LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA70_LEIIN
TriTrypDb:
LINF_340036100 *
Length:
294

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA70
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA70

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 153 155 PF00675 0.633
CLV_NRD_NRD_1 263 265 PF00675 0.403
CLV_NRD_NRD_1 36 38 PF00675 0.505
CLV_NRD_NRD_1 51 53 PF00675 0.613
CLV_NRD_NRD_1 9 11 PF00675 0.734
CLV_PCSK_KEX2_1 120 122 PF00082 0.666
CLV_PCSK_KEX2_1 151 153 PF00082 0.650
CLV_PCSK_KEX2_1 265 267 PF00082 0.533
CLV_PCSK_KEX2_1 35 37 PF00082 0.521
CLV_PCSK_KEX2_1 51 53 PF00082 0.620
CLV_PCSK_KEX2_1 9 11 PF00082 0.734
CLV_PCSK_PC1ET2_1 120 122 PF00082 0.687
CLV_PCSK_PC1ET2_1 151 153 PF00082 0.670
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.533
CLV_PCSK_SKI1_1 191 195 PF00082 0.528
CLV_PCSK_SKI1_1 41 45 PF00082 0.641
DOC_MAPK_MEF2A_6 131 138 PF00069 0.446
DOC_PP4_FxxP_1 65 68 PF00568 0.672
DOC_USP7_MATH_1 115 119 PF00917 0.625
DOC_USP7_MATH_1 226 230 PF00917 0.547
DOC_USP7_MATH_1 289 293 PF00917 0.733
DOC_WW_Pin1_4 284 289 PF00397 0.723
LIG_14-3-3_CanoR_1 114 124 PF00244 0.612
LIG_14-3-3_CanoR_1 280 285 PF00244 0.718
LIG_BIR_II_1 1 5 PF00653 0.661
LIG_BRCT_BRCA1_1 275 279 PF00533 0.581
LIG_BRCT_BRCA1_1 280 284 PF00533 0.688
LIG_FHA_1 192 198 PF00498 0.664
LIG_FHA_1 27 33 PF00498 0.591
LIG_FHA_1 92 98 PF00498 0.631
LIG_FHA_2 160 166 PF00498 0.700
LIG_FHA_2 56 62 PF00498 0.658
LIG_IBAR_NPY_1 273 275 PF08397 0.563
LIG_LIR_Apic_2 198 204 PF02991 0.556
LIG_LIR_Gen_1 94 104 PF02991 0.651
LIG_LIR_Nem_3 20 26 PF02991 0.489
LIG_LIR_Nem_3 249 254 PF02991 0.486
LIG_LIR_Nem_3 74 80 PF02991 0.629
LIG_PDZ_Class_1 289 294 PF00595 0.524
LIG_SH2_CRK 205 209 PF00017 0.554
LIG_SH2_CRK 275 279 PF00017 0.607
LIG_SH2_NCK_1 275 279 PF00017 0.607
LIG_SH2_PTP2 201 204 PF00017 0.540
LIG_SH2_STAP1 275 279 PF00017 0.581
LIG_SH2_STAT3 234 237 PF00017 0.637
LIG_SH2_STAT5 201 204 PF00017 0.561
LIG_SH3_3 21 27 PF00018 0.587
LIG_SUMO_SIM_par_1 255 260 PF11976 0.580
LIG_TYR_ITSM 73 80 PF00017 0.713
LIG_WW_3 287 291 PF00397 0.644
MOD_CDK_SPxK_1 284 290 PF00069 0.651
MOD_CK2_1 159 165 PF00069 0.701
MOD_CK2_1 210 216 PF00069 0.553
MOD_CK2_1 55 61 PF00069 0.655
MOD_Cter_Amidation 49 52 PF01082 0.694
MOD_Cter_Amidation 7 10 PF01082 0.657
MOD_GlcNHglycan 197 200 PF01048 0.698
MOD_GSK3_1 116 123 PF00069 0.634
MOD_GSK3_1 134 141 PF00069 0.555
MOD_GSK3_1 191 198 PF00069 0.670
MOD_GSK3_1 26 33 PF00069 0.583
MOD_GSK3_1 274 281 PF00069 0.574
MOD_GSK3_1 284 291 PF00069 0.701
MOD_GSK3_1 87 94 PF00069 0.600
MOD_N-GLC_1 211 216 PF02516 0.552
MOD_N-GLC_1 70 75 PF02516 0.642
MOD_NEK2_1 138 143 PF00069 0.585
MOD_NEK2_1 233 238 PF00069 0.520
MOD_NEK2_1 243 248 PF00069 0.423
MOD_NEK2_1 279 284 PF00069 0.712
MOD_NEK2_1 70 75 PF00069 0.693
MOD_NEK2_1 99 104 PF00069 0.646
MOD_NEK2_2 274 279 PF00069 0.584
MOD_PIKK_1 233 239 PF00454 0.611
MOD_PKA_1 120 126 PF00069 0.609
MOD_PKA_2 120 126 PF00069 0.650
MOD_PKA_2 195 201 PF00069 0.694
MOD_PKA_2 279 285 PF00069 0.589
MOD_Plk_1 211 217 PF00069 0.515
MOD_Plk_4 134 140 PF00069 0.565
MOD_Plk_4 226 232 PF00069 0.596
MOD_Plk_4 274 280 PF00069 0.591
MOD_Plk_4 99 105 PF00069 0.643
MOD_ProDKin_1 284 290 PF00069 0.725
MOD_SUMO_rev_2 178 185 PF00179 0.653
MOD_SUMO_rev_2 268 272 PF00179 0.540
TRG_DiLeu_BaEn_2 37 43 PF01217 0.646
TRG_ENDOCYTIC_2 205 208 PF00928 0.589
TRG_ENDOCYTIC_2 275 278 PF00928 0.602
TRG_ENDOCYTIC_2 77 80 PF00928 0.656
TRG_ER_diArg_1 152 154 PF00400 0.658
TRG_ER_diArg_1 263 266 PF00400 0.402
TRG_ER_diArg_1 34 37 PF00400 0.511
TRG_ER_diArg_1 9 11 PF00400 0.733
TRG_Pf-PMV_PEXEL_1 41 46 PF00026 0.666

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PAU8 Leptomonas seymouri 59% 100%
A0A0S4IYA0 Bodo saltans 24% 100%
A0A1X0PA38 Trypanosomatidae 29% 100%
A0A3Q8ILA3 Leishmania donovani 100% 96%
A0A3R7KSA4 Trypanosoma rangeli 31% 100%
A4HB13 Leishmania braziliensis 73% 100%
C9ZM36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9B583 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2Q0 Leishmania major 91% 100%
V5BV16 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS