LeishMANIAdb
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Cilia-and flagella-associated protein 58

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Cilia-and flagella-associated protein 58
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA22_LEIIN
TriTrypDb:
LINF_340030500
Length:
1074

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005856 cytoskeleton 5 1
GO:0005930 axoneme 2 1
GO:0043226 organelle 2 3
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0120025 plasma membrane bounded cell projection 3 2

Expansion

Sequence features

A4IA22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 1058 1062 PF00656 0.498
CLV_C14_Caspase3-7 2 6 PF00656 0.602
CLV_C14_Caspase3-7 754 758 PF00656 0.623
CLV_C14_Caspase3-7 778 782 PF00656 0.721
CLV_C14_Caspase3-7 838 842 PF00656 0.493
CLV_C14_Caspase3-7 90 94 PF00656 0.475
CLV_MEL_PAP_1 832 838 PF00089 0.548
CLV_NRD_NRD_1 1072 1074 PF00675 0.722
CLV_NRD_NRD_1 135 137 PF00675 0.384
CLV_NRD_NRD_1 211 213 PF00675 0.605
CLV_NRD_NRD_1 288 290 PF00675 0.546
CLV_NRD_NRD_1 359 361 PF00675 0.452
CLV_NRD_NRD_1 393 395 PF00675 0.498
CLV_NRD_NRD_1 443 445 PF00675 0.450
CLV_NRD_NRD_1 486 488 PF00675 0.403
CLV_NRD_NRD_1 50 52 PF00675 0.560
CLV_NRD_NRD_1 575 577 PF00675 0.458
CLV_NRD_NRD_1 594 596 PF00675 0.314
CLV_NRD_NRD_1 611 613 PF00675 0.398
CLV_NRD_NRD_1 65 67 PF00675 0.382
CLV_PCSK_KEX2_1 106 108 PF00082 0.531
CLV_PCSK_KEX2_1 1071 1073 PF00082 0.701
CLV_PCSK_KEX2_1 135 137 PF00082 0.524
CLV_PCSK_KEX2_1 276 278 PF00082 0.473
CLV_PCSK_KEX2_1 288 290 PF00082 0.396
CLV_PCSK_KEX2_1 359 361 PF00082 0.616
CLV_PCSK_KEX2_1 442 444 PF00082 0.423
CLV_PCSK_KEX2_1 452 454 PF00082 0.386
CLV_PCSK_KEX2_1 486 488 PF00082 0.399
CLV_PCSK_KEX2_1 493 495 PF00082 0.394
CLV_PCSK_KEX2_1 50 52 PF00082 0.482
CLV_PCSK_KEX2_1 594 596 PF00082 0.423
CLV_PCSK_KEX2_1 611 613 PF00082 0.345
CLV_PCSK_KEX2_1 65 67 PF00082 0.329
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.531
CLV_PCSK_PC1ET2_1 1071 1073 PF00082 0.572
CLV_PCSK_PC1ET2_1 276 278 PF00082 0.473
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.396
CLV_PCSK_PC1ET2_1 442 444 PF00082 0.432
CLV_PCSK_PC1ET2_1 452 454 PF00082 0.408
CLV_PCSK_PC1ET2_1 493 495 PF00082 0.405
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.493
CLV_PCSK_SKI1_1 306 310 PF00082 0.582
CLV_PCSK_SKI1_1 324 328 PF00082 0.423
CLV_PCSK_SKI1_1 402 406 PF00082 0.525
CLV_PCSK_SKI1_1 477 481 PF00082 0.559
CLV_PCSK_SKI1_1 51 55 PF00082 0.560
CLV_PCSK_SKI1_1 587 591 PF00082 0.399
CLV_PCSK_SKI1_1 664 668 PF00082 0.490
CLV_PCSK_SKI1_1 987 991 PF00082 0.677
DEG_APCC_DBOX_1 211 219 PF00400 0.607
DEG_APCC_DBOX_1 288 296 PF00400 0.485
DEG_APCC_DBOX_1 442 450 PF00400 0.478
DEG_SPOP_SBC_1 1056 1060 PF00917 0.707
DOC_CKS1_1 1043 1048 PF01111 0.632
DOC_CYCLIN_RxL_1 224 235 PF00134 0.542
DOC_CYCLIN_RxL_1 399 407 PF00134 0.609
DOC_CYCLIN_RxL_1 818 830 PF00134 0.475
DOC_CYCLIN_yCln2_LP_2 970 976 PF00134 0.656
DOC_MAPK_gen_1 135 142 PF00069 0.397
DOC_MAPK_gen_1 224 231 PF00069 0.495
DOC_MAPK_gen_1 339 347 PF00069 0.547
DOC_MAPK_gen_1 442 451 PF00069 0.412
DOC_MAPK_gen_1 493 501 PF00069 0.549
DOC_MAPK_gen_1 641 649 PF00069 0.474
DOC_MAPK_gen_1 723 731 PF00069 0.676
DOC_MAPK_gen_1 75 83 PF00069 0.501
DOC_MAPK_gen_1 818 826 PF00069 0.399
DOC_MAPK_MEF2A_6 122 130 PF00069 0.428
DOC_MAPK_MEF2A_6 686 694 PF00069 0.569
DOC_MAPK_MEF2A_6 723 731 PF00069 0.676
DOC_MAPK_MEF2A_6 981 990 PF00069 0.618
DOC_PP1_RVXF_1 400 407 PF00149 0.462
DOC_PP1_RVXF_1 985 991 PF00149 0.694
DOC_PP2B_LxvP_1 1023 1026 PF13499 0.579
DOC_PP2B_LxvP_1 729 732 PF13499 0.577
DOC_PP2B_LxvP_1 968 971 PF13499 0.550
DOC_PP4_FxxP_1 1065 1068 PF00568 0.510
DOC_PP4_FxxP_1 990 993 PF00568 0.503
DOC_USP7_MATH_1 1030 1034 PF00917 0.761
DOC_USP7_MATH_1 582 586 PF00917 0.553
DOC_USP7_MATH_1 685 689 PF00917 0.567
DOC_USP7_MATH_1 738 742 PF00917 0.636
DOC_USP7_MATH_1 775 779 PF00917 0.642
DOC_USP7_MATH_1 8 12 PF00917 0.713
DOC_USP7_MATH_1 938 942 PF00917 0.623
DOC_USP7_MATH_1 979 983 PF00917 0.690
DOC_USP7_MATH_1 995 999 PF00917 0.705
DOC_USP7_UBL2_3 412 416 PF12436 0.604
DOC_USP7_UBL2_3 493 497 PF12436 0.504
DOC_USP7_UBL2_3 50 54 PF12436 0.378
DOC_USP7_UBL2_3 531 535 PF12436 0.458
DOC_USP7_UBL2_3 577 581 PF12436 0.442
DOC_USP7_UBL2_3 814 818 PF12436 0.534
DOC_WW_Pin1_4 1004 1009 PF00397 0.776
DOC_WW_Pin1_4 1025 1030 PF00397 0.710
DOC_WW_Pin1_4 1042 1047 PF00397 0.743
DOC_WW_Pin1_4 1064 1069 PF00397 0.510
DOC_WW_Pin1_4 12 17 PF00397 0.553
DOC_WW_Pin1_4 765 770 PF00397 0.654
LIG_14-3-3_CanoR_1 1017 1022 PF00244 0.693
LIG_14-3-3_CanoR_1 256 261 PF00244 0.522
LIG_14-3-3_CanoR_1 277 282 PF00244 0.521
LIG_14-3-3_CanoR_1 289 293 PF00244 0.429
LIG_14-3-3_CanoR_1 306 313 PF00244 0.564
LIG_14-3-3_CanoR_1 346 352 PF00244 0.416
LIG_14-3-3_CanoR_1 486 495 PF00244 0.386
LIG_14-3-3_CanoR_1 87 92 PF00244 0.471
LIG_Actin_WH2_2 56 74 PF00022 0.374
LIG_BRCT_BRCA1_1 410 414 PF00533 0.629
LIG_BRCT_BRCA1_2 410 416 PF00533 0.561
LIG_FHA_1 25 31 PF00498 0.461
LIG_FHA_1 381 387 PF00498 0.538
LIG_FHA_1 399 405 PF00498 0.450
LIG_FHA_1 429 435 PF00498 0.590
LIG_FHA_1 528 534 PF00498 0.561
LIG_FHA_1 706 712 PF00498 0.518
LIG_FHA_1 845 851 PF00498 0.417
LIG_FHA_1 950 956 PF00498 0.681
LIG_FHA_2 1056 1062 PF00498 0.500
LIG_FHA_2 295 301 PF00498 0.452
LIG_FHA_2 604 610 PF00498 0.422
LIG_FHA_2 752 758 PF00498 0.689
LIG_FHA_2 869 875 PF00498 0.388
LIG_FHA_2 88 94 PF00498 0.550
LIG_LIR_Apic_2 1063 1068 PF02991 0.506
LIG_LIR_Gen_1 26 36 PF02991 0.464
LIG_LIR_Gen_1 500 510 PF02991 0.386
LIG_LIR_Gen_1 795 803 PF02991 0.491
LIG_LIR_Nem_3 26 32 PF02991 0.467
LIG_LIR_Nem_3 500 505 PF02991 0.382
LIG_LIR_Nem_3 795 801 PF02991 0.451
LIG_NRBOX 669 675 PF00104 0.415
LIG_RPA_C_Fungi 636 648 PF08784 0.472
LIG_SH2_NCK_1 910 914 PF00017 0.458
LIG_SH2_PTP2 29 32 PF00017 0.392
LIG_SH2_PTP2 798 801 PF00017 0.546
LIG_SH2_SRC 910 913 PF00017 0.458
LIG_SH2_STAP1 614 618 PF00017 0.469
LIG_SH2_STAT3 468 471 PF00017 0.321
LIG_SH2_STAT3 961 964 PF00017 0.602
LIG_SH2_STAT5 29 32 PF00017 0.562
LIG_SH2_STAT5 468 471 PF00017 0.402
LIG_SH2_STAT5 48 51 PF00017 0.253
LIG_SH2_STAT5 798 801 PF00017 0.546
LIG_SH2_STAT5 89 92 PF00017 0.471
LIG_SH2_STAT5 927 930 PF00017 0.494
LIG_SH2_STAT5 961 964 PF00017 0.566
LIG_SH3_2 718 723 PF14604 0.514
LIG_SH3_2 976 981 PF14604 0.588
LIG_SH3_3 1023 1029 PF00018 0.768
LIG_SH3_3 1040 1046 PF00018 0.641
LIG_SH3_3 715 721 PF00018 0.507
LIG_SH3_3 732 738 PF00018 0.492
LIG_SH3_3 788 794 PF00018 0.560
LIG_SH3_3 952 958 PF00018 0.603
LIG_SH3_3 970 976 PF00018 0.546
LIG_SH3_CIN85_PxpxPR_1 1006 1011 PF14604 0.624
LIG_SUMO_SIM_anti_2 536 541 PF11976 0.375
LIG_TRAF2_1 149 152 PF00917 0.402
LIG_TRAF2_1 245 248 PF00917 0.481
LIG_TRAF2_1 308 311 PF00917 0.556
LIG_TRAF2_1 436 439 PF00917 0.419
LIG_TRAF2_1 461 464 PF00917 0.465
LIG_WRC_WIRS_1 88 93 PF05994 0.470
LIG_WW_2 1047 1050 PF00397 0.555
LIG_WW_3 991 995 PF00397 0.591
MOD_CDK_SPxxK_3 1004 1011 PF00069 0.602
MOD_CDK_SPxxK_3 1064 1071 PF00069 0.508
MOD_CK1_1 1024 1030 PF00069 0.759
MOD_CK1_1 1064 1070 PF00069 0.752
MOD_CK1_1 12 18 PF00069 0.655
MOD_CK1_1 21 27 PF00069 0.424
MOD_CK1_1 457 463 PF00069 0.533
MOD_CK1_1 538 544 PF00069 0.521
MOD_CK1_1 764 770 PF00069 0.730
MOD_CK1_1 941 947 PF00069 0.650
MOD_CK1_1 998 1004 PF00069 0.620
MOD_CK2_1 217 223 PF00069 0.519
MOD_CK2_1 241 247 PF00069 0.538
MOD_CK2_1 263 269 PF00069 0.512
MOD_CK2_1 294 300 PF00069 0.440
MOD_CK2_1 346 352 PF00069 0.506
MOD_CK2_1 355 361 PF00069 0.454
MOD_CK2_1 457 463 PF00069 0.533
MOD_CK2_1 486 492 PF00069 0.449
MOD_CK2_1 582 588 PF00069 0.473
MOD_CK2_1 685 691 PF00069 0.568
MOD_CK2_1 76 82 PF00069 0.437
MOD_CK2_1 868 874 PF00069 0.389
MOD_CK2_1 891 897 PF00069 0.528
MOD_GlcNHglycan 1000 1003 PF01048 0.776
MOD_GlcNHglycan 1023 1026 PF01048 0.765
MOD_GlcNHglycan 1032 1035 PF01048 0.752
MOD_GlcNHglycan 11 14 PF01048 0.734
MOD_GlcNHglycan 459 462 PF01048 0.529
MOD_GlcNHglycan 543 546 PF01048 0.409
MOD_GlcNHglycan 757 760 PF01048 0.707
MOD_GlcNHglycan 763 766 PF01048 0.668
MOD_GlcNHglycan 776 780 PF01048 0.646
MOD_GlcNHglycan 981 984 PF01048 0.565
MOD_GSK3_1 1017 1024 PF00069 0.722
MOD_GSK3_1 1025 1032 PF00069 0.487
MOD_GSK3_1 1056 1063 PF00069 0.724
MOD_GSK3_1 164 171 PF00069 0.549
MOD_GSK3_1 291 298 PF00069 0.457
MOD_GSK3_1 302 309 PF00069 0.454
MOD_GSK3_1 511 518 PF00069 0.387
MOD_GSK3_1 665 672 PF00069 0.518
MOD_GSK3_1 751 758 PF00069 0.679
MOD_GSK3_1 761 768 PF00069 0.519
MOD_GSK3_1 8 15 PF00069 0.720
MOD_N-GLC_1 295 300 PF02516 0.440
MOD_NEK2_1 204 209 PF00069 0.514
MOD_NEK2_1 319 324 PF00069 0.403
MOD_NEK2_1 355 360 PF00069 0.424
MOD_NEK2_1 665 670 PF00069 0.505
MOD_NEK2_1 692 697 PF00069 0.497
MOD_NEK2_1 763 768 PF00069 0.647
MOD_NEK2_1 868 873 PF00069 0.389
MOD_NEK2_1 878 883 PF00069 0.374
MOD_NEK2_1 949 954 PF00069 0.741
MOD_NEK2_2 857 862 PF00069 0.470
MOD_NEK2_2 873 878 PF00069 0.301
MOD_PIKK_1 306 312 PF00454 0.490
MOD_PIKK_1 511 517 PF00454 0.418
MOD_PIKK_1 685 691 PF00454 0.553
MOD_PIKK_1 705 711 PF00454 0.309
MOD_PIKK_1 751 757 PF00454 0.573
MOD_PK_1 1017 1023 PF00069 0.599
MOD_PK_1 535 541 PF00069 0.504
MOD_PK_1 891 897 PF00069 0.427
MOD_PKA_1 288 294 PF00069 0.437
MOD_PKA_1 486 492 PF00069 0.524
MOD_PKA_2 1016 1022 PF00069 0.778
MOD_PKA_2 121 127 PF00069 0.384
MOD_PKA_2 263 269 PF00069 0.478
MOD_PKA_2 288 294 PF00069 0.441
MOD_PKA_2 380 386 PF00069 0.492
MOD_PKA_2 457 463 PF00069 0.488
MOD_PKA_2 486 492 PF00069 0.429
MOD_PKA_2 541 547 PF00069 0.372
MOD_PKA_2 653 659 PF00069 0.430
MOD_PKB_1 85 93 PF00069 0.559
MOD_Plk_1 1060 1066 PF00069 0.587
MOD_Plk_1 295 301 PF00069 0.440
MOD_Plk_1 361 367 PF00069 0.504
MOD_Plk_1 428 434 PF00069 0.557
MOD_Plk_1 462 468 PF00069 0.401
MOD_Plk_1 535 541 PF00069 0.480
MOD_Plk_1 559 565 PF00069 0.565
MOD_Plk_1 603 609 PF00069 0.514
MOD_Plk_1 66 72 PF00069 0.407
MOD_Plk_1 692 698 PF00069 0.499
MOD_Plk_1 844 850 PF00069 0.445
MOD_Plk_1 873 879 PF00069 0.389
MOD_Plk_1 941 947 PF00069 0.676
MOD_Plk_1 995 1001 PF00069 0.780
MOD_Plk_2-3 361 367 PF00069 0.544
MOD_Plk_4 121 127 PF00069 0.369
MOD_Plk_4 232 238 PF00069 0.390
MOD_Plk_4 535 541 PF00069 0.414
MOD_Plk_4 66 72 PF00069 0.407
MOD_Plk_4 669 675 PF00069 0.415
MOD_Plk_4 873 879 PF00069 0.389
MOD_Plk_4 891 897 PF00069 0.399
MOD_ProDKin_1 1004 1010 PF00069 0.776
MOD_ProDKin_1 1025 1031 PF00069 0.711
MOD_ProDKin_1 1042 1048 PF00069 0.743
MOD_ProDKin_1 1064 1070 PF00069 0.510
MOD_ProDKin_1 12 18 PF00069 0.547
MOD_ProDKin_1 765 771 PF00069 0.658
MOD_SUMO_for_1 157 160 PF00179 0.548
MOD_SUMO_for_1 191 194 PF00179 0.438
MOD_SUMO_for_1 436 439 PF00179 0.525
MOD_SUMO_for_1 505 508 PF00179 0.386
MOD_SUMO_rev_2 242 251 PF00179 0.430
MOD_SUMO_rev_2 584 591 PF00179 0.551
MOD_SUMO_rev_2 712 721 PF00179 0.629
TRG_DiLeu_BaEn_1 186 191 PF01217 0.435
TRG_DiLeu_BaEn_1 315 320 PF01217 0.491
TRG_DiLeu_BaEn_1 367 372 PF01217 0.547
TRG_DiLeu_BaEn_1 528 533 PF01217 0.522
TRG_DiLeu_BaEn_4 827 833 PF01217 0.405
TRG_ENDOCYTIC_2 29 32 PF00928 0.441
TRG_ENDOCYTIC_2 798 801 PF00928 0.511
TRG_ER_diArg_1 154 157 PF00400 0.456
TRG_ER_diArg_1 593 595 PF00400 0.417
TRG_ER_diArg_1 610 612 PF00400 0.391
TRG_ER_diArg_1 64 66 PF00400 0.512
TRG_ER_diArg_1 77 80 PF00400 0.430
TRG_ER_diArg_1 85 88 PF00400 0.537
TRG_NES_CRM1_1 560 571 PF08389 0.417
TRG_NLS_Bipartite_1 275 292 PF00514 0.544
TRG_NLS_MonoExtC_3 49 54 PF00514 0.391
TRG_Pf-PMV_PEXEL_1 107 111 PF00026 0.414
TRG_Pf-PMV_PEXEL_1 374 378 PF00026 0.408
TRG_Pf-PMV_PEXEL_1 403 407 PF00026 0.564
TRG_Pf-PMV_PEXEL_1 594 599 PF00026 0.509

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IC41 Leptomonas seymouri 64% 92%
A0A0S4JNC8 Bodo saltans 42% 100%
A0A1X0P9Q4 Trypanosomatidae 44% 100%
A0A3S7X809 Leishmania donovani 100% 100%
A0A422P0B4 Trypanosoma rangeli 44% 100%
A4HAW2 Leishmania braziliensis 82% 100%
C9ZMK0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
E9B537 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2U9 Leishmania major 95% 100%
Q8IYE0 Homo sapiens 21% 100%
V5DGR4 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS