LeishMANIAdb
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TPR_MLP1_2 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_MLP1_2 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA33_LEIIN
TriTrypDb:
LINF_340031700
Length:
557

Annotations

Annotations by Jardim et al.

Flagella, Flagellum attachment zone 8

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005856 cytoskeleton 5 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4IA33
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA33

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 137 141 PF00656 0.458
CLV_NRD_NRD_1 206 208 PF00675 0.573
CLV_NRD_NRD_1 220 222 PF00675 0.527
CLV_NRD_NRD_1 379 381 PF00675 0.549
CLV_PCSK_KEX2_1 379 381 PF00082 0.519
CLV_PCSK_SKI1_1 222 226 PF00082 0.473
CLV_PCSK_SKI1_1 257 261 PF00082 0.610
CLV_PCSK_SKI1_1 379 383 PF00082 0.636
CLV_PCSK_SKI1_1 443 447 PF00082 0.472
CLV_PCSK_SKI1_1 529 533 PF00082 0.477
CLV_PCSK_SKI1_1 553 557 PF00082 0.529
DEG_APCC_DBOX_1 528 536 PF00400 0.557
DEG_APCC_KENBOX_2 396 400 PF00400 0.598
DOC_CYCLIN_RxL_1 525 534 PF00134 0.547
DOC_MAPK_gen_1 145 153 PF00069 0.570
DOC_MAPK_gen_1 207 216 PF00069 0.627
DOC_MAPK_MEF2A_6 495 504 PF00069 0.456
DOC_MAPK_MEF2A_6 92 100 PF00069 0.390
DOC_PP1_RVXF_1 467 473 PF00149 0.490
DOC_PP2B_LxvP_1 79 82 PF13499 0.502
DOC_USP7_MATH_1 235 239 PF00917 0.445
DOC_USP7_MATH_1 292 296 PF00917 0.752
DOC_USP7_MATH_1 38 42 PF00917 0.589
DOC_USP7_MATH_1 437 441 PF00917 0.576
DOC_USP7_MATH_1 488 492 PF00917 0.474
DOC_USP7_MATH_1 493 497 PF00917 0.426
DOC_USP7_UBL2_3 25 29 PF12436 0.553
DOC_WW_Pin1_4 288 293 PF00397 0.719
LIG_14-3-3_CanoR_1 404 414 PF00244 0.550
LIG_14-3-3_CanoR_1 457 461 PF00244 0.516
LIG_BIR_II_1 1 5 PF00653 0.613
LIG_BRCT_BRCA1_1 15 19 PF00533 0.645
LIG_BRCT_BRCA1_1 43 47 PF00533 0.346
LIG_BRCT_BRCA1_2 43 49 PF00533 0.341
LIG_CaM_IQ_9 247 262 PF13499 0.498
LIG_FHA_1 31 37 PF00498 0.696
LIG_FHA_1 360 366 PF00498 0.545
LIG_FHA_1 405 411 PF00498 0.567
LIG_FHA_1 97 103 PF00498 0.372
LIG_FHA_2 101 107 PF00498 0.551
LIG_FHA_2 406 412 PF00498 0.422
LIG_FHA_2 431 437 PF00498 0.589
LIG_Integrin_RGD_1 164 166 PF01839 0.602
LIG_LIR_Gen_1 302 312 PF02991 0.488
LIG_LIR_Gen_1 5 12 PF02991 0.653
LIG_LIR_Gen_1 65 75 PF02991 0.393
LIG_LIR_Gen_1 95 102 PF02991 0.367
LIG_LIR_Nem_3 124 129 PF02991 0.538
LIG_LIR_Nem_3 302 308 PF02991 0.495
LIG_LIR_Nem_3 425 431 PF02991 0.462
LIG_LIR_Nem_3 5 11 PF02991 0.638
LIG_LIR_Nem_3 54 59 PF02991 0.410
LIG_LIR_Nem_3 65 71 PF02991 0.373
LIG_LIR_Nem_3 95 100 PF02991 0.365
LIG_NRBOX 335 341 PF00104 0.601
LIG_PCNA_PIPBox_1 90 99 PF02747 0.516
LIG_PCNA_yPIPBox_3 260 274 PF02747 0.595
LIG_PDZ_Class_2 552 557 PF00595 0.453
LIG_Pex14_2 122 126 PF04695 0.530
LIG_Pex14_2 43 47 PF04695 0.346
LIG_SH2_GRB2like 354 357 PF00017 0.452
LIG_SH2_STAP1 354 358 PF00017 0.469
LIG_SH2_STAP1 406 410 PF00017 0.436
LIG_SH2_STAP1 73 77 PF00017 0.380
LIG_SH2_STAT5 273 276 PF00017 0.591
LIG_SH2_STAT5 406 409 PF00017 0.557
LIG_SH2_STAT5 431 434 PF00017 0.578
LIG_SH2_STAT5 97 100 PF00017 0.361
LIG_SUMO_SIM_anti_2 7 13 PF11976 0.647
LIG_SUMO_SIM_par_1 2 7 PF11976 0.413
LIG_SUMO_SIM_par_1 295 300 PF11976 0.633
LIG_SUMO_SIM_par_1 413 419 PF11976 0.502
LIG_TRAF2_1 109 112 PF00917 0.590
LIG_TRAF2_1 180 183 PF00917 0.583
LIG_UBA3_1 196 202 PF00899 0.567
LIG_UBA3_1 245 254 PF00899 0.516
LIG_UBA3_1 274 279 PF00899 0.604
LIG_WRC_WIRS_1 40 45 PF05994 0.390
LIG_WRC_WIRS_1 68 73 PF05994 0.459
LIG_WRC_WIRS_1 97 102 PF05994 0.364
MOD_CDK_SPK_2 288 293 PF00069 0.748
MOD_CK1_1 41 47 PF00069 0.490
MOD_CK1_1 453 459 PF00069 0.542
MOD_CK1_1 62 68 PF00069 0.441
MOD_CK1_1 7 13 PF00069 0.649
MOD_CK2_1 100 106 PF00069 0.537
MOD_CK2_1 405 411 PF00069 0.552
MOD_CK2_1 430 436 PF00069 0.473
MOD_CK2_1 488 494 PF00069 0.619
MOD_GlcNHglycan 15 18 PF01048 0.713
MOD_GlcNHglycan 236 240 PF01048 0.551
MOD_GlcNHglycan 288 291 PF01048 0.699
MOD_GlcNHglycan 496 499 PF01048 0.510
MOD_GSK3_1 277 284 PF00069 0.548
MOD_GSK3_1 288 295 PF00069 0.664
MOD_GSK3_1 364 371 PF00069 0.548
MOD_GSK3_1 38 45 PF00069 0.517
MOD_GSK3_1 456 463 PF00069 0.604
MOD_GSK3_1 92 99 PF00069 0.397
MOD_N-GLC_1 286 291 PF02516 0.746
MOD_N-GLC_1 398 403 PF02516 0.492
MOD_NEK2_1 39 44 PF00069 0.512
MOD_NEK2_1 4 9 PF00069 0.644
MOD_NEK2_1 413 418 PF00069 0.555
MOD_NEK2_1 460 465 PF00069 0.573
MOD_NEK2_1 506 511 PF00069 0.421
MOD_NEK2_1 531 536 PF00069 0.448
MOD_NEK2_1 59 64 PF00069 0.338
MOD_NEK2_1 67 72 PF00069 0.367
MOD_NEK2_1 96 101 PF00069 0.363
MOD_PIKK_1 106 112 PF00454 0.592
MOD_PIKK_1 277 283 PF00454 0.615
MOD_PIKK_1 319 325 PF00454 0.487
MOD_PIKK_1 359 365 PF00454 0.584
MOD_PK_1 461 467 PF00069 0.587
MOD_PKA_2 292 298 PF00069 0.738
MOD_PKA_2 334 340 PF00069 0.477
MOD_PKA_2 368 374 PF00069 0.500
MOD_PKA_2 45 51 PF00069 0.420
MOD_PKA_2 456 462 PF00069 0.514
MOD_Plk_1 192 198 PF00069 0.613
MOD_Plk_1 398 404 PF00069 0.470
MOD_Plk_1 4 10 PF00069 0.589
MOD_Plk_1 73 79 PF00069 0.466
MOD_Plk_2-3 350 356 PF00069 0.580
MOD_Plk_4 192 198 PF00069 0.554
MOD_Plk_4 292 298 PF00069 0.738
MOD_Plk_4 398 404 PF00069 0.470
MOD_Plk_4 4 10 PF00069 0.609
MOD_Plk_4 62 68 PF00069 0.428
MOD_Plk_4 92 98 PF00069 0.407
MOD_ProDKin_1 288 294 PF00069 0.720
MOD_SUMO_for_1 228 231 PF00179 0.509
MOD_SUMO_rev_2 163 171 PF00179 0.597
MOD_SUMO_rev_2 218 224 PF00179 0.470
MOD_SUMO_rev_2 367 374 PF00179 0.534
MOD_SUMO_rev_2 448 456 PF00179 0.599
MOD_SUMO_rev_2 52 59 PF00179 0.433
TRG_DiLeu_BaEn_1 220 225 PF01217 0.591
TRG_DiLeu_BaEn_1 304 309 PF01217 0.488
TRG_DiLeu_BaEn_1 442 447 PF01217 0.478
TRG_ENDOCYTIC_2 68 71 PF00928 0.384
TRG_ENDOCYTIC_2 97 100 PF00928 0.361
TRG_Pf-PMV_PEXEL_1 222 226 PF00026 0.553
TRG_Pf-PMV_PEXEL_1 536 540 PF00026 0.569
TRG_Pf-PMV_PEXEL_1 547 551 PF00026 0.591

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P612 Leptomonas seymouri 70% 98%
A0A1X0P9R7 Trypanosomatidae 47% 96%
A0A3S7X860 Leishmania donovani 100% 100%
A0A422N8F5 Trypanosoma rangeli 48% 96%
A4HAX4 Leishmania braziliensis 84% 100%
C9ZMJ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 95%
E9B548 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4Q2T8 Leishmania major 97% 100%
V5BUY7 Trypanosoma cruzi 47% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS