Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain - G-beta repeat - putative

Species:

Leishmania infantum

UniProt:

A4IA44_LEIIN

TriTrypDb:

LINF_340032800

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4IA44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	234	240	PF00089	0.522
CLV_NRD_NRD_1	278	280	PF00675	0.511
CLV_NRD_NRD_1	421	423	PF00675	0.710
CLV_NRD_NRD_1	476	478	PF00675	0.462
CLV_NRD_NRD_1	523	525	PF00675	0.578
CLV_PCSK_KEX2_1	278	280	PF00082	0.628
CLV_PCSK_KEX2_1	476	478	PF00082	0.462
CLV_PCSK_KEX2_1	523	525	PF00082	0.578
CLV_PCSK_SKI1_1	199	203	PF00082	0.562
CLV_PCSK_SKI1_1	22	26	PF00082	0.565
CLV_PCSK_SKI1_1	27	31	PF00082	0.543
CLV_PCSK_SKI1_1	432	436	PF00082	0.567
CLV_PCSK_SKI1_1	476	480	PF00082	0.486
DEG_APCC_DBOX_1	39	47	PF00400	0.527
DEG_APCC_DBOX_1	431	439	PF00400	0.564
DEG_SPOP_SBC_1	296	300	PF00917	0.764
DOC_ANK_TNKS_1	421	428	PF00023	0.560
DOC_CKS1_1	64	69	PF01111	0.554
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.531
DOC_MAPK_gen_1	228	236	PF00069	0.419
DOC_MAPK_gen_1	422	430	PF00069	0.652
DOC_MAPK_gen_1	451	461	PF00069	0.639
DOC_MAPK_MEF2A_6	230	238	PF00069	0.427
DOC_MAPK_MEF2A_6	422	430	PF00069	0.535
DOC_MAPK_MEF2A_6	454	463	PF00069	0.686
DOC_MAPK_MEF2A_6	56	64	PF00069	0.563
DOC_MAPK_NFAT4_5	423	431	PF00069	0.524
DOC_USP7_MATH_1	15	19	PF00917	0.493
DOC_USP7_MATH_1	2	6	PF00917	0.602
DOC_USP7_MATH_1	287	291	PF00917	0.633
DOC_USP7_MATH_1	296	300	PF00917	0.701
DOC_USP7_MATH_1	341	345	PF00917	0.756
DOC_USP7_MATH_1	355	359	PF00917	0.681
DOC_USP7_MATH_1	531	535	PF00917	0.508
DOC_WW_Pin1_4	297	302	PF00397	0.799
DOC_WW_Pin1_4	378	383	PF00397	0.498
DOC_WW_Pin1_4	63	68	PF00397	0.554
DOC_WW_Pin1_4	93	98	PF00397	0.700
DOC_WW_Pin1_4	99	104	PF00397	0.709
LIG_14-3-3_CanoR_1	228	236	PF00244	0.419
LIG_14-3-3_CanoR_1	250	255	PF00244	0.459
LIG_14-3-3_CanoR_1	370	378	PF00244	0.540
LIG_14-3-3_CanoR_1	380	386	PF00244	0.416
LIG_14-3-3_CanoR_1	476	485	PF00244	0.443
LIG_APCC_ABBA_1	459	464	PF00400	0.710
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BIR_III_2	329	333	PF00653	0.721
LIG_BRCT_BRCA1_1	107	111	PF00533	0.444
LIG_BRCT_BRCA1_1	459	463	PF00533	0.623
LIG_CSL_BTD_1	541	544	PF09270	0.433
LIG_EH1_1	43	51	PF00400	0.566
LIG_eIF4E_1	44	50	PF01652	0.481
LIG_FHA_1	119	125	PF00498	0.487
LIG_FHA_1	184	190	PF00498	0.477
LIG_FHA_1	229	235	PF00498	0.396
LIG_FHA_1	393	399	PF00498	0.498
LIG_FHA_1	490	496	PF00498	0.438
LIG_FHA_1	536	542	PF00498	0.473
LIG_FHA_1	57	63	PF00498	0.557
LIG_FHA_1	73	79	PF00498	0.635
LIG_FHA_2	159	165	PF00498	0.449
LIG_FHA_2	195	201	PF00498	0.652
LIG_FHA_2	332	338	PF00498	0.823
LIG_FHA_2	370	376	PF00498	0.640
LIG_FHA_2	46	52	PF00498	0.550
LIG_FHA_2	477	483	PF00498	0.467
LIG_FHA_2	64	70	PF00498	0.617
LIG_HCF-1_HBM_1	246	249	PF13415	0.580
LIG_LIR_Nem_3	169	175	PF02991	0.373
LIG_MLH1_MIPbox_1	459	463	PF16413	0.623
LIG_MYND_1	304	308	PF01753	0.602
LIG_Pex14_2	385	389	PF04695	0.555
LIG_PROFILIN_1	301	307	PF00235	0.577
LIG_SH2_CRK	175	179	PF00017	0.373
LIG_SH2_CRK	90	94	PF00017	0.719
LIG_SH2_GRB2like	183	186	PF00017	0.562
LIG_SH2_NCK_1	256	260	PF00017	0.575
LIG_SH2_NCK_1	90	94	PF00017	0.681
LIG_SH2_SRC	256	259	PF00017	0.510
LIG_SH2_STAP1	183	187	PF00017	0.562
LIG_SH2_STAP1	256	260	PF00017	0.537
LIG_SH2_STAT5	151	154	PF00017	0.546
LIG_SH2_STAT5	205	208	PF00017	0.503
LIG_SH2_STAT5	429	432	PF00017	0.561
LIG_SH3_3	213	219	PF00018	0.483
LIG_SH3_3	298	304	PF00018	0.767
LIG_SH3_3	359	365	PF00018	0.691
LIG_SH3_3	468	474	PF00018	0.677
LIG_SUMO_SIM_par_1	270	276	PF11976	0.449
LIG_TRAF2_1	162	165	PF00917	0.562
LIG_UBA3_1	49	56	PF00899	0.452
LIG_WW_2	304	307	PF00397	0.600
LIG_WW_3	364	368	PF00397	0.778
LIG_WW_3	473	477	PF00397	0.637
MOD_CK1_1	358	364	PF00069	0.712
MOD_CK1_1	381	387	PF00069	0.468
MOD_CK1_1	415	421	PF00069	0.663
MOD_CK1_1	5	11	PF00069	0.642
MOD_CK1_1	534	540	PF00069	0.511
MOD_CK1_1	63	69	PF00069	0.638
MOD_CK1_1	96	102	PF00069	0.698
MOD_CK2_1	127	133	PF00069	0.562
MOD_CK2_1	158	164	PF00069	0.430
MOD_CK2_1	252	258	PF00069	0.508
MOD_CK2_1	331	337	PF00069	0.763
MOD_CK2_1	369	375	PF00069	0.570
MOD_Cter_Amidation	420	423	PF01082	0.711
MOD_GlcNHglycan	15	18	PF01048	0.490
MOD_GlcNHglycan	152	155	PF01048	0.564
MOD_GlcNHglycan	179	182	PF01048	0.281
MOD_GlcNHglycan	212	215	PF01048	0.439
MOD_GlcNHglycan	3	7	PF01048	0.629
MOD_GlcNHglycan	350	353	PF01048	0.696
MOD_GlcNHglycan	355	358	PF01048	0.658
MOD_GlcNHglycan	401	404	PF01048	0.426
MOD_GlcNHglycan	414	417	PF01048	0.473
MOD_GlcNHglycan	533	536	PF01048	0.408
MOD_GlcNHglycan	98	101	PF01048	0.726
MOD_GSK3_1	179	186	PF00069	0.475
MOD_GSK3_1	224	231	PF00069	0.400
MOD_GSK3_1	282	289	PF00069	0.575
MOD_GSK3_1	388	395	PF00069	0.544
MOD_GSK3_1	4	11	PF00069	0.600
MOD_GSK3_1	518	525	PF00069	0.489
MOD_GSK3_1	52	59	PF00069	0.447
MOD_GSK3_1	531	538	PF00069	0.367
MOD_LATS_1	313	319	PF00433	0.725
MOD_N-GLC_1	287	292	PF02516	0.763
MOD_N-GLC_1	412	417	PF02516	0.551
MOD_NEK2_1	136	141	PF00069	0.527
MOD_NEK2_1	210	215	PF00069	0.397
MOD_NEK2_1	265	270	PF00069	0.506
MOD_NEK2_1	34	39	PF00069	0.571
MOD_NEK2_1	353	358	PF00069	0.784
MOD_NEK2_1	483	488	PF00069	0.482
MOD_NEK2_2	183	188	PF00069	0.562
MOD_NEK2_2	535	540	PF00069	0.407
MOD_PIKK_1	15	21	PF00454	0.556
MOD_PIKK_1	8	14	PF00454	0.614
MOD_PK_1	315	321	PF00069	0.619
MOD_PKA_1	476	482	PF00069	0.475
MOD_PKA_2	366	372	PF00069	0.693
MOD_PKA_2	476	482	PF00069	0.453
MOD_PKA_2	515	521	PF00069	0.544
MOD_PKA_2	522	528	PF00069	0.575
MOD_Plk_1	183	189	PF00069	0.519
MOD_Plk_1	287	293	PF00069	0.639
MOD_Plk_1	34	40	PF00069	0.503
MOD_Plk_1	412	418	PF00069	0.602
MOD_Plk_1	457	463	PF00069	0.633
MOD_Plk_1	535	541	PF00069	0.390
MOD_Plk_4	217	223	PF00069	0.451
MOD_Plk_4	270	276	PF00069	0.515
MOD_Plk_4	34	40	PF00069	0.584
MOD_Plk_4	45	51	PF00069	0.570
MOD_Plk_4	457	463	PF00069	0.669
MOD_ProDKin_1	297	303	PF00069	0.799
MOD_ProDKin_1	378	384	PF00069	0.494
MOD_ProDKin_1	63	69	PF00069	0.553
MOD_ProDKin_1	93	99	PF00069	0.704
TRG_DiLeu_BaEn_1	480	485	PF01217	0.452
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.562
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.470
TRG_ENDOCYTIC_2	175	178	PF00928	0.373
TRG_ENDOCYTIC_2	90	93	PF00928	0.699
TRG_ER_diArg_1	277	279	PF00400	0.603
TRG_ER_diArg_1	475	477	PF00400	0.510
TRG_ER_diArg_1	522	524	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	71	76	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6E9	Leptomonas seymouri	67%	96%
A0A0S4JQH6	Bodo saltans	34%	100%
A0A1X0P9Q5	Trypanosomatidae	42%	100%
A0A3Q8IUQ4	Leishmania donovani	99%	100%
A0A3R7L5W7	Trypanosoma rangeli	40%	100%
A4HAY5	Leishmania braziliensis	85%	99%
C9ZM56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B558	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q4Q2S7	Leishmania major	94%	98%
V5BKS0	Trypanosoma cruzi	43%	100%