LeishMANIAdb
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Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Zeta_toxin domain-containing protein
Gene product:
AAA domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IA87_LEIIN
TriTrypDb:
LINF_340037700
Length:
257

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4IA87
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA87

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 170 172 PF00675 0.556
CLV_NRD_NRD_1 66 68 PF00675 0.731
CLV_NRD_NRD_1 93 95 PF00675 0.733
CLV_PCSK_KEX2_1 120 122 PF00082 0.607
CLV_PCSK_KEX2_1 170 172 PF00082 0.556
CLV_PCSK_KEX2_1 20 22 PF00082 0.465
CLV_PCSK_KEX2_1 6 8 PF00082 0.448
CLV_PCSK_KEX2_1 61 63 PF00082 0.739
CLV_PCSK_KEX2_1 66 68 PF00082 0.702
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.607
CLV_PCSK_PC1ET2_1 20 22 PF00082 0.385
CLV_PCSK_PC1ET2_1 6 8 PF00082 0.448
CLV_PCSK_PC1ET2_1 61 63 PF00082 0.800
CLV_PCSK_PC7_1 62 68 PF00082 0.727
CLV_PCSK_SKI1_1 201 205 PF00082 0.604
CLV_PCSK_SKI1_1 47 51 PF00082 0.393
CLV_PCSK_SKI1_1 69 73 PF00082 0.813
DEG_APCC_DBOX_1 186 194 PF00400 0.407
DEG_ODPH_VHL_1 193 205 PF01847 0.351
DOC_MAPK_DCC_7 96 106 PF00069 0.390
DOC_MAPK_gen_1 29 37 PF00069 0.563
DOC_MAPK_MEF2A_6 29 37 PF00069 0.545
DOC_PP1_RVXF_1 45 51 PF00149 0.424
DOC_USP7_MATH_1 137 141 PF00917 0.356
DOC_USP7_UBL2_3 73 77 PF12436 0.570
DOC_WW_Pin1_4 180 185 PF00397 0.379
LIG_14-3-3_CanoR_1 94 99 PF00244 0.530
LIG_Actin_WH2_2 156 172 PF00022 0.356
LIG_BRCT_BRCA1_1 182 186 PF00533 0.356
LIG_FHA_1 121 127 PF00498 0.380
LIG_FHA_1 14 20 PF00498 0.725
LIG_FHA_1 141 147 PF00498 0.171
LIG_FHA_1 148 154 PF00498 0.317
LIG_FHA_1 164 170 PF00498 0.279
LIG_FHA_1 58 64 PF00498 0.515
LIG_FHA_2 229 235 PF00498 0.317
LIG_FHA_2 246 252 PF00498 0.521
LIG_LIR_Gen_1 129 138 PF02991 0.336
LIG_LIR_Gen_1 211 217 PF02991 0.407
LIG_LIR_Gen_1 36 46 PF02991 0.373
LIG_LIR_Nem_3 129 133 PF02991 0.336
LIG_LIR_Nem_3 36 41 PF02991 0.378
LIG_Pex14_1 118 122 PF04695 0.317
LIG_SH2_PTP2 130 133 PF00017 0.372
LIG_SH2_SRC 130 133 PF00017 0.337
LIG_SH2_STAP1 122 126 PF00017 0.407
LIG_SH2_STAP1 149 153 PF00017 0.324
LIG_SH2_STAT5 122 125 PF00017 0.317
LIG_SH2_STAT5 130 133 PF00017 0.317
LIG_SH2_STAT5 149 152 PF00017 0.356
LIG_SH3_1 96 102 PF00018 0.433
LIG_SH3_3 96 102 PF00018 0.433
LIG_SUMO_SIM_anti_2 103 109 PF11976 0.356
LIG_SUMO_SIM_par_1 231 236 PF11976 0.356
LIG_SUMO_SIM_par_1 31 36 PF11976 0.551
LIG_UBA3_1 106 115 PF00899 0.376
MOD_CDK_SPxxK_3 180 187 PF00069 0.462
MOD_CK1_1 100 106 PF00069 0.467
MOD_CK1_1 113 119 PF00069 0.317
MOD_CK1_1 140 146 PF00069 0.430
MOD_CK1_1 57 63 PF00069 0.584
MOD_CK1_1 82 88 PF00069 0.653
MOD_CK1_1 90 96 PF00069 0.617
MOD_CK2_1 216 222 PF00069 0.420
MOD_CK2_1 228 234 PF00069 0.297
MOD_Cter_Amidation 64 67 PF01082 0.730
MOD_GlcNHglycan 11 14 PF01048 0.669
MOD_GlcNHglycan 112 115 PF01048 0.376
MOD_GlcNHglycan 63 66 PF01048 0.714
MOD_GlcNHglycan 84 87 PF01048 0.680
MOD_GSK3_1 204 211 PF00069 0.425
MOD_GSK3_1 53 60 PF00069 0.610
MOD_GSK3_1 61 68 PF00069 0.700
MOD_GSK3_1 75 82 PF00069 0.751
MOD_GSK3_1 9 16 PF00069 0.564
MOD_GSK3_1 90 97 PF00069 0.550
MOD_N-GLC_1 147 152 PF02516 0.433
MOD_N-GLC_1 180 185 PF02516 0.430
MOD_NEK2_1 142 147 PF00069 0.424
MOD_NEK2_1 169 174 PF00069 0.390
MOD_NEK2_1 245 250 PF00069 0.640
MOD_NEK2_1 25 30 PF00069 0.634
MOD_PK_1 204 210 PF00069 0.425
MOD_PKA_1 120 126 PF00069 0.501
MOD_PKA_1 61 67 PF00069 0.711
MOD_PKA_1 94 100 PF00069 0.594
MOD_PKA_2 120 126 PF00069 0.501
MOD_PKA_2 140 146 PF00069 0.171
MOD_PKA_2 169 175 PF00069 0.376
MOD_PKA_2 61 67 PF00069 0.681
MOD_PKA_2 82 88 PF00069 0.791
MOD_PKB_1 7 15 PF00069 0.562
MOD_Plk_1 155 161 PF00069 0.397
MOD_Plk_4 100 106 PF00069 0.470
MOD_Plk_4 113 119 PF00069 0.310
MOD_Plk_4 126 132 PF00069 0.368
MOD_Plk_4 155 161 PF00069 0.440
MOD_Plk_4 228 234 PF00069 0.382
MOD_Plk_4 33 39 PF00069 0.501
MOD_ProDKin_1 180 186 PF00069 0.462
MOD_SUMO_for_1 71 74 PF00179 0.592
MOD_SUMO_rev_2 56 63 PF00179 0.644
TRG_DiLeu_BaLyEn_6 44 49 PF01217 0.424
TRG_ENDOCYTIC_2 122 125 PF00928 0.430
TRG_ENDOCYTIC_2 130 133 PF00928 0.430
TRG_ENDOCYTIC_2 212 215 PF00928 0.436
TRG_ENDOCYTIC_2 52 55 PF00928 0.529
TRG_ER_diArg_1 138 141 PF00400 0.430
TRG_ER_diArg_1 169 171 PF00400 0.430
TRG_ER_diArg_1 29 32 PF00400 0.489
TRG_ER_diArg_1 66 69 PF00400 0.689
TRG_ER_diArg_1 7 10 PF00400 0.691
TRG_NLS_MonoExtN_4 3 10 PF00514 0.442
TRG_Pf-PMV_PEXEL_1 191 196 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5F6 Leptomonas seymouri 58% 100%
A0A3R7RME9 Trypanosoma rangeli 29% 100%
A0A3S7X8C5 Leishmania donovani 99% 100%
A4HB30 Leishmania braziliensis 70% 100%
E9B5A0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q2N3 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS