LeishMANIAdb
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RNA helicase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA helicase
Gene product:
ATP-dependent RNA and DNA helicase - mitochondrial - putative
Species:
Leishmania infantum
UniProt:
A4IA38_LEIIN
TriTrypDb:
LINF_340032200
Length:
687

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0000177 cytoplasmic exosome (RNase complex) 5 1
GO:0000178 exosome (RNase complex) 4 1
GO:0032991 protein-containing complex 1 1
GO:0045025 mitochondrial degradosome 3 1
GO:0098798 mitochondrial protein-containing complex 2 1
GO:1902494 catalytic complex 2 1
GO:1905354 exoribonuclease complex 3 1
GO:0005759 mitochondrial matrix 5 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1

Expansion

Sequence features

A4IA38
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA38

Function

Biological processes
Term Name Level Count
GO:0000959 mitochondrial RNA metabolic process 6 1
GO:0000963 mitochondrial RNA processing 6 1
GO:0000965 mitochondrial RNA 3'-end processing 7 1
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006401 RNA catabolic process 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010467 gene expression 4 1
GO:0016070 RNA metabolic process 5 1
GO:0019439 aromatic compound catabolic process 4 1
GO:0031123 RNA 3'-end processing 7 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034655 nucleobase-containing compound catabolic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0044270 cellular nitrogen compound catabolic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0046700 heterocycle catabolic process 4 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0140053 mitochondrial gene expression 5 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901361 organic cyclic compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003724 RNA helicase activity 3 13
GO:0003824 catalytic activity 1 13
GO:0004386 helicase activity 2 13
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0008186 ATP-dependent activity, acting on RNA 2 13
GO:0016787 hydrolase activity 2 13
GO:0016817 hydrolase activity, acting on acid anhydrides 3 13
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140098 catalytic activity, acting on RNA 3 13
GO:0140640 catalytic activity, acting on a nucleic acid 2 13
GO:0140657 ATP-dependent activity 1 13
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0016462 pyrophosphatase activity 5 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 320 324 PF00656 0.439
CLV_MEL_PAP_1 655 661 PF00089 0.262
CLV_NRD_NRD_1 117 119 PF00675 0.459
CLV_NRD_NRD_1 141 143 PF00675 0.339
CLV_NRD_NRD_1 274 276 PF00675 0.480
CLV_NRD_NRD_1 424 426 PF00675 0.443
CLV_NRD_NRD_1 5 7 PF00675 0.577
CLV_NRD_NRD_1 506 508 PF00675 0.487
CLV_PCSK_KEX2_1 140 142 PF00082 0.367
CLV_PCSK_KEX2_1 284 286 PF00082 0.463
CLV_PCSK_KEX2_1 4 6 PF00082 0.580
CLV_PCSK_PC1ET2_1 284 286 PF00082 0.470
CLV_PCSK_PC7_1 137 143 PF00082 0.408
CLV_PCSK_SKI1_1 142 146 PF00082 0.368
CLV_PCSK_SKI1_1 243 247 PF00082 0.321
CLV_PCSK_SKI1_1 316 320 PF00082 0.362
CLV_PCSK_SKI1_1 354 358 PF00082 0.493
CLV_PCSK_SKI1_1 399 403 PF00082 0.361
CLV_PCSK_SKI1_1 418 422 PF00082 0.329
CLV_PCSK_SKI1_1 545 549 PF00082 0.390
CLV_PCSK_SKI1_1 55 59 PF00082 0.533
CLV_PCSK_SKI1_1 565 569 PF00082 0.242
DEG_APCC_DBOX_1 274 282 PF00400 0.514
DEG_APCC_DBOX_1 321 329 PF00400 0.490
DOC_CYCLIN_RxL_1 542 552 PF00134 0.468
DOC_CYCLIN_RxL_1 665 675 PF00134 0.548
DOC_CYCLIN_yCln2_LP_2 16 22 PF00134 0.595
DOC_MAPK_gen_1 186 195 PF00069 0.505
DOC_MAPK_gen_1 284 291 PF00069 0.429
DOC_MAPK_gen_1 315 321 PF00069 0.509
DOC_MAPK_gen_1 507 516 PF00069 0.376
DOC_MAPK_MEF2A_6 284 291 PF00069 0.431
DOC_MAPK_MEF2A_6 507 516 PF00069 0.602
DOC_PP1_RVXF_1 563 569 PF00149 0.442
DOC_PP2B_LxvP_1 246 249 PF13499 0.325
DOC_SPAK_OSR1_1 600 604 PF12202 0.479
DOC_USP7_MATH_1 149 153 PF00917 0.372
DOC_USP7_MATH_1 176 180 PF00917 0.428
DOC_USP7_MATH_1 32 36 PF00917 0.612
DOC_USP7_MATH_1 362 366 PF00917 0.578
DOC_USP7_MATH_1 375 379 PF00917 0.663
DOC_USP7_MATH_1 387 391 PF00917 0.756
DOC_USP7_MATH_1 444 448 PF00917 0.484
DOC_USP7_MATH_1 474 478 PF00917 0.416
DOC_USP7_UBL2_3 119 123 PF12436 0.470
DOC_USP7_UBL2_3 426 430 PF12436 0.437
DOC_WW_Pin1_4 15 20 PF00397 0.634
DOC_WW_Pin1_4 212 217 PF00397 0.341
DOC_WW_Pin1_4 28 33 PF00397 0.451
DOC_WW_Pin1_4 289 294 PF00397 0.401
DOC_WW_Pin1_4 379 384 PF00397 0.724
DOC_WW_Pin1_4 388 393 PF00397 0.593
DOC_WW_Pin1_4 621 626 PF00397 0.672
LIG_14-3-3_CanoR_1 110 117 PF00244 0.419
LIG_14-3-3_CanoR_1 418 427 PF00244 0.371
LIG_14-3-3_CanoR_1 460 464 PF00244 0.356
LIG_14-3-3_CanoR_1 473 483 PF00244 0.418
LIG_14-3-3_CanoR_1 658 664 PF00244 0.437
LIG_Actin_WH2_2 536 551 PF00022 0.445
LIG_APCC_ABBA_1 495 500 PF00400 0.479
LIG_BIR_II_1 1 5 PF00653 0.483
LIG_BRCT_BRCA1_1 20 24 PF00533 0.679
LIG_BRCT_BRCA1_1 446 450 PF00533 0.489
LIG_BRCT_BRCA1_1 534 538 PF00533 0.405
LIG_BRCT_BRCA1_1 655 659 PF00533 0.510
LIG_BRCT_BRCA1_2 655 661 PF00533 0.533
LIG_deltaCOP1_diTrp_1 236 241 PF00928 0.348
LIG_deltaCOP1_diTrp_1 86 93 PF00928 0.510
LIG_eIF4E_1 133 139 PF01652 0.507
LIG_FHA_1 240 246 PF00498 0.323
LIG_FHA_1 355 361 PF00498 0.440
LIG_FHA_1 396 402 PF00498 0.428
LIG_FHA_1 403 409 PF00498 0.306
LIG_FHA_1 489 495 PF00498 0.369
LIG_FHA_1 511 517 PF00498 0.544
LIG_FHA_1 561 567 PF00498 0.513
LIG_FHA_1 615 621 PF00498 0.638
LIG_FHA_1 675 681 PF00498 0.493
LIG_FHA_1 89 95 PF00498 0.489
LIG_FHA_2 213 219 PF00498 0.363
LIG_FHA_2 231 237 PF00498 0.360
LIG_FHA_2 51 57 PF00498 0.476
LIG_FHA_2 638 644 PF00498 0.389
LIG_FHA_2 660 666 PF00498 0.522
LIG_LIR_Apic_2 167 173 PF02991 0.342
LIG_LIR_Gen_1 112 121 PF02991 0.513
LIG_LIR_Gen_1 179 190 PF02991 0.302
LIG_LIR_Gen_1 308 318 PF02991 0.446
LIG_LIR_Gen_1 520 530 PF02991 0.435
LIG_LIR_Gen_1 650 659 PF02991 0.436
LIG_LIR_Nem_3 112 117 PF02991 0.449
LIG_LIR_Nem_3 179 185 PF02991 0.416
LIG_LIR_Nem_3 308 313 PF02991 0.428
LIG_LIR_Nem_3 520 524 PF02991 0.410
LIG_LIR_Nem_3 650 655 PF02991 0.436
LIG_PCNA_yPIPBox_3 351 360 PF02747 0.498
LIG_PCNA_yPIPBox_3 413 426 PF02747 0.396
LIG_PCNA_yPIPBox_3 644 655 PF02747 0.501
LIG_Pex14_1 89 93 PF04695 0.492
LIG_Pex14_2 659 663 PF04695 0.442
LIG_PTB_Apo_2 264 271 PF02174 0.462
LIG_PTB_Phospho_1 264 270 PF10480 0.459
LIG_SH2_CRK 170 174 PF00017 0.321
LIG_SH2_GRB2like 359 362 PF00017 0.456
LIG_SH2_SRC 359 362 PF00017 0.456
LIG_SH2_STAT5 170 173 PF00017 0.312
LIG_SH2_STAT5 359 362 PF00017 0.512
LIG_SH2_STAT5 570 573 PF00017 0.453
LIG_SH2_STAT5 652 655 PF00017 0.447
LIG_SH3_3 214 220 PF00018 0.448
LIG_SH3_3 26 32 PF00018 0.526
LIG_SUMO_SIM_par_1 287 292 PF11976 0.405
LIG_SUMO_SIM_par_1 317 323 PF11976 0.500
LIG_SUMO_SIM_par_1 512 517 PF11976 0.581
LIG_UBA3_1 497 505 PF00899 0.517
LIG_WRC_WIRS_1 525 530 PF05994 0.453
MOD_CDK_SPxK_1 393 399 PF00069 0.573
MOD_CDK_SPxxK_3 289 296 PF00069 0.507
MOD_CDK_SPxxK_3 379 386 PF00069 0.545
MOD_CDK_SPxxK_3 621 628 PF00069 0.682
MOD_CK1_1 152 158 PF00069 0.375
MOD_CK1_1 18 24 PF00069 0.622
MOD_CK1_1 294 300 PF00069 0.490
MOD_CK1_1 31 37 PF00069 0.602
MOD_CK1_1 329 335 PF00069 0.504
MOD_CK1_1 378 384 PF00069 0.755
MOD_CK1_1 391 397 PF00069 0.629
MOD_CK1_1 503 509 PF00069 0.530
MOD_CK1_1 517 523 PF00069 0.493
MOD_CK1_1 574 580 PF00069 0.344
MOD_CK1_1 66 72 PF00069 0.516
MOD_CK1_1 98 104 PF00069 0.522
MOD_CK2_1 276 282 PF00069 0.470
MOD_CK2_1 387 393 PF00069 0.781
MOD_CK2_1 50 56 PF00069 0.413
MOD_CK2_1 517 523 PF00069 0.516
MOD_CK2_1 528 534 PF00069 0.498
MOD_CK2_1 637 643 PF00069 0.411
MOD_CK2_1 659 665 PF00069 0.442
MOD_CMANNOS 654 657 PF00535 0.294
MOD_GlcNHglycan 151 154 PF01048 0.363
MOD_GlcNHglycan 166 169 PF01048 0.336
MOD_GlcNHglycan 328 331 PF01048 0.456
MOD_GlcNHglycan 333 336 PF01048 0.412
MOD_GlcNHglycan 34 37 PF01048 0.574
MOD_GlcNHglycan 362 365 PF01048 0.531
MOD_GlcNHglycan 366 369 PF01048 0.582
MOD_GlcNHglycan 446 449 PF01048 0.497
MOD_GlcNHglycan 476 479 PF01048 0.517
MOD_GlcNHglycan 50 53 PF01048 0.298
MOD_GlcNHglycan 502 505 PF01048 0.500
MOD_GlcNHglycan 515 519 PF01048 0.545
MOD_GlcNHglycan 575 579 PF01048 0.442
MOD_GlcNHglycan 68 71 PF01048 0.363
MOD_GSK3_1 109 116 PF00069 0.458
MOD_GSK3_1 208 215 PF00069 0.325
MOD_GSK3_1 28 35 PF00069 0.656
MOD_GSK3_1 287 294 PF00069 0.417
MOD_GSK3_1 326 333 PF00069 0.318
MOD_GSK3_1 360 367 PF00069 0.588
MOD_GSK3_1 375 382 PF00069 0.504
MOD_GSK3_1 387 394 PF00069 0.759
MOD_GSK3_1 510 517 PF00069 0.511
MOD_GSK3_1 524 531 PF00069 0.379
MOD_GSK3_1 573 580 PF00069 0.421
MOD_GSK3_1 653 660 PF00069 0.229
MOD_GSK3_1 674 681 PF00069 0.353
MOD_GSK3_1 88 95 PF00069 0.498
MOD_N-GLC_1 276 281 PF02516 0.459
MOD_N-GLC_1 360 365 PF02516 0.536
MOD_N-GLC_1 558 563 PF02516 0.326
MOD_N-GLC_2 43 45 PF02516 0.442
MOD_NEK2_1 419 424 PF00069 0.406
MOD_NEK2_1 450 455 PF00069 0.452
MOD_NEK2_1 514 519 PF00069 0.518
MOD_NEK2_1 524 529 PF00069 0.377
MOD_NEK2_1 573 578 PF00069 0.345
MOD_NEK2_1 659 664 PF00069 0.294
MOD_NEK2_1 672 677 PF00069 0.294
MOD_NEK2_1 94 99 PF00069 0.512
MOD_PIKK_1 176 182 PF00454 0.404
MOD_PIKK_1 99 105 PF00454 0.521
MOD_PKA_2 109 115 PF00069 0.434
MOD_PKA_2 326 332 PF00069 0.512
MOD_PKA_2 387 393 PF00069 0.750
MOD_PKA_2 459 465 PF00069 0.361
MOD_PKA_2 657 663 PF00069 0.296
MOD_PKB_1 298 306 PF00069 0.466
MOD_Plk_1 276 282 PF00069 0.509
MOD_Plk_1 558 564 PF00069 0.382
MOD_Plk_2-3 637 643 PF00069 0.478
MOD_Plk_4 459 465 PF00069 0.459
MOD_Plk_4 517 523 PF00069 0.411
MOD_Plk_4 659 665 PF00069 0.321
MOD_ProDKin_1 15 21 PF00069 0.633
MOD_ProDKin_1 212 218 PF00069 0.352
MOD_ProDKin_1 28 34 PF00069 0.441
MOD_ProDKin_1 289 295 PF00069 0.397
MOD_ProDKin_1 379 385 PF00069 0.727
MOD_ProDKin_1 388 394 PF00069 0.587
MOD_ProDKin_1 621 627 PF00069 0.671
MOD_SUMO_rev_2 279 286 PF00179 0.494
MOD_SUMO_rev_2 665 675 PF00179 0.442
TRG_DiLeu_BaEn_1 282 287 PF01217 0.440
TRG_DiLeu_BaLyEn_6 260 265 PF01217 0.344
TRG_DiLeu_BaLyEn_6 69 74 PF01217 0.517
TRG_ENDOCYTIC_2 337 340 PF00928 0.378
TRG_ENDOCYTIC_2 570 573 PF00928 0.322
TRG_ENDOCYTIC_2 652 655 PF00928 0.287
TRG_ER_diArg_1 139 142 PF00400 0.375
TRG_ER_diArg_1 163 166 PF00400 0.477
TRG_ER_diArg_1 295 298 PF00400 0.495
TRG_ER_diArg_1 3 6 PF00400 0.575
TRG_NES_CRM1_1 552 564 PF08389 0.296
TRG_Pf-PMV_PEXEL_1 636 641 PF00026 0.378
TRG_Pf-PMV_PEXEL_1 72 76 PF00026 0.470

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL37 Leptomonas seymouri 68% 98%
A0A0S4JQD9 Bodo saltans 44% 100%
A0A0S4JTX4 Bodo saltans 44% 100%
A0A1X0PB30 Trypanosomatidae 54% 100%
A0A3R7MLZ5 Trypanosoma rangeli 51% 100%
A0A3S5H7X1 Leishmania donovani 99% 100%
A4HAX9 Leishmania braziliensis 83% 100%
A4IG62 Danio rerio 31% 90%
C9ZM61 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B553 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
F4KFV7 Arabidopsis thaliana 32% 89%
O74727 Saccharomyces paradoxus 31% 93%
P32580 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 93%
Q01IJ3 Oryza sativa subsp. indica 31% 94%
Q10D00 Oryza sativa subsp. japonica 32% 100%
Q17828 Caenorhabditis elegans 32% 96%
Q295E6 Drosophila pseudoobscura pseudoobscura 35% 90%
Q4Q2T3 Leishmania major 94% 100%
Q59TB2 Candida albicans (strain SC5314 / ATCC MYA-2876) 29% 95%
Q5EBA1 Rattus norvegicus 33% 89%
Q5ZJT0 Gallus gallus 32% 87%
Q61SU7 Caenorhabditis briggsae 32% 95%
Q7X745 Oryza sativa subsp. japonica 31% 94%
Q80YD1 Mus musculus 32% 88%
Q8IYB8 Homo sapiens 34% 87%
Q9SMX1 Arabidopsis thaliana 32% 100%
Q9VN03 Drosophila melanogaster 33% 90%
V5DLS8 Trypanosoma cruzi 52% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS