DRMBL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair metallo-beta-lactamase - putative

Species:

Leishmania infantum

UniProt:

A4IA93_LEIIN

TriTrypDb:

LINF_340039500

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

A4IA93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA93

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0016043	cellular component organization	3	1
GO:0031848	protection from non-homologous end joining at telomere	6	1
GO:0032200	telomere organization	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0036297	interstrand cross-link repair	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043247	telomere maintenance in response to DNA damage	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0051276	chromosome organization	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0035312	5'-3' DNA exonuclease activity	7	1
GO:0097159	organic cyclic compound binding	2	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.532
CLV_C14_Caspase3-7	517	521	PF00656	0.567
CLV_C14_Caspase3-7	698	702	PF00656	0.701
CLV_MEL_PAP_1	654	660	PF00089	0.512
CLV_NRD_NRD_1	485	487	PF00675	0.590
CLV_NRD_NRD_1	683	685	PF00675	0.668
CLV_NRD_NRD_1	731	733	PF00675	0.652
CLV_PCSK_KEX2_1	264	266	PF00082	0.687
CLV_PCSK_KEX2_1	487	489	PF00082	0.478
CLV_PCSK_KEX2_1	592	594	PF00082	0.293
CLV_PCSK_KEX2_1	683	685	PF00082	0.680
CLV_PCSK_KEX2_1	733	735	PF00082	0.731
CLV_PCSK_KEX2_1	772	774	PF00082	0.621
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.536
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.478
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.308
CLV_PCSK_PC1ET2_1	733	735	PF00082	0.731
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.658
CLV_PCSK_SKI1_1	297	301	PF00082	0.488
CLV_PCSK_SKI1_1	331	335	PF00082	0.397
CLV_PCSK_SKI1_1	371	375	PF00082	0.323
CLV_PCSK_SKI1_1	377	381	PF00082	0.368
CLV_PCSK_SKI1_1	418	422	PF00082	0.448
CLV_PCSK_SKI1_1	697	701	PF00082	0.559
CLV_Separin_Metazoa	328	332	PF03568	0.466
DEG_APCC_DBOX_1	296	304	PF00400	0.381
DEG_APCC_DBOX_1	735	743	PF00400	0.444
DEG_Nend_UBRbox_3	1	3	PF02207	0.689
DEG_SCF_FBW7_1	754	761	PF00400	0.487
DEG_SPOP_SBC_1	746	750	PF00917	0.558
DOC_CKS1_1	169	174	PF01111	0.368
DOC_CYCLIN_RxL_1	292	301	PF00134	0.384
DOC_MAPK_gen_1	354	362	PF00069	0.372
DOC_MAPK_gen_1	369	376	PF00069	0.232
DOC_MAPK_MEF2A_6	297	304	PF00069	0.435
DOC_MAPK_MEF2A_6	369	376	PF00069	0.364
DOC_MAPK_MEF2A_6	509	518	PF00069	0.546
DOC_PP2B_LxvP_1	139	142	PF13499	0.288
DOC_PP2B_LxvP_1	181	184	PF13499	0.506
DOC_PP2B_LxvP_1	606	609	PF13499	0.442
DOC_PP4_FxxP_1	219	222	PF00568	0.333
DOC_PP4_FxxP_1	309	312	PF00568	0.334
DOC_PP4_FxxP_1	542	545	PF00568	0.335
DOC_PP4_FxxP_1	625	628	PF00568	0.442
DOC_USP7_MATH_1	10	14	PF00917	0.669
DOC_USP7_MATH_1	184	188	PF00917	0.659
DOC_USP7_MATH_1	344	348	PF00917	0.513
DOC_USP7_MATH_1	391	395	PF00917	0.573
DOC_USP7_MATH_1	437	441	PF00917	0.612
DOC_USP7_MATH_1	545	549	PF00917	0.383
DOC_USP7_MATH_1	633	637	PF00917	0.442
DOC_USP7_MATH_1	70	74	PF00917	0.639
DOC_USP7_MATH_1	756	760	PF00917	0.693
DOC_USP7_MATH_1	91	95	PF00917	0.505
DOC_WW_Pin1_4	168	173	PF00397	0.484
DOC_WW_Pin1_4	179	184	PF00397	0.580
DOC_WW_Pin1_4	218	223	PF00397	0.388
DOC_WW_Pin1_4	412	417	PF00397	0.370
DOC_WW_Pin1_4	559	564	PF00397	0.574
DOC_WW_Pin1_4	60	65	PF00397	0.583
DOC_WW_Pin1_4	72	77	PF00397	0.637
DOC_WW_Pin1_4	754	759	PF00397	0.528
DOC_WW_Pin1_4	776	781	PF00397	0.774
DOC_WW_Pin1_4	78	83	PF00397	0.558
LIG_14-3-3_CanoR_1	129	135	PF00244	0.322
LIG_14-3-3_CanoR_1	252	256	PF00244	0.480
LIG_14-3-3_CanoR_1	439	445	PF00244	0.511
LIG_14-3-3_CanoR_1	501	508	PF00244	0.637
LIG_14-3-3_CanoR_1	607	616	PF00244	0.489
LIG_14-3-3_CanoR_1	666	671	PF00244	0.571
LIG_14-3-3_CanoR_1	98	103	PF00244	0.280
LIG_BIR_III_2	378	382	PF00653	0.485
LIG_BRCT_BRCA1_1	143	147	PF00533	0.307
LIG_BRCT_BRCA1_1	220	224	PF00533	0.338
LIG_BRCT_BRCA1_1	423	427	PF00533	0.469
LIG_Clathr_ClatBox_1	146	150	PF01394	0.386
LIG_CtBP_PxDLS_1	148	152	PF00389	0.245
LIG_deltaCOP1_diTrp_1	240	245	PF00928	0.398
LIG_FHA_1	129	135	PF00498	0.300
LIG_FHA_1	321	327	PF00498	0.416
LIG_FHA_1	460	466	PF00498	0.579
LIG_FHA_1	530	536	PF00498	0.461
LIG_FHA_1	755	761	PF00498	0.583
LIG_FHA_1	78	84	PF00498	0.589
LIG_FHA_2	18	24	PF00498	0.569
LIG_FHA_2	444	450	PF00498	0.745
LIG_FHA_2	632	638	PF00498	0.543
LIG_FHA_2	696	702	PF00498	0.543
LIG_Integrin_isoDGR_2	250	252	PF01839	0.420
LIG_LIR_Apic_2	144	148	PF02991	0.248
LIG_LIR_Apic_2	254	258	PF02991	0.388
LIG_LIR_Apic_2	306	312	PF02991	0.321
LIG_LIR_Apic_2	540	545	PF02991	0.364
LIG_LIR_Apic_2	624	628	PF02991	0.452
LIG_LIR_Gen_1	240	246	PF02991	0.483
LIG_LIR_Gen_1	417	427	PF02991	0.355
LIG_LIR_Gen_1	548	558	PF02991	0.477
LIG_LIR_Gen_1	577	587	PF02991	0.545
LIG_LIR_Gen_1	621	629	PF02991	0.472
LIG_LIR_Gen_1	665	676	PF02991	0.614
LIG_LIR_Gen_1	765	776	PF02991	0.698
LIG_LIR_Nem_3	101	105	PF02991	0.256
LIG_LIR_Nem_3	110	116	PF02991	0.260
LIG_LIR_Nem_3	221	227	PF02991	0.327
LIG_LIR_Nem_3	240	245	PF02991	0.392
LIG_LIR_Nem_3	378	383	PF02991	0.406
LIG_LIR_Nem_3	41	46	PF02991	0.358
LIG_LIR_Nem_3	417	422	PF02991	0.368
LIG_LIR_Nem_3	429	435	PF02991	0.349
LIG_LIR_Nem_3	548	554	PF02991	0.459
LIG_LIR_Nem_3	577	582	PF02991	0.565
LIG_LIR_Nem_3	621	625	PF02991	0.457
LIG_LIR_Nem_3	637	643	PF02991	0.347
LIG_LIR_Nem_3	665	671	PF02991	0.606
LIG_LIR_Nem_3	765	771	PF02991	0.693
LIG_MYND_1	469	473	PF01753	0.412
LIG_NRBOX	299	305	PF00104	0.319
LIG_PCNA_yPIPBox_3	17	25	PF02747	0.489
LIG_PCNA_yPIPBox_3	292	303	PF02747	0.449
LIG_Pex14_2	104	108	PF04695	0.266
LIG_Pex14_2	316	320	PF04695	0.463
LIG_Pex14_2	428	432	PF04695	0.423
LIG_SH2_CRK	113	117	PF00017	0.278
LIG_SH2_CRK	314	318	PF00017	0.444
LIG_SH2_CRK	419	423	PF00017	0.432
LIG_SH2_CRK	551	555	PF00017	0.498
LIG_SH2_CRK	579	583	PF00017	0.535
LIG_SH2_PTP2	255	258	PF00017	0.522
LIG_SH2_SRC	255	258	PF00017	0.425
LIG_SH2_STAP1	281	285	PF00017	0.480
LIG_SH2_STAP1	579	583	PF00017	0.535
LIG_SH2_STAP1	643	647	PF00017	0.417
LIG_SH2_STAT5	103	106	PF00017	0.320
LIG_SH2_STAT5	126	129	PF00017	0.395
LIG_SH2_STAT5	155	158	PF00017	0.304
LIG_SH2_STAT5	24	27	PF00017	0.535
LIG_SH2_STAT5	255	258	PF00017	0.522
LIG_SH2_STAT5	365	368	PF00017	0.360
LIG_SH3_3	166	172	PF00018	0.485
LIG_SH3_3	273	279	PF00018	0.449
LIG_SH3_3	467	473	PF00018	0.382
LIG_SH3_3	59	65	PF00018	0.497
LIG_SH3_3	710	716	PF00018	0.562
LIG_SH3_3	741	747	PF00018	0.567
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.315
LIG_SUMO_SIM_anti_2	580	586	PF11976	0.518
LIG_SUMO_SIM_par_1	301	306	PF11976	0.315
LIG_SUMO_SIM_par_1	36	41	PF11976	0.242
LIG_SUMO_SIM_par_1	472	478	PF11976	0.491
LIG_SUMO_SIM_par_1	564	570	PF11976	0.517
LIG_SUMO_SIM_par_1	580	586	PF11976	0.488
LIG_SUMO_SIM_par_1	804	812	PF11976	0.593
LIG_TRAF2_1	784	787	PF00917	0.596
LIG_TYR_ITIM	549	554	PF00017	0.315
MOD_CDC14_SPxK_1	415	418	PF00782	0.362
MOD_CDK_SPxK_1	412	418	PF00069	0.336
MOD_CK1_1	128	134	PF00069	0.277
MOD_CK1_1	158	164	PF00069	0.475
MOD_CK1_1	238	244	PF00069	0.431
MOD_CK1_1	386	392	PF00069	0.605
MOD_CK1_1	438	444	PF00069	0.694
MOD_CK1_1	63	69	PF00069	0.611
MOD_CK1_1	656	662	PF00069	0.669
MOD_CK1_1	703	709	PF00069	0.617
MOD_CK1_1	725	731	PF00069	0.531
MOD_CK1_1	749	755	PF00069	0.582
MOD_CK1_1	78	84	PF00069	0.628
MOD_CK2_1	1	7	PF00069	0.529
MOD_CK2_1	17	23	PF00069	0.447
MOD_CK2_1	315	321	PF00069	0.361
MOD_CK2_1	523	529	PF00069	0.703
MOD_CK2_1	631	637	PF00069	0.422
MOD_GlcNHglycan	121	124	PF01048	0.399
MOD_GlcNHglycan	346	349	PF01048	0.624
MOD_GlcNHglycan	490	493	PF01048	0.629
MOD_GlcNHglycan	502	505	PF01048	0.760
MOD_GlcNHglycan	525	528	PF01048	0.720
MOD_GlcNHglycan	65	68	PF01048	0.589
MOD_GlcNHglycan	693	696	PF01048	0.704
MOD_GlcNHglycan	72	75	PF01048	0.605
MOD_GlcNHglycan	724	727	PF01048	0.643
MOD_GlcNHglycan	77	80	PF01048	0.627
MOD_GSK3_1	103	110	PF00069	0.235
MOD_GSK3_1	121	128	PF00069	0.262
MOD_GSK3_1	130	137	PF00069	0.391
MOD_GSK3_1	151	158	PF00069	0.350
MOD_GSK3_1	223	230	PF00069	0.298
MOD_GSK3_1	382	389	PF00069	0.546
MOD_GSK3_1	391	398	PF00069	0.631
MOD_GSK3_1	453	460	PF00069	0.677
MOD_GSK3_1	597	604	PF00069	0.334
MOD_GSK3_1	662	669	PF00069	0.571
MOD_GSK3_1	687	694	PF00069	0.628
MOD_GSK3_1	745	752	PF00069	0.682
MOD_GSK3_1	754	761	PF00069	0.659
MOD_GSK3_1	77	84	PF00069	0.650
MOD_N-GLC_1	17	22	PF02516	0.513
MOD_N-GLC_1	235	240	PF02516	0.385
MOD_N-GLC_1	523	528	PF02516	0.587
MOD_N-GLC_2	209	211	PF02516	0.314
MOD_NEK2_1	134	139	PF00069	0.412
MOD_NEK2_1	151	156	PF00069	0.343
MOD_NEK2_1	157	162	PF00069	0.368
MOD_NEK2_1	245	250	PF00069	0.454
MOD_NEK2_1	305	310	PF00069	0.325
MOD_NEK2_1	395	400	PF00069	0.582
MOD_NEK2_1	421	426	PF00069	0.516
MOD_NEK2_1	435	440	PF00069	0.507
MOD_NEK2_1	700	705	PF00069	0.631
MOD_NEK2_1	90	95	PF00069	0.564
MOD_NEK2_2	391	396	PF00069	0.645
MOD_PIKK_1	132	138	PF00454	0.414
MOD_PIKK_1	31	37	PF00454	0.288
MOD_PIKK_1	315	321	PF00454	0.476
MOD_PIKK_1	395	401	PF00454	0.613
MOD_PK_1	666	672	PF00069	0.676
MOD_PKA_2	128	134	PF00069	0.277
MOD_PKA_2	238	244	PF00069	0.459
MOD_PKA_2	246	252	PF00069	0.462
MOD_PKA_2	31	37	PF00069	0.427
MOD_PKA_2	383	389	PF00069	0.585
MOD_PKA_2	391	397	PF00069	0.657
MOD_PKA_2	438	444	PF00069	0.544
MOD_PKA_2	500	506	PF00069	0.655
MOD_PKA_2	508	514	PF00069	0.668
MOD_PKA_2	656	662	PF00069	0.576
MOD_PKB_1	486	494	PF00069	0.487
MOD_Plk_1	193	199	PF00069	0.402
MOD_Plk_1	305	311	PF00069	0.298
MOD_Plk_2-3	529	535	PF00069	0.497
MOD_Plk_4	121	127	PF00069	0.305
MOD_Plk_4	141	147	PF00069	0.379
MOD_Plk_4	151	157	PF00069	0.330
MOD_Plk_4	223	229	PF00069	0.308
MOD_Plk_4	251	257	PF00069	0.537
MOD_Plk_4	537	543	PF00069	0.352
MOD_Plk_4	601	607	PF00069	0.284
MOD_Plk_4	98	104	PF00069	0.273
MOD_ProDKin_1	168	174	PF00069	0.489
MOD_ProDKin_1	179	185	PF00069	0.591
MOD_ProDKin_1	218	224	PF00069	0.389
MOD_ProDKin_1	412	418	PF00069	0.366
MOD_ProDKin_1	559	565	PF00069	0.466
MOD_ProDKin_1	60	66	PF00069	0.584
MOD_ProDKin_1	72	78	PF00069	0.636
MOD_ProDKin_1	754	760	PF00069	0.525
MOD_ProDKin_1	776	782	PF00069	0.775
TRG_DiLeu_BaEn_1	534	539	PF01217	0.500
TRG_DiLeu_BaEn_1	601	606	PF01217	0.403
TRG_DiLeu_BaEn_2	617	623	PF01217	0.266
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.389
TRG_ENDOCYTIC_2	113	116	PF00928	0.272
TRG_ENDOCYTIC_2	281	284	PF00928	0.487
TRG_ENDOCYTIC_2	419	422	PF00928	0.361
TRG_ENDOCYTIC_2	551	554	PF00928	0.340
TRG_ENDOCYTIC_2	579	582	PF00928	0.399
TRG_ENDOCYTIC_2	643	646	PF00928	0.429
TRG_ER_diArg_1	486	489	PF00400	0.479
TRG_ER_diArg_1	652	655	PF00400	0.374
TRG_ER_diArg_1	731	734	PF00400	0.710
TRG_NES_CRM1_1	662	677	PF08389	0.518
TRG_NLS_MonoExtC_3	731	736	PF00514	0.738
TRG_NLS_MonoExtN_4	732	737	PF00514	0.758
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB91	Leptomonas seymouri	44%	93%
A0A0S4INP1	Bodo saltans	26%	100%
A0A1X0P9Y1	Trypanosomatidae	31%	100%
A0A3Q8IHR3	Leishmania donovani	99%	100%
A0A3R7MJM0	Trypanosoma rangeli	31%	100%
A4HB44	Leishmania braziliensis	66%	98%
C9ZM02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B5B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2L8	Leishmania major	90%	100%
V5BQH0	Trypanosoma cruzi	32%	100%