LeishMANIAdb
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RuvB-like helicase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RuvB-like helicase
Gene product:
ruvB-like DNA helicase - putative
Species:
Leishmania infantum
UniProt:
A4IA37_LEIIN
TriTrypDb:
LINF_340032100
Length:
483

Annotations

Annotations by Jardim et al.

Helicases, ATP-dependent DNA helicase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000123 histone acetyltransferase complex 4 12
GO:0031011 Ino80 complex 5 12
GO:0031248 protein acetyltransferase complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0035267 NuA4 histone acetyltransferase complex 7 12
GO:0043189 H4/H2A histone acetyltransferase complex 6 12
GO:0070603 SWI/SNF superfamily-type complex 3 12
GO:0097255 R2TP complex 2 12
GO:0097346 INO80-type complex 4 12
GO:0140513 nuclear protein-containing complex 2 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902493 acetyltransferase complex 4 12
GO:1902494 catalytic complex 2 12
GO:1902562 H4 histone acetyltransferase complex 5 12
GO:1904949 ATPase complex 3 12
GO:1990234 transferase complex 3 12
GO:0000118 histone deacetylase complex 3 1
GO:0000812 Swr1 complex 4 1
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IA37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA37

Function

Biological processes
Term Name Level Count
GO:0000491 small nucleolar ribonucleoprotein complex assembly 7 1
GO:0000492 box C/D snoRNP assembly 8 1
GO:0006325 chromatin organization 4 1
GO:0006338 chromatin remodeling 5 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0006473 protein acetylation 6 1
GO:0006475 internal protein amino acid acetylation 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0016043 cellular component organization 3 1
GO:0016570 histone modification 5 1
GO:0016573 histone acetylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018205 peptidyl-lysine modification 6 1
GO:0018393 internal peptidyl-lysine acetylation 8 1
GO:0018394 peptidyl-lysine acetylation 7 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0019538 protein metabolic process 3 1
GO:0022607 cellular component assembly 4 1
GO:0022618 ribonucleoprotein complex assembly 6 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0044238 primary metabolic process 2 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065003 protein-containing complex assembly 5 1
GO:0065007 biological regulation 1 1
GO:0071704 organic substance metabolic process 2 1
GO:0071826 ribonucleoprotein complex subunit organization 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003678 DNA helicase activity 3 12
GO:0003824 catalytic activity 1 12
GO:0004386 helicase activity 2 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0008094 ATP-dependent activity, acting on DNA 2 12
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 12
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0016887 ATP hydrolysis activity 7 11
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140097 catalytic activity, acting on DNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 35 41 PF00089 0.301
CLV_NRD_NRD_1 122 124 PF00675 0.215
CLV_NRD_NRD_1 235 237 PF00675 0.205
CLV_NRD_NRD_1 416 418 PF00675 0.228
CLV_NRD_NRD_1 438 440 PF00675 0.345
CLV_NRD_NRD_1 51 53 PF00675 0.226
CLV_PCSK_KEX2_1 122 124 PF00082 0.215
CLV_PCSK_KEX2_1 235 237 PF00082 0.215
CLV_PCSK_KEX2_1 416 418 PF00082 0.215
CLV_PCSK_KEX2_1 438 440 PF00082 0.354
CLV_PCSK_KEX2_1 51 53 PF00082 0.224
CLV_PCSK_PC1ET2_1 235 237 PF00082 0.215
CLV_PCSK_PC1ET2_1 416 418 PF00082 0.215
CLV_PCSK_SKI1_1 12 16 PF00082 0.574
CLV_PCSK_SKI1_1 401 405 PF00082 0.215
CLV_PCSK_SKI1_1 449 453 PF00082 0.439
CLV_PCSK_SKI1_1 69 73 PF00082 0.226
DEG_APCC_DBOX_1 400 408 PF00400 0.415
DEG_SCF_FBW7_2 226 232 PF00400 0.415
DOC_CKS1_1 226 231 PF01111 0.415
DOC_CKS1_1 94 99 PF01111 0.501
DOC_CYCLIN_RxL_1 23 34 PF00134 0.415
DOC_CYCLIN_yCln2_LP_2 317 323 PF00134 0.415
DOC_MAPK_DCC_7 289 298 PF00069 0.415
DOC_MAPK_gen_1 122 129 PF00069 0.415
DOC_MAPK_gen_1 416 424 PF00069 0.415
DOC_MAPK_gen_1 428 435 PF00069 0.415
DOC_MAPK_gen_1 51 58 PF00069 0.407
DOC_MAPK_MEF2A_6 122 129 PF00069 0.415
DOC_MAPK_MEF2A_6 289 298 PF00069 0.407
DOC_MAPK_MEF2A_6 342 351 PF00069 0.415
DOC_MAPK_MEF2A_6 428 437 PF00069 0.426
DOC_MAPK_MEF2A_6 51 60 PF00069 0.415
DOC_USP7_MATH_1 37 41 PF00917 0.455
DOC_WW_Pin1_4 225 230 PF00397 0.415
DOC_WW_Pin1_4 316 321 PF00397 0.415
DOC_WW_Pin1_4 93 98 PF00397 0.415
LIG_14-3-3_CanoR_1 38 45 PF00244 0.413
LIG_14-3-3_CanoR_1 417 423 PF00244 0.413
LIG_14-3-3_CanoR_1 438 442 PF00244 0.359
LIG_Actin_WH2_2 387 403 PF00022 0.417
LIG_Actin_WH2_2 423 440 PF00022 0.415
LIG_APCC_ABBAyCdc20_2 449 455 PF00400 0.441
LIG_BRCT_BRCA1_1 103 107 PF00533 0.415
LIG_BRCT_BRCA1_1 212 216 PF00533 0.475
LIG_Clathr_ClatBox_1 432 436 PF01394 0.520
LIG_FHA_1 112 118 PF00498 0.409
LIG_FHA_1 131 137 PF00498 0.412
LIG_FHA_1 157 163 PF00498 0.411
LIG_FHA_1 170 176 PF00498 0.415
LIG_FHA_1 198 204 PF00498 0.426
LIG_FHA_1 221 227 PF00498 0.415
LIG_FHA_1 240 246 PF00498 0.409
LIG_FHA_1 264 270 PF00498 0.415
LIG_FHA_1 419 425 PF00498 0.449
LIG_FHA_2 13 19 PF00498 0.535
LIG_FHA_2 242 248 PF00498 0.415
LIG_IBAR_NPY_1 361 363 PF08397 0.520
LIG_LIR_Apic_2 339 344 PF02991 0.415
LIG_LIR_Gen_1 213 221 PF02991 0.475
LIG_LIR_Gen_1 308 317 PF02991 0.415
LIG_LIR_Gen_1 385 394 PF02991 0.478
LIG_LIR_Gen_1 95 106 PF02991 0.415
LIG_LIR_Nem_3 308 313 PF02991 0.415
LIG_LIR_Nem_3 385 391 PF02991 0.478
LIG_LIR_Nem_3 95 101 PF02991 0.415
LIG_Pex14_2 258 262 PF04695 0.415
LIG_SH2_CRK 341 345 PF00017 0.415
LIG_SH2_STAT3 402 405 PF00017 0.415
LIG_SH2_STAT5 402 405 PF00017 0.415
LIG_SH2_STAT5 431 434 PF00017 0.475
LIG_SH3_3 223 229 PF00018 0.415
LIG_SH3_3 317 323 PF00018 0.407
LIG_SH3_3 91 97 PF00018 0.501
LIG_SUMO_SIM_anti_2 247 253 PF11976 0.415
LIG_SUMO_SIM_anti_2 440 446 PF11976 0.387
LIG_SUMO_SIM_par_1 139 144 PF11976 0.422
LIG_SUMO_SIM_par_1 192 197 PF11976 0.415
LIG_SUMO_SIM_par_1 241 247 PF11976 0.415
LIG_SUMO_SIM_par_1 303 308 PF11976 0.415
LIG_SUMO_SIM_par_1 323 329 PF11976 0.475
LIG_SUMO_SIM_par_1 347 353 PF11976 0.415
LIG_SUMO_SIM_par_1 419 426 PF11976 0.428
LIG_TRAF2_1 364 367 PF00917 0.501
LIG_UBA3_1 106 113 PF00899 0.415
LIG_UBA3_1 179 187 PF00899 0.415
LIG_UBA3_1 390 397 PF00899 0.415
MOD_CK1_1 220 226 PF00069 0.415
MOD_CK1_1 420 426 PF00069 0.432
MOD_CK1_1 79 85 PF00069 0.475
MOD_CK2_1 109 115 PF00069 0.415
MOD_CK2_1 12 18 PF00069 0.543
MOD_CK2_1 164 170 PF00069 0.415
MOD_CK2_1 241 247 PF00069 0.415
MOD_CK2_1 361 367 PF00069 0.415
MOD_GlcNHglycan 219 222 PF01048 0.262
MOD_GlcNHglycan 78 81 PF01048 0.275
MOD_GSK3_1 101 108 PF00069 0.415
MOD_GSK3_1 111 118 PF00069 0.415
MOD_GSK3_1 164 171 PF00069 0.428
MOD_GSK3_1 197 204 PF00069 0.433
MOD_GSK3_1 206 213 PF00069 0.398
MOD_GSK3_1 357 364 PF00069 0.414
MOD_GSK3_1 416 423 PF00069 0.495
MOD_LATS_1 128 134 PF00433 0.520
MOD_N-GLC_1 461 466 PF02516 0.640
MOD_NEK2_1 109 114 PF00069 0.415
MOD_NEK2_1 121 126 PF00069 0.415
MOD_NEK2_1 179 184 PF00069 0.415
MOD_NEK2_1 206 211 PF00069 0.415
MOD_NEK2_1 356 361 PF00069 0.520
MOD_NEK2_1 390 395 PF00069 0.423
MOD_NEK2_1 406 411 PF00069 0.357
MOD_PIKK_1 115 121 PF00454 0.415
MOD_PIKK_1 336 342 PF00454 0.439
MOD_PIKK_1 361 367 PF00454 0.505
MOD_PIKK_1 38 44 PF00454 0.415
MOD_PKA_1 416 422 PF00069 0.428
MOD_PKA_2 121 127 PF00069 0.415
MOD_PKA_2 146 152 PF00069 0.415
MOD_PKA_2 201 207 PF00069 0.486
MOD_PKA_2 336 342 PF00069 0.415
MOD_PKA_2 37 43 PF00069 0.424
MOD_PKA_2 416 422 PF00069 0.425
MOD_PKA_2 437 443 PF00069 0.358
MOD_Plk_1 12 18 PF00069 0.574
MOD_Plk_1 141 147 PF00069 0.418
MOD_Plk_1 169 175 PF00069 0.415
MOD_Plk_1 31 37 PF00069 0.415
MOD_Plk_1 461 467 PF00069 0.631
MOD_Plk_2-3 105 111 PF00069 0.415
MOD_Plk_2-3 192 198 PF00069 0.426
MOD_ProDKin_1 225 231 PF00069 0.415
MOD_ProDKin_1 316 322 PF00069 0.415
MOD_ProDKin_1 93 99 PF00069 0.415
MOD_SUMO_for_1 129 132 PF00179 0.415
MOD_SUMO_for_1 269 272 PF00179 0.415
MOD_SUMO_rev_2 265 271 PF00179 0.501
MOD_SUMO_rev_2 420 430 PF00179 0.415
TRG_DiLeu_BaEn_3 366 372 PF01217 0.464
TRG_DiLeu_BaEn_4 378 384 PF01217 0.501
TRG_ENDOCYTIC_2 431 434 PF00928 0.413
TRG_ER_diArg_1 121 123 PF00400 0.415
TRG_ER_diArg_1 437 439 PF00400 0.361
TRG_ER_diArg_1 465 468 PF00400 0.637
TRG_NES_CRM1_1 134 146 PF08389 0.520
TRG_NES_CRM1_1 425 436 PF08389 0.416
TRG_NLS_Bipartite_1 51 66 PF00514 0.520
TRG_Pf-PMV_PEXEL_1 27 32 PF00026 0.215

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I796 Leptomonas seymouri 94% 100%
A0A0N1IKW9 Leptomonas seymouri 44% 100%
A0A0S4JTM7 Bodo saltans 84% 100%
A0A0S4KMK6 Bodo saltans 44% 100%
A0A1X0P9Z8 Trypanosomatidae 45% 100%
A0A1X0PAP4 Trypanosomatidae 87% 100%
A0A3Q8IEM3 Leishmania donovani 43% 100%
A0A3Q8IFN2 Leishmania donovani 100% 100%
A0A422NEN7 Trypanosoma rangeli 44% 100%
A0A422NS36 Trypanosoma rangeli 86% 100%
A4HAX8 Leishmania braziliensis 97% 100%
A4HB68 Leishmania braziliensis 43% 100%
A4IAB6 Leishmania infantum 43% 100%
C9ZLY0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZM62 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 85% 100%
E9B552 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B5D9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
O17607 Caenorhabditis elegans 43% 100%
O94692 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 64% 100%
P0CR26 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 44% 100%
P0CR27 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 44% 100%
P0CR28 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 65% 100%
P0CR29 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 65% 100%
P60122 Mus musculus 43% 100%
P60123 Rattus norvegicus 43% 100%
P83571 Danio rerio 69% 100%
Q03940 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 45% 100%
Q0IFL2 Aedes aegypti 43% 100%
Q12464 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 63% 100%
Q16TA2 Aedes aegypti 67% 100%
Q29AK9 Drosophila pseudoobscura pseudoobscura 44% 100%
Q29DI0 Drosophila pseudoobscura pseudoobscura 69% 100%
Q2TBU9 Bos taurus 70% 100%
Q4I948 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 60% 100%
Q4ICA8 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 44% 100%
Q4P112 Ustilago maydis (strain 521 / FGSC 9021) 43% 99%
Q4P6N7 Ustilago maydis (strain 521 / FGSC 9021) 64% 100%
Q4Q2J4 Leishmania major 43% 100%
Q4Q2T4 Leishmania major 99% 100%
Q4WKH9 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 62% 100%
Q4WPW8 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 44% 100%
Q54UW5 Dictyostelium discoideum 63% 100%
Q5A0W7 Candida albicans (strain SC5314 / ATCC MYA-2876) 45% 100%
Q5AGZ9 Candida albicans (strain SC5314 / ATCC MYA-2876) 61% 97%
Q5BBV9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 44% 100%
Q5BGK3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 61% 100%
Q6BI60 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 45% 100%
Q6BSB8 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 61% 100%
Q6C3X6 Yarrowia lipolytica (strain CLIB 122 / E 150) 63% 100%
Q6CB52 Yarrowia lipolytica (strain CLIB 122 / E 150) 45% 100%
Q6CQA9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 45% 100%
Q6CT29 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 63% 100%
Q6FSF1 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 62% 100%
Q6FU78 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 44% 100%
Q750R1 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 44% 100%
Q755G5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 62% 100%
Q873C7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 61% 100%
Q8AWW7 Danio rerio 43% 100%
Q8STP2 Encephalitozoon cuniculi (strain GB-M1) 41% 100%
Q8SU27 Encephalitozoon cuniculi (strain GB-M1) 45% 100%
Q8WZS3 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 43% 100%
Q9C0X6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 100%
Q9DE26 Xenopus laevis 44% 100%
Q9DE27 Xenopus laevis 69% 100%
Q9FMR9 Arabidopsis thaliana 43% 100%
Q9GZH2 Caenorhabditis elegans 54% 100%
Q9V3K3 Drosophila melanogaster 68% 100%
Q9VH07 Drosophila melanogaster 44% 100%
Q9WTM5 Mus musculus 70% 100%
Q9Y230 Homo sapiens 70% 100%
Q9Y265 Homo sapiens 43% 100%
V5B579 Trypanosoma cruzi 86% 100%
V5BQJ1 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS