Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calcineurin-like phosphoesterase-like protein

Species:

Leishmania infantum

UniProt:

A4IA54_LEIIN

TriTrypDb:

LINF_340033800

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IA54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA54

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004721	phosphoprotein phosphatase activity	3	8
GO:0004722	protein serine/threonine phosphatase activity	4	8
GO:0016787	hydrolase activity	2	8
GO:0016788	hydrolase activity, acting on ester bonds	3	8
GO:0016791	phosphatase activity	5	8
GO:0017018	myosin phosphatase activity	5	8
GO:0042578	phosphoric ester hydrolase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.276
CLV_C14_Caspase3-7	2	6	PF00656	0.574
CLV_C14_Caspase3-7	323	327	PF00656	0.512
CLV_NRD_NRD_1	116	118	PF00675	0.398
CLV_NRD_NRD_1	363	365	PF00675	0.563
CLV_NRD_NRD_1	451	453	PF00675	0.398
CLV_PCSK_FUR_1	370	374	PF00082	0.486
CLV_PCSK_KEX2_1	363	365	PF00082	0.563
CLV_PCSK_KEX2_1	372	374	PF00082	0.388
CLV_PCSK_KEX2_1	412	414	PF00082	0.611
CLV_PCSK_KEX2_1	451	453	PF00082	0.451
CLV_PCSK_KEX2_1	479	481	PF00082	0.705
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.555
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.611
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.705
CLV_PCSK_SKI1_1	121	125	PF00082	0.398
CLV_PCSK_SKI1_1	183	187	PF00082	0.391
CLV_PCSK_SKI1_1	363	367	PF00082	0.573
CLV_PCSK_SKI1_1	451	455	PF00082	0.456
CLV_PCSK_SKI1_1	67	71	PF00082	0.459
DEG_SCF_FBW7_1	145	152	PF00400	0.398
DEG_SCF_FBW7_1	384	389	PF00400	0.683
DEG_SCF_TRCP1_1	135	141	PF00400	0.311
DOC_CKS1_1	146	151	PF01111	0.363
DOC_CYCLIN_RxL_1	180	189	PF00134	0.391
DOC_CYCLIN_yClb3_PxF_3	597	605	PF00134	0.675
DOC_CYCLIN_yCln2_LP_2	151	157	PF00134	0.290
DOC_CYCLIN_yCln2_LP_2	18	21	PF00134	0.523
DOC_MAPK_gen_1	193	203	PF00069	0.373
DOC_MAPK_HePTP_8	69	81	PF00069	0.445
DOC_MAPK_MEF2A_6	193	202	PF00069	0.391
DOC_MAPK_MEF2A_6	72	81	PF00069	0.445
DOC_PP1_RVXF_1	178	185	PF00149	0.391
DOC_PP1_RVXF_1	553	559	PF00149	0.448
DOC_PP2B_LxvP_1	151	154	PF13499	0.276
DOC_PP2B_LxvP_1	18	21	PF13499	0.523
DOC_PP2B_LxvP_1	358	361	PF13499	0.414
DOC_PP4_FxxP_1	525	528	PF00568	0.360
DOC_USP7_MATH_1	261	265	PF00917	0.647
DOC_USP7_MATH_1	327	331	PF00917	0.504
DOC_USP7_MATH_1	547	551	PF00917	0.573
DOC_USP7_UBL2_3	579	583	PF12436	0.653
DOC_WW_Pin1_4	145	150	PF00397	0.355
DOC_WW_Pin1_4	266	271	PF00397	0.646
DOC_WW_Pin1_4	282	287	PF00397	0.634
DOC_WW_Pin1_4	356	361	PF00397	0.370
DOC_WW_Pin1_4	382	387	PF00397	0.709
DOC_WW_Pin1_4	394	399	PF00397	0.586
DOC_WW_Pin1_4	405	410	PF00397	0.684
DOC_WW_Pin1_4	462	467	PF00397	0.576
LIG_14-3-3_CanoR_1	139	144	PF00244	0.494
LIG_14-3-3_CanoR_1	28	37	PF00244	0.401
LIG_14-3-3_CanoR_1	308	316	PF00244	0.664
LIG_14-3-3_CanoR_1	363	371	PF00244	0.497
LIG_Actin_WH2_2	102	119	PF00022	0.276
LIG_Actin_WH2_2	39	55	PF00022	0.479
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	170	174	PF00533	0.391
LIG_deltaCOP1_diTrp_1	326	335	PF00928	0.513
LIG_FHA_1	140	146	PF00498	0.379
LIG_FHA_1	225	231	PF00498	0.391
LIG_FHA_1	383	389	PF00498	0.718
LIG_FHA_1	463	469	PF00498	0.610
LIG_FHA_2	321	327	PF00498	0.600
LIG_LIR_Apic_2	252	256	PF02991	0.600
LIG_LIR_Apic_2	523	528	PF02991	0.358
LIG_LIR_Gen_1	24	34	PF02991	0.479
LIG_LIR_Gen_1	326	335	PF02991	0.474
LIG_LIR_Gen_1	85	93	PF02991	0.465
LIG_LIR_LC3C_4	518	522	PF02991	0.398
LIG_LIR_Nem_3	24	29	PF02991	0.493
LIG_LIR_Nem_3	326	331	PF02991	0.428
LIG_LIR_Nem_3	334	340	PF02991	0.307
LIG_LIR_Nem_3	557	561	PF02991	0.433
LIG_LIR_Nem_3	616	622	PF02991	0.657
LIG_LIR_Nem_3	8	14	PF02991	0.430
LIG_LIR_Nem_3	85	90	PF02991	0.465
LIG_MYND_1	149	153	PF01753	0.276
LIG_MYND_1	16	20	PF01753	0.513
LIG_PCNA_yPIPBox_3	412	423	PF02747	0.574
LIG_PCNA_yPIPBox_3	605	619	PF02747	0.601
LIG_PCNA_yPIPBox_3	98	111	PF02747	0.391
LIG_Pex14_2	331	335	PF04695	0.416
LIG_Rb_pABgroove_1	8	16	PF01858	0.480
LIG_SH2_CRK	406	410	PF00017	0.723
LIG_SH2_PTP2	26	29	PF00017	0.420
LIG_SH2_SRC	253	256	PF00017	0.658
LIG_SH2_STAP1	38	42	PF00017	0.454
LIG_SH2_STAT5	12	15	PF00017	0.446
LIG_SH2_STAT5	190	193	PF00017	0.346
LIG_SH2_STAT5	253	256	PF00017	0.658
LIG_SH2_STAT5	26	29	PF00017	0.430
LIG_SH2_STAT5	42	45	PF00017	0.496
LIG_SH2_STAT5	530	533	PF00017	0.417
LIG_SH2_STAT5	618	621	PF00017	0.576
LIG_SH3_2	600	605	PF14604	0.747
LIG_SH3_3	143	149	PF00018	0.413
LIG_SH3_3	151	157	PF00018	0.322
LIG_SH3_3	594	600	PF00018	0.752
LIG_SH3_3	607	613	PF00018	0.581
LIG_SH3_4	579	586	PF00018	0.569
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.408
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.402
LIG_SUMO_SIM_par_1	520	526	PF11976	0.357
LIG_SxIP_EBH_1	157	166	PF03271	0.276
LIG_TRAF2_2	126	131	PF00917	0.381
LIG_TRAF2_2	415	420	PF00917	0.466
LIG_UBA3_1	203	208	PF00899	0.391
LIG_WRC_WIRS_1	561	566	PF05994	0.441
LIG_WW_3	486	490	PF00397	0.705
MOD_CDC14_SPxK_1	397	400	PF00782	0.750
MOD_CDK_SPK_2	398	403	PF00069	0.687
MOD_CDK_SPxK_1	394	400	PF00069	0.752
MOD_CDK_SPxxK_3	356	363	PF00069	0.518
MOD_CDK_SPxxK_3	405	412	PF00069	0.658
MOD_CDK_SPxxK_3	462	469	PF00069	0.593
MOD_CK1_1	103	109	PF00069	0.391
MOD_CK1_1	158	164	PF00069	0.364
MOD_CK1_1	304	310	PF00069	0.765
MOD_CK1_1	393	399	PF00069	0.690
MOD_CK1_1	408	414	PF00069	0.648
MOD_CK1_1	425	431	PF00069	0.470
MOD_CK1_1	467	473	PF00069	0.590
MOD_CK1_1	550	556	PF00069	0.511
MOD_CK1_1	573	579	PF00069	0.758
MOD_CK1_1	585	591	PF00069	0.585
MOD_CK1_1	68	74	PF00069	0.467
MOD_CK2_1	249	255	PF00069	0.614
MOD_CK2_1	309	315	PF00069	0.732
MOD_CK2_1	393	399	PF00069	0.658
MOD_CK2_1	408	414	PF00069	0.655
MOD_CK2_1	425	431	PF00069	0.470
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	111	114	PF01048	0.369
MOD_GlcNHglycan	133	138	PF01048	0.473
MOD_GlcNHglycan	303	306	PF01048	0.708
MOD_GlcNHglycan	312	315	PF01048	0.620
MOD_GlcNHglycan	388	391	PF01048	0.607
MOD_GlcNHglycan	484	487	PF01048	0.622
MOD_GlcNHglycan	525	528	PF01048	0.360
MOD_GlcNHglycan	549	552	PF01048	0.518
MOD_GlcNHglycan	584	587	PF01048	0.694
MOD_GlcNHglycan	589	592	PF01048	0.679
MOD_GlcNHglycan	624	627	PF01048	0.509
MOD_GSK3_1	103	110	PF00069	0.372
MOD_GSK3_1	117	124	PF00069	0.496
MOD_GSK3_1	133	140	PF00069	0.458
MOD_GSK3_1	145	152	PF00069	0.452
MOD_GSK3_1	155	162	PF00069	0.332
MOD_GSK3_1	300	307	PF00069	0.764
MOD_GSK3_1	327	334	PF00069	0.486
MOD_GSK3_1	347	354	PF00069	0.189
MOD_GSK3_1	382	389	PF00069	0.643
MOD_GSK3_1	390	397	PF00069	0.672
MOD_GSK3_1	460	467	PF00069	0.696
MOD_GSK3_1	478	485	PF00069	0.504
MOD_GSK3_1	585	592	PF00069	0.744
MOD_GSK3_1	618	625	PF00069	0.580
MOD_GSK3_1	68	75	PF00069	0.545
MOD_N-GLC_1	309	314	PF02516	0.677
MOD_N-GLC_1	331	336	PF02516	0.357
MOD_N-GLC_2	529	531	PF02516	0.390
MOD_NEK2_1	100	105	PF00069	0.400
MOD_NEK2_1	109	114	PF00069	0.400
MOD_NEK2_1	159	164	PF00069	0.506
MOD_NEK2_1	300	305	PF00069	0.716
MOD_NEK2_1	331	336	PF00069	0.417
MOD_NEK2_1	351	356	PF00069	0.476
MOD_NEK2_1	380	385	PF00069	0.705
MOD_NEK2_1	388	393	PF00069	0.622
MOD_NEK2_1	520	525	PF00069	0.416
MOD_NEK2_1	589	594	PF00069	0.655
MOD_NEK2_2	347	352	PF00069	0.497
MOD_PIKK_1	121	127	PF00454	0.468
MOD_PIKK_1	363	369	PF00454	0.492
MOD_PIKK_1	460	466	PF00454	0.647
MOD_PIKK_1	493	499	PF00454	0.590
MOD_PIKK_1	513	519	PF00454	0.239
MOD_PKA_1	117	123	PF00069	0.398
MOD_PKA_1	363	369	PF00069	0.562
MOD_PKA_1	372	378	PF00069	0.403
MOD_PKA_2	138	144	PF00069	0.494
MOD_PKA_2	295	301	PF00069	0.642
MOD_PKA_2	363	369	PF00069	0.492
MOD_PKA_2	372	378	PF00069	0.493
MOD_Plk_1	331	337	PF00069	0.361
MOD_Plk_1	38	44	PF00069	0.473
MOD_Plk_2-3	249	255	PF00069	0.620
MOD_Plk_4	100	106	PF00069	0.391
MOD_Plk_4	249	255	PF00069	0.667
MOD_Plk_4	261	267	PF00069	0.590
MOD_Plk_4	315	321	PF00069	0.632
MOD_Plk_4	347	353	PF00069	0.419
MOD_Plk_4	38	44	PF00069	0.495
MOD_Plk_4	520	526	PF00069	0.366
MOD_Plk_4	65	71	PF00069	0.485
MOD_Plk_4	72	78	PF00069	0.425
MOD_ProDKin_1	145	151	PF00069	0.355
MOD_ProDKin_1	266	272	PF00069	0.648
MOD_ProDKin_1	282	288	PF00069	0.637
MOD_ProDKin_1	356	362	PF00069	0.370
MOD_ProDKin_1	382	388	PF00069	0.713
MOD_ProDKin_1	394	400	PF00069	0.586
MOD_ProDKin_1	405	411	PF00069	0.676
MOD_ProDKin_1	462	468	PF00069	0.582
MOD_SUMO_for_1	207	210	PF00179	0.391
MOD_SUMO_for_1	371	374	PF00179	0.548
MOD_SUMO_rev_2	471	481	PF00179	0.685
MOD_SUMO_rev_2	552	560	PF00179	0.458
MOD_SUMO_rev_2	61	69	PF00179	0.542
TRG_DiLeu_BaEn_1	199	204	PF01217	0.391
TRG_DiLeu_BaEn_1	315	320	PF01217	0.509
TRG_ENDOCYTIC_2	231	234	PF00928	0.391
TRG_ENDOCYTIC_2	26	29	PF00928	0.430
TRG_ENDOCYTIC_2	530	533	PF00928	0.470
TRG_ENDOCYTIC_2	561	564	PF00928	0.416
TRG_ER_diArg_1	362	364	PF00400	0.545
TRG_ER_diArg_1	451	453	PF00400	0.451
TRG_NES_CRM1_1	199	210	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E6	Leptomonas seymouri	55%	100%
A0A3S7X863	Leishmania donovani	100%	100%
A4HAZ4	Leishmania braziliensis	72%	100%
D0A366	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9B568	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2R7	Leishmania major	91%	100%