LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

CNNM transmembrane domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CNNM transmembrane domain-containing protein
Gene product:
Domain of unknown function DUF21 - putative
Species:
Leishmania infantum
UniProt:
A4IA41_LEIIN
TriTrypDb:
LINF_340032500
Length:
608

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 5
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 8
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4IA41
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA41

Function

Biological processes
Term Name Level Count
GO:0010960 magnesium ion homeostasis 8 12
GO:0042592 homeostatic process 3 12
GO:0048878 chemical homeostasis 4 12
GO:0050801 monoatomic ion homeostasis 5 12
GO:0055065 obsolete metal ion homeostasis 7 12
GO:0055080 monoatomic cation homeostasis 6 12
GO:0065007 biological regulation 1 12
GO:0065008 regulation of biological quality 2 12
GO:0072507 obsolete divalent inorganic cation homeostasis 7 12
GO:0098771 inorganic ion homeostasis 6 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 73 77 PF00656 0.446
CLV_NRD_NRD_1 21 23 PF00675 0.687
CLV_NRD_NRD_1 347 349 PF00675 0.479
CLV_NRD_NRD_1 443 445 PF00675 0.524
CLV_NRD_NRD_1 55 57 PF00675 0.506
CLV_NRD_NRD_1 600 602 PF00675 0.605
CLV_PCSK_KEX2_1 21 23 PF00082 0.687
CLV_PCSK_KEX2_1 347 349 PF00082 0.493
CLV_PCSK_KEX2_1 432 434 PF00082 0.610
CLV_PCSK_KEX2_1 443 445 PF00082 0.517
CLV_PCSK_KEX2_1 55 57 PF00082 0.550
CLV_PCSK_PC1ET2_1 432 434 PF00082 0.624
CLV_PCSK_SKI1_1 240 244 PF00082 0.412
CLV_PCSK_SKI1_1 325 329 PF00082 0.485
CLV_PCSK_SKI1_1 337 341 PF00082 0.462
CLV_Separin_Metazoa 577 581 PF03568 0.351
DEG_APCC_DBOX_1 11 19 PF00400 0.593
DEG_APCC_DBOX_1 234 242 PF00400 0.212
DEG_COP1_1 549 557 PF00400 0.304
DEG_Nend_Nbox_1 1 3 PF02207 0.471
DOC_CKS1_1 276 281 PF01111 0.279
DOC_MAPK_gen_1 10 17 PF00069 0.702
DOC_MAPK_gen_1 21 29 PF00069 0.472
DOC_MAPK_MEF2A_6 10 17 PF00069 0.537
DOC_MAPK_MEF2A_6 198 205 PF00069 0.284
DOC_MAPK_MEF2A_6 315 323 PF00069 0.264
DOC_MAPK_MEF2A_6 337 344 PF00069 0.303
DOC_MAPK_MEF2A_6 530 537 PF00069 0.323
DOC_MAPK_NFAT4_5 10 18 PF00069 0.532
DOC_MAPK_NFAT4_5 530 538 PF00069 0.304
DOC_PP1_RVXF_1 237 244 PF00149 0.212
DOC_PP2B_LxvP_1 13 16 PF13499 0.580
DOC_PP2B_LxvP_1 552 555 PF13499 0.319
DOC_USP7_MATH_1 16 20 PF00917 0.520
DOC_USP7_MATH_1 186 190 PF00917 0.431
DOC_USP7_MATH_1 246 250 PF00917 0.226
DOC_USP7_MATH_1 490 494 PF00917 0.446
DOC_USP7_MATH_1 547 551 PF00917 0.338
DOC_USP7_UBL2_3 223 227 PF12436 0.314
DOC_WW_Pin1_4 275 280 PF00397 0.291
LIG_14-3-3_CanoR_1 10 16 PF00244 0.458
LIG_14-3-3_CanoR_1 22 28 PF00244 0.572
LIG_14-3-3_CanoR_1 55 59 PF00244 0.305
LIG_14-3-3_CanoR_1 601 606 PF00244 0.430
LIG_APCC_ABBA_1 504 509 PF00400 0.376
LIG_BIR_III_4 76 80 PF00653 0.381
LIG_BRCT_BRCA1_1 405 409 PF00533 0.307
LIG_BRCT_BRCA1_1 512 516 PF00533 0.266
LIG_BRCT_BRCA1_1 549 553 PF00533 0.353
LIG_Clathr_ClatBox_1 104 108 PF01394 0.514
LIG_Clathr_ClatBox_1 393 397 PF01394 0.248
LIG_Clathr_ClatBox_1 83 87 PF01394 0.330
LIG_EH1_1 387 395 PF00400 0.256
LIG_eIF4E_1 388 394 PF01652 0.254
LIG_FHA_1 107 113 PF00498 0.422
LIG_FHA_1 141 147 PF00498 0.265
LIG_FHA_1 24 30 PF00498 0.480
LIG_FHA_1 294 300 PF00498 0.328
LIG_FHA_1 334 340 PF00498 0.277
LIG_FHA_1 354 360 PF00498 0.165
LIG_FHA_1 515 521 PF00498 0.244
LIG_FHA_1 543 549 PF00498 0.332
LIG_FHA_1 99 105 PF00498 0.273
LIG_FHA_2 270 276 PF00498 0.275
LIG_FHA_2 393 399 PF00498 0.244
LIG_FHA_2 44 50 PF00498 0.316
LIG_LIR_Gen_1 513 524 PF02991 0.249
LIG_LIR_Gen_1 539 548 PF02991 0.260
LIG_LIR_Gen_1 573 581 PF02991 0.318
LIG_LIR_Gen_1 78 86 PF02991 0.314
LIG_LIR_LC3C_4 517 520 PF02991 0.338
LIG_LIR_Nem_3 385 390 PF02991 0.296
LIG_LIR_Nem_3 406 412 PF02991 0.312
LIG_LIR_Nem_3 513 519 PF02991 0.248
LIG_LIR_Nem_3 539 543 PF02991 0.260
LIG_LIR_Nem_3 78 83 PF02991 0.335
LIG_NRBOX 28 34 PF00104 0.416
LIG_PCNA_yPIPBox_3 134 145 PF02747 0.412
LIG_PDZ_Class_3 603 608 PF00595 0.436
LIG_Pex14_2 206 210 PF04695 0.250
LIG_Pex14_2 553 557 PF04695 0.309
LIG_Pex14_2 93 97 PF04695 0.265
LIG_SH2_STAP1 126 130 PF00017 0.437
LIG_SH2_STAT5 364 367 PF00017 0.272
LIG_SH2_STAT5 575 578 PF00017 0.361
LIG_SH3_3 210 216 PF00018 0.309
LIG_SH3_3 273 279 PF00018 0.271
LIG_SH3_3 484 490 PF00018 0.305
LIG_SUMO_SIM_anti_2 101 106 PF11976 0.118
LIG_SUMO_SIM_anti_2 111 118 PF11976 0.412
LIG_SUMO_SIM_anti_2 258 263 PF11976 0.285
LIG_SUMO_SIM_anti_2 26 31 PF11976 0.562
LIG_SUMO_SIM_anti_2 336 342 PF11976 0.272
LIG_SUMO_SIM_anti_2 370 377 PF11976 0.265
LIG_SUMO_SIM_anti_2 82 88 PF11976 0.245
LIG_SUMO_SIM_par_1 108 113 PF11976 0.412
LIG_SUMO_SIM_par_1 281 287 PF11976 0.318
LIG_SUMO_SIM_par_1 516 521 PF11976 0.253
LIG_SUMO_SIM_par_1 82 88 PF11976 0.316
LIG_SxIP_EBH_1 303 314 PF03271 0.305
LIG_TYR_ITIM 447 452 PF00017 0.299
LIG_UBA3_1 358 363 PF00899 0.265
LIG_WRC_WIRS_1 554 559 PF05994 0.287
MOD_CK1_1 249 255 PF00069 0.367
MOD_CK1_1 439 445 PF00069 0.410
MOD_CK1_1 514 520 PF00069 0.359
MOD_CK1_1 587 593 PF00069 0.436
MOD_CK2_1 115 121 PF00069 0.418
MOD_CK2_1 269 275 PF00069 0.374
MOD_CK2_1 43 49 PF00069 0.354
MOD_CK2_1 459 465 PF00069 0.341
MOD_Cter_Amidation 19 22 PF01082 0.637
MOD_GlcNHglycan 117 120 PF01048 0.212
MOD_GlcNHglycan 18 21 PF01048 0.544
MOD_GlcNHglycan 188 191 PF01048 0.217
MOD_GlcNHglycan 198 201 PF01048 0.237
MOD_GlcNHglycan 248 251 PF01048 0.522
MOD_GlcNHglycan 4 7 PF01048 0.647
MOD_GlcNHglycan 469 474 PF01048 0.615
MOD_GlcNHglycan 520 523 PF01048 0.500
MOD_GlcNHglycan 594 597 PF01048 0.633
MOD_GlcNHglycan 76 80 PF01048 0.601
MOD_GSK3_1 166 173 PF00069 0.250
MOD_GSK3_1 353 360 PF00069 0.272
MOD_GSK3_1 435 442 PF00069 0.379
MOD_GSK3_1 510 517 PF00069 0.287
MOD_GSK3_1 538 545 PF00069 0.363
MOD_GSK3_1 587 594 PF00069 0.450
MOD_GSK3_1 75 82 PF00069 0.356
MOD_N-GLC_1 425 430 PF02516 0.689
MOD_NEK2_1 11 16 PF00069 0.713
MOD_NEK2_1 140 145 PF00069 0.250
MOD_NEK2_1 150 155 PF00069 0.250
MOD_NEK2_1 2 7 PF00069 0.601
MOD_NEK2_1 43 48 PF00069 0.525
MOD_NEK2_1 459 464 PF00069 0.302
MOD_NEK2_1 479 484 PF00069 0.359
MOD_NEK2_1 518 523 PF00069 0.274
MOD_NEK2_1 75 80 PF00069 0.370
MOD_NEK2_2 555 560 PF00069 0.257
MOD_PKA_1 601 607 PF00069 0.397
MOD_PKA_2 11 17 PF00069 0.472
MOD_PKA_2 54 60 PF00069 0.346
MOD_Plk_1 122 128 PF00069 0.423
MOD_Plk_1 269 275 PF00069 0.269
MOD_Plk_1 293 299 PF00069 0.304
MOD_Plk_1 464 470 PF00069 0.361
MOD_Plk_1 479 485 PF00069 0.318
MOD_Plk_1 563 569 PF00069 0.273
MOD_Plk_2-3 108 114 PF00069 0.412
MOD_Plk_2-3 117 123 PF00069 0.442
MOD_Plk_4 140 146 PF00069 0.270
MOD_Plk_4 150 156 PF00069 0.312
MOD_Plk_4 166 172 PF00069 0.118
MOD_Plk_4 215 221 PF00069 0.259
MOD_Plk_4 25 31 PF00069 0.479
MOD_Plk_4 269 275 PF00069 0.269
MOD_Plk_4 480 486 PF00069 0.336
MOD_Plk_4 511 517 PF00069 0.365
MOD_Plk_4 563 569 PF00069 0.265
MOD_Plk_4 79 85 PF00069 0.295
MOD_ProDKin_1 275 281 PF00069 0.296
MOD_SUMO_rev_2 234 241 PF00179 0.212
MOD_SUMO_rev_2 354 359 PF00179 0.256
MOD_SUMO_rev_2 385 393 PF00179 0.272
MOD_SUMO_rev_2 594 604 PF00179 0.443
TRG_DiLeu_BaEn_1 237 242 PF01217 0.212
TRG_DiLeu_BaEn_1 295 300 PF01217 0.310
TRG_DiLeu_BaEn_1 389 394 PF01217 0.257
TRG_ENDOCYTIC_2 387 390 PF00928 0.285
TRG_ENDOCYTIC_2 449 452 PF00928 0.397
TRG_ENDOCYTIC_2 575 578 PF00928 0.302
TRG_ER_diArg_1 10 13 PF00400 0.707
TRG_ER_diArg_1 443 445 PF00400 0.317
TRG_ER_diArg_1 485 488 PF00400 0.399
TRG_NES_CRM1_1 275 290 PF08389 0.311
TRG_Pf-PMV_PEXEL_1 134 139 PF00026 0.212
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.555

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0B7P9G0 Drosophila melanogaster 33% 73%
A0A0N1PDI6 Leptomonas seymouri 84% 100%
A0A0S4JSF9 Bodo saltans 69% 100%
A0A131MCZ8 Caenorhabditis elegans 31% 76%
A0A1X0PAL3 Trypanosomatidae 75% 100%
A0A3Q8IC75 Leishmania donovani 24% 100%
A0A3Q8IL77 Leishmania donovani 100% 100%
A0A3Q8ITK0 Leishmania donovani 23% 100%
A0A3S7WUR9 Leishmania donovani 29% 82%
A0A422NS01 Trypanosoma rangeli 71% 100%
A0JPA0 Xenopus tropicalis 36% 79%
A3QM97 Caenorhabditis elegans 31% 75%
A4HAY2 Leishmania braziliensis 90% 99%
A4HIN7 Leishmania braziliensis 23% 100%
A4HKU5 Leishmania braziliensis 23% 100%
A4HXP0 Leishmania infantum 30% 82%
A4I5Y4 Leishmania infantum 24% 100%
A4I8C4 Leishmania infantum 22% 100%
C9ZM59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 100%
D0A017 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 82%
E9ARF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 82%
E9B177 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B383 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 100%
E9B555 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P0C588 Rattus norvegicus 35% 79%
Q32NY4 Mus musculus 28% 85%
Q3TWN3 Mus musculus 35% 69%
Q4Q2T0 Leishmania major 96% 100%
Q4Q4X2 Leishmania major 22% 100%
Q4Q6Y7 Leishmania major 24% 100%
Q4QE28 Leishmania major 29% 82%
Q4QE29 Leishmania major 31% 100%
Q5U2P1 Rattus norvegicus 35% 69%
Q69ZF7 Mus musculus 36% 79%
Q6P4Q7 Homo sapiens 36% 78%
Q8NE01 Homo sapiens 27% 86%
Q9GYL2 Caenorhabditis elegans 29% 80%
Q9H8M5 Homo sapiens 35% 69%
V5BKR5 Trypanosoma cruzi 73% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS