Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IA80_LEIIN

TriTrypDb:

LINF_340037100

Length:

599

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IA80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.431
CLV_C14_Caspase3-7	57	61	PF00656	0.462
CLV_C14_Caspase3-7	82	86	PF00656	0.623
CLV_NRD_NRD_1	158	160	PF00675	0.382
CLV_NRD_NRD_1	247	249	PF00675	0.542
CLV_NRD_NRD_1	359	361	PF00675	0.536
CLV_NRD_NRD_1	531	533	PF00675	0.403
CLV_PCSK_KEX2_1	158	160	PF00082	0.382
CLV_PCSK_KEX2_1	531	533	PF00082	0.446
CLV_PCSK_SKI1_1	15	19	PF00082	0.548
CLV_PCSK_SKI1_1	226	230	PF00082	0.664
CLV_PCSK_SKI1_1	290	294	PF00082	0.480
CLV_PCSK_SKI1_1	323	327	PF00082	0.480
CLV_PCSK_SKI1_1	361	365	PF00082	0.363
CLV_PCSK_SKI1_1	441	445	PF00082	0.503
DOC_ANK_TNKS_1	531	538	PF00023	0.401
DOC_CKS1_1	491	496	PF01111	0.497
DOC_CYCLIN_RxL_1	358	365	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.643
DOC_CYCLIN_yCln2_LP_2	321	327	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.508
DOC_MAPK_DCC_7	14	24	PF00069	0.454
DOC_MAPK_gen_1	158	166	PF00069	0.398
DOC_MAPK_RevD_3	236	250	PF00069	0.586
DOC_MAPK_RevD_3	517	532	PF00069	0.401
DOC_PP2B_LxvP_1	207	210	PF13499	0.596
DOC_PP2B_LxvP_1	73	76	PF13499	0.517
DOC_PP4_FxxP_1	278	281	PF00568	0.453
DOC_PP4_FxxP_1	294	297	PF00568	0.366
DOC_PP4_FxxP_1	341	344	PF00568	0.322
DOC_USP7_MATH_1	10	14	PF00917	0.648
DOC_USP7_MATH_1	218	222	PF00917	0.752
DOC_USP7_MATH_1	303	307	PF00917	0.448
DOC_USP7_MATH_1	351	355	PF00917	0.444
DOC_USP7_MATH_1	387	391	PF00917	0.584
DOC_USP7_MATH_1	48	52	PF00917	0.404
DOC_USP7_UBL2_3	225	229	PF12436	0.620
DOC_USP7_UBL2_3	231	235	PF12436	0.578
DOC_USP7_UBL2_3	488	492	PF12436	0.524
DOC_USP7_UBL2_3	5	9	PF12436	0.627
DOC_WW_Pin1_4	236	241	PF00397	0.626
DOC_WW_Pin1_4	378	383	PF00397	0.525
DOC_WW_Pin1_4	405	410	PF00397	0.617
DOC_WW_Pin1_4	490	495	PF00397	0.640
LIG_14-3-3_CanoR_1	158	166	PF00244	0.490
LIG_14-3-3_CanoR_1	259	265	PF00244	0.476
LIG_14-3-3_CanoR_1	290	295	PF00244	0.435
LIG_14-3-3_CanoR_1	302	308	PF00244	0.456
LIG_14-3-3_CanoR_1	531	535	PF00244	0.480
LIG_APCC_ABBA_1	148	153	PF00400	0.579
LIG_BIR_III_4	58	62	PF00653	0.582
LIG_BRCT_BRCA1_1	507	511	PF00533	0.347
LIG_deltaCOP1_diTrp_1	282	289	PF00928	0.326
LIG_eIF4E_1	160	166	PF01652	0.331
LIG_FHA_1	159	165	PF00498	0.483
LIG_FHA_1	26	32	PF00498	0.579
LIG_FHA_1	316	322	PF00498	0.417
LIG_FHA_1	479	485	PF00498	0.499
LIG_FHA_1	562	568	PF00498	0.492
LIG_FHA_1	68	74	PF00498	0.412
LIG_FHA_2	502	508	PF00498	0.438
LIG_FHA_2	55	61	PF00498	0.451
LIG_IBAR_NPY_1	149	151	PF08397	0.560
LIG_LIR_Apic_2	277	281	PF02991	0.555
LIG_LIR_Apic_2	293	297	PF02991	0.455
LIG_LIR_Apic_2	340	344	PF02991	0.311
LIG_LIR_Apic_2	587	593	PF02991	0.498
LIG_LIR_Gen_1	282	292	PF02991	0.396
LIG_LIR_Gen_1	37	45	PF02991	0.450
LIG_LIR_Gen_1	466	475	PF02991	0.371
LIG_LIR_Gen_1	508	519	PF02991	0.390
LIG_LIR_Gen_1	579	585	PF02991	0.475
LIG_LIR_Nem_3	282	287	PF02991	0.373
LIG_LIR_Nem_3	329	334	PF02991	0.395
LIG_LIR_Nem_3	37	42	PF02991	0.473
LIG_LIR_Nem_3	466	470	PF02991	0.334
LIG_LIR_Nem_3	479	483	PF02991	0.539
LIG_LIR_Nem_3	508	514	PF02991	0.387
LIG_LIR_Nem_3	579	583	PF02991	0.515
LIG_MYND_1	236	240	PF01753	0.540
LIG_Pex14_2	32	36	PF04695	0.519
LIG_PTB_Apo_2	306	313	PF02174	0.530
LIG_SH2_CRK	331	335	PF00017	0.448
LIG_SH2_CRK	350	354	PF00017	0.216
LIG_SH2_CRK	590	594	PF00017	0.537
LIG_SH2_NCK_1	350	354	PF00017	0.462
LIG_SH2_NCK_1	39	43	PF00017	0.553
LIG_SH2_SRC	151	154	PF00017	0.510
LIG_SH2_SRC	534	537	PF00017	0.398
LIG_SH2_STAP1	151	155	PF00017	0.553
LIG_SH2_STAP1	160	164	PF00017	0.516
LIG_SH2_STAP1	480	484	PF00017	0.530
LIG_SH2_STAT3	257	260	PF00017	0.519
LIG_SH2_STAT5	160	163	PF00017	0.485
LIG_SH2_STAT5	274	277	PF00017	0.651
LIG_SH2_STAT5	331	334	PF00017	0.332
LIG_SH2_STAT5	475	478	PF00017	0.471
LIG_SH2_STAT5	480	483	PF00017	0.551
LIG_SH2_STAT5	534	537	PF00017	0.519
LIG_SH2_STAT5	558	561	PF00017	0.420
LIG_SH3_1	488	494	PF00018	0.556
LIG_SH3_2	194	199	PF14604	0.528
LIG_SH3_3	122	128	PF00018	0.630
LIG_SH3_3	188	194	PF00018	0.443
LIG_SH3_3	488	494	PF00018	0.596
LIG_SH3_3	60	66	PF00018	0.492
LIG_SUMO_SIM_anti_2	70	78	PF11976	0.478
LIG_SUMO_SIM_par_1	322	329	PF11976	0.406
LIG_SUMO_SIM_par_1	70	78	PF11976	0.492
LIG_SUMO_SIM_par_1	93	99	PF11976	0.474
LIG_TRAF2_1	142	145	PF00917	0.612
LIG_TRAF2_1	268	271	PF00917	0.424
LIG_WRC_WIRS_1	275	280	PF05994	0.564
MOD_CK1_1	38	44	PF00069	0.486
MOD_CK1_1	46	52	PF00069	0.421
MOD_CK1_1	505	511	PF00069	0.351
MOD_CK2_1	10	16	PF00069	0.669
MOD_CK2_1	530	536	PF00069	0.398
MOD_GlcNHglycan	353	356	PF01048	0.405
MOD_GlcNHglycan	397	402	PF01048	0.601
MOD_GlcNHglycan	414	419	PF01048	0.448
MOD_GlcNHglycan	445	450	PF01048	0.434
MOD_GlcNHglycan	536	540	PF01048	0.520
MOD_GlcNHglycan	85	88	PF01048	0.543
MOD_GSK3_1	227	234	PF00069	0.638
MOD_GSK3_1	34	41	PF00069	0.524
MOD_GSK3_1	403	410	PF00069	0.520
MOD_GSK3_1	478	485	PF00069	0.568
MOD_GSK3_1	5	12	PF00069	0.708
MOD_GSK3_1	501	508	PF00069	0.439
MOD_GSK3_1	522	529	PF00069	0.401
MOD_N-GLC_1	10	15	PF02516	0.607
MOD_N-GLC_1	25	30	PF02516	0.398
MOD_NEK2_1	326	331	PF00069	0.391
MOD_NEK2_1	521	526	PF00069	0.491
MOD_NEK2_2	27	32	PF00069	0.516
MOD_NEK2_2	478	483	PF00069	0.524
MOD_NEK2_2	561	566	PF00069	0.426
MOD_NEK2_2	594	599	PF00069	0.521
MOD_PIKK_1	158	164	PF00454	0.588
MOD_PIKK_1	326	332	PF00454	0.338
MOD_PIKK_1	43	49	PF00454	0.376
MOD_PK_1	526	532	PF00069	0.379
MOD_PKA_1	158	164	PF00069	0.376
MOD_PKA_1	224	230	PF00069	0.623
MOD_PKA_1	231	237	PF00069	0.608
MOD_PKA_1	4	10	PF00069	0.617
MOD_PKA_2	158	164	PF00069	0.501
MOD_PKA_2	258	264	PF00069	0.373
MOD_PKA_2	522	528	PF00069	0.419
MOD_PKA_2	530	536	PF00069	0.335
MOD_Plk_1	502	508	PF00069	0.419
MOD_Plk_1	561	567	PF00069	0.519
MOD_Plk_1	586	592	PF00069	0.482
MOD_Plk_2-3	203	209	PF00069	0.602
MOD_Plk_4	27	33	PF00069	0.551
MOD_Plk_4	478	484	PF00069	0.489
MOD_Plk_4	548	554	PF00069	0.382
MOD_ProDKin_1	236	242	PF00069	0.618
MOD_ProDKin_1	378	384	PF00069	0.535
MOD_ProDKin_1	405	411	PF00069	0.618
MOD_ProDKin_1	490	496	PF00069	0.641
MOD_SUMO_for_1	268	271	PF00179	0.450
MOD_SUMO_rev_2	241	251	PF00179	0.455
MOD_SUMO_rev_2	414	423	PF00179	0.482
TRG_DiLeu_BaEn_1	271	276	PF01217	0.461
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.438
TRG_ENDOCYTIC_2	331	334	PF00928	0.332
TRG_ENDOCYTIC_2	39	42	PF00928	0.460
TRG_ER_diArg_1	158	160	PF00400	0.382
TRG_ER_diArg_1	530	532	PF00400	0.445
TRG_ER_diArg_1	565	568	PF00400	0.415
TRG_NLS_MonoCore_2	222	227	PF00514	0.604
TRG_NLS_MonoExtC_3	230	235	PF00514	0.702
TRG_NLS_MonoExtN_4	2	8	PF00514	0.621
TRG_NLS_MonoExtN_4	223	228	PF00514	0.658
TRG_NLS_MonoExtN_4	229	236	PF00514	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5J9	Leptomonas seymouri	58%	100%
A0A1X0PAQ0	Trypanosomatidae	28%	100%
A0A3S5H7X4	Leishmania donovani	99%	100%
A4HB23	Leishmania braziliensis	75%	100%
C9ZM29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B593	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2P0	Leishmania major	91%	100%
V5B5F7	Trypanosoma cruzi	30%	100%