DRMBL domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair metallo-beta-lactamase - putative

Species:

Leishmania infantum

UniProt:

A4IA93_LEIIN

TriTrypDb:

LINF_340039500

Length:

812

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4IA93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA93

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006303	double-strand break repair via nonhomologous end joining	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003684	damaged DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	1
GO:0008409	5'-3' exonuclease activity	6	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	446	450	PF00656	0.532
CLV_C14_Caspase3-7	517	521	PF00656	0.567
CLV_C14_Caspase3-7	698	702	PF00656	0.701
CLV_MEL_PAP_1	654	660	PF00089	0.512
CLV_NRD_NRD_1	485	487	PF00675	0.590
CLV_NRD_NRD_1	683	685	PF00675	0.668
CLV_NRD_NRD_1	731	733	PF00675	0.652
CLV_PCSK_KEX2_1	264	266	PF00082	0.687
CLV_PCSK_KEX2_1	487	489	PF00082	0.478
CLV_PCSK_KEX2_1	592	594	PF00082	0.293

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB91	Leptomonas seymouri	44%	93%
A0A0S4INP1	Bodo saltans	26%	100%
A0A1X0P9Y1	Trypanosomatidae	31%	100%
A0A3Q8IHR3	Leishmania donovani	99%	100%
A0A3R7MJM0	Trypanosoma rangeli	31%	100%
A4HB44	Leishmania braziliensis	66%	98%
C9ZM02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B5B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2L8	Leishmania major	90%	100%
V5BQH0	Trypanosoma cruzi	32%	100%

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