This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.
Phosphatase, phosphatase 2C-like
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
Related structures:
AlphaFold database: A4IA26
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | 5 | 11 |
| GO:0006793 | phosphorus metabolic process | 3 | 11 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 11 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 11 |
| GO:0008152 | metabolic process | 1 | 11 |
| GO:0009987 | cellular process | 1 | 11 |
| GO:0016311 | dephosphorylation | 5 | 11 |
| GO:0019538 | protein metabolic process | 3 | 11 |
| GO:0036211 | protein modification process | 4 | 11 |
| GO:0043170 | macromolecule metabolic process | 3 | 11 |
| GO:0043412 | macromolecule modification | 4 | 11 |
| GO:0044237 | cellular metabolic process | 2 | 11 |
| GO:0044238 | primary metabolic process | 2 | 11 |
| GO:0071704 | organic substance metabolic process | 2 | 11 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 11 |
| GO:0004721 | phosphoprotein phosphatase activity | 3 | 11 |
| GO:0004722 | protein serine/threonine phosphatase activity | 4 | 11 |
| GO:0005488 | binding | 1 | 11 |
| GO:0016787 | hydrolase activity | 2 | 11 |
| GO:0016788 | hydrolase activity, acting on ester bonds | 3 | 11 |
| GO:0016791 | phosphatase activity | 5 | 11 |
| GO:0017018 | myosin phosphatase activity | 5 | 10 |
| GO:0042578 | phosphoric ester hydrolase activity | 4 | 11 |
| GO:0043167 | ion binding | 2 | 11 |
| GO:0043169 | cation binding | 3 | 11 |
| GO:0046872 | metal ion binding | 4 | 11 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 11 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 12 | 14 | PF00675 | 0.637 |
| CLV_NRD_NRD_1 | 153 | 155 | PF00675 | 0.505 |
| CLV_NRD_NRD_1 | 171 | 173 | PF00675 | 0.274 |
| CLV_NRD_NRD_1 | 424 | 426 | PF00675 | 0.441 |
| CLV_PCSK_KEX2_1 | 424 | 426 | PF00082 | 0.441 |
| CLV_PCSK_SKI1_1 | 155 | 159 | PF00082 | 0.405 |
| CLV_PCSK_SKI1_1 | 235 | 239 | PF00082 | 0.496 |
| CLV_PCSK_SKI1_1 | 335 | 339 | PF00082 | 0.277 |
| CLV_PCSK_SKI1_1 | 39 | 43 | PF00082 | 0.597 |
| DEG_APCC_DBOX_1 | 204 | 212 | PF00400 | 0.496 |
| DEG_COP1_1 | 430 | 438 | PF00400 | 0.529 |
| DEG_SPOP_SBC_1 | 439 | 443 | PF00917 | 0.500 |
| DOC_MAPK_DCC_7 | 43 | 53 | PF00069 | 0.575 |
| DOC_MAPK_gen_1 | 154 | 161 | PF00069 | 0.411 |
| DOC_MAPK_gen_1 | 45 | 53 | PF00069 | 0.591 |
| DOC_MAPK_JIP1_4 | 279 | 285 | PF00069 | 0.294 |
| DOC_MAPK_MEF2A_6 | 45 | 53 | PF00069 | 0.568 |
| DOC_PP1_SILK_1 | 39 | 44 | PF00149 | 0.596 |
| DOC_PP4_FxxP_1 | 71 | 74 | PF00568 | 0.608 |
| DOC_USP7_MATH_1 | 134 | 138 | PF00917 | 0.779 |
| DOC_USP7_MATH_1 | 319 | 323 | PF00917 | 0.274 |
| DOC_USP7_MATH_1 | 32 | 36 | PF00917 | 0.609 |
| DOC_USP7_MATH_1 | 351 | 355 | PF00917 | 0.496 |
| DOC_USP7_MATH_1 | 438 | 442 | PF00917 | 0.509 |
| DOC_USP7_MATH_2 | 2 | 8 | PF00917 | 0.577 |
| DOC_WW_Pin1_4 | 14 | 19 | PF00397 | 0.591 |
| DOC_WW_Pin1_4 | 20 | 25 | PF00397 | 0.567 |
| DOC_WW_Pin1_4 | 70 | 75 | PF00397 | 0.733 |
| DOC_WW_Pin1_4 | 76 | 81 | PF00397 | 0.590 |
| LIG_14-3-3_CanoR_1 | 138 | 147 | PF00244 | 0.564 |
| LIG_14-3-3_CanoR_1 | 149 | 154 | PF00244 | 0.528 |
| LIG_14-3-3_CanoR_1 | 172 | 176 | PF00244 | 0.484 |
| LIG_14-3-3_CanoR_1 | 298 | 303 | PF00244 | 0.321 |
| LIG_14-3-3_CanoR_1 | 357 | 365 | PF00244 | 0.321 |
| LIG_FHA_1 | 154 | 160 | PF00498 | 0.567 |
| LIG_FHA_1 | 324 | 330 | PF00498 | 0.274 |
| LIG_FHA_1 | 410 | 416 | PF00498 | 0.274 |
| LIG_FHA_1 | 442 | 448 | PF00498 | 0.529 |
| LIG_FHA_1 | 48 | 54 | PF00498 | 0.590 |
| LIG_FHA_2 | 172 | 178 | PF00498 | 0.310 |
| LIG_FHA_2 | 218 | 224 | PF00498 | 0.321 |
| LIG_FHA_2 | 357 | 363 | PF00498 | 0.274 |
| LIG_FHA_2 | 375 | 381 | PF00498 | 0.274 |
| LIG_FHA_2 | 421 | 427 | PF00498 | 0.406 |
| LIG_FHA_2 | 98 | 104 | PF00498 | 0.537 |
| LIG_GBD_Chelix_1 | 254 | 262 | PF00786 | 0.274 |
| LIG_LIR_Gen_1 | 156 | 165 | PF02991 | 0.403 |
| LIG_LIR_Gen_1 | 361 | 372 | PF02991 | 0.337 |
| LIG_LIR_Gen_1 | 377 | 384 | PF02991 | 0.337 |
| LIG_LIR_LC3C_4 | 259 | 264 | PF02991 | 0.321 |
| LIG_LIR_Nem_3 | 156 | 161 | PF02991 | 0.417 |
| LIG_LIR_Nem_3 | 361 | 367 | PF02991 | 0.337 |
| LIG_LIR_Nem_3 | 377 | 381 | PF02991 | 0.337 |
| LIG_SH2_SRC | 378 | 381 | PF00017 | 0.496 |
| LIG_SH2_STAP1 | 378 | 382 | PF00017 | 0.496 |
| LIG_SH2_STAT5 | 203 | 206 | PF00017 | 0.337 |
| LIG_SH2_STAT5 | 339 | 342 | PF00017 | 0.337 |
| LIG_SH3_2 | 83 | 88 | PF14604 | 0.555 |
| LIG_SH3_3 | 12 | 18 | PF00018 | 0.592 |
| LIG_SH3_3 | 122 | 128 | PF00018 | 0.574 |
| LIG_SH3_3 | 308 | 314 | PF00018 | 0.337 |
| LIG_SH3_3 | 46 | 52 | PF00018 | 0.647 |
| LIG_SH3_3 | 77 | 83 | PF00018 | 0.649 |
| LIG_SH3_3 | 90 | 96 | PF00018 | 0.537 |
| LIG_SUMO_SIM_par_1 | 279 | 284 | PF11976 | 0.337 |
| LIG_SUMO_SIM_par_1 | 345 | 354 | PF11976 | 0.337 |
| LIG_TRAF2_1 | 293 | 296 | PF00917 | 0.274 |
| MOD_CDC14_SPxK_1 | 79 | 82 | PF00782 | 0.655 |
| MOD_CDK_SPK_2 | 17 | 22 | PF00069 | 0.596 |
| MOD_CDK_SPxK_1 | 76 | 82 | PF00069 | 0.606 |
| MOD_CK1_1 | 129 | 135 | PF00069 | 0.581 |
| MOD_CK1_1 | 17 | 23 | PF00069 | 0.573 |
| MOD_CK1_1 | 291 | 297 | PF00069 | 0.271 |
| MOD_CK1_1 | 441 | 447 | PF00069 | 0.521 |
| MOD_CK1_1 | 56 | 62 | PF00069 | 0.615 |
| MOD_CK1_1 | 7 | 13 | PF00069 | 0.609 |
| MOD_CK1_1 | 78 | 84 | PF00069 | 0.678 |
| MOD_CK2_1 | 217 | 223 | PF00069 | 0.321 |
| MOD_CK2_1 | 238 | 244 | PF00069 | 0.274 |
| MOD_CK2_1 | 291 | 297 | PF00069 | 0.274 |
| MOD_CK2_1 | 374 | 380 | PF00069 | 0.337 |
| MOD_CK2_1 | 420 | 426 | PF00069 | 0.387 |
| MOD_CK2_1 | 427 | 433 | PF00069 | 0.517 |
| MOD_CK2_1 | 97 | 103 | PF00069 | 0.605 |
| MOD_GlcNHglycan | 103 | 108 | PF01048 | 0.677 |
| MOD_GlcNHglycan | 109 | 112 | PF01048 | 0.628 |
| MOD_GlcNHglycan | 132 | 135 | PF01048 | 0.549 |
| MOD_GlcNHglycan | 247 | 250 | PF01048 | 0.335 |
| MOD_GlcNHglycan | 25 | 28 | PF01048 | 0.635 |
| MOD_GlcNHglycan | 34 | 37 | PF01048 | 0.561 |
| MOD_GlcNHglycan | 344 | 347 | PF01048 | 0.337 |
| MOD_GSK3_1 | 103 | 110 | PF00069 | 0.692 |
| MOD_GSK3_1 | 126 | 133 | PF00069 | 0.573 |
| MOD_GSK3_1 | 134 | 141 | PF00069 | 0.637 |
| MOD_GSK3_1 | 149 | 156 | PF00069 | 0.544 |
| MOD_GSK3_1 | 23 | 30 | PF00069 | 0.619 |
| MOD_GSK3_1 | 238 | 245 | PF00069 | 0.335 |
| MOD_GSK3_1 | 319 | 326 | PF00069 | 0.337 |
| MOD_GSK3_1 | 405 | 412 | PF00069 | 0.287 |
| MOD_GSK3_1 | 441 | 448 | PF00069 | 0.526 |
| MOD_GSK3_1 | 53 | 60 | PF00069 | 0.610 |
| MOD_N-GLC_1 | 129 | 134 | PF02516 | 0.659 |
| MOD_N-GLC_1 | 139 | 144 | PF02516 | 0.517 |
| MOD_N-GLC_1 | 245 | 250 | PF02516 | 0.289 |
| MOD_N-GLC_1 | 413 | 418 | PF02516 | 0.388 |
| MOD_N-GLC_1 | 445 | 450 | PF02516 | 0.562 |
| MOD_N-GLC_1 | 53 | 58 | PF02516 | 0.632 |
| MOD_NEK2_1 | 153 | 158 | PF00069 | 0.622 |
| MOD_NEK2_1 | 323 | 328 | PF00069 | 0.337 |
| MOD_PIKK_1 | 195 | 201 | PF00454 | 0.274 |
| MOD_PIKK_1 | 383 | 389 | PF00454 | 0.277 |
| MOD_PK_1 | 298 | 304 | PF00069 | 0.321 |
| MOD_PK_1 | 37 | 43 | PF00069 | 0.642 |
| MOD_PKA_1 | 37 | 43 | PF00069 | 0.642 |
| MOD_PKA_2 | 148 | 154 | PF00069 | 0.563 |
| MOD_PKA_2 | 171 | 177 | PF00069 | 0.480 |
| MOD_PKA_2 | 356 | 362 | PF00069 | 0.482 |
| MOD_Plk_1 | 139 | 145 | PF00069 | 0.567 |
| MOD_Plk_1 | 351 | 357 | PF00069 | 0.274 |
| MOD_Plk_1 | 413 | 419 | PF00069 | 0.389 |
| MOD_Plk_2-3 | 374 | 380 | PF00069 | 0.337 |
| MOD_Plk_4 | 177 | 183 | PF00069 | 0.323 |
| MOD_Plk_4 | 37 | 43 | PF00069 | 0.701 |
| MOD_ProDKin_1 | 14 | 20 | PF00069 | 0.590 |
| MOD_ProDKin_1 | 70 | 76 | PF00069 | 0.736 |
| TRG_DiLeu_BaEn_1 | 361 | 366 | PF01217 | 0.376 |
| TRG_ENDOCYTIC_2 | 378 | 381 | PF00928 | 0.274 |
| TRG_NES_CRM1_1 | 202 | 217 | PF08389 | 0.274 |
| TRG_Pf-PMV_PEXEL_1 | 327 | 331 | PF00026 | 0.274 |
| TRG_Pf-PMV_PEXEL_1 | 445 | 449 | PF00026 | 0.558 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1I8W9 | Leptomonas seymouri | 74% | 100% |
| A0A0S4ILP4 | Bodo saltans | 24% | 86% |
| A0A3Q8IEK6 | Leishmania donovani | 32% | 100% |
| A0A3Q8IFG7 | Leishmania donovani | 28% | 100% |
| A0A3Q8IK65 | Leishmania donovani | 31% | 100% |
| A0A3Q8IL63 | Leishmania donovani | 41% | 100% |
| A0A3S7WTA2 | Leishmania donovani | 29% | 100% |
| A0A3S7X808 | Leishmania donovani | 100% | 100% |
| A3A8W6 | Oryza sativa subsp. japonica | 25% | 78% |
| A4H7Y6 | Leishmania braziliensis | 31% | 100% |
| A4HAW5 | Leishmania braziliensis | 48% | 100% |
| A4HAW6 | Leishmania braziliensis | 88% | 100% |
| A4HG10 | Leishmania braziliensis | 31% | 100% |
| A4HHY5 | Leishmania braziliensis | 29% | 100% |
| A4HNR1 | Leishmania braziliensis | 31% | 100% |
| A4HWB4 | Leishmania infantum | 29% | 100% |
| A4I329 | Leishmania infantum | 32% | 100% |
| A4I565 | Leishmania infantum | 28% | 100% |
| A4IA25 | Leishmania infantum | 41% | 100% |
| A4ICT4 | Leishmania infantum | 31% | 100% |
| D0AA51 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 100% |
| E9ACV0 | Leishmania major | 32% | 100% |
| E9AQ14 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9ASH0 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9AZD9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 32% | 100% |
| E9B0G2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 28% | 100% |
| E9B540 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 48% | 100% |
| O81716 | Arabidopsis thaliana | 30% | 100% |
| O81760 | Arabidopsis thaliana | 22% | 100% |
| P38089 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 27% | 100% |
| P39966 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 29% | 97% |
| P49597 | Arabidopsis thaliana | 30% | 100% |
| P49599 | Arabidopsis thaliana | 28% | 100% |
| Q0IIF0 | Bos taurus | 29% | 100% |
| Q0J2L7 | Oryza sativa subsp. japonica | 30% | 100% |
| Q3EAF9 | Arabidopsis thaliana | 32% | 100% |
| Q4Q225 | Leishmania major | 32% | 100% |
| Q4Q2U5 | Leishmania major | 97% | 100% |
| Q4Q2U6 | Leishmania major | 49% | 100% |
| Q4Q7S1 | Leishmania major | 28% | 100% |
| Q4QFG7 | Leishmania major | 28% | 100% |
| Q5JKN1 | Oryza sativa subsp. japonica | 28% | 100% |
| Q5MFV5 | Oryza sativa subsp. indica | 26% | 100% |
| Q5N9N2 | Oryza sativa subsp. japonica | 30% | 100% |
| Q5SN75 | Oryza sativa subsp. japonica | 30% | 100% |
| Q653S3 | Oryza sativa subsp. japonica | 30% | 100% |
| Q65XK7 | Oryza sativa subsp. japonica | 30% | 100% |
| Q67UP9 | Oryza sativa subsp. japonica | 28% | 100% |
| Q6AUQ4 | Oryza sativa subsp. japonica | 32% | 100% |
| Q6ETK3 | Oryza sativa subsp. japonica | 28% | 100% |
| Q6K1U4 | Oryza sativa subsp. japonica | 27% | 87% |
| Q6K5I0 | Oryza sativa subsp. japonica | 29% | 87% |
| Q6NKS1 | Arabidopsis thaliana | 26% | 100% |
| Q7XU84 | Oryza sativa subsp. japonica | 34% | 100% |
| Q94H98 | Oryza sativa subsp. japonica | 26% | 100% |
| Q9CAJ0 | Arabidopsis thaliana | 32% | 88% |
| Q9FG61 | Arabidopsis thaliana | 25% | 100% |
| Q9FLI3 | Arabidopsis thaliana | 26% | 100% |
| Q9H0C8 | Homo sapiens | 28% | 100% |
| Q9LNP9 | Arabidopsis thaliana | 30% | 88% |
| Q9LUS8 | Arabidopsis thaliana | 24% | 91% |
| Q9SLA1 | Arabidopsis thaliana | 36% | 100% |
| Q9SZ53 | Arabidopsis thaliana | 31% | 100% |
| Q9ZW21 | Arabidopsis thaliana | 31% | 100% |