LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA68_LEIIN
TriTrypDb:
LINF_340035900
Length:
89

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 7
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4IA68
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA68

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 6 8 PF00675 0.421
CLV_NRD_NRD_1 75 77 PF00675 0.672
CLV_PCSK_KEX2_1 6 8 PF00082 0.421
CLV_PCSK_KEX2_1 75 77 PF00082 0.614
CLV_PCSK_SKI1_1 46 50 PF00082 0.369
DEG_Nend_Nbox_1 1 3 PF02207 0.648
DEG_SCF_FBW7_2 65 72 PF00400 0.616
DOC_CKS1_1 66 71 PF01111 0.449
DOC_MAPK_DCC_7 49 59 PF00069 0.390
DOC_MAPK_gen_1 45 55 PF00069 0.502
DOC_MAPK_MEF2A_6 45 54 PF00069 0.502
DOC_USP7_UBL2_3 41 45 PF12436 0.589
DOC_WW_Pin1_4 65 70 PF00397 0.481
LIG_14-3-3_CanoR_1 12 18 PF00244 0.615
LIG_14-3-3_CanoR_1 6 10 PF00244 0.621
LIG_DCNL_PONY_1 1 4 PF03556 0.687
LIG_FHA_1 35 41 PF00498 0.629
LIG_FHA_2 66 72 PF00498 0.425
LIG_SH2_STAP1 81 85 PF00017 0.411
LIG_SH3_3 50 56 PF00018 0.373
LIG_TRAF2_1 69 72 PF00917 0.423
MOD_CK1_1 13 19 PF00069 0.498
MOD_CK2_1 65 71 PF00069 0.485
MOD_GlcNHglycan 24 27 PF01048 0.639
MOD_NEK2_1 2 7 PF00069 0.560
MOD_PKA_2 13 19 PF00069 0.495
MOD_PKA_2 2 8 PF00069 0.471
MOD_Plk_1 32 38 PF00069 0.563
MOD_ProDKin_1 65 71 PF00069 0.485
MOD_SUMO_for_1 40 43 PF00179 0.483
TRG_ER_diArg_1 12 15 PF00400 0.529
TRG_ER_diArg_1 75 78 PF00400 0.599
TRG_Pf-PMV_PEXEL_1 7 11 PF00026 0.543

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5F0 Leptomonas seymouri 71% 100%
A0A0S4J4S3 Bodo saltans 53% 100%
A0A3Q8INJ8 Leishmania donovani 99% 100%
A4HB11 Leishmania braziliensis 81% 100%
C9ZM38 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9B581 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q2Q2 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS