LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Signal recognition particle subunit SRP68

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Signal recognition particle subunit SRP68
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA56_LEIIN
TriTrypDb:
LINF_340034000
Length:
602

Annotations

Annotations by Jardim et al.

Translation, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0005786 signal recognition particle, endoplasmic reticulum targeting 4 11
GO:0032991 protein-containing complex 1 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0048500 signal recognition particle 3 11
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

A4IA56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA56

Function

Biological processes
Term Name Level Count
GO:0006605 protein targeting 5 11
GO:0006612 protein targeting to membrane 5 11
GO:0006613 cotranslational protein targeting to membrane 6 11
GO:0006614 SRP-dependent cotranslational protein targeting to membrane 7 11
GO:0006810 transport 3 11
GO:0006886 intracellular protein transport 4 11
GO:0008104 protein localization 4 11
GO:0009987 cellular process 1 11
GO:0015031 protein transport 4 11
GO:0033036 macromolecule localization 2 11
GO:0033365 protein localization to organelle 5 11
GO:0045047 protein targeting to ER 6 11
GO:0045184 establishment of protein localization 3 11
GO:0046907 intracellular transport 3 11
GO:0051179 localization 1 11
GO:0051234 establishment of localization 2 11
GO:0051641 cellular localization 2 11
GO:0051649 establishment of localization in cell 3 11
GO:0051668 localization within membrane 3 11
GO:0070727 cellular macromolecule localization 3 11
GO:0070972 protein localization to endoplasmic reticulum 6 11
GO:0071702 organic substance transport 4 11
GO:0071705 nitrogen compound transport 4 11
GO:0072594 establishment of protein localization to organelle 4 11
GO:0072599 establishment of protein localization to endoplasmic reticulum 5 11
GO:0072657 protein localization to membrane 4 11
GO:0090150 establishment of protein localization to membrane 4 11
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005047 signal recognition particle binding 4 11
GO:0005048 signal sequence binding 4 11
GO:0005488 binding 1 11
GO:0008312 7S RNA binding 5 11
GO:0030942 endoplasmic reticulum signal peptide binding 5 11
GO:0033218 amide binding 2 11
GO:0042277 peptide binding 3 11
GO:0043021 ribonucleoprotein complex binding 3 11
GO:0044877 protein-containing complex binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 562 566 PF00656 0.750
CLV_NRD_NRD_1 113 115 PF00675 0.246
CLV_NRD_NRD_1 297 299 PF00675 0.275
CLV_NRD_NRD_1 342 344 PF00675 0.296
CLV_NRD_NRD_1 353 355 PF00675 0.220
CLV_NRD_NRD_1 384 386 PF00675 0.311
CLV_NRD_NRD_1 40 42 PF00675 0.317
CLV_NRD_NRD_1 468 470 PF00675 0.356
CLV_NRD_NRD_1 507 509 PF00675 0.623
CLV_NRD_NRD_1 53 55 PF00675 0.337
CLV_PCSK_KEX2_1 115 117 PF00082 0.243
CLV_PCSK_KEX2_1 297 299 PF00082 0.267
CLV_PCSK_KEX2_1 342 344 PF00082 0.296
CLV_PCSK_KEX2_1 352 354 PF00082 0.228
CLV_PCSK_KEX2_1 40 42 PF00082 0.317
CLV_PCSK_KEX2_1 468 470 PF00082 0.317
CLV_PCSK_KEX2_1 507 509 PF00082 0.657
CLV_PCSK_PC1ET2_1 115 117 PF00082 0.261
CLV_PCSK_SKI1_1 119 123 PF00082 0.275
CLV_PCSK_SKI1_1 162 166 PF00082 0.287
CLV_PCSK_SKI1_1 258 262 PF00082 0.269
CLV_PCSK_SKI1_1 343 347 PF00082 0.248
CLV_PCSK_SKI1_1 35 39 PF00082 0.341
CLV_PCSK_SKI1_1 360 364 PF00082 0.365
CLV_PCSK_SKI1_1 468 472 PF00082 0.311
CLV_PCSK_SKI1_1 50 54 PF00082 0.282
CLV_PCSK_SKI1_1 543 547 PF00082 0.461
CLV_PCSK_SKI1_1 55 59 PF00082 0.254
CLV_PCSK_SKI1_1 573 577 PF00082 0.665
CLV_Separin_Metazoa 401 405 PF03568 0.475
DEG_APCC_DBOX_1 309 317 PF00400 0.429
DEG_SPOP_SBC_1 366 370 PF00917 0.503
DOC_ANK_TNKS_1 313 320 PF00023 0.565
DOC_CYCLIN_RxL_1 340 349 PF00134 0.466
DOC_CYCLIN_RxL_1 35 48 PF00134 0.525
DOC_MAPK_MEF2A_6 66 73 PF00069 0.465
DOC_MAPK_NFAT4_5 66 74 PF00069 0.541
DOC_PP1_RVXF_1 117 124 PF00149 0.461
DOC_USP7_MATH_1 366 370 PF00917 0.517
DOC_USP7_MATH_1 409 413 PF00917 0.528
DOC_USP7_MATH_1 433 437 PF00917 0.516
DOC_USP7_MATH_1 557 561 PF00917 0.644
DOC_USP7_UBL2_3 115 119 PF12436 0.461
DOC_USP7_UBL2_3 122 126 PF12436 0.461
DOC_USP7_UBL2_3 379 383 PF12436 0.412
DOC_USP7_UBL2_3 51 55 PF12436 0.513
DOC_WW_Pin1_4 368 373 PF00397 0.541
DOC_WW_Pin1_4 395 400 PF00397 0.472
DOC_WW_Pin1_4 507 512 PF00397 0.655
DOC_WW_Pin1_4 55 60 PF00397 0.507
LIG_14-3-3_CanoR_1 116 122 PF00244 0.443
LIG_14-3-3_CanoR_1 153 161 PF00244 0.492
LIG_14-3-3_CanoR_1 179 189 PF00244 0.511
LIG_14-3-3_CanoR_1 200 204 PF00244 0.513
LIG_14-3-3_CanoR_1 248 253 PF00244 0.550
LIG_14-3-3_CanoR_1 342 346 PF00244 0.492
LIG_14-3-3_CanoR_1 35 40 PF00244 0.503
LIG_14-3-3_CanoR_1 41 46 PF00244 0.491
LIG_14-3-3_CanoR_1 507 511 PF00244 0.634
LIG_Actin_WH2_2 326 344 PF00022 0.541
LIG_APCC_ABBA_1 71 76 PF00400 0.492
LIG_BIR_II_1 1 5 PF00653 0.510
LIG_BRCT_BRCA1_1 370 374 PF00533 0.567
LIG_deltaCOP1_diTrp_1 445 453 PF00928 0.541
LIG_FHA_1 247 253 PF00498 0.496
LIG_FHA_1 277 283 PF00498 0.562
LIG_FHA_1 31 37 PF00498 0.473
LIG_FHA_1 342 348 PF00498 0.528
LIG_FHA_1 512 518 PF00498 0.576
LIG_FHA_1 521 527 PF00498 0.527
LIG_FHA_1 572 578 PF00498 0.776
LIG_FHA_1 6 12 PF00498 0.457
LIG_Integrin_isoDGR_2 246 248 PF01839 0.276
LIG_LIR_Apic_2 394 399 PF02991 0.459
LIG_LIR_Gen_1 173 181 PF02991 0.498
LIG_LIR_Gen_1 184 194 PF02991 0.432
LIG_LIR_Nem_3 173 178 PF02991 0.460
LIG_LIR_Nem_3 184 190 PF02991 0.446
LIG_LIR_Nem_3 23 28 PF02991 0.459
LIG_LIR_Nem_3 551 556 PF02991 0.506
LIG_SH2_CRK 175 179 PF00017 0.514
LIG_SH2_CRK 396 400 PF00017 0.442
LIG_SH2_GRB2like 301 304 PF00017 0.541
LIG_SH2_STAP1 253 257 PF00017 0.565
LIG_SH2_STAT3 203 206 PF00017 0.523
LIG_SH2_STAT5 146 149 PF00017 0.513
LIG_SH2_STAT5 203 206 PF00017 0.475
LIG_SH2_STAT5 31 34 PF00017 0.457
LIG_SH2_STAT5 460 463 PF00017 0.574
LIG_SH2_STAT5 515 518 PF00017 0.528
LIG_SH3_3 369 375 PF00018 0.481
LIG_SH3_3 467 473 PF00018 0.441
LIG_SH3_3 528 534 PF00018 0.571
LIG_SH3_3 538 544 PF00018 0.420
LIG_SUMO_SIM_anti_2 398 404 PF11976 0.475
LIG_SUMO_SIM_anti_2 462 468 PF11976 0.524
LIG_SUMO_SIM_par_1 248 254 PF11976 0.412
LIG_SUMO_SIM_par_1 290 296 PF11976 0.466
LIG_TRAF2_1 412 415 PF00917 0.481
LIG_TRAF2_1 477 480 PF00917 0.525
LIG_TRAF2_1 519 522 PF00917 0.553
LIG_WW_1 534 537 PF00397 0.472
MOD_CK1_1 180 186 PF00069 0.492
MOD_CK1_1 241 247 PF00069 0.539
MOD_CK1_1 251 257 PF00069 0.536
MOD_CK1_1 368 374 PF00069 0.501
MOD_CK1_1 95 101 PF00069 0.509
MOD_CK2_1 395 401 PF00069 0.480
MOD_CK2_1 409 415 PF00069 0.450
MOD_CK2_1 474 480 PF00069 0.551
MOD_CK2_1 557 563 PF00069 0.683
MOD_GlcNHglycan 142 146 PF01048 0.303
MOD_GlcNHglycan 224 227 PF01048 0.316
MOD_GlcNHglycan 232 235 PF01048 0.372
MOD_GlcNHglycan 435 438 PF01048 0.308
MOD_GlcNHglycan 559 562 PF01048 0.727
MOD_GlcNHglycan 567 572 PF01048 0.750
MOD_GlcNHglycan 584 587 PF01048 0.654
MOD_GSK3_1 337 344 PF00069 0.461
MOD_GSK3_1 358 365 PF00069 0.516
MOD_GSK3_1 366 373 PF00069 0.466
MOD_GSK3_1 391 398 PF00069 0.459
MOD_GSK3_1 443 450 PF00069 0.480
MOD_GSK3_1 503 510 PF00069 0.569
MOD_GSK3_1 563 570 PF00069 0.740
MOD_GSK3_1 573 580 PF00069 0.555
MOD_N-GLC_1 117 122 PF02516 0.275
MOD_N-GLC_1 582 587 PF02516 0.780
MOD_N-GLC_1 60 65 PF02516 0.275
MOD_NEK2_1 117 122 PF00069 0.464
MOD_NEK2_1 147 152 PF00069 0.572
MOD_NEK2_1 276 281 PF00069 0.527
MOD_NEK2_1 341 346 PF00069 0.461
MOD_NEK2_1 362 367 PF00069 0.497
MOD_NEK2_1 495 500 PF00069 0.507
MOD_NEK2_1 5 10 PF00069 0.344
MOD_NEK2_1 581 586 PF00069 0.563
MOD_NEK2_2 337 342 PF00069 0.541
MOD_PIKK_1 11 17 PF00454 0.462
MOD_PIKK_1 182 188 PF00454 0.481
MOD_PIKK_1 238 244 PF00454 0.541
MOD_PIKK_1 391 397 PF00454 0.459
MOD_PIKK_1 521 527 PF00454 0.650
MOD_PK_1 248 254 PF00069 0.412
MOD_PKA_1 92 98 PF00069 0.565
MOD_PKA_2 171 177 PF00069 0.502
MOD_PKA_2 199 205 PF00069 0.535
MOD_PKA_2 341 347 PF00069 0.541
MOD_PKA_2 447 453 PF00069 0.475
MOD_PKA_2 506 512 PF00069 0.630
MOD_PKA_2 95 101 PF00069 0.570
MOD_Plk_1 117 123 PF00069 0.475
MOD_Plk_1 141 147 PF00069 0.513
MOD_Plk_1 358 364 PF00069 0.513
MOD_Plk_1 5 11 PF00069 0.372
MOD_Plk_1 521 527 PF00069 0.575
MOD_Plk_2-3 563 569 PF00069 0.683
MOD_Plk_4 248 254 PF00069 0.412
MOD_Plk_4 495 501 PF00069 0.472
MOD_Plk_4 5 11 PF00069 0.405
MOD_Plk_4 511 517 PF00069 0.631
MOD_Plk_4 549 555 PF00069 0.463
MOD_ProDKin_1 368 374 PF00069 0.541
MOD_ProDKin_1 395 401 PF00069 0.472
MOD_ProDKin_1 507 513 PF00069 0.649
MOD_ProDKin_1 55 61 PF00069 0.507
MOD_SUMO_for_1 139 142 PF00179 0.495
MOD_SUMO_for_1 91 94 PF00179 0.537
MOD_SUMO_rev_2 157 167 PF00179 0.513
MOD_SUMO_rev_2 268 276 PF00179 0.532
MOD_SUMO_rev_2 44 52 PF00179 0.521
TRG_DiLeu_BaEn_1 414 419 PF01217 0.481
TRG_DiLeu_BaEn_4 414 420 PF01217 0.536
TRG_ENDOCYTIC_2 175 178 PF00928 0.461
TRG_ER_diArg_1 113 116 PF00400 0.459
TRG_ER_diArg_1 297 299 PF00400 0.475
TRG_ER_diArg_1 341 343 PF00400 0.498
TRG_ER_diArg_1 351 354 PF00400 0.423
TRG_ER_diArg_1 39 41 PF00400 0.486
TRG_ER_diArg_1 467 469 PF00400 0.561
TRG_NLS_MonoCore_2 384 389 PF00514 0.440
TRG_NLS_MonoExtC_3 384 390 PF00514 0.440
TRG_NLS_MonoExtN_4 383 389 PF00514 0.445
TRG_NLS_MonoExtN_4 591 596 PF00514 0.680
TRG_PTS2 1 43 PF00400 0.320

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IH42 Leptomonas seymouri 69% 100%
A0A0S4J2Z5 Bodo saltans 43% 100%
A0A1X0PAR6 Trypanosomatidae 48% 100%
A0A3S7X839 Leishmania donovani 99% 100%
A4HAZ6 Leishmania braziliensis 81% 100%
C9ZM46 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B570 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q00004 Canis lupus familiaris 25% 97%
Q1ZXE8 Dictyostelium discoideum 21% 98%
Q4Q2R5 Leishmania major 93% 100%
Q8BMA6 Mus musculus 25% 96%
Q9UHB9 Homo sapiens 25% 96%
Q9VSS2 Drosophila melanogaster 24% 100%
V5BV06 Trypanosoma cruzi 49% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS