Cilia- and flagella-associated protein 418

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Retinal Maintenance - putative

Species:

Leishmania infantum

UniProt:

A4IA79_LEIIN

TriTrypDb:

LINF_340037000

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0001917	photoreceptor inner segment	2	9
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4IA79

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA79

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.560
CLV_C14_Caspase3-7	91	95	PF00656	0.631
CLV_NRD_NRD_1	192	194	PF00675	0.279
CLV_NRD_NRD_1	31	33	PF00675	0.699
CLV_NRD_NRD_1	338	340	PF00675	0.530
CLV_PCSK_KEX2_1	30	32	PF00082	0.699
CLV_PCSK_KEX2_1	337	339	PF00082	0.520
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.486
CLV_PCSK_SKI1_1	120	124	PF00082	0.629
CLV_PCSK_SKI1_1	127	131	PF00082	0.594
CLV_PCSK_SKI1_1	194	198	PF00082	0.274
CLV_PCSK_SKI1_1	278	282	PF00082	0.340
CLV_PCSK_SKI1_1	300	304	PF00082	0.321
CLV_PCSK_SKI1_1	46	50	PF00082	0.617
DEG_APCC_DBOX_1	149	157	PF00400	0.591
DOC_CKS1_1	156	161	PF01111	0.546
DOC_MAPK_DCC_7	127	135	PF00069	0.672
DOC_MAPK_gen_1	337	344	PF00069	0.533
DOC_MAPK_HePTP_8	224	236	PF00069	0.521
DOC_MAPK_MEF2A_6	227	236	PF00069	0.521
DOC_MAPK_MEF2A_6	337	344	PF00069	0.467
DOC_PP1_RVXF_1	125	132	PF00149	0.587
DOC_PP2B_LxvP_1	330	333	PF13499	0.609
DOC_PP4_FxxP_1	131	134	PF00568	0.667
DOC_USP7_MATH_1	102	106	PF00917	0.639
DOC_USP7_MATH_1	134	138	PF00917	0.618
DOC_USP7_MATH_1	146	150	PF00917	0.500
DOC_USP7_MATH_1	26	30	PF00917	0.695
DOC_USP7_MATH_1	274	278	PF00917	0.504
DOC_USP7_MATH_1	69	73	PF00917	0.616
DOC_USP7_MATH_1	85	89	PF00917	0.650
DOC_WW_Pin1_4	155	160	PF00397	0.546
DOC_WW_Pin1_4	263	268	PF00397	0.521
LIG_14-3-3_CanoR_1	261	270	PF00244	0.454
LIG_14-3-3_CanoR_1	282	290	PF00244	0.509
LIG_14-3-3_CanoR_1	309	315	PF00244	0.658
LIG_14-3-3_CanoR_1	46	56	PF00244	0.515
LIG_14-3-3_CanoR_1	59	65	PF00244	0.603
LIG_BIR_II_1	1	5	PF00653	0.503
LIG_BIR_III_4	94	98	PF00653	0.658
LIG_FHA_1	156	162	PF00498	0.544
LIG_FHA_1	183	189	PF00498	0.474
LIG_FHA_1	79	85	PF00498	0.656
LIG_LIR_Gen_1	258	267	PF02991	0.482
LIG_LIR_Gen_1	295	304	PF02991	0.454
LIG_LIR_Nem_3	258	262	PF02991	0.494
LIG_LIR_Nem_3	295	299	PF02991	0.454
LIG_MYND_1	128	132	PF01753	0.566
LIG_Pex14_2	131	135	PF04695	0.698
LIG_SH2_CRK	231	235	PF00017	0.454
LIG_SH2_NCK_1	145	149	PF00017	0.588
LIG_SH2_STAT3	290	293	PF00017	0.454
LIG_SH2_STAT5	152	155	PF00017	0.583
LIG_SH2_STAT5	249	252	PF00017	0.483
LIG_SH2_STAT5	290	293	PF00017	0.489
LIG_SH3_3	126	132	PF00018	0.596
LIG_UBA3_1	7	15	PF00899	0.527
MOD_CDK_SPxxK_3	155	162	PF00069	0.553
MOD_CK1_1	118	124	PF00069	0.723
MOD_CK1_1	141	147	PF00069	0.575
MOD_CK1_1	182	188	PF00069	0.457
MOD_CK1_1	295	301	PF00069	0.454
MOD_CK1_1	63	69	PF00069	0.687
MOD_CK1_1	74	80	PF00069	0.623
MOD_CK2_1	136	142	PF00069	0.632
MOD_CK2_1	85	91	PF00069	0.612
MOD_GlcNHglycan	116	120	PF01048	0.569
MOD_GlcNHglycan	138	141	PF01048	0.522
MOD_GlcNHglycan	23	26	PF01048	0.637
MOD_GlcNHglycan	263	266	PF01048	0.308
MOD_GlcNHglycan	284	287	PF01048	0.302
MOD_GlcNHglycan	300	303	PF01048	0.270
MOD_GlcNHglycan	73	76	PF01048	0.697
MOD_GSK3_1	134	141	PF00069	0.627
MOD_GSK3_1	151	158	PF00069	0.444
MOD_GSK3_1	17	24	PF00069	0.703
MOD_GSK3_1	179	186	PF00069	0.499
MOD_GSK3_1	26	33	PF00069	0.735
MOD_GSK3_1	59	66	PF00069	0.718
MOD_GSK3_1	69	76	PF00069	0.610
MOD_N-GLC_1	17	22	PF02516	0.618
MOD_N-GLC_2	206	208	PF02516	0.279
MOD_NEK2_1	183	188	PF00069	0.474
MOD_NEK2_1	248	253	PF00069	0.454
MOD_NEK2_1	281	286	PF00069	0.509
MOD_NEK2_1	47	52	PF00069	0.532
MOD_PKA_1	30	36	PF00069	0.695
MOD_PKA_2	123	129	PF00069	0.570
MOD_PKA_2	281	287	PF00069	0.509
MOD_PKA_2	30	36	PF00069	0.713
MOD_PKA_2	308	314	PF00069	0.667
MOD_Plk_1	183	189	PF00069	0.522
MOD_Plk_1	213	219	PF00069	0.592
MOD_Plk_1	311	317	PF00069	0.619
MOD_Plk_2-3	179	185	PF00069	0.465
MOD_Plk_2-3	3	9	PF00069	0.566
MOD_Plk_2-3	36	42	PF00069	0.674
MOD_Plk_4	292	298	PF00069	0.516
MOD_Plk_4	3	9	PF00069	0.599
MOD_ProDKin_1	155	161	PF00069	0.548
MOD_ProDKin_1	263	269	PF00069	0.521
TRG_DiLeu_BaEn_1	3	8	PF01217	0.566
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.521
TRG_ENDOCYTIC_2	231	234	PF00928	0.483
TRG_ENDOCYTIC_2	249	252	PF00928	0.483
TRG_ER_diArg_1	30	32	PF00400	0.699
TRG_ER_diArg_1	338	340	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P513	Leptomonas seymouri	55%	95%
A0A3S7X892	Leishmania donovani	99%	100%
A0A422N4K3	Trypanosoma rangeli	41%	100%
A4HB22	Leishmania braziliensis	73%	100%
C9ZM30	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B592	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2P1	Leishmania major	91%	100%