Cytosolic carboxypeptidase-like protein 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase - Clan MC - Family M14

Species:

Leishmania infantum

UniProt:

A4IA60_LEIIN

TriTrypDb:

LINF_340035000

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0005819	spindle	5	10
GO:0030496	midbody	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4IA60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA60

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018200	peptidyl-glutamic acid modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0035608	protein deglutamylation	7	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004180	carboxypeptidase activity	5	10
GO:0004181	metallocarboxypeptidase activity	6	10
GO:0005488	binding	1	10
GO:0008233	peptidase activity	3	10
GO:0008235	metalloexopeptidase activity	5	10
GO:0008237	metallopeptidase activity	4	10
GO:0008238	exopeptidase activity	4	10
GO:0008270	zinc ion binding	6	10
GO:0016787	hydrolase activity	2	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.662
CLV_C14_Caspase3-7	188	192	PF00656	0.683
CLV_C14_Caspase3-7	315	319	PF00656	0.687
CLV_C14_Caspase3-7	478	482	PF00656	0.444
CLV_NRD_NRD_1	289	291	PF00675	0.546
CLV_NRD_NRD_1	307	309	PF00675	0.499
CLV_NRD_NRD_1	495	497	PF00675	0.435
CLV_NRD_NRD_1	580	582	PF00675	0.629
CLV_NRD_NRD_1	803	805	PF00675	0.683
CLV_NRD_NRD_1	828	830	PF00675	0.655
CLV_PCSK_KEX2_1	289	291	PF00082	0.577
CLV_PCSK_KEX2_1	307	309	PF00082	0.499
CLV_PCSK_KEX2_1	497	499	PF00082	0.333
CLV_PCSK_KEX2_1	528	530	PF00082	0.442
CLV_PCSK_KEX2_1	580	582	PF00082	0.629
CLV_PCSK_KEX2_1	803	805	PF00082	0.722
CLV_PCSK_KEX2_1	827	829	PF00082	0.691
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.333
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.482
CLV_PCSK_PC1ET2_1	580	582	PF00082	0.627
CLV_PCSK_SKI1_1	363	367	PF00082	0.431
CLV_PCSK_SKI1_1	373	377	PF00082	0.401
CLV_PCSK_SKI1_1	515	519	PF00082	0.329
CLV_PCSK_SKI1_1	648	652	PF00082	0.374
CLV_PCSK_SKI1_1	772	776	PF00082	0.523
CLV_PCSK_SKI1_1	831	835	PF00082	0.742
DEG_APCC_DBOX_1	647	655	PF00400	0.474
DEG_Nend_UBRbox_3	1	3	PF02207	0.675
DOC_CDC14_PxL_1	388	396	PF14671	0.310
DOC_CDC14_PxL_1	462	470	PF14671	0.401
DOC_CKS1_1	163	168	PF01111	0.474
DOC_CKS1_1	555	560	PF01111	0.373
DOC_CYCLIN_RxL_1	769	778	PF00134	0.549
DOC_MAPK_gen_1	226	238	PF00069	0.605
DOC_MAPK_gen_1	827	835	PF00069	0.707
DOC_MAPK_MEF2A_6	113	121	PF00069	0.591
DOC_MAPK_MEF2A_6	231	240	PF00069	0.518
DOC_MAPK_MEF2A_6	258	266	PF00069	0.549
DOC_MAPK_MEF2A_6	515	522	PF00069	0.326
DOC_PP1_RVXF_1	585	592	PF00149	0.545
DOC_PP2B_LxvP_1	299	302	PF13499	0.635
DOC_PP2B_LxvP_1	30	33	PF13499	0.542
DOC_PP2B_PxIxI_1	261	267	PF00149	0.531
DOC_PP4_FxxP_1	44	47	PF00568	0.585
DOC_USP7_MATH_1	20	24	PF00917	0.755
DOC_USP7_MATH_1	288	292	PF00917	0.575
DOC_USP7_MATH_1	306	310	PF00917	0.585
DOC_USP7_MATH_1	330	334	PF00917	0.601
DOC_USP7_MATH_1	401	405	PF00917	0.344
DOC_USP7_MATH_1	705	709	PF00917	0.530
DOC_USP7_UBL2_3	174	178	PF12436	0.618
DOC_USP7_UBL2_3	226	230	PF12436	0.628
DOC_USP7_UBL2_3	699	703	PF12436	0.557
DOC_WW_Pin1_4	162	167	PF00397	0.473
DOC_WW_Pin1_4	212	217	PF00397	0.782
DOC_WW_Pin1_4	250	255	PF00397	0.595
DOC_WW_Pin1_4	258	263	PF00397	0.534
DOC_WW_Pin1_4	554	559	PF00397	0.371
DOC_WW_Pin1_4	629	634	PF00397	0.582
DOC_WW_Pin1_4	636	641	PF00397	0.481
DOC_WW_Pin1_4	804	809	PF00397	0.753
LIG_14-3-3_CanoR_1	26	31	PF00244	0.781
LIG_14-3-3_CanoR_1	289	295	PF00244	0.512
LIG_14-3-3_CanoR_1	307	317	PF00244	0.746
LIG_14-3-3_CanoR_1	411	416	PF00244	0.388
LIG_14-3-3_CanoR_1	743	747	PF00244	0.526
LIG_APCC_ABBA_1	516	521	PF00400	0.344
LIG_APCC_ABBAyCdc20_2	515	521	PF00400	0.321
LIG_BRCT_BRCA1_1	126	130	PF00533	0.561
LIG_BRCT_BRCA1_1	352	356	PF00533	0.617
LIG_BRCT_BRCA1_1	563	567	PF00533	0.387
LIG_BRCT_BRCA1_1	63	67	PF00533	0.499
LIG_BRCT_BRCA1_1	806	810	PF00533	0.681
LIG_Clathr_ClatBox_1	72	76	PF01394	0.490
LIG_deltaCOP1_diTrp_1	38	44	PF00928	0.676
LIG_EH1_1	502	510	PF00400	0.369
LIG_eIF4E_1	503	509	PF01652	0.401
LIG_EVH1_1	630	634	PF00568	0.510
LIG_FHA_1	343	349	PF00498	0.624
LIG_FHA_1	422	428	PF00498	0.369
LIG_FHA_1	555	561	PF00498	0.422
LIG_FHA_1	602	608	PF00498	0.423
LIG_FHA_1	621	627	PF00498	0.457
LIG_FHA_1	672	678	PF00498	0.471
LIG_FHA_1	755	761	PF00498	0.542
LIG_FHA_1	814	820	PF00498	0.762
LIG_FHA_2	291	297	PF00498	0.495
LIG_FHA_2	377	383	PF00498	0.369
LIG_FHA_2	640	646	PF00498	0.462
LIG_FHA_2	732	738	PF00498	0.509
LIG_FHA_2	837	843	PF00498	0.791
LIG_FHA_2	85	91	PF00498	0.508
LIG_GBD_Chelix_1	677	685	PF00786	0.543
LIG_HOMEOBOX	132	135	PF00046	0.561
LIG_IRF3_LxIS_1	375	381	PF10401	0.444
LIG_LIR_Apic_2	251	255	PF02991	0.702
LIG_LIR_Gen_1	131	140	PF02991	0.581
LIG_LIR_Gen_1	353	361	PF02991	0.516
LIG_LIR_Gen_1	557	567	PF02991	0.415
LIG_LIR_Nem_3	131	137	PF02991	0.518
LIG_LIR_Nem_3	165	171	PF02991	0.498
LIG_LIR_Nem_3	273	277	PF02991	0.425
LIG_LIR_Nem_3	353	359	PF02991	0.562
LIG_LIR_Nem_3	557	562	PF02991	0.379
LIG_LIR_Nem_3	744	749	PF02991	0.425
LIG_LIR_Nem_3	751	755	PF02991	0.362
LIG_LYPXL_yS_3	168	171	PF13949	0.543
LIG_MYND_1	466	470	PF01753	0.401
LIG_NRBOX	650	656	PF00104	0.375
LIG_Pex14_1	339	343	PF04695	0.512
LIG_Pex14_2	130	134	PF04695	0.508
LIG_Pex14_2	63	67	PF04695	0.490
LIG_Pex14_2	694	698	PF04695	0.442
LIG_PTB_Apo_2	543	550	PF02174	0.424
LIG_PTB_Phospho_1	543	549	PF10480	0.426
LIG_REV1ctd_RIR_1	413	422	PF16727	0.272
LIG_SH2_CRK	147	151	PF00017	0.473
LIG_SH2_CRK	252	256	PF00017	0.717
LIG_SH2_CRK	503	507	PF00017	0.412
LIG_SH2_CRK	549	553	PF00017	0.387
LIG_SH2_NCK_1	147	151	PF00017	0.605
LIG_SH2_NCK_1	252	256	PF00017	0.717
LIG_SH2_PTP2	420	423	PF00017	0.401
LIG_SH2_STAP1	147	151	PF00017	0.515
LIG_SH2_STAP1	352	356	PF00017	0.568
LIG_SH2_STAP1	503	507	PF00017	0.444
LIG_SH2_STAP1	549	553	PF00017	0.387
LIG_SH2_STAT3	275	278	PF00017	0.474
LIG_SH2_STAT5	147	150	PF00017	0.439
LIG_SH2_STAT5	252	255	PF00017	0.712
LIG_SH2_STAT5	265	268	PF00017	0.333
LIG_SH2_STAT5	272	275	PF00017	0.401
LIG_SH2_STAT5	360	363	PF00017	0.413
LIG_SH2_STAT5	420	423	PF00017	0.401
LIG_SH2_STAT5	55	58	PF00017	0.502
LIG_SH2_STAT5	559	562	PF00017	0.401
LIG_SH2_STAT5	600	603	PF00017	0.385
LIG_SH2_STAT5	86	89	PF00017	0.493
LIG_SH3_2	767	772	PF14604	0.483
LIG_SH3_3	139	145	PF00018	0.557
LIG_SH3_3	160	166	PF00018	0.469
LIG_SH3_3	169	175	PF00018	0.510
LIG_SH3_3	256	262	PF00018	0.529
LIG_SH3_3	628	634	PF00018	0.611
LIG_SH3_3	764	770	PF00018	0.482
LIG_SH3_4	174	181	PF00018	0.630
LIG_SUMO_SIM_anti_2	374	379	PF11976	0.401
LIG_SUMO_SIM_anti_2	756	763	PF11976	0.523
LIG_SUMO_SIM_par_1	376	382	PF11976	0.344
LIG_SUMO_SIM_par_1	551	557	PF11976	0.368
LIG_SUMO_SIM_par_1	613	619	PF11976	0.438
LIG_SUMO_SIM_par_1	756	763	PF11976	0.541
LIG_TRAF2_1	725	728	PF00917	0.619
LIG_TYR_ITIM	547	552	PF00017	0.375
LIG_UBA3_1	650	658	PF00899	0.407
LIG_UBA3_1	716	722	PF00899	0.453
LIG_WRC_WIRS_1	340	345	PF05994	0.499
LIG_WRC_WIRS_1	749	754	PF05994	0.510
LIG_WW_3	769	773	PF00397	0.481
MOD_CDK_SPxxK_3	212	219	PF00069	0.784
MOD_CK1_1	220	226	PF00069	0.758
MOD_CK1_1	333	339	PF00069	0.702
MOD_CK1_1	342	348	PF00069	0.687
MOD_CK1_1	381	387	PF00069	0.392
MOD_CK1_1	511	517	PF00069	0.463
MOD_CK1_1	554	560	PF00069	0.366
MOD_CK1_1	639	645	PF00069	0.550
MOD_CK1_1	689	695	PF00069	0.458
MOD_CK1_1	712	718	PF00069	0.463
MOD_CK1_1	836	842	PF00069	0.708
MOD_CK2_1	290	296	PF00069	0.589
MOD_CK2_1	306	312	PF00069	0.789
MOD_CK2_1	705	711	PF00069	0.639
MOD_CK2_1	731	737	PF00069	0.531
MOD_CK2_1	836	842	PF00069	0.793
MOD_Cter_Amidation	578	581	PF01082	0.659
MOD_DYRK1A_RPxSP_1	258	262	PF00069	0.507
MOD_GlcNHglycan	220	223	PF01048	0.710
MOD_GlcNHglycan	314	317	PF01048	0.727
MOD_GlcNHglycan	332	335	PF01048	0.490
MOD_GlcNHglycan	352	355	PF01048	0.674
MOD_GlcNHglycan	403	406	PF01048	0.394
MOD_GlcNHglycan	577	580	PF01048	0.585
MOD_GlcNHglycan	68	71	PF01048	0.344
MOD_GlcNHglycan	688	691	PF01048	0.512
MOD_GlcNHglycan	711	714	PF01048	0.600
MOD_GlcNHglycan	746	749	PF01048	0.498
MOD_GlcNHglycan	777	780	PF01048	0.694
MOD_GlcNHglycan	784	787	PF01048	0.635
MOD_GlcNHglycan	799	802	PF01048	0.588
MOD_GlcNHglycan	810	813	PF01048	0.687
MOD_GSK3_1	124	131	PF00069	0.410
MOD_GSK3_1	210	217	PF00069	0.750
MOD_GSK3_1	226	233	PF00069	0.515
MOD_GSK3_1	284	291	PF00069	0.409
MOD_GSK3_1	308	315	PF00069	0.753
MOD_GSK3_1	329	336	PF00069	0.662
MOD_GSK3_1	350	357	PF00069	0.635
MOD_GSK3_1	475	482	PF00069	0.358
MOD_GSK3_1	561	568	PF00069	0.386
MOD_GSK3_1	598	605	PF00069	0.435
MOD_GSK3_1	616	623	PF00069	0.442
MOD_GSK3_1	62	69	PF00069	0.344
MOD_GSK3_1	625	632	PF00069	0.618
MOD_GSK3_1	639	646	PF00069	0.405
MOD_GSK3_1	666	673	PF00069	0.501
MOD_GSK3_1	705	712	PF00069	0.558
MOD_GSK3_1	716	723	PF00069	0.506
MOD_GSK3_1	744	751	PF00069	0.524
MOD_GSK3_1	804	811	PF00069	0.721
MOD_GSK3_1	823	830	PF00069	0.743
MOD_GSK3_1	833	840	PF00069	0.631
MOD_LATS_1	477	483	PF00433	0.369
MOD_LATS_1	82	88	PF00433	0.310
MOD_N-GLC_1	236	241	PF02516	0.397
MOD_N-GLC_1	446	451	PF02516	0.444
MOD_N-GLC_1	565	570	PF02516	0.390
MOD_N-GLC_1	813	818	PF02516	0.735
MOD_N-GLC_2	813	815	PF02516	0.706
MOD_NEK2_1	104	109	PF00069	0.444
MOD_NEK2_1	124	129	PF00069	0.155
MOD_NEK2_1	236	241	PF00069	0.498
MOD_NEK2_1	406	411	PF00069	0.458
MOD_NEK2_1	508	513	PF00069	0.375
MOD_NEK2_1	573	578	PF00069	0.550
MOD_NEK2_1	61	66	PF00069	0.369
MOD_NEK2_1	643	648	PF00069	0.489
MOD_NEK2_1	671	676	PF00069	0.471
MOD_NEK2_1	716	721	PF00069	0.508
MOD_NEK2_1	762	767	PF00069	0.509
MOD_NEK2_1	775	780	PF00069	0.642
MOD_PIKK_1	20	26	PF00454	0.726
MOD_PIKK_1	406	412	PF00454	0.408
MOD_PIKK_1	62	68	PF00454	0.444
MOD_PIKK_1	666	672	PF00454	0.587
MOD_PIKK_1	760	766	PF00454	0.508
MOD_PK_1	230	236	PF00069	0.561
MOD_PKA_1	226	232	PF00069	0.672
MOD_PKA_1	307	313	PF00069	0.624
MOD_PKA_1	528	534	PF00069	0.500
MOD_PKA_1	581	587	PF00069	0.574
MOD_PKA_1	803	809	PF00069	0.799
MOD_PKA_1	827	833	PF00069	0.781
MOD_PKA_2	218	224	PF00069	0.580
MOD_PKA_2	288	294	PF00069	0.627
MOD_PKA_2	306	312	PF00069	0.762
MOD_PKA_2	528	534	PF00069	0.500
MOD_PKA_2	643	649	PF00069	0.511
MOD_PKA_2	742	748	PF00069	0.542
MOD_PKA_2	803	809	PF00069	0.768
MOD_PKA_2	827	833	PF00069	0.739
MOD_Plk_1	236	242	PF00069	0.400
MOD_Plk_1	295	301	PF00069	0.729
MOD_Plk_1	373	379	PF00069	0.444
MOD_Plk_1	381	387	PF00069	0.444
MOD_Plk_1	6	12	PF00069	0.697
MOD_Plk_1	602	608	PF00069	0.423
MOD_Plk_1	837	843	PF00069	0.711
MOD_Plk_2-3	731	737	PF00069	0.542
MOD_Plk_4	270	276	PF00069	0.515
MOD_Plk_4	373	379	PF00069	0.415
MOD_Plk_4	411	417	PF00069	0.272
MOD_Plk_4	528	534	PF00069	0.490
MOD_Plk_4	689	695	PF00069	0.474
MOD_Plk_4	712	718	PF00069	0.480
MOD_ProDKin_1	162	168	PF00069	0.470
MOD_ProDKin_1	212	218	PF00069	0.781
MOD_ProDKin_1	250	256	PF00069	0.597
MOD_ProDKin_1	258	264	PF00069	0.528
MOD_ProDKin_1	554	560	PF00069	0.371
MOD_ProDKin_1	629	635	PF00069	0.574
MOD_ProDKin_1	636	642	PF00069	0.470
MOD_ProDKin_1	804	810	PF00069	0.753
MOD_SUMO_for_1	242	245	PF00179	0.568
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.585
TRG_DiLeu_BaLyEn_6	736	741	PF01217	0.559
TRG_DiLeu_LyEn_5	389	394	PF01217	0.408
TRG_ENDOCYTIC_2	132	135	PF00928	0.389
TRG_ENDOCYTIC_2	147	150	PF00928	0.364
TRG_ENDOCYTIC_2	168	171	PF00928	0.487
TRG_ENDOCYTIC_2	274	277	PF00928	0.429
TRG_ENDOCYTIC_2	413	416	PF00928	0.349
TRG_ENDOCYTIC_2	420	423	PF00928	0.341
TRG_ENDOCYTIC_2	503	506	PF00928	0.421
TRG_ENDOCYTIC_2	549	552	PF00928	0.347
TRG_ENDOCYTIC_2	559	562	PF00928	0.357
TRG_ENDOCYTIC_2	86	89	PF00928	0.444
TRG_ER_diArg_1	827	829	PF00400	0.735
TRG_NLS_MonoCore_2	224	229	PF00514	0.684
TRG_NLS_MonoExtC_3	225	230	PF00514	0.704
TRG_NLS_MonoExtC_3	495	500	PF00514	0.366
TRG_NLS_MonoExtN_4	225	231	PF00514	0.737
TRG_NLS_MonoExtN_4	494	500	PF00514	0.366
TRG_Pf-PMV_PEXEL_1	683	688	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSB1	Leptomonas seymouri	65%	67%
A0A0S4J4P7	Bodo saltans	40%	100%
A0A1X0PB49	Trypanosomatidae	47%	100%
A0A3S7X873	Leishmania donovani	99%	100%
A4HB04	Leishmania braziliensis	77%	100%
C9ZM45	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B572	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2R3	Leishmania major	93%	99%