3_CanoR_1 465 475 PF00244 0.525
LIG_14-3-3_CanoR_1 516 524 PF00244 0.474
LIG_Actin_WH2_2 489 506 PF00022 0.500
LIG_AP2alpha_2 269 271 PF02296 0.464
LIG_EH1_1 318 326 PF00400 0.567
LIG_FHA_1 10 16 PF00498 0.402
LIG_FHA_1 222 228 PF00498 0.497
LIG_FHA_1 304 310 PF00498 0.451
LIG_FHA_1 45 51 PF00498 0.383
LIG_FHA_1 466 472 PF00498 0.620
LIG_FHA_1 487 493 PF00498 0.541
LIG_FHA_1 91 97 PF00498 0.495
LIG_FHA_2 17 23 PF00498 0.503
LIG_FHA_2 173 179 PF00498 0.538
LIG_FHA_2 432 438 PF00498 0.612
LIG_FHA_2 447 453 PF00498 0.589
LIG_FHA_2 482 488 PF00498 0.579
LIG_FHA_2 525 531 PF00498 0.446
LIG_LIR_Apic_2 183 189 PF02991 0.380
LIG_LIR_Apic_2 44 48 PF02991 0.392
LIG_LIR_Gen_1 269 279 PF02991 0.453
LIG_LIR_Gen_1 282 289 PF02991 0.454
LIG_LIR_Gen_1 331 338 PF02991 0.604
LIG_LIR_Gen_1 443 451 PF02991 0.623
LIG_LIR_Gen_1 51 60 PF02991 0.425
LIG_LIR_Nem_3 183 188 PF02991 0.368
LIG_LIR_Nem_3 269 274 PF02991 0.453
LIG_LIR_Nem_3 331 337 PF02991 0.598
LIG_LIR_Nem_3 44 49 PF02991 0.401
LIG_LIR_Nem_3 443 447 PF02991 0.614
LIG_LIR_Nem_3 449 454 PF02991 0.569
LIG_LIR_Nem_3 51 57 PF02991 0.290
LIG_PCNA_PIPBox_1 99 108 PF02747 0.425
LIG_Pex14_2 41 45 PF04695 0.349
LIG_SH2_CRK 389 393 PF00017 0.569
LIG_SH2_PTP2 444 447 PF00017 0.453
LIG_SH2_PTP2 54 57 PF00017 0.267
LIG_SH2_STAP1 378 382 PF00017 0.520
LIG_SH2_STAP1 389 393 PF00017 0.413
LIG_SH2_STAP1 404 408 PF00017 0.457
LIG_SH2_STAT3 205 208 PF00017 0.529
LIG_SH2_STAT3 243 246 PF00017 0.509
LIG_SH2_STAT3 404 407 PF00017 0.572
LIG_SH2_STAT5 163 166 PF00017 0.470
LIG_SH2_STAT5 187 190 PF00017 0.351
LIG_SH2_STAT5 278 281 PF00017 0.492
LIG_SH2_STAT5 444 447 PF00017 0.561
LIG_SH2_STAT5 54 57 PF00017 0.267
LIG_SH3_1 186 192 PF00018 0.446
LIG_SH3_3 186 192 PF00018 0.446
LIG_SUMO_SIM_anti_2 139 145 PF11976 0.467
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.613
LIG_SUMO_SIM_par_1 12 23 PF11976 0.452
LIG_SUMO_SIM_par_1 320 329 PF11976 0.446
LIG_SUMO_SIM_par_1 92 97 PF11976 0.327
LIG_TYR_ITIM 2 7 PF00017 0.306
LIG_TYR_ITSM 181 188 PF00017 0.399
LIG_UBA3_1 458 464 PF00899 0.514
MOD_CK1_1 100 106 PF00069 0.376
MOD_CK1_1 20 26 PF00069 0.483
MOD_CK1_1 221 227 PF00069 0.546
MOD_CK1_1 328 334 PF00069 0.471
MOD_CK1_1 44 50 PF00069 0.388
MOD_CK1_1 498 504 PF00069 0.554
MOD_CK1_1 90 96 PF00069 0.467
MOD_CK2_1 16 22 PF00069 0.523
MOD_CK2_1 431 437 PF00069 0.591
MOD_CK2_1 446 452 PF00069 0.592
MOD_CK2_1 481 487 PF00069 0.547
MOD_CK2_1 517 523 PF00069 0.496
MOD_Cter_Amidation 572 575 PF01082 0.656
MOD_GlcNHglycan 102 105 PF01048 0.469
MOD_GlcNHglycan 124 127 PF01048 0.343
MOD_GlcNHglycan 202 205 PF01048 0.429
MOD_GlcNHglycan 216 219 PF01048 0.513
MOD_GlcNHglycan 255 258 PF01048 0.619
MOD_GlcNHglycan 352 355 PF01048 0.667
MOD_GlcNHglycan 374 377 PF01048 0.647
MOD_GlcNHglycan 413 416 PF01048 0.682
MOD_GlcNHglycan 558 561 PF01048 0.664
MOD_GlcNHglycan 81 84 PF01048 0.676
MOD_GSK3_1 20 27 PF00069 0.360
MOD_GSK3_1 200 207 PF00069 0.438
MOD_GSK3_1 210 217 PF00069 0.419
MOD_GSK3_1 324 331 PF00069 0.531
MOD_GSK3_1 44 51 PF00069 0.508
MOD_GSK3_1 498 505 PF00069 0.457
MOD_GSK3_1 68 75 PF00069 0.650
MOD_GSK3_1 9 16 PF00069 0.454
MOD_NEK2_1 198 203 PF00069 0.469
MOD_NEK2_1 226 231 PF00069 0.450
MOD_NEK2_1 324 329 PF00069 0.506
MOD_NEK2_1 382 387 PF00069 0.569
MOD_NEK2_1 403 408 PF00069 0.542
MOD_NEK2_1 41 46 PF00069 0.360
MOD_NEK2_1 515 520 PF00069 0.479
MOD_NEK2_1 524 529 PF00069 0.396
MOD_NEK2_1 77 82 PF00069 0.718
MOD_OFUCOSY 225 231 PF10250 0.374
MOD_PIKK_1 204 210 PF00454 0.555
MOD_PIKK_1 218 224 PF00454 0.345
MOD_PIKK_1 303 309 PF00454 0.455
MOD_PIKK_1 403 409 PF00454 0.579
MOD_PIKK_1 534 540 PF00454 0.574
MOD_PIKK_1 9 15 PF00454 0.453
MOD_PKA_1 380 386 PF00069 0.619
MOD_PKA_1 465 471 PF00069 0.592
MOD_PKA_2 157 163 PF00069 0.486
MOD_PKA_2 465 471 PF00069 0.539
MOD_PKA_2 515 521 PF00069 0.497
MOD_PKA_2 573 579 PF00069 0.770
MOD_PKA_2 9 15 PF00069 0.428
MOD_Plk_1 198 204 PF00069 0.481
MOD_Plk_1 487 493 PF00069 0.504
MOD_Plk_1 87 93 PF00069 0.426
MOD_Plk_4 139 145 PF00069 0.438
MOD_Plk_4 158 164 PF00069 0.490
MOD_Plk_4 181 187 PF00069 0.500
MOD_Plk_4 24 30 PF00069 0.310
MOD_Plk_4 330 336 PF00069 0.589
MOD_Plk_4 41 47 PF00069 0.268
MOD_Plk_4 453 459 PF00069 0.552
MOD_ProDKin_1 206 212 PF00069 0.476
MOD_ProDKin_1 360 366 PF00069 0.700
MOD_ProDKin_1 44 50 PF00069 0.508
MOD_SUMO_for_1 259 262 PF00179 0.508
MOD_SUMO_for_1 393 396 PF00179 0.532
MOD_SUMO_for_1 478 481 PF00179 0.520
MOD_SUMO_rev_2 365 374 PF00179 0.642
MOD_SUMO_rev_2 375 383 PF00179 0.556
MOD_SUMO_rev_2 395 402 PF00179 0.535
MOD_SUMO_rev_2 518 527 PF00179 0.521
TRG_DiLeu_BaEn_4 487 493 PF01217 0.587
TRG_DiLeu_BaLyEn_6 31 36 PF01217 0.402
TRG_ENDOCYTIC_2 185 188 PF00928 0.340
TRG_ENDOCYTIC_2 284 287 PF00928 0.513
TRG_ENDOCYTIC_2 389 392 PF00928 0.563
TRG_ENDOCYTIC_2 4 7 PF00928 0.303
TRG_ENDOCYTIC_2 444 447 PF00928 0.601
TRG_ENDOCYTIC_2 54 57 PF00928 0.286
TRG_ER_diArg_1 235 237 PF00400 0.489
TRG_ER_diArg_1 539 541 PF00400 0.565
TRG_NLS_MonoExtN_4 34 41 PF00514 0.311
TRG_Pf-PMV_PEXEL_1 401 405 PF00026 0.556
TRG_Pf-PMV_PEXEL_1 522 526 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 539 544 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAV0 Leptomonas seymouri 63% 98%
A0A0S4ILW6 Bodo saltans 28% 100%
A0A1X0PAX0 Trypanosomatidae 33% 100%
A0A3Q8IEL0 Leishmania donovani 100% 100%
A0A422NNH1 Trypanosoma rangeli 33% 100%
A4HB46 Leishmania braziliensis 83% 100%
C9ZLZ9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9B5B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q2L6 Leishmania major 92% 99%
Q99MP8 Mus musculus 23% 99%
V5DLZ1 Trypanosoma cruzi 34% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS