LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Cytochrome b5-like Heme/Steroid binding domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IA81_LEIIN
TriTrypDb:
LINF_340037200
Length:
178

Annotations

Annotations by Jardim et al.

Mitochondrial protein, cytochrome b5-like Heme/Steroid binding domain containing , putative (POMP29 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0012505 endomembrane system 2 2
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11
GO:0005741 mitochondrial outer membrane 5 1
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0098588 bounding membrane of organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IA81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA81

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 48 50 PF00675 0.616
CLV_PCSK_KEX2_1 50 52 PF00082 0.599
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.593
DOC_MAPK_gen_1 87 95 PF00069 0.232
DOC_MAPK_MEF2A_6 90 97 PF00069 0.173
DOC_PP4_FxxP_1 106 109 PF00568 0.262
DOC_USP7_MATH_1 20 24 PF00917 0.382
DOC_USP7_UBL2_3 156 160 PF12436 0.289
DOC_USP7_UBL2_3 31 35 PF12436 0.373
LIG_14-3-3_CanoR_1 51 60 PF00244 0.353
LIG_14-3-3_CanoR_1 90 96 PF00244 0.224
LIG_BIR_II_1 1 5 PF00653 0.590
LIG_LIR_Gen_1 89 100 PF02991 0.231
LIG_LIR_Nem_3 159 164 PF02991 0.257
LIG_LIR_Nem_3 170 176 PF02991 0.328
LIG_LIR_Nem_3 81 86 PF02991 0.217
LIG_LIR_Nem_3 89 95 PF02991 0.247
LIG_LYPXL_yS_3 161 164 PF13949 0.270
LIG_SH2_CRK 83 87 PF00017 0.213
LIG_SH2_GRB2like 134 137 PF00017 0.189
LIG_SH2_NCK_1 100 104 PF00017 0.195
LIG_SH2_STAT3 134 137 PF00017 0.189
LIG_SH2_STAT5 134 137 PF00017 0.189
LIG_SH2_STAT5 153 156 PF00017 0.106
LIG_SH2_STAT5 167 170 PF00017 0.246
LIG_SH2_STAT5 26 29 PF00017 0.455
LIG_SH2_STAT5 75 78 PF00017 0.294
LIG_SUMO_SIM_anti_2 143 152 PF11976 0.262
LIG_TRAF2_1 143 146 PF00917 0.279
LIG_UBA3_1 24 31 PF00899 0.311
MOD_CK2_1 140 146 PF00069 0.227
MOD_CK2_1 52 58 PF00069 0.475
MOD_GlcNHglycan 54 57 PF01048 0.634
MOD_GlcNHglycan 61 64 PF01048 0.543
MOD_GlcNHglycan 67 70 PF01048 0.498
MOD_N-GLC_1 140 145 PF02516 0.462
MOD_NEK2_2 20 25 PF00069 0.195
MOD_PIKK_1 78 84 PF00454 0.227
MOD_PKA_1 49 55 PF00069 0.433
MOD_PKA_2 50 56 PF00069 0.476
MOD_PKB_1 49 57 PF00069 0.331
MOD_Plk_4 20 26 PF00069 0.324
MOD_SUMO_for_1 86 89 PF00179 0.262
TRG_DiLeu_BaEn_4 145 151 PF01217 0.219
TRG_ENDOCYTIC_2 113 116 PF00928 0.268
TRG_ENDOCYTIC_2 161 164 PF00928 0.239
TRG_ENDOCYTIC_2 83 86 PF00928 0.206
TRG_ER_diArg_1 48 51 PF00400 0.388

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I427 Leptomonas seymouri 71% 95%
A0A0S4IWT4 Bodo saltans 38% 100%
A0A0S4KHZ8 Bodo saltans 40% 100%
A0A3Q8IGX1 Leishmania donovani 41% 100%
A0A3R7RC54 Trypanosoma rangeli 41% 99%
A0A3S7X865 Leishmania donovani 100% 100%
A2CES0 Danio rerio 31% 67%
A4H7Y9 Leishmania braziliensis 40% 100%
A4HB24 Leishmania braziliensis 83% 100%
A4HQJ0 Leishmania braziliensis 37% 100%
E9AHZ9 Leishmania infantum 41% 100%
E9AUA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B594 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O00264 Homo sapiens 32% 91%
O55022 Mus musculus 32% 91%
Q12091 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 100%
Q1JQA5 Bos taurus 34% 100%
Q4Q088 Leishmania major 40% 100%
Q4Q2N9 Leishmania major 96% 100%
Q5RED0 Pongo abelii 32% 91%
Q5XIU9 Rattus norvegicus 34% 82%
Q5ZKN2 Gallus gallus 36% 93%
Q80UU9 Mus musculus 34% 82%
Q9UMX5 Homo sapiens 33% 100%
V5DM24 Trypanosoma cruzi 54% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS