LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
EF-hand domain pair/EF-hand domain/EF hand - putative
Species:
Leishmania infantum
UniProt:
A4IA71_LEIIN
TriTrypDb:
LINF_340036200
Length:
422

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IA71
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA71

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 12
GO:0005509 calcium ion binding 5 12
GO:0043167 ion binding 2 12
GO:0043169 cation binding 3 12
GO:0046872 metal ion binding 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 163 167 PF00656 0.458
CLV_C14_Caspase3-7 309 313 PF00656 0.328
CLV_C14_Caspase3-7 345 349 PF00656 0.474
CLV_NRD_NRD_1 104 106 PF00675 0.408
CLV_NRD_NRD_1 151 153 PF00675 0.581
CLV_NRD_NRD_1 359 361 PF00675 0.597
CLV_PCSK_KEX2_1 104 106 PF00082 0.334
CLV_PCSK_KEX2_1 19 21 PF00082 0.418
CLV_PCSK_PC1ET2_1 19 21 PF00082 0.502
CLV_PCSK_SKI1_1 19 23 PF00082 0.414
CLV_PCSK_SKI1_1 242 246 PF00082 0.490
CLV_PCSK_SKI1_1 332 336 PF00082 0.424
CLV_PCSK_SKI1_1 370 374 PF00082 0.463
DEG_APCC_DBOX_1 104 112 PF00400 0.327
DEG_APCC_DBOX_1 241 249 PF00400 0.504
DEG_Nend_UBRbox_3 1 3 PF02207 0.674
DOC_CYCLIN_RxL_1 16 26 PF00134 0.434
DOC_CYCLIN_RxL_1 262 270 PF00134 0.435
DOC_PP2B_LxvP_1 296 299 PF13499 0.503
DOC_PP2B_LxvP_1 323 326 PF13499 0.455
DOC_USP7_MATH_1 179 183 PF00917 0.466
DOC_USP7_MATH_1 202 206 PF00917 0.510
DOC_USP7_MATH_1 234 238 PF00917 0.564
DOC_USP7_MATH_1 240 244 PF00917 0.554
DOC_USP7_MATH_1 299 303 PF00917 0.549
DOC_WW_Pin1_4 23 28 PF00397 0.609
DOC_WW_Pin1_4 363 368 PF00397 0.587
DOC_WW_Pin1_4 98 103 PF00397 0.382
LIG_Actin_WH2_2 88 106 PF00022 0.483
LIG_BRCT_BRCA1_1 204 208 PF00533 0.529
LIG_BRCT_BRCA1_1 340 344 PF00533 0.508
LIG_eIF4E_1 319 325 PF01652 0.479
LIG_FHA_1 291 297 PF00498 0.501
LIG_FHA_1 299 305 PF00498 0.520
LIG_FHA_1 88 94 PF00498 0.382
LIG_FHA_2 145 151 PF00498 0.558
LIG_FHA_2 161 167 PF00498 0.455
LIG_FHA_2 307 313 PF00498 0.331
LIG_FHA_2 373 379 PF00498 0.480
LIG_FHA_2 50 56 PF00498 0.351
LIG_FHA_2 75 81 PF00498 0.449
LIG_LIR_Apic_2 348 354 PF02991 0.513
LIG_LIR_Gen_1 188 198 PF02991 0.414
LIG_LIR_Gen_1 406 413 PF02991 0.455
LIG_LIR_Gen_1 90 100 PF02991 0.470
LIG_LIR_Nem_3 173 177 PF02991 0.379
LIG_LIR_Nem_3 188 194 PF02991 0.367
LIG_LIR_Nem_3 406 412 PF02991 0.476
LIG_LIR_Nem_3 90 95 PF02991 0.470
LIG_Pex14_1 340 344 PF04695 0.481
LIG_Pex14_2 155 159 PF04695 0.431
LIG_Pex14_2 373 377 PF04695 0.394
LIG_RPA_C_Fungi 233 245 PF08784 0.541
LIG_SH2_CRK 178 182 PF00017 0.382
LIG_SH2_CRK 351 355 PF00017 0.501
LIG_SH2_STAP1 320 324 PF00017 0.477
LIG_SH2_STAT3 396 399 PF00017 0.464
LIG_SH2_STAT5 297 300 PF00017 0.420
LIG_SH2_STAT5 396 399 PF00017 0.428
LIG_SUMO_SIM_anti_2 188 196 PF11976 0.385
LIG_SUMO_SIM_anti_2 90 97 PF11976 0.475
LIG_TRAF2_1 170 173 PF00917 0.398
LIG_TRAF2_1 52 55 PF00917 0.448
LIG_TRAF2_1 59 62 PF00917 0.402
LIG_TRAF2_1 66 69 PF00917 0.377
LIG_UBA3_1 75 84 PF00899 0.475
LIG_WRC_WIRS_1 33 38 PF05994 0.542
MOD_CDC14_SPxK_1 101 104 PF00782 0.475
MOD_CDK_SPxK_1 98 104 PF00069 0.376
MOD_CDK_SPxxK_3 363 370 PF00069 0.586
MOD_CDK_SPxxK_3 98 105 PF00069 0.418
MOD_CK1_1 222 228 PF00069 0.603
MOD_CK2_1 144 150 PF00069 0.546
MOD_CK2_1 167 173 PF00069 0.408
MOD_CK2_1 225 231 PF00069 0.541
MOD_CK2_1 299 305 PF00069 0.538
MOD_CK2_1 49 55 PF00069 0.396
MOD_CK2_1 63 69 PF00069 0.308
MOD_GlcNHglycan 156 159 PF01048 0.520
MOD_GlcNHglycan 169 172 PF01048 0.503
MOD_GlcNHglycan 181 184 PF01048 0.417
MOD_GlcNHglycan 242 245 PF01048 0.557
MOD_GlcNHglycan 259 262 PF01048 0.382
MOD_GlcNHglycan 27 30 PF01048 0.462
MOD_GlcNHglycan 278 281 PF01048 0.503
MOD_GlcNHglycan 328 331 PF01048 0.522
MOD_GlcNHglycan 399 402 PF01048 0.494
MOD_GSK3_1 202 209 PF00069 0.459
MOD_GSK3_1 240 247 PF00069 0.500
MOD_GSK3_1 276 283 PF00069 0.474
MOD_GSK3_1 32 39 PF00069 0.482
MOD_GSK3_1 45 52 PF00069 0.405
MOD_GSK3_1 83 90 PF00069 0.444
MOD_N-GLC_1 159 164 PF02516 0.488
MOD_N-GLC_1 299 304 PF02516 0.484
MOD_N-GLC_1 63 68 PF02516 0.437
MOD_N-GLC_1 98 103 PF02516 0.465
MOD_NEK2_1 11 16 PF00069 0.461
MOD_NEK2_1 159 164 PF00069 0.479
MOD_NEK2_1 208 213 PF00069 0.447
MOD_NEK2_1 267 272 PF00069 0.499
MOD_NEK2_1 36 41 PF00069 0.516
MOD_NEK2_1 46 51 PF00069 0.460
MOD_PIKK_1 46 52 PF00454 0.586
MOD_PK_1 206 212 PF00069 0.391
MOD_Plk_1 187 193 PF00069 0.390
MOD_Plk_1 206 212 PF00069 0.316
MOD_Plk_1 225 231 PF00069 0.540
MOD_Plk_1 299 305 PF00069 0.528
MOD_Plk_1 63 69 PF00069 0.421
MOD_Plk_4 187 193 PF00069 0.388
MOD_Plk_4 244 250 PF00069 0.449
MOD_Plk_4 299 305 PF00069 0.504
MOD_ProDKin_1 23 29 PF00069 0.609
MOD_ProDKin_1 363 369 PF00069 0.586
MOD_ProDKin_1 98 104 PF00069 0.376
MOD_SUMO_for_1 213 216 PF00179 0.510
MOD_SUMO_rev_2 161 170 PF00179 0.565
MOD_SUMO_rev_2 226 235 PF00179 0.533
TRG_DiLeu_BaEn_1 388 393 PF01217 0.446
TRG_DiLeu_BaLyEn_6 17 22 PF01217 0.403
TRG_ENDOCYTIC_2 178 181 PF00928 0.383
TRG_ENDOCYTIC_2 320 323 PF00928 0.358
TRG_ER_diArg_1 103 105 PF00400 0.377
TRG_Pf-PMV_PEXEL_1 20 24 PF00026 0.496
TRG_Pf-PMV_PEXEL_1 58 62 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2R2 Leptomonas seymouri 66% 100%
A0A0S4J207 Bodo saltans 35% 97%
A0A1X0PAP2 Trypanosomatidae 42% 100%
A0A3Q8IHP2 Leishmania donovani 99% 100%
A0A422N4H8 Trypanosoma rangeli 42% 100%
A4HB14 Leishmania braziliensis 84% 100%
C9ZM35 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
E9B584 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q2P9 Leishmania major 95% 100%
V5B5A3 Trypanosoma cruzi 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS