UL46

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UL46

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IA47_LEIIN

TriTrypDb:

LINF_340033100

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.722
CLV_C14_Caspase3-7	236	240	PF00656	0.845
CLV_C14_Caspase3-7	72	76	PF00656	0.759
CLV_NRD_NRD_1	165	167	PF00675	0.689
CLV_NRD_NRD_1	211	213	PF00675	0.767
CLV_NRD_NRD_1	267	269	PF00675	0.600
CLV_NRD_NRD_1	357	359	PF00675	0.571
CLV_NRD_NRD_1	383	385	PF00675	0.511
CLV_NRD_NRD_1	4	6	PF00675	0.727
CLV_NRD_NRD_1	51	53	PF00675	0.763
CLV_NRD_NRD_1	96	98	PF00675	0.834
CLV_PCSK_KEX2_1	167	169	PF00082	0.648
CLV_PCSK_KEX2_1	211	213	PF00082	0.767
CLV_PCSK_KEX2_1	267	269	PF00082	0.508
CLV_PCSK_KEX2_1	357	359	PF00082	0.571
CLV_PCSK_KEX2_1	382	384	PF00082	0.584
CLV_PCSK_KEX2_1	4	6	PF00082	0.727
CLV_PCSK_KEX2_1	51	53	PF00082	0.763
CLV_PCSK_KEX2_1	95	97	PF00082	0.837
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.648
CLV_PCSK_PC7_1	379	385	PF00082	0.539
CLV_PCSK_PC7_1	92	98	PF00082	0.832
CLV_PCSK_SKI1_1	250	254	PF00082	0.698
DEG_SCF_FBW7_1	176	181	PF00400	0.782
DEG_SPOP_SBC_1	87	91	PF00917	0.713
DOC_CYCLIN_RxL_1	357	367	PF00134	0.471
DOC_MAPK_gen_1	357	365	PF00069	0.533
DOC_MAPK_gen_1	416	426	PF00069	0.426
DOC_MAPK_gen_1	78	87	PF00069	0.780
DOC_MAPK_MEF2A_6	299	306	PF00069	0.489
DOC_PP1_RVXF_1	356	363	PF00149	0.541
DOC_PP2B_LxvP_1	196	199	PF13499	0.755
DOC_USP7_MATH_1	178	182	PF00917	0.814
DOC_USP7_MATH_1	245	249	PF00917	0.722
DOC_USP7_MATH_1	71	75	PF00917	0.791
DOC_WW_Pin1_4	174	179	PF00397	0.785
DOC_WW_Pin1_4	181	186	PF00397	0.717
DOC_WW_Pin1_4	254	259	PF00397	0.627
DOC_WW_Pin1_4	8	13	PF00397	0.699
LIG_14-3-3_CanoR_1	111	116	PF00244	0.625
LIG_14-3-3_CanoR_1	250	260	PF00244	0.660
LIG_14-3-3_CanoR_1	352	360	PF00244	0.600
LIG_14-3-3_CanoR_1	382	387	PF00244	0.582
LIG_14-3-3_CanoR_1	51	55	PF00244	0.678
LIG_Actin_WH2_2	290	307	PF00022	0.578
LIG_BIR_II_1	1	5	PF00653	0.784
LIG_BIR_III_2	197	201	PF00653	0.803
LIG_FHA_1	255	261	PF00498	0.730
LIG_FHA_1	32	38	PF00498	0.662
LIG_FHA_1	398	404	PF00498	0.538
LIG_FHA_1	421	427	PF00498	0.406
LIG_FHA_1	430	436	PF00498	0.401
LIG_FHA_2	231	237	PF00498	0.745
LIG_FHA_2	88	94	PF00498	0.688
LIG_HCF-1_HBM_1	377	380	PF13415	0.509
LIG_LIR_Gen_1	57	66	PF02991	0.639
LIG_MYND_1	258	262	PF01753	0.580
LIG_Pex14_2	317	321	PF04695	0.461
LIG_Pex14_2	407	411	PF04695	0.432
LIG_REV1ctd_RIR_1	314	324	PF16727	0.480
LIG_SH2_CRK	122	126	PF00017	0.618
LIG_SH2_CRK	276	280	PF00017	0.486
LIG_SH2_NCK_1	122	126	PF00017	0.618
LIG_SH2_STAP1	133	137	PF00017	0.770
LIG_SH2_STAP1	28	32	PF00017	0.655
LIG_SH2_STAP1	64	68	PF00017	0.678
LIG_SH2_STAT3	64	67	PF00017	0.682
LIG_SH2_STAT5	133	136	PF00017	0.671
LIG_SH2_STAT5	296	299	PF00017	0.474
LIG_SH2_STAT5	380	383	PF00017	0.518
LIG_SH2_STAT5	402	405	PF00017	0.520
LIG_SH2_STAT5	434	437	PF00017	0.533
LIG_SH2_STAT5	60	63	PF00017	0.710
LIG_SH2_STAT5	64	67	PF00017	0.687
LIG_SH3_1	187	193	PF00018	0.688
LIG_SH3_1	277	283	PF00018	0.631
LIG_SH3_3	102	108	PF00018	0.696
LIG_SH3_3	187	193	PF00018	0.778
LIG_SH3_3	276	282	PF00018	0.463
LIG_SUMO_SIM_anti_2	421	429	PF11976	0.568
LIG_TRAF2_1	148	151	PF00917	0.723
LIG_WRC_WIRS_1	440	445	PF05994	0.429
MOD_CDC14_SPxK_1	184	187	PF00782	0.685
MOD_CDK_SPxK_1	181	187	PF00069	0.698
MOD_CK1_1	100	106	PF00069	0.840
MOD_CK1_1	126	132	PF00069	0.756
MOD_CK1_1	174	180	PF00069	0.779
MOD_CK1_1	181	187	PF00069	0.731
MOD_CK1_1	254	260	PF00069	0.617
MOD_CK1_1	298	304	PF00069	0.522
MOD_CK1_1	353	359	PF00069	0.404
MOD_CK1_1	415	421	PF00069	0.519
MOD_CK1_1	442	448	PF00069	0.424
MOD_CK1_1	47	53	PF00069	0.724
MOD_CK2_1	144	150	PF00069	0.721
MOD_CK2_1	415	421	PF00069	0.519
MOD_Cter_Amidation	209	212	PF01082	0.768
MOD_GlcNHglycan	102	105	PF01048	0.830
MOD_GlcNHglycan	12	15	PF01048	0.751
MOD_GlcNHglycan	137	140	PF01048	0.800
MOD_GlcNHglycan	180	183	PF01048	0.753
MOD_GlcNHglycan	23	27	PF01048	0.703
MOD_GlcNHglycan	253	256	PF01048	0.697
MOD_GlcNHglycan	352	355	PF01048	0.499
MOD_GlcNHglycan	395	398	PF01048	0.677
MOD_GSK3_1	123	130	PF00069	0.723
MOD_GSK3_1	131	138	PF00069	0.615
MOD_GSK3_1	170	177	PF00069	0.729
MOD_GSK3_1	22	29	PF00069	0.739
MOD_GSK3_1	220	227	PF00069	0.820
MOD_GSK3_1	256	263	PF00069	0.581
MOD_GSK3_1	346	353	PF00069	0.531
MOD_GSK3_1	393	400	PF00069	0.554
MOD_GSK3_1	50	57	PF00069	0.745
MOD_N-GLC_1	220	225	PF02516	0.700
MOD_N-GLC_1	429	434	PF02516	0.452
MOD_N-GLC_1	47	52	PF02516	0.685
MOD_NEK2_1	325	330	PF00069	0.586
MOD_NEK2_1	398	403	PF00069	0.438
MOD_NEK2_2	245	250	PF00069	0.663
MOD_PIKK_1	429	435	PF00454	0.458
MOD_PIKK_1	442	448	PF00454	0.479
MOD_PK_1	111	117	PF00069	0.625
MOD_PKA_1	382	388	PF00069	0.589
MOD_PKA_2	100	106	PF00069	0.840
MOD_PKA_2	21	27	PF00069	0.767
MOD_PKA_2	298	304	PF00069	0.427
MOD_PKA_2	339	345	PF00069	0.458
MOD_PKA_2	382	388	PF00069	0.536
MOD_PKA_2	415	421	PF00069	0.519
MOD_PKA_2	50	56	PF00069	0.799
MOD_PKB_1	166	174	PF00069	0.675
MOD_PKB_1	95	103	PF00069	0.836
MOD_Plk_1	420	426	PF00069	0.472
MOD_Plk_1	429	435	PF00069	0.475
MOD_Plk_2-3	146	152	PF00069	0.727
MOD_Plk_4	298	304	PF00069	0.584
MOD_Plk_4	339	345	PF00069	0.639
MOD_Plk_4	346	352	PF00069	0.442
MOD_Plk_4	398	404	PF00069	0.441
MOD_Plk_4	439	445	PF00069	0.383
MOD_ProDKin_1	174	180	PF00069	0.785
MOD_ProDKin_1	181	187	PF00069	0.721
MOD_ProDKin_1	254	260	PF00069	0.612
MOD_ProDKin_1	8	14	PF00069	0.698
MOD_SUMO_rev_2	220	225	PF00179	0.767
MOD_SUMO_rev_2	367	373	PF00179	0.433
TRG_DiLeu_BaEn_1	422	427	PF01217	0.425
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.721
TRG_ENDOCYTIC_2	276	279	PF00928	0.440
TRG_ENDOCYTIC_2	60	63	PF00928	0.732
TRG_ER_diArg_1	211	214	PF00400	0.684
TRG_ER_diArg_1	266	268	PF00400	0.546
TRG_ER_diArg_1	357	359	PF00400	0.571
TRG_ER_diArg_1	381	384	PF00400	0.563
TRG_ER_diArg_1	4	7	PF00400	0.707
TRG_ER_diArg_1	95	97	PF00400	0.827

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ09	Leptomonas seymouri	50%	92%
A0A3Q8IIN3	Leishmania donovani	99%	100%
A4HAY8	Leishmania braziliensis	68%	100%
E9B561	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%