Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoside diphosphate kinase - putative

Species:

Leishmania infantum

UniProt:

A4IA74_LEIIN

TriTrypDb:

LINF_340036500

Length:

343

Annotations

Annotations by Jardim et al.

Pyrimidine metabolism, Nucleoside diphosphate kinase Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	2
GO:0005815	microtubule organizing center	2	2
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4IA74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA74

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0044237	cellular metabolic process	2	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0004550	nucleoside diphosphate kinase activity	5	9
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	9
GO:0019205	nucleobase-containing compound kinase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.463
CLV_NRD_NRD_1	156	158	PF00675	0.508
CLV_PCSK_KEX2_1	51	53	PF00082	0.357
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.377
CLV_PCSK_PC7_1	47	53	PF00082	0.396
CLV_PCSK_SKI1_1	256	260	PF00082	0.213
CLV_PCSK_SKI1_1	338	342	PF00082	0.305
CLV_PCSK_SKI1_1	9	13	PF00082	0.325
DEG_APCC_DBOX_1	255	263	PF00400	0.507
DOC_MAPK_gen_1	51	57	PF00069	0.312
DOC_MAPK_RevD_3	38	52	PF00069	0.479
DOC_PP4_FxxP_1	139	142	PF00568	0.308
DOC_PP4_FxxP_1	251	254	PF00568	0.440
DOC_USP7_MATH_1	204	208	PF00917	0.317
DOC_USP7_MATH_1	90	94	PF00917	0.395
DOC_USP7_UBL2_3	159	163	PF12436	0.284
DOC_USP7_UBL2_3	305	309	PF12436	0.523
LIG_Actin_WH2_2	36	53	PF00022	0.419
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_FHA_1	1	7	PF00498	0.660
LIG_FHA_1	146	152	PF00498	0.334
LIG_FHA_1	270	276	PF00498	0.438
LIG_FHA_1	282	288	PF00498	0.451
LIG_FHA_1	35	41	PF00498	0.396
LIG_FHA_1	65	71	PF00498	0.365
LIG_FHA_1	83	89	PF00498	0.295
LIG_FHA_1	94	100	PF00498	0.318
LIG_FHA_2	120	126	PF00498	0.376
LIG_FHA_2	174	180	PF00498	0.455
LIG_LIR_Apic_2	137	142	PF02991	0.432
LIG_LIR_Apic_2	250	254	PF02991	0.442
LIG_LIR_Gen_1	162	171	PF02991	0.444
LIG_LIR_Gen_1	223	233	PF02991	0.372
LIG_LIR_Nem_3	102	108	PF02991	0.388
LIG_LIR_Nem_3	162	168	PF02991	0.437
LIG_LIR_Nem_3	223	228	PF02991	0.372
LIG_LIR_Nem_3	253	258	PF02991	0.454
LIG_MYND_3	259	263	PF01753	0.413
LIG_SH2_CRK	255	259	PF00017	0.434
LIG_SH2_CRK	298	302	PF00017	0.523
LIG_SH2_STAP1	298	302	PF00017	0.523
LIG_SH2_STAP1	336	340	PF00017	0.434
LIG_SH2_STAT5	111	114	PF00017	0.335
LIG_SH2_STAT5	31	34	PF00017	0.382
LIG_SH2_STAT5	336	339	PF00017	0.452
LIG_SH2_STAT5	49	52	PF00017	0.312
LIG_SH3_3	16	22	PF00018	0.549
LIG_SH3_3	207	213	PF00018	0.428
LIG_SH3_3	52	58	PF00018	0.341
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.435
LIG_SUMO_SIM_anti_2	282	290	PF11976	0.427
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.461
LIG_SUMO_SIM_par_1	150	156	PF11976	0.443
LIG_SUMO_SIM_par_1	282	290	PF11976	0.456
LIG_SUMO_SIM_par_1	34	42	PF11976	0.456
MOD_CK1_1	60	66	PF00069	0.357
MOD_CK1_1	93	99	PF00069	0.353
MOD_CK2_1	121	127	PF00069	0.425
MOD_CK2_1	277	283	PF00069	0.492
MOD_CK2_1	315	321	PF00069	0.477
MOD_GlcNHglycan	136	139	PF01048	0.452
MOD_GlcNHglycan	216	219	PF01048	0.291
MOD_GlcNHglycan	222	225	PF01048	0.284
MOD_GlcNHglycan	244	247	PF01048	0.273
MOD_GlcNHglycan	34	37	PF01048	0.419
MOD_GlcNHglycan	44	47	PF01048	0.465
MOD_GlcNHglycan	59	62	PF01048	0.348
MOD_GSK3_1	169	176	PF00069	0.391
MOD_GSK3_1	233	240	PF00069	0.486
MOD_GSK3_1	265	272	PF00069	0.496
MOD_GSK3_1	277	284	PF00069	0.433
MOD_GSK3_1	60	67	PF00069	0.396
MOD_N-GLC_1	204	209	PF02516	0.293
MOD_N-GLC_2	293	295	PF02516	0.176
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	145	150	PF00069	0.349
MOD_NEK2_1	262	267	PF00069	0.454
MOD_NEK2_1	269	274	PF00069	0.438
MOD_NEK2_1	32	37	PF00069	0.506
MOD_NEK2_1	50	55	PF00069	0.358
MOD_PKA_2	169	175	PF00069	0.406
MOD_Plk_1	204	210	PF00069	0.278
MOD_Plk_1	281	287	PF00069	0.450
MOD_Plk_1	93	99	PF00069	0.356
MOD_Plk_2-3	34	40	PF00069	0.361
MOD_Plk_4	204	210	PF00069	0.278
MOD_Plk_4	265	271	PF00069	0.496
MOD_Plk_4	297	303	PF00069	0.506
MOD_Plk_4	64	70	PF00069	0.339
TRG_DiLeu_BaEn_3	102	108	PF01217	0.254
TRG_ENDOCYTIC_2	111	114	PF00928	0.347
TRG_ENDOCYTIC_2	255	258	PF00928	0.428
TRG_ENDOCYTIC_2	298	301	PF00928	0.523
TRG_ENDOCYTIC_2	336	339	PF00928	0.447
TRG_NES_CRM1_1	277	289	PF08389	0.470
TRG_NLS_MonoExtC_3	156	162	PF00514	0.291
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJQ8	Leptomonas seymouri	72%	100%
A0A0N1PC23	Leptomonas seymouri	27%	100%
A0A0S4IXH2	Bodo saltans	28%	100%
A0A1X0P5C0	Trypanosomatidae	30%	100%
A0A1X0PAT4	Trypanosomatidae	46%	98%
A0A3Q8IJQ8	Leishmania donovani	28%	100%
A0A3R7M6K1	Trypanosoma rangeli	46%	99%
A0A3R7N390	Trypanosoma rangeli	30%	100%
A0A3S7X855	Leishmania donovani	99%	100%
A4HB17	Leishmania braziliensis	84%	100%
A4HN58	Leishmania braziliensis	28%	100%
A4IBS5	Leishmania infantum	28%	100%
C9ZM33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
C9ZYU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFL1	Leishmania major	28%	100%
E9B587	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6R5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q2P6	Leishmania major	94%	100%
Q5E9Y9	Bos taurus	25%	91%
Q9QXL7	Rattus norvegicus	25%	87%
Q9QXL8	Mus musculus	24%	87%
Q9Y5B8	Homo sapiens	24%	91%
V5BXY9	Trypanosoma cruzi	28%	99%
V5DLW4	Trypanosoma cruzi	45%	98%