LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IA21_LEIIN
TriTrypDb:
LINF_340030400
Length:
405

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA21

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 139 143 PF00656 0.631
CLV_C14_Caspase3-7 320 324 PF00656 0.738
CLV_NRD_NRD_1 302 304 PF00675 0.591
CLV_NRD_NRD_1 350 352 PF00675 0.706
CLV_PCSK_KEX2_1 350 352 PF00082 0.685
DEG_Nend_UBRbox_1 1 4 PF02207 0.696
DOC_CDC14_PxL_1 257 265 PF14671 0.565
DOC_CYCLIN_yCln2_LP_2 381 387 PF00134 0.469
DOC_PP4_FxxP_1 266 269 PF00568 0.568
DOC_SPAK_OSR1_1 18 22 PF12202 0.597
DOC_USP7_MATH_1 118 122 PF00917 0.626
DOC_USP7_MATH_1 150 154 PF00917 0.665
DOC_USP7_MATH_1 184 188 PF00917 0.509
DOC_USP7_MATH_1 204 208 PF00917 0.559
DOC_USP7_MATH_1 244 248 PF00917 0.579
DOC_USP7_MATH_1 289 293 PF00917 0.616
DOC_USP7_MATH_1 307 311 PF00917 0.566
DOC_USP7_MATH_1 358 362 PF00917 0.583
DOC_USP7_MATH_1 36 40 PF00917 0.600
DOC_USP7_MATH_1 58 62 PF00917 0.600
DOC_WW_Pin1_4 228 233 PF00397 0.637
DOC_WW_Pin1_4 265 270 PF00397 0.589
DOC_WW_Pin1_4 67 72 PF00397 0.642
LIG_14-3-3_CanoR_1 149 159 PF00244 0.695
LIG_14-3-3_CanoR_1 251 257 PF00244 0.561
LIG_14-3-3_CanoR_1 339 344 PF00244 0.636
LIG_14-3-3_CanoR_1 391 396 PF00244 0.495
LIG_BIR_III_2 217 221 PF00653 0.635
LIG_BRCT_BRCA1_1 176 180 PF00533 0.609
LIG_BRCT_BRCA1_1 371 375 PF00533 0.621
LIG_DLG_GKlike_1 391 399 PF00625 0.450
LIG_eIF4E_1 95 101 PF01652 0.540
LIG_FHA_1 121 127 PF00498 0.612
LIG_FHA_1 183 189 PF00498 0.613
LIG_FHA_1 195 201 PF00498 0.515
LIG_FHA_1 229 235 PF00498 0.772
LIG_FHA_1 71 77 PF00498 0.559
LIG_FHA_1 95 101 PF00498 0.540
LIG_LIR_Apic_2 265 269 PF02991 0.564
LIG_LIR_Gen_1 177 188 PF02991 0.618
LIG_LIR_Nem_3 177 183 PF02991 0.618
LIG_LIR_Nem_3 341 346 PF02991 0.528
LIG_LIR_Nem_3 5 10 PF02991 0.537
LIG_Pex14_1 172 176 PF04695 0.517
LIG_PTAP_UEV_1 273 278 PF05743 0.556
LIG_SH2_NCK_1 308 312 PF00017 0.627
LIG_SH2_STAP1 122 126 PF00017 0.564
LIG_SH2_STAP1 176 180 PF00017 0.609
LIG_SH2_STAP1 308 312 PF00017 0.627
LIG_SH2_STAT5 122 125 PF00017 0.545
LIG_SH2_STAT5 208 211 PF00017 0.557
LIG_SH2_STAT5 308 311 PF00017 0.626
LIG_SH3_3 183 189 PF00018 0.516
LIG_SH3_3 255 261 PF00018 0.597
LIG_SH3_3 271 277 PF00018 0.620
LIG_SH3_3 352 358 PF00018 0.542
LIG_SH3_3 364 370 PF00018 0.518
LIG_SUMO_SIM_anti_2 252 259 PF11976 0.557
LIG_SUMO_SIM_par_1 97 104 PF11976 0.536
LIG_TRAF2_1 152 155 PF00917 0.665
LIG_UBA3_1 162 171 PF00899 0.482
MOD_CK1_1 191 197 PF00069 0.654
MOD_CK1_1 268 274 PF00069 0.607
MOD_CK1_1 292 298 PF00069 0.632
MOD_CK1_1 3 9 PF00069 0.656
MOD_CK1_1 306 312 PF00069 0.590
MOD_CK1_1 39 45 PF00069 0.590
MOD_CK1_1 394 400 PF00069 0.462
MOD_CK1_1 70 76 PF00069 0.558
MOD_CK1_1 94 100 PF00069 0.536
MOD_CK2_1 148 154 PF00069 0.684
MOD_CK2_1 161 167 PF00069 0.466
MOD_CK2_1 314 320 PF00069 0.758
MOD_CK2_1 390 396 PF00069 0.580
MOD_GlcNHglycan 131 134 PF01048 0.675
MOD_GlcNHglycan 150 153 PF01048 0.496
MOD_GlcNHglycan 246 249 PF01048 0.569
MOD_GlcNHglycan 291 294 PF01048 0.565
MOD_GlcNHglycan 305 308 PF01048 0.650
MOD_GlcNHglycan 309 312 PF01048 0.692
MOD_GlcNHglycan 34 37 PF01048 0.639
MOD_GlcNHglycan 396 399 PF01048 0.563
MOD_GlcNHglycan 40 44 PF01048 0.680
MOD_GlcNHglycan 60 63 PF01048 0.471
MOD_GSK3_1 113 120 PF00069 0.604
MOD_GSK3_1 174 181 PF00069 0.623
MOD_GSK3_1 184 191 PF00069 0.527
MOD_GSK3_1 252 259 PF00069 0.530
MOD_GSK3_1 268 275 PF00069 0.623
MOD_GSK3_1 288 295 PF00069 0.615
MOD_GSK3_1 303 310 PF00069 0.645
MOD_GSK3_1 314 321 PF00069 0.550
MOD_GSK3_1 32 39 PF00069 0.730
MOD_GSK3_1 390 397 PF00069 0.503
MOD_GSK3_1 70 77 PF00069 0.584
MOD_N-GLC_1 191 196 PF02516 0.597
MOD_PIKK_1 268 274 PF00454 0.597
MOD_PKA_1 303 309 PF00069 0.612
MOD_PKA_2 148 154 PF00069 0.688
MOD_PKA_2 178 184 PF00069 0.624
MOD_PKA_2 220 226 PF00069 0.774
MOD_PKA_2 338 344 PF00069 0.615
MOD_PKA_2 390 396 PF00069 0.580
MOD_Plk_1 106 112 PF00069 0.556
MOD_Plk_1 39 45 PF00069 0.654
MOD_Plk_1 48 54 PF00069 0.532
MOD_Plk_1 81 87 PF00069 0.551
MOD_Plk_2-3 48 54 PF00069 0.571
MOD_Plk_4 204 210 PF00069 0.551
MOD_Plk_4 252 258 PF00069 0.557
MOD_ProDKin_1 228 234 PF00069 0.635
MOD_ProDKin_1 265 271 PF00069 0.591
MOD_ProDKin_1 67 73 PF00069 0.639
TRG_DiLeu_BaEn_1 40 45 PF01217 0.552
TRG_DiLeu_BaEn_4 154 160 PF01217 0.646
TRG_ER_diArg_1 158 161 PF00400 0.593
TRG_ER_diArg_1 16 19 PF00400 0.485
TRG_ER_diArg_1 85 88 PF00400 0.589
TRG_NLS_MonoExtN_4 300 307 PF00514 0.531

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMR5 Leptomonas seymouri 34% 100%
A0A3S5H7X0 Leishmania donovani 99% 100%
A4HAW1 Leishmania braziliensis 67% 100%
E9B536 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q2V0 Leishmania major 80% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS