Putative amastin-like surface protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4IA59_LEIIN

TriTrypDb:

LINF_340034600

Length:

260

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 182
NetGPI	no	yes: 0, no: 191

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	169
GO:0110165	cellular anatomical entity	1	169

Expansion

Sequence features

A4IA59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA59

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.474
CLV_NRD_NRD_1	60	62	PF00675	0.318
CLV_PCSK_KEX2_1	139	141	PF00082	0.516
CLV_PCSK_KEX2_1	60	62	PF00082	0.323
CLV_PCSK_PC7_1	135	141	PF00082	0.415
DOC_CKS1_1	40	45	PF01111	0.543
DOC_CKS1_1	88	93	PF01111	0.362
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.558
DOC_MAPK_MEF2A_6	100	109	PF00069	0.211
DOC_MAPK_MEF2A_6	175	183	PF00069	0.583
DOC_PP2B_LxvP_1	207	210	PF13499	0.206
DOC_PP2B_LxvP_1	30	33	PF13499	0.559
DOC_PP4_FxxP_1	240	243	PF00568	0.510
DOC_USP7_UBL2_3	212	216	PF12436	0.210
DOC_USP7_UBL2_3	65	69	PF12436	0.489
DOC_WW_Pin1_4	39	44	PF00397	0.548
DOC_WW_Pin1_4	51	56	PF00397	0.529
DOC_WW_Pin1_4	87	92	PF00397	0.372
LIG_14-3-3_CanoR_1	135	143	PF00244	0.288
LIG_14-3-3_CanoR_1	38	43	PF00244	0.552
LIG_Actin_RPEL_3	168	187	PF02755	0.210
LIG_Actin_WH2_2	159	177	PF00022	0.320
LIG_BRCT_BRCA1_1	23	27	PF00533	0.548
LIG_EH1_1	74	82	PF00400	0.345
LIG_eIF4E_1	157	163	PF01652	0.280
LIG_eIF4E_1	219	225	PF01652	0.209
LIG_eIF4E_1	75	81	PF01652	0.336
LIG_FHA_1	186	192	PF00498	0.435
LIG_FHA_1	69	75	PF00498	0.459
LIG_FHA_2	112	118	PF00498	0.205
LIG_FHA_2	88	94	PF00498	0.438
LIG_FHA_2	96	102	PF00498	0.369
LIG_GBD_Chelix_1	159	167	PF00786	0.270
LIG_LIR_Gen_1	234	245	PF02991	0.442
LIG_LIR_Gen_1	24	34	PF02991	0.554
LIG_LIR_Gen_1	54	63	PF02991	0.525
LIG_LIR_LC3C_4	147	151	PF02991	0.203
LIG_LIR_Nem_3	234	240	PF02991	0.337
LIG_LIR_Nem_3	24	30	PF02991	0.551
LIG_LIR_Nem_3	42	48	PF02991	0.540
LIG_LIR_Nem_3	54	59	PF02991	0.528
LIG_LIR_Nem_3	71	75	PF02991	0.301
LIG_NRBOX	158	164	PF00104	0.235
LIG_PALB2_WD40_1	41	49	PF16756	0.541
LIG_Pex14_1	112	116	PF04695	0.222
LIG_Pex14_2	118	122	PF04695	0.204
LIG_Pex14_2	165	169	PF04695	0.404
LIG_Pex14_2	217	221	PF04695	0.347
LIG_SH2_CRK	75	79	PF00017	0.354
LIG_SH2_NCK_1	157	161	PF00017	0.220
LIG_SH2_PTP2	4	7	PF00017	0.509
LIG_SH2_STAP1	157	161	PF00017	0.222
LIG_SH2_STAT3	116	119	PF00017	0.203
LIG_SH2_STAT5	10	13	PF00017	0.504
LIG_SH2_STAT5	4	7	PF00017	0.509
LIG_SH3_3	203	209	PF00018	0.229
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.262
LIG_SUMO_SIM_anti_2	231	237	PF11976	0.262
LIG_SUMO_SIM_par_1	147	153	PF11976	0.233
LIG_SUMO_SIM_par_1	228	234	PF11976	0.267
LIG_TRFH_1	237	241	PF08558	0.270
LIG_TYR_ITIM	73	78	PF00017	0.427
MOD_CK1_1	247	253	PF00069	0.612
MOD_CK1_1	54	60	PF00069	0.525
MOD_CK2_1	87	93	PF00069	0.330
MOD_GlcNHglycan	51	54	PF01048	0.332
MOD_GlcNHglycan	56	59	PF01048	0.323
MOD_GSK3_1	103	110	PF00069	0.249
MOD_GSK3_1	185	192	PF00069	0.355
MOD_N-GLC_1	103	108	PF02516	0.424
MOD_N-GLC_1	253	258	PF02516	0.405
MOD_NEK2_1	107	112	PF00069	0.276
MOD_NEK2_1	169	174	PF00069	0.374
MOD_NEK2_1	189	194	PF00069	0.421
MOD_NEK2_1	21	26	PF00069	0.542
MOD_NEK2_1	48	53	PF00069	0.547
MOD_NEK2_1	95	100	PF00069	0.300
MOD_PKA_2	134	140	PF00069	0.242
MOD_PKA_2	95	101	PF00069	0.252
MOD_Plk_1	103	109	PF00069	0.257
MOD_Plk_1	253	259	PF00069	0.598
MOD_Plk_4	169	175	PF00069	0.400
MOD_Plk_4	82	88	PF00069	0.269
MOD_ProDKin_1	39	45	PF00069	0.547
MOD_ProDKin_1	51	57	PF00069	0.526
MOD_ProDKin_1	87	93	PF00069	0.372
TRG_ENDOCYTIC_2	10	13	PF00928	0.504
TRG_ENDOCYTIC_2	219	222	PF00928	0.222
TRG_ENDOCYTIC_2	4	7	PF00928	0.509
TRG_ENDOCYTIC_2	75	78	PF00928	0.435
TRG_ER_diArg_1	13	16	PF00400	0.513
TRG_ER_diArg_1	59	61	PF00400	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWY5	Leptomonas seymouri	27%	100%
A0A0N1PDH0	Leptomonas seymouri	36%	100%
A0A1X0P2R3	Trypanosomatidae	28%	100%
A0A381MTA7	Leishmania infantum	41%	100%
A0A381MTB8	Leishmania infantum	41%	98%
A0A381MTC7	Leishmania infantum	42%	100%
A0A381MTN2	Leishmania infantum	100%	100%
A0A381MVY0	Leishmania infantum	43%	100%
A0A3Q8ID16	Leishmania donovani	25%	100%
A0A3Q8IEC2	Leishmania donovani	42%	100%
A0A3Q8IEI1	Leishmania donovani	73%	100%
A0A3Q8IF65	Leishmania donovani	38%	100%
A0A3Q8IFB9	Leishmania donovani	34%	100%
A0A3Q8IFH7	Leishmania donovani	42%	100%
A0A3Q8IFI8	Leishmania donovani	25%	100%
A0A3Q8IH65	Leishmania donovani	42%	100%
A0A3Q8IHN2	Leishmania donovani	74%	100%
A0A3Q8IHW7	Leishmania donovani	47%	100%
A0A3Q8IHZ6	Leishmania donovani	47%	100%
A0A3Q8IIH1	Leishmania donovani	41%	100%
A0A3Q8IL03	Leishmania donovani	37%	100%
A0A3Q8IUK8	Leishmania donovani	38%	100%
A0A3Q8IUR5	Leishmania donovani	100%	100%
A0A3S5H662	Leishmania donovani	41%	100%
A0A3S5H663	Leishmania donovani	41%	100%
A0A3S5H665	Leishmania donovani	41%	100%
A0A3S5H666	Leishmania donovani	63%	100%
A0A3S5H667	Leishmania donovani	41%	100%
A0A3S5H7D2	Leishmania donovani	31%	92%
A0A3S5H7L2	Leishmania donovani	45%	100%
A0A3S5H7V9	Leishmania donovani	41%	100%
A0A3S5H7W2	Leishmania donovani	27%	100%
A0A3S5H7W6	Leishmania donovani	42%	100%
A0A3S7WQA0	Leishmania donovani	41%	100%
A0A3S7WQA8	Leishmania donovani	50%	100%
A0A3S7WQC1	Leishmania donovani	43%	100%
A0A3S7X2E6	Leishmania donovani	46%	100%
A0A3S7X381	Leishmania donovani	25%	100%
A0A3S7X453	Leishmania donovani	38%	100%
A0A3S7X472	Leishmania donovani	40%	100%
A0A3S7X7E5	Leishmania donovani	46%	100%
A0A3S7X7M4	Leishmania donovani	48%	100%
A0A3S7X7U1	Leishmania donovani	40%	100%
A0A3S7X7U4	Leishmania donovani	40%	100%
A0A3S7X7W2	Leishmania donovani	36%	100%
A0A3S7X7Y0	Leishmania donovani	44%	100%
A4H595	Leishmania braziliensis	40%	100%
A4H596	Leishmania braziliensis	42%	100%
A4H597	Leishmania braziliensis	40%	100%
A4H5D1	Leishmania braziliensis	45%	99%
A4H5D2	Leishmania braziliensis	39%	100%
A4H5G0	Leishmania braziliensis	50%	100%
A4H5G4	Leishmania braziliensis	39%	99%
A4H5G6	Leishmania braziliensis	40%	100%
A4H5G7	Leishmania braziliensis	46%	100%
A4H5G9	Leishmania braziliensis	44%	98%
A4H5H0	Leishmania braziliensis	46%	98%
A4H5H1	Leishmania braziliensis	44%	100%
A4H5H2	Leishmania braziliensis	45%	100%
A4H5H3	Leishmania braziliensis	39%	99%
A4H6C8	Leishmania braziliensis	42%	100%
A4H7D7	Leishmania braziliensis	43%	100%
A4H9E8	Leishmania braziliensis	43%	100%
A4H9E9	Leishmania braziliensis	40%	100%
A4HAJ4	Leishmania braziliensis	41%	100%
A4HAJ5	Leishmania braziliensis	44%	100%
A4HAJ6	Leishmania braziliensis	40%	100%
A4HAL2	Leishmania braziliensis	28%	99%
A4HAM2	Leishmania braziliensis	43%	100%
A4HAM4	Leishmania braziliensis	43%	100%
A4HAR1	Leishmania braziliensis	44%	98%
A4HAZ8	Leishmania braziliensis	41%	100%
A4HB00	Leishmania braziliensis	42%	98%
A4HB02	Leishmania braziliensis	40%	100%
A4HB47	Leishmania braziliensis	34%	100%
A4HBJ0	Leishmania braziliensis	44%	100%
A4HBJ1	Leishmania braziliensis	43%	100%
A4HBJ2	Leishmania braziliensis	43%	100%
A4HDI4	Leishmania braziliensis	26%	100%
A4HDL3	Leishmania braziliensis	27%	100%
A4HDL4	Leishmania braziliensis	26%	100%
A4HTM3	Leishmania infantum	45%	99%
A4HTM4	Leishmania infantum	49%	100%
A4HTM5	Leishmania infantum	44%	99%
A4I0W4	Leishmania infantum	30%	98%
A4I0W5	Leishmania infantum	25%	100%
A4I4J2	Leishmania infantum	44%	100%
A4I4J3	Leishmania infantum	44%	100%
A4I5B8	Leishmania infantum	25%	100%
A4I6E5	Leishmania infantum	39%	100%
A4I9R4	Leishmania infantum	27%	99%
A4I9R5	Leishmania infantum	34%	100%
A4I9R7	Leishmania infantum	49%	100%
A4I9W8	Leishmania infantum	40%	100%
A4I9X0	Leishmania infantum	35%	100%
A4IAL7	Leishmania infantum	48%	100%
A4IAM1	Leishmania infantum	66%	100%
A4IAM2	Leishmania infantum	74%	100%
E8NHC3	Leishmania infantum	42%	100%
E8NHD3	Leishmania infantum	46%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	98%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	76%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	99%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AG81	Leishmania infantum	42%	100%
E9AG82	Leishmania infantum	42%	100%
E9AG83	Leishmania infantum	57%	100%
E9AG85	Leishmania infantum	42%	100%
E9AHI9	Leishmania infantum	47%	100%
E9AHT2	Leishmania infantum	49%	100%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	99%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	99%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B0L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q1U9	Leishmania major	42%	100%
Q4Q305	Leishmania major	44%	98%
Q4Q309	Leishmania major	45%	100%
Q4Q313	Leishmania major	44%	98%
Q4Q317	Leishmania major	41%	100%
Q4Q325	Leishmania major	47%	100%
Q4Q327	Leishmania major	41%	98%
Q4Q329	Leishmania major	44%	98%
Q4Q333	Leishmania major	43%	98%
Q4Q335	Leishmania major	44%	98%
Q4Q337	Leishmania major	43%	100%
Q4Q339	Leishmania major	44%	98%
Q4Q341	Leishmania major	48%	100%
Q4Q397	Leishmania major	45%	100%
Q4Q3A7	Leishmania major	28%	98%
Q4Q3A8	Leishmania major	33%	100%
Q4Q3A9	Leishmania major	44%	100%
Q4Q3F7	Leishmania major	45%	100%
Q4Q6L8	Leishmania major	39%	100%
Q4Q7L6	Leishmania major	27%	100%
Q4Q7L7	Leishmania major	25%	100%
Q4Q7L8	Leishmania major	25%	100%
Q4QAK5	Leishmania major	23%	100%
Q4QAK6	Leishmania major	32%	92%
Q4QI84	Leishmania major	48%	100%
Q4QI85	Leishmania major	48%	99%
Q4QI86	Leishmania major	49%	100%
Q4QI87	Leishmania major	46%	99%
Q4QI88	Leishmania major	44%	99%
Q4QI92	Leishmania major	40%	100%
Q4QI93	Leishmania major	40%	100%
Q4QI95	Leishmania major	40%	100%
Q4QI97	Leishmania major	40%	100%
Q4QIA0	Leishmania major	40%	99%
Q4QIA1	Leishmania major	40%	99%