LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
protein kinase - putative
Species:
Leishmania infantum
UniProt:
A4IA78_LEIIN
TriTrypDb:
LINF_340036900
Length:
941

Annotations

Annotations by Jardim et al.

Protein kinase, kinase Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 153, 164

Expansion

Sequence features

A4IA78
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA78

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0016310 phosphorylation 5 7
GO:0019538 protein metabolic process 3 7
GO:0036211 protein modification process 4 7
GO:0043170 macromolecule metabolic process 3 7
GO:0043412 macromolecule modification 4 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0071704 organic substance metabolic process 2 7
GO:1901564 organonitrogen compound metabolic process 3 7
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 7
GO:0003824 catalytic activity 1 7
GO:0004672 protein kinase activity 3 7
GO:0005488 binding 1 7
GO:0005524 ATP binding 5 7
GO:0016301 kinase activity 4 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 7
GO:0017076 purine nucleotide binding 4 7
GO:0030554 adenyl nucleotide binding 5 7
GO:0032553 ribonucleotide binding 3 7
GO:0032555 purine ribonucleotide binding 4 7
GO:0032559 adenyl ribonucleotide binding 5 7
GO:0035639 purine ribonucleoside triphosphate binding 4 7
GO:0036094 small molecule binding 2 7
GO:0043167 ion binding 2 7
GO:0043168 anion binding 3 7
GO:0097159 organic cyclic compound binding 2 7
GO:0097367 carbohydrate derivative binding 2 7
GO:0140096 catalytic activity, acting on a protein 2 7
GO:1901265 nucleoside phosphate binding 3 7
GO:1901363 heterocyclic compound binding 2 7
GO:0004674 protein serine/threonine kinase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 614 618 PF00656 0.595
CLV_MEL_PAP_1 703 709 PF00089 0.733
CLV_NRD_NRD_1 264 266 PF00675 0.672
CLV_NRD_NRD_1 306 308 PF00675 0.503
CLV_NRD_NRD_1 417 419 PF00675 0.415
CLV_NRD_NRD_1 480 482 PF00675 0.411
CLV_NRD_NRD_1 483 485 PF00675 0.411
CLV_NRD_NRD_1 538 540 PF00675 0.411
CLV_NRD_NRD_1 598 600 PF00675 0.541
CLV_NRD_NRD_1 60 62 PF00675 0.720
CLV_NRD_NRD_1 672 674 PF00675 0.727
CLV_NRD_NRD_1 85 87 PF00675 0.710
CLV_NRD_NRD_1 873 875 PF00675 0.764
CLV_PCSK_FUR_1 304 308 PF00082 0.593
CLV_PCSK_FUR_1 481 485 PF00082 0.411
CLV_PCSK_FUR_1 82 86 PF00082 0.664
CLV_PCSK_KEX2_1 264 266 PF00082 0.672
CLV_PCSK_KEX2_1 306 308 PF00082 0.503
CLV_PCSK_KEX2_1 416 418 PF00082 0.411
CLV_PCSK_KEX2_1 480 482 PF00082 0.411
CLV_PCSK_KEX2_1 483 485 PF00082 0.411
CLV_PCSK_KEX2_1 598 600 PF00082 0.541
CLV_PCSK_KEX2_1 60 62 PF00082 0.720
CLV_PCSK_KEX2_1 672 674 PF00082 0.783
CLV_PCSK_KEX2_1 84 86 PF00082 0.713
CLV_PCSK_KEX2_1 872 874 PF00082 0.759
CLV_PCSK_KEX2_1 891 893 PF00082 0.557
CLV_PCSK_PC1ET2_1 872 874 PF00082 0.744
CLV_PCSK_PC1ET2_1 891 893 PF00082 0.555
CLV_PCSK_PC7_1 594 600 PF00082 0.519
CLV_PCSK_PC7_1 868 874 PF00082 0.738
CLV_PCSK_SKI1_1 252 256 PF00082 0.648
CLV_PCSK_SKI1_1 369 373 PF00082 0.352
CLV_PCSK_SKI1_1 451 455 PF00082 0.411
CLV_PCSK_SKI1_1 686 690 PF00082 0.657
DEG_Nend_UBRbox_3 1 3 PF02207 0.699
DEG_SCF_FBW7_1 147 153 PF00400 0.601
DEG_SCF_FBW7_1 462 469 PF00400 0.394
DEG_SPOP_SBC_1 151 155 PF00917 0.706
DOC_CKS1_1 147 152 PF01111 0.601
DOC_CKS1_1 193 198 PF01111 0.662
DOC_CKS1_1 463 468 PF01111 0.394
DOC_CYCLIN_yCln2_LP_2 689 695 PF00134 0.616
DOC_MAPK_gen_1 304 311 PF00069 0.579
DOC_MAPK_gen_1 82 91 PF00069 0.661
DOC_MAPK_MEF2A_6 357 364 PF00069 0.501
DOC_PIKK_1 343 351 PF02985 0.645
DOC_PP1_RVXF_1 603 610 PF00149 0.536
DOC_PP2B_LxvP_1 188 191 PF13499 0.745
DOC_PP2B_LxvP_1 667 670 PF13499 0.754
DOC_PP2B_LxvP_1 689 692 PF13499 0.618
DOC_USP7_MATH_1 150 154 PF00917 0.743
DOC_USP7_MATH_1 432 436 PF00917 0.512
DOC_USP7_MATH_1 718 722 PF00917 0.735
DOC_USP7_MATH_1 730 734 PF00917 0.600
DOC_USP7_MATH_1 78 82 PF00917 0.687
DOC_USP7_MATH_1 788 792 PF00917 0.707
DOC_USP7_MATH_1 796 800 PF00917 0.737
DOC_USP7_MATH_1 831 835 PF00917 0.764
DOC_USP7_MATH_1 844 848 PF00917 0.759
DOC_USP7_UBL2_3 540 544 PF12436 0.411
DOC_USP7_UBL2_3 927 931 PF12436 0.689
DOC_WW_Pin1_4 110 115 PF00397 0.747
DOC_WW_Pin1_4 120 125 PF00397 0.720
DOC_WW_Pin1_4 146 151 PF00397 0.789
DOC_WW_Pin1_4 192 197 PF00397 0.777
DOC_WW_Pin1_4 202 207 PF00397 0.667
DOC_WW_Pin1_4 212 217 PF00397 0.735
DOC_WW_Pin1_4 231 236 PF00397 0.488
DOC_WW_Pin1_4 288 293 PF00397 0.683
DOC_WW_Pin1_4 462 467 PF00397 0.394
DOC_WW_Pin1_4 553 558 PF00397 0.493
DOC_WW_Pin1_4 790 795 PF00397 0.685
DOC_WW_Pin1_4 816 821 PF00397 0.735
DOC_WW_Pin1_4 839 844 PF00397 0.698
LIG_14-3-3_CanoR_1 117 127 PF00244 0.607
LIG_14-3-3_CanoR_1 146 150 PF00244 0.747
LIG_14-3-3_CanoR_1 173 183 PF00244 0.646
LIG_14-3-3_CanoR_1 416 424 PF00244 0.512
LIG_14-3-3_CanoR_1 503 508 PF00244 0.411
LIG_14-3-3_CanoR_1 737 743 PF00244 0.800
LIG_14-3-3_CanoR_1 795 803 PF00244 0.793
LIG_14-3-3_CanoR_1 84 90 PF00244 0.723
LIG_14-3-3_CanoR_1 99 103 PF00244 0.713
LIG_Actin_WH2_2 367 382 PF00022 0.411
LIG_APCC_ABBA_1 691 696 PF00400 0.619
LIG_BIR_III_4 621 625 PF00653 0.777
LIG_BIR_III_4 650 654 PF00653 0.763
LIG_BRCT_BRCA1_1 522 526 PF00533 0.411
LIG_deltaCOP1_diTrp_1 519 526 PF00928 0.411
LIG_FHA_1 133 139 PF00498 0.702
LIG_FHA_1 193 199 PF00498 0.623
LIG_FHA_1 421 427 PF00498 0.411
LIG_FHA_1 468 474 PF00498 0.387
LIG_FHA_1 531 537 PF00498 0.396
LIG_FHA_1 733 739 PF00498 0.719
LIG_FHA_1 781 787 PF00498 0.788
LIG_FHA_1 903 909 PF00498 0.707
LIG_FHA_2 322 328 PF00498 0.477
LIG_FHA_2 862 868 PF00498 0.798
LIG_LIR_Apic_2 815 821 PF02991 0.682
LIG_LIR_Gen_1 321 331 PF02991 0.537
LIG_LIR_Gen_1 501 508 PF02991 0.411
LIG_LIR_Gen_1 519 529 PF02991 0.249
LIG_LIR_Gen_1 582 592 PF02991 0.480
LIG_LIR_Nem_3 101 105 PF02991 0.622
LIG_LIR_Nem_3 423 427 PF02991 0.411
LIG_LIR_Nem_3 501 507 PF02991 0.411
LIG_LIR_Nem_3 519 525 PF02991 0.249
LIG_LIR_Nem_3 535 541 PF02991 0.305
LIG_LIR_Nem_3 566 570 PF02991 0.470
LIG_LIR_Nem_3 582 588 PF02991 0.485
LIG_MYND_1 127 131 PF01753 0.763
LIG_NRBOX 184 190 PF00104 0.625
LIG_NRBOX 520 526 PF00104 0.411
LIG_Pex14_1 522 526 PF04695 0.411
LIG_Pex14_2 319 323 PF04695 0.499
LIG_SH2_CRK 427 431 PF00017 0.411
LIG_SH2_CRK 504 508 PF00017 0.411
LIG_SH2_CRK 585 589 PF00017 0.478
LIG_SH2_CRK 818 822 PF00017 0.731
LIG_SH2_GRB2like 63 66 PF00017 0.706
LIG_SH2_GRB2like 827 830 PF00017 0.599
LIG_SH2_NCK_1 504 508 PF00017 0.411
LIG_SH2_STAP1 504 508 PF00017 0.411
LIG_SH2_STAP1 585 589 PF00017 0.578
LIG_SH2_STAT5 391 394 PF00017 0.383
LIG_SH2_STAT5 402 405 PF00017 0.314
LIG_SH2_STAT5 427 430 PF00017 0.411
LIG_SH2_STAT5 472 475 PF00017 0.375
LIG_SH2_STAT5 827 830 PF00017 0.599
LIG_SH3_1 818 824 PF00018 0.626
LIG_SH3_3 121 127 PF00018 0.740
LIG_SH3_3 176 182 PF00018 0.672
LIG_SH3_3 325 331 PF00018 0.548
LIG_SH3_3 460 466 PF00018 0.394
LIG_SH3_3 600 606 PF00018 0.539
LIG_SH3_3 663 669 PF00018 0.768
LIG_SH3_3 689 695 PF00018 0.772
LIG_SH3_3 774 780 PF00018 0.616
LIG_SH3_3 818 824 PF00018 0.688
LIG_SxIP_EBH_1 164 173 PF03271 0.638
LIG_TRAF2_1 331 334 PF00917 0.728
LIG_TRAF2_1 353 356 PF00917 0.603
LIG_WW_3 490 494 PF00397 0.411
LIG_WW_3 669 673 PF00397 0.766
MOD_CAAXbox 938 941 PF01239 0.647
MOD_CDK_SPK_2 110 115 PF00069 0.731
MOD_CDK_SPK_2 288 293 PF00069 0.683
MOD_CDK_SPK_2 790 795 PF00069 0.796
MOD_CDK_SPxK_1 212 218 PF00069 0.732
MOD_CDK_SPxxK_3 110 117 PF00069 0.679
MOD_CK1_1 118 124 PF00069 0.769
MOD_CK1_1 16 22 PF00069 0.616
MOD_CK1_1 161 167 PF00069 0.745
MOD_CK1_1 394 400 PF00069 0.352
MOD_CK1_1 435 441 PF00069 0.512
MOD_CK1_1 506 512 PF00069 0.411
MOD_CK1_1 702 708 PF00069 0.774
MOD_CK1_1 92 98 PF00069 0.701
MOD_CK2_1 16 22 PF00069 0.616
MOD_CK2_1 315 321 PF00069 0.517
MOD_CK2_1 482 488 PF00069 0.411
MOD_CK2_1 796 802 PF00069 0.782
MOD_CK2_1 806 812 PF00069 0.665
MOD_CK2_1 848 854 PF00069 0.705
MOD_CK2_1 861 867 PF00069 0.736
MOD_GlcNHglycan 117 120 PF01048 0.744
MOD_GlcNHglycan 168 171 PF01048 0.676
MOD_GlcNHglycan 19 22 PF01048 0.565
MOD_GlcNHglycan 266 271 PF01048 0.789
MOD_GlcNHglycan 393 396 PF01048 0.352
MOD_GlcNHglycan 637 640 PF01048 0.676
MOD_GlcNHglycan 662 665 PF01048 0.794
MOD_GlcNHglycan 708 711 PF01048 0.787
MOD_GlcNHglycan 720 723 PF01048 0.651
MOD_GlcNHglycan 732 735 PF01048 0.711
MOD_GlcNHglycan 745 748 PF01048 0.711
MOD_GlcNHglycan 799 802 PF01048 0.776
MOD_GlcNHglycan 814 817 PF01048 0.550
MOD_GlcNHglycan 833 836 PF01048 0.569
MOD_GlcNHglycan 850 853 PF01048 0.698
MOD_GlcNHglycan 874 877 PF01048 0.685
MOD_GlcNHglycan 94 97 PF01048 0.689
MOD_GSK3_1 109 116 PF00069 0.793
MOD_GSK3_1 12 19 PF00069 0.653
MOD_GSK3_1 132 139 PF00069 0.703
MOD_GSK3_1 142 149 PF00069 0.596
MOD_GSK3_1 208 215 PF00069 0.777
MOD_GSK3_1 315 322 PF00069 0.516
MOD_GSK3_1 416 423 PF00069 0.411
MOD_GSK3_1 453 460 PF00069 0.411
MOD_GSK3_1 462 469 PF00069 0.411
MOD_GSK3_1 499 506 PF00069 0.411
MOD_GSK3_1 611 618 PF00069 0.546
MOD_GSK3_1 702 709 PF00069 0.792
MOD_GSK3_1 732 739 PF00069 0.823
MOD_GSK3_1 812 819 PF00069 0.750
MOD_GSK3_1 844 851 PF00069 0.662
MOD_GSK3_1 85 92 PF00069 0.711
MOD_N-GLC_1 12 17 PF02516 0.636
MOD_N-GLC_1 151 156 PF02516 0.789
MOD_N-GLC_1 158 163 PF02516 0.714
MOD_N-GLC_1 166 171 PF02516 0.573
MOD_N-GLC_1 248 253 PF02516 0.748
MOD_N-GLC_1 6 11 PF02516 0.699
MOD_N-GLC_1 660 665 PF02516 0.757
MOD_N-GLC_1 78 83 PF02516 0.758
MOD_N-GLC_1 812 817 PF02516 0.752
MOD_N-GLC_1 856 861 PF02516 0.707
MOD_N-GLC_1 89 94 PF02516 0.619
MOD_N-GLC_2 882 884 PF02516 0.777
MOD_NEK2_1 136 141 PF00069 0.739
MOD_NEK2_1 294 299 PF00069 0.572
MOD_NEK2_1 319 324 PF00069 0.498
MOD_NEK2_1 482 487 PF00069 0.411
MOD_NEK2_1 498 503 PF00069 0.411
MOD_NEK2_1 587 592 PF00069 0.473
MOD_NEK2_1 615 620 PF00069 0.644
MOD_NEK2_1 848 853 PF00069 0.705
MOD_NEK2_1 89 94 PF00069 0.688
MOD_NEK2_1 908 913 PF00069 0.716
MOD_NEK2_2 749 754 PF00069 0.727
MOD_PIKK_1 118 124 PF00454 0.759
MOD_PIKK_1 416 422 PF00454 0.411
MOD_PIKK_1 55 61 PF00454 0.714
MOD_PK_1 503 509 PF00069 0.411
MOD_PK_1 551 557 PF00069 0.512
MOD_PKA_1 416 422 PF00069 0.411
MOD_PKA_1 84 90 PF00069 0.707
MOD_PKA_1 872 878 PF00069 0.632
MOD_PKA_2 145 151 PF00069 0.746
MOD_PKA_2 416 422 PF00069 0.411
MOD_PKA_2 482 488 PF00069 0.411
MOD_PKA_2 498 504 PF00069 0.411
MOD_PKA_2 736 742 PF00069 0.811
MOD_PKA_2 84 90 PF00069 0.721
MOD_PKA_2 861 867 PF00069 0.738
MOD_PKA_2 872 878 PF00069 0.682
MOD_PKA_2 92 98 PF00069 0.704
MOD_PKB_1 82 90 PF00069 0.658
MOD_Plk_1 158 164 PF00069 0.740
MOD_Plk_1 334 340 PF00069 0.556
MOD_Plk_1 551 557 PF00069 0.512
MOD_Plk_1 6 12 PF00069 0.700
MOD_Plk_1 611 617 PF00069 0.628
MOD_Plk_1 761 767 PF00069 0.742
MOD_Plk_1 78 84 PF00069 0.756
MOD_Plk_1 806 812 PF00069 0.763
MOD_Plk_1 856 862 PF00069 0.706
MOD_Plk_1 908 914 PF00069 0.714
MOD_Plk_4 13 19 PF00069 0.625
MOD_Plk_4 52 58 PF00069 0.617
MOD_Plk_4 587 593 PF00069 0.480
MOD_Plk_4 6 12 PF00069 0.679
MOD_Plk_4 823 829 PF00069 0.587
MOD_ProDKin_1 110 116 PF00069 0.745
MOD_ProDKin_1 120 126 PF00069 0.722
MOD_ProDKin_1 146 152 PF00069 0.790
MOD_ProDKin_1 192 198 PF00069 0.779
MOD_ProDKin_1 202 208 PF00069 0.667
MOD_ProDKin_1 212 218 PF00069 0.735
MOD_ProDKin_1 231 237 PF00069 0.486
MOD_ProDKin_1 288 294 PF00069 0.674
MOD_ProDKin_1 462 468 PF00069 0.394
MOD_ProDKin_1 553 559 PF00069 0.487
MOD_ProDKin_1 790 796 PF00069 0.687
MOD_ProDKin_1 816 822 PF00069 0.734
MOD_ProDKin_1 839 845 PF00069 0.700
MOD_SUMO_for_1 362 365 PF00179 0.411
MOD_SUMO_rev_2 365 371 PF00179 0.411
MOD_SUMO_rev_2 919 929 PF00179 0.786
TRG_DiLeu_BaEn_1 343 348 PF01217 0.639
TRG_DiLeu_BaEn_2 565 571 PF01217 0.477
TRG_DiLeu_BaEn_4 333 339 PF01217 0.693
TRG_ENDOCYTIC_2 402 405 PF00928 0.394
TRG_ENDOCYTIC_2 427 430 PF00928 0.411
TRG_ENDOCYTIC_2 504 507 PF00928 0.411
TRG_ENDOCYTIC_2 585 588 PF00928 0.480
TRG_ER_diArg_1 114 117 PF00400 0.715
TRG_ER_diArg_1 303 306 PF00400 0.495
TRG_ER_diArg_1 415 418 PF00400 0.411
TRG_ER_diArg_1 480 482 PF00400 0.411
TRG_ER_diArg_1 60 62 PF00400 0.703
TRG_ER_diArg_1 671 673 PF00400 0.781
TRG_ER_diArg_1 82 85 PF00400 0.665
TRG_NES_CRM1_1 519 530 PF08389 0.411
TRG_Pf-PMV_PEXEL_1 24 28 PF00026 0.536
TRG_Pf-PMV_PEXEL_1 561 566 PF00026 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IK71 Leptomonas seymouri 49% 100%
A0A3Q8IFR1 Leishmania donovani 100% 100%
A4HB21 Leishmania braziliensis 63% 96%
E9B591 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 99%
Q4Q2P2 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS