LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA52_LEIIN
TriTrypDb:
LINF_340033600
Length:
301

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0005930 axoneme 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IA52
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA52

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 214 218 PF00656 0.586
CLV_C14_Caspase3-7 98 102 PF00656 0.768
CLV_NRD_NRD_1 131 133 PF00675 0.553
CLV_NRD_NRD_1 275 277 PF00675 0.554
CLV_NRD_NRD_1 279 281 PF00675 0.544
CLV_NRD_NRD_1 282 284 PF00675 0.440
CLV_NRD_NRD_1 57 59 PF00675 0.621
CLV_PCSK_FUR_1 280 284 PF00082 0.523
CLV_PCSK_KEX2_1 131 133 PF00082 0.553
CLV_PCSK_KEX2_1 275 277 PF00082 0.526
CLV_PCSK_KEX2_1 279 281 PF00082 0.515
CLV_PCSK_KEX2_1 282 284 PF00082 0.492
CLV_PCSK_KEX2_1 57 59 PF00082 0.621
CLV_PCSK_PC7_1 271 277 PF00082 0.524
CLV_PCSK_SKI1_1 183 187 PF00082 0.507
CLV_PCSK_SKI1_1 222 226 PF00082 0.711
CLV_Separin_Metazoa 254 258 PF03568 0.643
DEG_Nend_UBRbox_3 1 3 PF02207 0.737
DOC_CYCLIN_RxL_1 177 190 PF00134 0.510
DOC_MAPK_HePTP_8 189 201 PF00069 0.383
DOC_MAPK_MEF2A_6 192 201 PF00069 0.382
DOC_USP7_MATH_1 104 108 PF00917 0.803
DOC_WW_Pin1_4 191 196 PF00397 0.511
LIG_Actin_WH2_2 194 209 PF00022 0.492
LIG_FHA_1 20 26 PF00498 0.519
LIG_FHA_1 226 232 PF00498 0.567
LIG_FHA_1 45 51 PF00498 0.517
LIG_FHA_2 145 151 PF00498 0.492
LIG_FHA_2 165 171 PF00498 0.314
LIG_FHA_2 84 90 PF00498 0.636
LIG_LIR_Gen_1 156 166 PF02991 0.490
LIG_LIR_Nem_3 134 139 PF02991 0.507
LIG_LIR_Nem_3 156 162 PF02991 0.483
LIG_LYPXL_yS_3 61 64 PF13949 0.595
LIG_NRBOX 181 187 PF00104 0.499
LIG_PALB2_WD40_1 237 245 PF16756 0.605
LIG_Pex14_1 238 242 PF04695 0.613
LIG_RPA_C_Fungi 120 132 PF08784 0.597
LIG_RPA_C_Insects 120 135 PF08784 0.579
LIG_SH2_CRK 159 163 PF00017 0.501
LIG_SH2_STAP1 208 212 PF00017 0.550
LIG_SH2_STAT5 200 203 PF00017 0.490
LIG_SH3_3 61 67 PF00018 0.619
LIG_SUMO_SIM_par_1 187 194 PF11976 0.514
LIG_TRAF2_1 288 291 PF00917 0.634
LIG_TYR_ITIM 59 64 PF00017 0.587
MOD_CDK_SPxxK_3 191 198 PF00069 0.604
MOD_CK1_1 193 199 PF00069 0.577
MOD_CK1_1 258 264 PF00069 0.593
MOD_CK1_1 69 75 PF00069 0.624
MOD_CK2_1 164 170 PF00069 0.546
MOD_CK2_1 69 75 PF00069 0.824
MOD_CK2_1 76 82 PF00069 0.791
MOD_CK2_1 8 14 PF00069 0.725
MOD_CMANNOS 238 241 PF00535 0.616
MOD_GlcNHglycan 106 109 PF01048 0.618
MOD_GlcNHglycan 208 211 PF01048 0.561
MOD_GlcNHglycan 233 236 PF01048 0.509
MOD_GSK3_1 206 213 PF00069 0.528
MOD_GSK3_1 4 11 PF00069 0.730
MOD_GSK3_1 66 73 PF00069 0.780
MOD_LATS_1 68 74 PF00433 0.720
MOD_N-GLC_2 40 42 PF02516 0.469
MOD_NEK2_1 206 211 PF00069 0.498
MOD_NEK2_1 231 236 PF00069 0.615
MOD_OFUCOSY 142 148 PF10250 0.494
MOD_PIKK_1 126 132 PF00454 0.499
MOD_PIKK_1 95 101 PF00454 0.824
MOD_PKA_1 131 137 PF00069 0.546
MOD_PKA_2 124 130 PF00069 0.714
MOD_PKA_2 131 137 PF00069 0.522
MOD_PKA_2 206 212 PF00069 0.514
MOD_Plk_1 144 150 PF00069 0.491
MOD_Plk_2-3 76 82 PF00069 0.763
MOD_Plk_2-3 8 14 PF00069 0.725
MOD_Plk_2-3 83 89 PF00069 0.706
MOD_Plk_4 157 163 PF00069 0.564
MOD_ProDKin_1 191 197 PF00069 0.506
TRG_DiLeu_BaEn_1 184 189 PF01217 0.481
TRG_DiLeu_BaEn_4 226 232 PF01217 0.392
TRG_ENDOCYTIC_2 114 117 PF00928 0.584
TRG_ENDOCYTIC_2 159 162 PF00928 0.492
TRG_ENDOCYTIC_2 208 211 PF00928 0.510
TRG_ENDOCYTIC_2 61 64 PF00928 0.595
TRG_ER_diArg_1 56 58 PF00400 0.612
TRG_Pf-PMV_PEXEL_1 115 119 PF00026 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P606 Leptomonas seymouri 59% 100%
A0A3S7X837 Leishmania donovani 100% 100%
A4HAZ2 Leishmania braziliensis 84% 100%
E9B566 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q2R9 Leishmania major 95% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS