Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4379) - putative

Species:

Leishmania infantum

UniProt:

A4IA94_LEIIN

TriTrypDb:

LINF_340039700

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IA94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	46	48	PF00675	0.437
CLV_PCSK_FUR_1	172	176	PF00082	0.532
CLV_PCSK_KEX2_1	114	116	PF00082	0.300
CLV_PCSK_KEX2_1	174	176	PF00082	0.552
CLV_PCSK_KEX2_1	56	58	PF00082	0.453
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.300
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.552
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.453
DEG_Nend_UBRbox_3	1	3	PF02207	0.477
DOC_CKS1_1	31	36	PF01111	0.647
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.546
DOC_MAPK_gen_1	172	181	PF00069	0.539
DOC_MAPK_gen_1	36	44	PF00069	0.471
DOC_MAPK_gen_1	47	54	PF00069	0.417
DOC_USP7_MATH_1	15	19	PF00917	0.562
DOC_WW_Pin1_4	30	35	PF00397	0.592
LIG_14-3-3_CanoR_1	102	112	PF00244	0.380
LIG_14-3-3_CanoR_1	11	19	PF00244	0.600
LIG_14-3-3_CanoR_1	172	181	PF00244	0.657
LIG_14-3-3_CanoR_1	36	44	PF00244	0.452
LIG_APCC_ABBA_1	82	87	PF00400	0.325
LIG_BRCT_BRCA1_1	132	136	PF00533	0.472
LIG_FHA_1	174	180	PF00498	0.601
LIG_FHA_1	39	45	PF00498	0.518
LIG_LIR_Apic_2	90	96	PF02991	0.394
LIG_LYPXL_S_1	84	88	PF13949	0.300
LIG_LYPXL_yS_3	85	88	PF13949	0.300
LIG_MAD2	115	123	PF02301	0.300
LIG_SH2_CRK	58	62	PF00017	0.485
LIG_SH3_3	158	164	PF00018	0.623
LIG_SH3_3	16	22	PF00018	0.484
LIG_SH3_3	63	69	PF00018	0.492
LIG_TRAF2_1	164	167	PF00917	0.614
LIG_UBA3_1	178	184	PF00899	0.530
MOD_CDK_SPxK_1	30	36	PF00069	0.546
MOD_Cter_Amidation	54	57	PF01082	0.460
MOD_GlcNHglycan	13	16	PF01048	0.653
MOD_GlcNHglycan	144	147	PF01048	0.588
MOD_GlcNHglycan	156	159	PF01048	0.482
MOD_GlcNHglycan	19	22	PF01048	0.520
MOD_GSK3_1	104	111	PF00069	0.308
MOD_GSK3_1	6	13	PF00069	0.556
MOD_N-GLC_1	167	172	PF02516	0.581
MOD_NEK2_1	130	135	PF00069	0.488
MOD_NEK2_1	23	28	PF00069	0.551
MOD_NEK2_2	6	11	PF00069	0.564
MOD_PKA_1	174	180	PF00069	0.657
MOD_PKA_2	10	16	PF00069	0.532
MOD_PKA_2	174	180	PF00069	0.666
MOD_Plk_1	167	173	PF00069	0.586
MOD_Plk_1	23	29	PF00069	0.432
MOD_Plk_4	174	180	PF00069	0.650
MOD_ProDKin_1	30	36	PF00069	0.595
TRG_DiLeu_BaEn_4	166	172	PF01217	0.554
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.587
TRG_ENDOCYTIC_2	85	88	PF00928	0.322
TRG_ER_diArg_1	63	66	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU88	Leptomonas seymouri	68%	92%
A0A1X0PA15	Trypanosomatidae	55%	100%
A0A3R7NSK5	Trypanosoma rangeli	57%	100%
A0A3S7X894	Leishmania donovani	99%	100%
A4HB45	Leishmania braziliensis	76%	100%
C9ZM00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9B5B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2L7	Leishmania major	91%	99%