LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA24_LEIIN
TriTrypDb:
LINF_340030700
Length:
536

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA24
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA24

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 4
GO:0008104 protein localization 4 4
GO:0009966 regulation of signal transduction 4 4
GO:0009967 positive regulation of signal transduction 5 4
GO:0009987 cellular process 1 4
GO:0010646 regulation of cell communication 4 4
GO:0010647 positive regulation of cell communication 5 4
GO:0015031 protein transport 4 4
GO:0023051 regulation of signaling 3 4
GO:0023056 positive regulation of signaling 4 4
GO:0032006 regulation of TOR signaling 6 4
GO:0032008 positive regulation of TOR signaling 7 4
GO:0033036 macromolecule localization 2 4
GO:0045184 establishment of protein localization 3 4
GO:0048518 positive regulation of biological process 3 4
GO:0048522 positive regulation of cellular process 4 4
GO:0048583 regulation of response to stimulus 3 4
GO:0048584 positive regulation of response to stimulus 4 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051179 localization 1 4
GO:0051234 establishment of localization 2 4
GO:0051641 cellular localization 2 4
GO:0065007 biological regulation 1 4
GO:0070727 cellular macromolecule localization 3 4
GO:0071702 organic substance transport 4 4
GO:0071705 nitrogen compound transport 4 4
GO:1902531 regulation of intracellular signal transduction 5 4
GO:1902533 positive regulation of intracellular signal transduction 6 4
GO:1903432 regulation of TORC1 signaling 7 4
GO:1904263 positive regulation of TORC1 signaling 8 4
Molecular functions
Term Name Level Count
GO:0005198 structural molecule activity 1 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 246 250 PF00656 0.786
CLV_C14_Caspase3-7 25 29 PF00656 0.755
CLV_NRD_NRD_1 219 221 PF00675 0.447
CLV_NRD_NRD_1 305 307 PF00675 0.530
CLV_NRD_NRD_1 387 389 PF00675 0.518
CLV_NRD_NRD_1 523 525 PF00675 0.456
CLV_PCSK_FUR_1 302 306 PF00082 0.607
CLV_PCSK_KEX2_1 219 221 PF00082 0.447
CLV_PCSK_KEX2_1 304 306 PF00082 0.575
CLV_PCSK_KEX2_1 387 389 PF00082 0.426
CLV_PCSK_KEX2_1 514 516 PF00082 0.557
CLV_PCSK_KEX2_1 523 525 PF00082 0.504
CLV_PCSK_PC1ET2_1 514 516 PF00082 0.479
CLV_PCSK_SKI1_1 268 272 PF00082 0.514
CLV_PCSK_SKI1_1 368 372 PF00082 0.389
CLV_PCSK_SKI1_1 382 386 PF00082 0.327
CLV_PCSK_SKI1_1 451 455 PF00082 0.439
DEG_SPOP_SBC_1 13 17 PF00917 0.710
DEG_SPOP_SBC_1 293 297 PF00917 0.590
DOC_CKS1_1 132 137 PF01111 0.590
DOC_CKS1_1 68 73 PF01111 0.633
DOC_CYCLIN_RxL_1 265 276 PF00134 0.506
DOC_MAPK_gen_1 219 227 PF00069 0.490
DOC_MAPK_gen_1 302 311 PF00069 0.587
DOC_MAPK_gen_1 514 522 PF00069 0.536
DOC_MAPK_MEF2A_6 219 227 PF00069 0.446
DOC_MAPK_MEF2A_6 368 375 PF00069 0.393
DOC_MAPK_MEF2A_6 514 522 PF00069 0.553
DOC_MAPK_NFAT4_5 368 376 PF00069 0.390
DOC_PP1_RVXF_1 137 144 PF00149 0.638
DOC_PP1_RVXF_1 356 363 PF00149 0.393
DOC_PP1_RVXF_1 380 387 PF00149 0.463
DOC_PP1_RVXF_1 440 446 PF00149 0.537
DOC_PP2B_LxvP_1 120 123 PF13499 0.625
DOC_PP2B_LxvP_1 270 273 PF13499 0.517
DOC_PP4_FxxP_1 386 389 PF00568 0.438
DOC_USP7_MATH_1 12 16 PF00917 0.752
DOC_USP7_MATH_1 146 150 PF00917 0.513
DOC_USP7_MATH_1 241 245 PF00917 0.687
DOC_USP7_MATH_1 293 297 PF00917 0.708
DOC_USP7_MATH_1 400 404 PF00917 0.655
DOC_USP7_MATH_1 415 419 PF00917 0.584
DOC_USP7_MATH_1 64 68 PF00917 0.571
DOC_WW_Pin1_4 131 136 PF00397 0.699
DOC_WW_Pin1_4 239 244 PF00397 0.732
DOC_WW_Pin1_4 352 357 PF00397 0.507
DOC_WW_Pin1_4 360 365 PF00397 0.414
DOC_WW_Pin1_4 422 427 PF00397 0.533
DOC_WW_Pin1_4 67 72 PF00397 0.605
LIG_14-3-3_CanoR_1 186 194 PF00244 0.438
LIG_14-3-3_CanoR_1 21 30 PF00244 0.729
LIG_14-3-3_CanoR_1 228 237 PF00244 0.667
LIG_14-3-3_CanoR_1 268 273 PF00244 0.542
LIG_14-3-3_CanoR_1 523 531 PF00244 0.490
LIG_BRCT_BRCA1_1 208 212 PF00533 0.419
LIG_CSL_BTD_1 361 364 PF09270 0.457
LIG_deltaCOP1_diTrp_1 161 167 PF00928 0.501
LIG_FHA_1 145 151 PF00498 0.460
LIG_FHA_1 199 205 PF00498 0.441
LIG_FHA_1 260 266 PF00498 0.503
LIG_FHA_1 306 312 PF00498 0.469
LIG_FHA_1 376 382 PF00498 0.515
LIG_FHA_1 399 405 PF00498 0.518
LIG_FHA_1 430 436 PF00498 0.532
LIG_FHA_1 448 454 PF00498 0.376
LIG_FHA_1 523 529 PF00498 0.573
LIG_FHA_2 132 138 PF00498 0.655
LIG_FHA_2 156 162 PF00498 0.488
LIG_FHA_2 273 279 PF00498 0.556
LIG_FHA_2 74 80 PF00498 0.530
LIG_LIR_Apic_2 467 473 PF02991 0.564
LIG_LIR_Apic_2 67 71 PF02991 0.671
LIG_LIR_Gen_1 106 114 PF02991 0.565
LIG_LIR_Gen_1 343 353 PF02991 0.589
LIG_LIR_Gen_1 369 377 PF02991 0.364
LIG_LIR_Nem_3 106 110 PF02991 0.543
LIG_LIR_Nem_3 343 349 PF02991 0.570
LIG_LIR_Nem_3 369 373 PF02991 0.376
LIG_LIR_Nem_3 40 44 PF02991 0.614
LIG_Pex14_1 41 45 PF04695 0.644
LIG_Pex14_1 464 468 PF04695 0.547
LIG_SH2_CRK 346 350 PF00017 0.568
LIG_SH2_CRK 531 535 PF00017 0.725
LIG_SH2_CRK 68 72 PF00017 0.691
LIG_SH2_SRC 470 473 PF00017 0.523
LIG_SH2_STAP1 32 36 PF00017 0.494
LIG_SH2_STAT5 157 160 PF00017 0.501
LIG_SH2_STAT5 172 175 PF00017 0.260
LIG_SH2_STAT5 32 35 PF00017 0.496
LIG_SH2_STAT5 330 333 PF00017 0.508
LIG_TRAF2_1 426 429 PF00917 0.497
LIG_TRAF2_1 436 439 PF00917 0.457
LIG_TYR_ITIM 344 349 PF00017 0.490
LIG_UBA3_1 93 100 PF00899 0.465
MOD_CDC14_SPxK_1 355 358 PF00782 0.341
MOD_CDK_SPxK_1 352 358 PF00069 0.372
MOD_CK1_1 200 206 PF00069 0.543
MOD_CK1_1 207 213 PF00069 0.411
MOD_CK1_1 260 266 PF00069 0.414
MOD_CK1_1 363 369 PF00069 0.548
MOD_CK1_1 493 499 PF00069 0.733
MOD_CK1_1 67 73 PF00069 0.591
MOD_CK2_1 155 161 PF00069 0.486
MOD_CK2_1 422 428 PF00069 0.555
MOD_CMANNOS 164 167 PF00535 0.398
MOD_GlcNHglycan 245 248 PF01048 0.736
MOD_GlcNHglycan 288 292 PF01048 0.757
MOD_GlcNHglycan 296 299 PF01048 0.636
MOD_GlcNHglycan 314 318 PF01048 0.310
MOD_GlcNHglycan 350 353 PF01048 0.565
MOD_GlcNHglycan 365 368 PF01048 0.537
MOD_GlcNHglycan 47 50 PF01048 0.600
MOD_GlcNHglycan 495 498 PF01048 0.595
MOD_GlcNHglycan 525 528 PF01048 0.490
MOD_GSK3_1 13 20 PF00069 0.672
MOD_GSK3_1 198 205 PF00069 0.426
MOD_GSK3_1 206 213 PF00069 0.357
MOD_GSK3_1 228 235 PF00069 0.613
MOD_GSK3_1 239 246 PF00069 0.687
MOD_GSK3_1 268 275 PF00069 0.432
MOD_GSK3_1 332 339 PF00069 0.509
MOD_GSK3_1 348 355 PF00069 0.370
MOD_GSK3_1 362 369 PF00069 0.504
MOD_GSK3_1 441 448 PF00069 0.486
MOD_GSK3_1 51 58 PF00069 0.596
MOD_GSK3_1 518 525 PF00069 0.500
MOD_LATS_1 303 309 PF00433 0.371
MOD_N-GLC_1 210 215 PF02516 0.524
MOD_N-GLC_1 445 450 PF02516 0.491
MOD_N-GLC_1 479 484 PF02516 0.721
MOD_N-GLC_1 52 57 PF02516 0.691
MOD_N-GLC_2 89 91 PF02516 0.582
MOD_NEK2_1 375 380 PF00069 0.509
MOD_NEK2_1 4 9 PF00069 0.706
MOD_NEK2_1 457 462 PF00069 0.559
MOD_NEK2_1 51 56 PF00069 0.651
MOD_PIKK_1 105 111 PF00454 0.496
MOD_PIKK_1 23 29 PF00454 0.756
MOD_PIKK_1 332 338 PF00454 0.547
MOD_PKA_1 305 311 PF00069 0.321
MOD_PKA_1 523 529 PF00069 0.489
MOD_PKA_2 185 191 PF00069 0.433
MOD_PKA_2 198 204 PF00069 0.428
MOD_PKA_2 20 26 PF00069 0.707
MOD_PKA_2 227 233 PF00069 0.645
MOD_PKA_2 305 311 PF00069 0.509
MOD_PKA_2 522 528 PF00069 0.601
MOD_Plk_1 160 166 PF00069 0.467
MOD_Plk_1 210 216 PF00069 0.520
MOD_Plk_1 336 342 PF00069 0.585
MOD_Plk_1 457 463 PF00069 0.507
MOD_Plk_1 503 509 PF00069 0.638
MOD_Plk_1 78 84 PF00069 0.586
MOD_Plk_4 14 20 PF00069 0.740
MOD_Plk_4 146 152 PF00069 0.459
MOD_Plk_4 260 266 PF00069 0.524
MOD_Plk_4 325 331 PF00069 0.474
MOD_Plk_4 503 509 PF00069 0.570
MOD_Plk_4 64 70 PF00069 0.615
MOD_Plk_4 78 84 PF00069 0.440
MOD_ProDKin_1 131 137 PF00069 0.694
MOD_ProDKin_1 239 245 PF00069 0.735
MOD_ProDKin_1 352 358 PF00069 0.504
MOD_ProDKin_1 360 366 PF00069 0.428
MOD_ProDKin_1 422 428 PF00069 0.529
MOD_ProDKin_1 67 73 PF00069 0.595
TRG_DiLeu_BaEn_1 315 320 PF01217 0.420
TRG_DiLeu_BaEn_4 438 444 PF01217 0.438
TRG_DiLeu_BaLyEn_6 136 141 PF01217 0.658
TRG_DiLeu_BaLyEn_6 89 94 PF01217 0.509
TRG_ENDOCYTIC_2 346 349 PF00928 0.490
TRG_ENDOCYTIC_2 531 534 PF00928 0.734
TRG_ER_diArg_1 219 222 PF00400 0.504
TRG_ER_diArg_1 302 305 PF00400 0.665
TRG_ER_diArg_1 386 388 PF00400 0.468
TRG_ER_diArg_1 522 524 PF00400 0.553
TRG_Pf-PMV_PEXEL_1 139 144 PF00026 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3R7 Leptomonas seymouri 61% 90%
A0A1X0P9T6 Trypanosomatidae 34% 100%
A0A3Q8IHB0 Leishmania donovani 100% 100%
A0A3R7N181 Trypanosoma rangeli 33% 100%
A4HAW4 Leishmania braziliensis 79% 100%
C9ZMJ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9B539 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q2U7 Leishmania major 93% 100%
V5BFU9 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS