LeishMANIAdb
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Putative acyl-CoA binding protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative acyl-CoA binding protein
Gene product:
acyl-CoA binding protein - putative
Species:
Leishmania infantum
UniProt:
A4IA36_LEIIN
TriTrypDb:
LINF_340032000
Length:
89

Annotations

Annotations by Jardim et al.

Fatty acid metabolism, acyl-CoA binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IA36
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA36

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006631 fatty acid metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0019752 carboxylic acid metabolic process 5 1
GO:0032787 monocarboxylic acid metabolic process 6 1
GO:0043436 oxoacid metabolic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044281 small molecule metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0000062 fatty-acyl-CoA binding 4 9
GO:0000166 nucleotide binding 3 9
GO:0005488 binding 1 9
GO:0008289 lipid binding 2 9
GO:0017076 purine nucleotide binding 4 9
GO:0030554 adenyl nucleotide binding 5 9
GO:0032553 ribonucleotide binding 3 9
GO:0032555 purine ribonucleotide binding 4 9
GO:0032559 adenyl ribonucleotide binding 5 9
GO:0033218 amide binding 2 9
GO:0036094 small molecule binding 2 9
GO:0097159 organic cyclic compound binding 2 9
GO:0097367 carbohydrate derivative binding 2 9
GO:0120227 acyl-CoA binding 3 9
GO:1901265 nucleoside phosphate binding 3 9
GO:1901363 heterocyclic compound binding 2 9
GO:1901567 fatty acid derivative binding 3 9
GO:1901681 sulfur compound binding 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 71 75 PF00082 0.428
DOC_CYCLIN_RxL_1 68 76 PF00134 0.417
DOC_PP2B_LxvP_1 20 23 PF13499 0.403
DOC_USP7_UBL2_3 39 43 PF12436 0.468
LIG_14-3-3_CanoR_1 37 43 PF00244 0.403
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_FHA_1 8 14 PF00498 0.382
LIG_GBD_Chelix_1 12 20 PF00786 0.400
LIG_LIR_Gen_1 7 16 PF02991 0.281
LIG_LIR_Nem_3 4 9 PF02991 0.316
LIG_PDZ_Class_1 84 89 PF00595 0.459
LIG_SH2_CRK 9 13 PF00017 0.360
LIG_SH2_STAP1 9 13 PF00017 0.396
LIG_SH2_STAT5 9 12 PF00017 0.375
LIG_TRAF2_1 2 5 PF00917 0.483
MOD_CK1_1 18 24 PF00069 0.336
MOD_CMANNOS 56 59 PF00535 0.403
MOD_GlcNHglycan 1 4 PF01048 0.564
MOD_GSK3_1 7 14 PF00069 0.414
MOD_N-GLC_1 18 23 PF02516 0.386
MOD_NEK2_2 38 43 PF00069 0.418
MOD_PKA_2 7 13 PF00069 0.365
MOD_Plk_1 18 24 PF00069 0.408
TRG_ENDOCYTIC_2 62 65 PF00928 0.322
TRG_ENDOCYTIC_2 9 12 PF00928 0.327
TRG_Pf-PMV_PEXEL_1 71 76 PF00026 0.457
TRG_PTS1 86 89 PF00515 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P610 Leptomonas seymouri 70% 100%
A0A0S4JQG1 Bodo saltans 34% 99%
A0A3Q8II94 Leishmania donovani 100% 100%
A4HAX7 Leishmania braziliensis 76% 100%
C9ZM63 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 96%
E9B551 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
P0C8L7 Hypsibius exemplaris 35% 100%
Q4Q2T5 Leishmania major 93% 100%
V5DM18 Trypanosoma cruzi 39% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS