Serine O-acetyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine acetyltransferase

Species:

Leishmania infantum

UniProt:

A4IA64_LEIIN

TriTrypDb:

LINF_340035400

Length:

411

Annotations

Annotations by Jardim et al.

Transferases, Serine acetyltransferase SAT

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IA64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA64

Function

Biological processes
Term	Name	Level	Count
GO:0000096	sulfur amino acid metabolic process	4	1
GO:0000097	sulfur amino acid biosynthetic process	5	1
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006534	cysteine metabolic process	5	1
GO:0006535	cysteine biosynthetic process from serine	7	1
GO:0006563	L-serine metabolic process	6	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008652	amino acid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009069	serine family amino acid metabolic process	5	1
GO:0009070	serine family amino acid biosynthetic process	6	1
GO:0009987	cellular process	1	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019344	cysteine biosynthetic process	6	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044272	sulfur compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901607	alpha-amino acid biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008374	O-acyltransferase activity	5	6
GO:0009001	serine O-acetyltransferase activity	7	6
GO:0016407	acetyltransferase activity	5	6
GO:0016412	serine O-acyltransferase activity	6	6
GO:0016413	O-acetyltransferase activity	6	6
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.482
CLV_PCSK_KEX2_1	2	4	PF00082	0.506
CLV_PCSK_KEX2_1	200	202	PF00082	0.504
CLV_PCSK_KEX2_1	337	339	PF00082	0.534
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.506
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.504
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.534
CLV_PCSK_SKI1_1	100	104	PF00082	0.693
CLV_PCSK_SKI1_1	119	123	PF00082	0.662
CLV_PCSK_SKI1_1	219	223	PF00082	0.356
CLV_PCSK_SKI1_1	272	276	PF00082	0.432
CLV_PCSK_SKI1_1	401	405	PF00082	0.652
CLV_PCSK_SKI1_1	8	12	PF00082	0.512
DEG_APCC_DBOX_1	28	36	PF00400	0.566
DEG_APCC_DBOX_1	7	15	PF00400	0.569
DEG_Nend_UBRbox_1	1	4	PF02207	0.517
DOC_CYCLIN_RxL_1	214	225	PF00134	0.360
DOC_PP2B_LxvP_1	264	267	PF13499	0.427
DOC_USP7_MATH_1	127	131	PF00917	0.690
DOC_USP7_MATH_1	384	388	PF00917	0.458
DOC_USP7_UBL2_3	145	149	PF12436	0.644
DOC_WW_Pin1_4	172	177	PF00397	0.654
DOC_WW_Pin1_4	235	240	PF00397	0.501
DOC_WW_Pin1_4	55	60	PF00397	0.630
LIG_14-3-3_CanoR_1	119	124	PF00244	0.748
LIG_14-3-3_CanoR_1	29	33	PF00244	0.513
LIG_APCC_ABBA_1	87	92	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.419
LIG_Clathr_ClatBox_1	125	129	PF01394	0.691
LIG_FHA_1	120	126	PF00498	0.753
LIG_FHA_1	182	188	PF00498	0.715
LIG_FHA_1	206	212	PF00498	0.439
LIG_FHA_1	269	275	PF00498	0.464
LIG_FHA_1	300	306	PF00498	0.422
LIG_FHA_1	307	313	PF00498	0.409
LIG_FHA_1	337	343	PF00498	0.653
LIG_FHA_2	109	115	PF00498	0.655
LIG_FHA_2	222	228	PF00498	0.408
LIG_FHA_2	280	286	PF00498	0.447
LIG_FHA_2	363	369	PF00498	0.525
LIG_FHA_2	58	64	PF00498	0.583
LIG_LIR_Gen_1	81	89	PF02991	0.532
LIG_LIR_Nem_3	317	322	PF02991	0.403
LIG_LIR_Nem_3	40	46	PF02991	0.401
LIG_LIR_Nem_3	81	87	PF02991	0.454
LIG_LIR_Nem_3	99	105	PF02991	0.619
LIG_LYPXL_yS_3	246	249	PF13949	0.411
LIG_PDZ_Class_1	406	411	PF00595	0.622
LIG_Pex14_2	43	47	PF04695	0.443
LIG_SH2_CRK	319	323	PF00017	0.422
LIG_SH2_GRB2like	355	358	PF00017	0.512
LIG_SH2_SRC	355	358	PF00017	0.509
LIG_SH2_STAP1	355	359	PF00017	0.509
LIG_SH2_STAT5	44	47	PF00017	0.427
LIG_SH2_STAT5	84	87	PF00017	0.453
LIG_SH3_1	340	346	PF00018	0.563
LIG_SH3_3	340	346	PF00018	0.563
LIG_SH3_3	392	398	PF00018	0.637
LIG_SH3_3	42	48	PF00018	0.448
LIG_SH3_3	98	104	PF00018	0.647
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.685
LIG_TRAF2_1	151	154	PF00917	0.679
LIG_TYR_ITIM	244	249	PF00017	0.431
LIG_WRC_WIRS_1	23	28	PF05994	0.672
MOD_CDK_SPK_2	172	177	PF00069	0.607
MOD_CK1_1	108	114	PF00069	0.652
MOD_CK1_1	130	136	PF00069	0.749
MOD_CK1_1	170	176	PF00069	0.784
MOD_CK1_1	237	243	PF00069	0.485
MOD_CK1_1	328	334	PF00069	0.601
MOD_CK1_1	55	61	PF00069	0.556
MOD_CK2_1	108	114	PF00069	0.708
MOD_CK2_1	221	227	PF00069	0.405
MOD_CK2_1	235	241	PF00069	0.445
MOD_CK2_1	362	368	PF00069	0.525
MOD_CK2_1	57	63	PF00069	0.638
MOD_Cter_Amidation	335	338	PF01082	0.458
MOD_GlcNHglycan	188	191	PF01048	0.516
MOD_GlcNHglycan	20	23	PF01048	0.592
MOD_GlcNHglycan	407	411	PF01048	0.592
MOD_GSK3_1	104	111	PF00069	0.601
MOD_GSK3_1	163	170	PF00069	0.769
MOD_GSK3_1	18	25	PF00069	0.716
MOD_GSK3_1	268	275	PF00069	0.435
MOD_GSK3_1	328	335	PF00069	0.601
MOD_GSK3_1	48	55	PF00069	0.478
MOD_N-GLC_1	105	110	PF02516	0.639
MOD_N-GLC_1	268	273	PF02516	0.441
MOD_NEK2_1	105	110	PF00069	0.620
MOD_NEK2_1	128	133	PF00069	0.693
MOD_NEK2_1	155	160	PF00069	0.776
MOD_NEK2_2	28	33	PF00069	0.580
MOD_PIKK_1	105	111	PF00454	0.609
MOD_PIKK_1	78	84	PF00454	0.399
MOD_PKA_2	155	161	PF00069	0.652
MOD_PKA_2	28	34	PF00069	0.575
MOD_PKA_2	362	368	PF00069	0.550
MOD_PKB_1	161	169	PF00069	0.780
MOD_Plk_1	268	274	PF00069	0.437
MOD_Plk_1	367	373	PF00069	0.550
MOD_Plk_4	121	127	PF00069	0.655
MOD_Plk_4	314	320	PF00069	0.399
MOD_Plk_4	350	356	PF00069	0.509
MOD_Plk_4	384	390	PF00069	0.438
MOD_ProDKin_1	172	178	PF00069	0.653
MOD_ProDKin_1	235	241	PF00069	0.499
MOD_ProDKin_1	55	61	PF00069	0.637
MOD_SUMO_rev_2	328	335	PF00179	0.548
MOD_SUMO_rev_2	92	102	PF00179	0.668
TRG_DiLeu_BaEn_1	63	68	PF01217	0.538
TRG_ENDOCYTIC_2	246	249	PF00928	0.411
TRG_ENDOCYTIC_2	319	322	PF00928	0.486
TRG_ENDOCYTIC_2	44	47	PF00928	0.389
TRG_ENDOCYTIC_2	84	87	PF00928	0.453
TRG_ER_diArg_1	161	164	PF00400	0.770
TRG_NES_CRM1_1	77	92	PF08389	0.410
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B6	Leptomonas seymouri	68%	100%
A0A1X0P9S3	Trypanosomatidae	47%	100%
A0A3Q8IFQ2	Leishmania donovani	99%	100%
E9B576	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2Q9	Leishmania major	93%	100%