LeishMANIAdb
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Regulatory subunit of protein kinase a-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Regulatory subunit of protein kinase a-like protein
Gene product:
regulatory subunit of protein kinase a-like protein
Species:
Leishmania infantum
UniProt:
A4IA61_LEIIN
TriTrypDb:
LINF_340035100
Length:
647

Annotations

Annotations by Jardim et al.

Protein kinase, Regulatory subunit of kinase a-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 123, 254, 262, 3
Promastigote: 349, 390
Promastigote/Amastigote: 124, 229, 241, 246, 247, 329, 331, 332, 342, 346

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IA61
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA61

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 5
GO:0006796 phosphate-containing compound metabolic process 4 5
GO:0008152 metabolic process 1 5
GO:0009987 cellular process 1 5
GO:0016310 phosphorylation 5 5
GO:0044237 cellular metabolic process 2 5
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016301 kinase activity 4 5
GO:0016740 transferase activity 2 5
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 290 294 PF00656 0.635
CLV_NRD_NRD_1 103 105 PF00675 0.554
CLV_NRD_NRD_1 13 15 PF00675 0.489
CLV_NRD_NRD_1 170 172 PF00675 0.510
CLV_NRD_NRD_1 315 317 PF00675 0.487
CLV_NRD_NRD_1 460 462 PF00675 0.276
CLV_NRD_NRD_1 476 478 PF00675 0.219
CLV_NRD_NRD_1 585 587 PF00675 0.276
CLV_NRD_NRD_1 59 61 PF00675 0.484
CLV_NRD_NRD_1 63 65 PF00675 0.403
CLV_NRD_NRD_1 73 75 PF00675 0.604
CLV_PCSK_FUR_1 71 75 PF00082 0.517
CLV_PCSK_KEX2_1 13 15 PF00082 0.478
CLV_PCSK_KEX2_1 170 172 PF00082 0.586
CLV_PCSK_KEX2_1 226 228 PF00082 0.604
CLV_PCSK_KEX2_1 314 316 PF00082 0.484
CLV_PCSK_KEX2_1 460 462 PF00082 0.308
CLV_PCSK_KEX2_1 474 476 PF00082 0.376
CLV_PCSK_KEX2_1 58 60 PF00082 0.468
CLV_PCSK_KEX2_1 585 587 PF00082 0.276
CLV_PCSK_KEX2_1 614 616 PF00082 0.545
CLV_PCSK_KEX2_1 71 73 PF00082 0.390
CLV_PCSK_PC1ET2_1 226 228 PF00082 0.604
CLV_PCSK_PC1ET2_1 474 476 PF00082 0.350
CLV_PCSK_PC1ET2_1 58 60 PF00082 0.518
CLV_PCSK_PC1ET2_1 614 616 PF00082 0.502
CLV_PCSK_SKI1_1 362 366 PF00082 0.351
CLV_PCSK_SKI1_1 464 468 PF00082 0.358
CLV_PCSK_SKI1_1 579 583 PF00082 0.276
CLV_PCSK_SKI1_1 64 68 PF00082 0.521
DOC_CKS1_1 344 349 PF01111 0.439
DOC_CYCLIN_yCln2_LP_2 41 47 PF00134 0.448
DOC_MAPK_gen_1 143 151 PF00069 0.530
DOC_MAPK_gen_1 21 31 PF00069 0.468
DOC_MAPK_gen_1 352 361 PF00069 0.360
DOC_MAPK_gen_1 474 481 PF00069 0.341
DOC_MAPK_MEF2A_6 24 31 PF00069 0.454
DOC_MAPK_NFAT4_5 24 32 PF00069 0.457
DOC_PP1_RVXF_1 475 482 PF00149 0.335
DOC_PP2B_LxvP_1 255 258 PF13499 0.600
DOC_PP2B_LxvP_1 84 87 PF13499 0.513
DOC_PP4_FxxP_1 630 633 PF00568 0.499
DOC_PP4_MxPP_1 228 231 PF00568 0.620
DOC_USP7_MATH_1 112 116 PF00917 0.753
DOC_USP7_MATH_1 175 179 PF00917 0.519
DOC_USP7_MATH_1 449 453 PF00917 0.366
DOC_USP7_MATH_1 489 493 PF00917 0.414
DOC_USP7_UBL2_3 101 105 PF12436 0.616
DOC_USP7_UBL2_3 348 352 PF12436 0.414
DOC_WW_Pin1_4 193 198 PF00397 0.757
DOC_WW_Pin1_4 226 231 PF00397 0.586
DOC_WW_Pin1_4 343 348 PF00397 0.437
DOC_WW_Pin1_4 624 629 PF00397 0.552
LIG_14-3-3_CanoR_1 325 335 PF00244 0.523
LIG_14-3-3_CanoR_1 339 344 PF00244 0.448
LIG_14-3-3_CanoR_1 428 433 PF00244 0.409
LIG_14-3-3_CanoR_1 450 454 PF00244 0.382
LIG_14-3-3_CanoR_1 460 464 PF00244 0.225
LIG_14-3-3_CanoR_1 585 589 PF00244 0.276
LIG_14-3-3_CanoR_1 638 642 PF00244 0.466
LIG_BIR_II_1 1 5 PF00653 0.475
LIG_BIR_III_2 631 635 PF00653 0.585
LIG_BRCT_BRCA1_1 586 590 PF00533 0.313
LIG_EVH1_1 81 85 PF00568 0.590
LIG_FHA_1 24 30 PF00498 0.392
LIG_FHA_1 252 258 PF00498 0.575
LIG_FHA_1 388 394 PF00498 0.339
LIG_FHA_1 399 405 PF00498 0.226
LIG_FHA_1 410 416 PF00498 0.276
LIG_FHA_1 578 584 PF00498 0.276
LIG_FHA_2 104 110 PF00498 0.577
LIG_FHA_2 203 209 PF00498 0.566
LIG_FHA_2 366 372 PF00498 0.367
LIG_FHA_2 429 435 PF00498 0.276
LIG_LIR_Apic_2 627 633 PF02991 0.499
LIG_LIR_Gen_1 36 45 PF02991 0.466
LIG_LIR_Gen_1 400 410 PF02991 0.276
LIG_LIR_Gen_1 560 571 PF02991 0.265
LIG_LIR_Gen_1 587 595 PF02991 0.375
LIG_LIR_Nem_3 2 7 PF02991 0.448
LIG_LIR_Nem_3 267 272 PF02991 0.590
LIG_LIR_Nem_3 36 41 PF02991 0.464
LIG_LIR_Nem_3 400 406 PF02991 0.276
LIG_LIR_Nem_3 430 435 PF02991 0.366
LIG_LIR_Nem_3 462 466 PF02991 0.344
LIG_LIR_Nem_3 560 566 PF02991 0.265
LIG_LIR_Nem_3 587 591 PF02991 0.276
LIG_LIR_Nem_3 606 612 PF02991 0.442
LIG_MYND_1 82 86 PF01753 0.486
LIG_PDZ_Class_3 642 647 PF00595 0.557
LIG_PTAP_UEV_1 200 205 PF05743 0.532
LIG_SH2_CRK 38 42 PF00017 0.510
LIG_SH2_CRK 463 467 PF00017 0.348
LIG_SH2_SRC 439 442 PF00017 0.286
LIG_SH2_STAT3 7 10 PF00017 0.424
LIG_SH2_STAT5 478 481 PF00017 0.338
LIG_SH2_STAT5 508 511 PF00017 0.366
LIG_SH2_STAT5 7 10 PF00017 0.424
LIG_SH3_2 83 88 PF14604 0.503
LIG_SH3_3 198 204 PF00018 0.556
LIG_SH3_3 341 347 PF00018 0.446
LIG_SH3_3 419 425 PF00018 0.393
LIG_SH3_3 531 537 PF00018 0.276
LIG_SH3_3 79 85 PF00018 0.528
LIG_SH3_CIN85_PxpxPR_1 83 88 PF14604 0.518
LIG_SUMO_SIM_anti_2 546 551 PF11976 0.276
LIG_SUMO_SIM_par_1 570 575 PF11976 0.313
LIG_SxIP_EBH_1 215 229 PF03271 0.543
LIG_TRAF2_1 182 185 PF00917 0.557
LIG_TRAF2_1 264 267 PF00917 0.514
LIG_TRAF2_1 602 605 PF00917 0.500
LIG_TRAF2_1 66 69 PF00917 0.469
LIG_UBA3_1 27 32 PF00899 0.453
LIG_WRC_WIRS_1 1 6 PF05994 0.566
LIG_WRC_WIRS_1 269 274 PF05994 0.534
LIG_WW_2 82 85 PF00397 0.526
LIG_WW_3 85 89 PF00397 0.524
MOD_CDK_SPK_2 343 348 PF00069 0.437
MOD_CK1_1 100 106 PF00069 0.565
MOD_CK1_1 121 127 PF00069 0.680
MOD_CK1_1 202 208 PF00069 0.591
MOD_CK1_1 209 215 PF00069 0.570
MOD_CK1_1 329 335 PF00069 0.439
MOD_CK1_1 342 348 PF00069 0.443
MOD_CK1_1 584 590 PF00069 0.276
MOD_CK2_1 103 109 PF00069 0.703
MOD_CK2_1 120 126 PF00069 0.562
MOD_CK2_1 179 185 PF00069 0.568
MOD_CK2_1 202 208 PF00069 0.566
MOD_CK2_1 238 244 PF00069 0.617
MOD_CK2_1 261 267 PF00069 0.517
MOD_CK2_1 282 288 PF00069 0.698
MOD_GlcNHglycan 109 113 PF01048 0.643
MOD_GlcNHglycan 120 123 PF01048 0.486
MOD_GlcNHglycan 134 137 PF01048 0.578
MOD_GlcNHglycan 201 204 PF01048 0.741
MOD_GlcNHglycan 220 223 PF01048 0.486
MOD_GlcNHglycan 540 543 PF01048 0.339
MOD_GlcNHglycan 574 577 PF01048 0.313
MOD_GlcNHglycan 617 620 PF01048 0.530
MOD_GSK3_1 108 115 PF00069 0.524
MOD_GSK3_1 175 182 PF00069 0.555
MOD_GSK3_1 199 206 PF00069 0.573
MOD_GSK3_1 257 264 PF00069 0.640
MOD_GSK3_1 339 346 PF00069 0.456
MOD_GSK3_1 365 372 PF00069 0.362
MOD_GSK3_1 577 584 PF00069 0.276
MOD_GSK3_1 86 93 PF00069 0.583
MOD_GSK3_1 95 102 PF00069 0.648
MOD_N-GLC_1 118 123 PF02516 0.636
MOD_N-GLC_1 244 249 PF02516 0.624
MOD_N-GLC_1 280 285 PF02516 0.626
MOD_N-GLC_1 288 293 PF02516 0.573
MOD_N-GLC_1 398 403 PF02516 0.276
MOD_N-GLC_1 90 95 PF02516 0.555
MOD_NEK2_1 120 125 PF00069 0.603
MOD_NEK2_1 15 20 PF00069 0.503
MOD_NEK2_1 179 184 PF00069 0.595
MOD_NEK2_1 23 28 PF00069 0.393
MOD_NEK2_1 233 238 PF00069 0.693
MOD_NEK2_1 364 369 PF00069 0.358
MOD_NEK2_1 465 470 PF00069 0.364
MOD_NEK2_1 481 486 PF00069 0.210
MOD_NEK2_1 528 533 PF00069 0.229
MOD_NEK2_1 637 642 PF00069 0.602
MOD_NEK2_2 265 270 PF00069 0.614
MOD_PIKK_1 180 186 PF00454 0.590
MOD_PIKK_1 288 294 PF00454 0.668
MOD_PIKK_1 346 352 PF00454 0.424
MOD_PIKK_1 387 393 PF00454 0.286
MOD_PIKK_1 90 96 PF00454 0.556
MOD_PK_1 376 382 PF00069 0.350
MOD_PKA_1 314 320 PF00069 0.492
MOD_PKA_2 103 109 PF00069 0.562
MOD_PKA_2 23 29 PF00069 0.395
MOD_PKA_2 314 320 PF00069 0.492
MOD_PKA_2 321 327 PF00069 0.499
MOD_PKA_2 427 433 PF00069 0.409
MOD_PKA_2 449 455 PF00069 0.382
MOD_PKA_2 459 465 PF00069 0.225
MOD_PKA_2 584 590 PF00069 0.276
MOD_PKA_2 637 643 PF00069 0.481
MOD_Plk_1 233 239 PF00069 0.693
MOD_Plk_1 243 249 PF00069 0.577
MOD_Plk_1 251 257 PF00069 0.478
MOD_Plk_1 329 335 PF00069 0.439
MOD_Plk_1 398 404 PF00069 0.276
MOD_Plk_1 410 416 PF00069 0.276
MOD_Plk_1 504 510 PF00069 0.366
MOD_Plk_1 605 611 PF00069 0.449
MOD_Plk_2-3 261 267 PF00069 0.601
MOD_Plk_4 23 29 PF00069 0.395
MOD_Plk_4 376 382 PF00069 0.350
MOD_Plk_4 398 404 PF00069 0.276
MOD_Plk_4 410 416 PF00069 0.276
MOD_Plk_4 504 510 PF00069 0.409
MOD_ProDKin_1 193 199 PF00069 0.759
MOD_ProDKin_1 226 232 PF00069 0.586
MOD_ProDKin_1 343 349 PF00069 0.436
MOD_ProDKin_1 624 630 PF00069 0.556
MOD_SUMO_for_1 66 69 PF00179 0.506
MOD_SUMO_rev_2 278 287 PF00179 0.531
MOD_SUMO_rev_2 538 547 PF00179 0.366
TRG_AP2beta_CARGO_1 267 276 PF09066 0.643
TRG_DiLeu_BaEn_2 301 307 PF01217 0.573
TRG_DiLeu_BaLyEn_6 595 600 PF01217 0.382
TRG_ENDOCYTIC_2 38 41 PF00928 0.474
TRG_ENDOCYTIC_2 463 466 PF00928 0.345
TRG_ENDOCYTIC_2 478 481 PF00928 0.338
TRG_ENDOCYTIC_2 563 566 PF00928 0.265
TRG_ER_diArg_1 12 14 PF00400 0.458
TRG_ER_diArg_1 169 171 PF00400 0.500
TRG_ER_diArg_1 314 316 PF00400 0.484
TRG_ER_diArg_1 475 477 PF00400 0.369
TRG_ER_diArg_1 71 74 PF00400 0.459
TRG_NES_CRM1_1 373 387 PF08389 0.356
TRG_NES_CRM1_1 558 570 PF08389 0.286
TRG_NLS_MonoCore_2 56 61 PF00514 0.507
TRG_NLS_MonoExtN_4 215 221 PF00514 0.545
TRG_NLS_MonoExtN_4 57 62 PF00514 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PC94 Leptomonas seymouri 47% 93%
A0A3S7X836 Leishmania donovani 99% 100%
A4HB05 Leishmania braziliensis 63% 99%
E9B573 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q2R2 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS