LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
Uncharacterized conserved protein H4 (DUF2046) - putative
Species:
Leishmania infantum
UniProt:
A4IA15_LEIIN
TriTrypDb:
LINF_340029000
Length:
431

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 205, 209, 212, 213

Expansion

Sequence features

A4IA15
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 103 105 PF00675 0.267
CLV_NRD_NRD_1 131 133 PF00675 0.319
CLV_NRD_NRD_1 138 140 PF00675 0.284
CLV_NRD_NRD_1 24 26 PF00675 0.360
CLV_NRD_NRD_1 309 311 PF00675 0.541
CLV_NRD_NRD_1 45 47 PF00675 0.328
CLV_NRD_NRD_1 75 77 PF00675 0.360
CLV_PCSK_FUR_1 22 26 PF00082 0.376
CLV_PCSK_KEX2_1 103 105 PF00082 0.315
CLV_PCSK_KEX2_1 24 26 PF00082 0.360
CLV_PCSK_KEX2_1 75 77 PF00082 0.360
CLV_PCSK_SKI1_1 103 107 PF00082 0.325
CLV_PCSK_SKI1_1 132 136 PF00082 0.300
CLV_PCSK_SKI1_1 415 419 PF00082 0.483
CLV_PCSK_SKI1_1 57 61 PF00082 0.376
DEG_APCC_DBOX_1 364 372 PF00400 0.527
DEG_APCC_DBOX_1 414 422 PF00400 0.545
DEG_SCF_FBW7_1 291 296 PF00400 0.690
DEG_SPOP_SBC_1 171 175 PF00917 0.667
DOC_CYCLIN_RxL_1 129 136 PF00134 0.302
DOC_CYCLIN_RxL_1 411 420 PF00134 0.532
DOC_CYCLIN_yCln2_LP_2 244 250 PF00134 0.603
DOC_MAPK_gen_1 152 160 PF00069 0.474
DOC_MAPK_gen_1 22 30 PF00069 0.369
DOC_MAPK_gen_1 310 317 PF00069 0.550
DOC_MAPK_MEF2A_6 152 160 PF00069 0.491
DOC_MIT_MIM_1 157 167 PF04212 0.487
DOC_PP2B_LxvP_1 199 202 PF13499 0.575
DOC_PP2B_LxvP_1 244 247 PF13499 0.599
DOC_USP7_MATH_1 206 210 PF00917 0.560
DOC_USP7_MATH_1 231 235 PF00917 0.776
DOC_USP7_MATH_1 260 264 PF00917 0.605
DOC_USP7_MATH_1 293 297 PF00917 0.661
DOC_USP7_MATH_1 352 356 PF00917 0.527
DOC_USP7_MATH_1 6 10 PF00917 0.647
DOC_WW_Pin1_4 183 188 PF00397 0.681
DOC_WW_Pin1_4 210 215 PF00397 0.644
DOC_WW_Pin1_4 248 253 PF00397 0.641
DOC_WW_Pin1_4 282 287 PF00397 0.625
DOC_WW_Pin1_4 289 294 PF00397 0.656
DOC_WW_Pin1_4 379 384 PF00397 0.573
DOC_WW_Pin1_4 8 13 PF00397 0.552
LIG_14-3-3_CanoR_1 109 119 PF00244 0.376
LIG_14-3-3_CanoR_1 139 148 PF00244 0.302
LIG_14-3-3_CanoR_1 279 286 PF00244 0.712
LIG_14-3-3_CanoR_1 325 335 PF00244 0.489
LIG_14-3-3_CanoR_1 86 91 PF00244 0.267
LIG_Actin_WH2_2 16 33 PF00022 0.360
LIG_BIR_II_1 1 5 PF00653 0.628
LIG_FHA_1 190 196 PF00498 0.641
LIG_FHA_1 211 217 PF00498 0.650
LIG_FHA_1 335 341 PF00498 0.523
LIG_FHA_1 412 418 PF00498 0.495
LIG_FHA_1 96 102 PF00498 0.333
LIG_FHA_2 111 117 PF00498 0.376
LIG_FHA_2 140 146 PF00498 0.507
LIG_FHA_2 345 351 PF00498 0.456
LIG_FHA_2 36 42 PF00498 0.507
LIG_FHA_2 48 54 PF00498 0.384
LIG_LIR_Gen_1 124 130 PF02991 0.360
LIG_LIR_Gen_1 26 35 PF02991 0.360
LIG_LIR_Nem_3 26 30 PF02991 0.360
LIG_NRBOX 311 317 PF00104 0.500
LIG_PTB_Apo_2 68 75 PF02174 0.360
LIG_SH2_CRK 87 91 PF00017 0.376
LIG_SH2_NCK_1 239 243 PF00017 0.510
LIG_SH2_PTP2 27 30 PF00017 0.360
LIG_SH2_SRC 155 158 PF00017 0.490
LIG_SH2_STAP1 35 39 PF00017 0.360
LIG_SH2_STAT5 125 128 PF00017 0.360
LIG_SH2_STAT5 155 158 PF00017 0.414
LIG_SH2_STAT5 239 242 PF00017 0.642
LIG_SH2_STAT5 27 30 PF00017 0.340
LIG_SH3_3 198 204 PF00018 0.649
LIG_SH3_3 246 252 PF00018 0.637
LIG_SH3_3 377 383 PF00018 0.548
LIG_SH3_3 418 424 PF00018 0.570
LIG_SUMO_SIM_par_1 246 251 PF11976 0.563
LIG_TRAF2_1 118 121 PF00917 0.328
LIG_TRAF2_1 342 345 PF00917 0.495
LIG_TRAF2_1 38 41 PF00917 0.360
LIG_UBA3_1 126 133 PF00899 0.360
LIG_UBA3_1 134 141 PF00899 0.360
LIG_UBA3_1 73 82 PF00899 0.329
MOD_CDK_SPK_2 282 287 PF00069 0.647
MOD_CDK_SPK_2 289 294 PF00069 0.615
MOD_CDK_SPxxK_3 210 217 PF00069 0.606
MOD_CK1_1 110 116 PF00069 0.376
MOD_CK1_1 174 180 PF00069 0.659
MOD_CK1_1 183 189 PF00069 0.715
MOD_CK1_1 209 215 PF00069 0.529
MOD_CK1_1 281 287 PF00069 0.672
MOD_CK1_1 29 35 PF00069 0.360
MOD_CK1_1 295 301 PF00069 0.503
MOD_CK1_1 388 394 PF00069 0.574
MOD_CK1_1 406 412 PF00069 0.396
MOD_CK2_1 110 116 PF00069 0.201
MOD_CK2_1 139 145 PF00069 0.300
MOD_CK2_1 170 176 PF00069 0.645
MOD_CK2_1 183 189 PF00069 0.529
MOD_CK2_1 324 330 PF00069 0.521
MOD_CK2_1 35 41 PF00069 0.355
MOD_CK2_1 406 412 PF00069 0.512
MOD_CK2_1 47 53 PF00069 0.300
MOD_CK2_1 93 99 PF00069 0.376
MOD_DYRK1A_RPxSP_1 8 12 PF00069 0.619
MOD_GlcNHglycan 262 265 PF01048 0.635
MOD_GlcNHglycan 276 279 PF01048 0.785
MOD_GlcNHglycan 280 283 PF01048 0.759
MOD_GlcNHglycan 287 290 PF01048 0.573
MOD_GlcNHglycan 326 329 PF01048 0.511
MOD_GlcNHglycan 390 393 PF01048 0.625
MOD_GlcNHglycan 401 404 PF01048 0.484
MOD_GSK3_1 170 177 PF00069 0.632
MOD_GSK3_1 202 209 PF00069 0.628
MOD_GSK3_1 26 33 PF00069 0.337
MOD_GSK3_1 262 269 PF00069 0.729
MOD_GSK3_1 270 277 PF00069 0.668
MOD_GSK3_1 278 285 PF00069 0.538
MOD_GSK3_1 289 296 PF00069 0.566
MOD_GSK3_1 35 42 PF00069 0.297
MOD_GSK3_1 384 391 PF00069 0.668
MOD_GSK3_1 393 400 PF00069 0.603
MOD_GSK3_1 4 11 PF00069 0.667
MOD_GSK3_1 93 100 PF00069 0.376
MOD_N-GLC_1 224 229 PF02516 0.775
MOD_N-GLC_1 266 271 PF02516 0.646
MOD_N-GLC_1 273 278 PF02516 0.569
MOD_N-GLC_1 393 398 PF02516 0.630
MOD_NEK2_1 215 220 PF00069 0.633
MOD_NEK2_1 266 271 PF00069 0.632
MOD_NEK2_1 280 285 PF00069 0.758
MOD_NEK2_1 30 35 PF00069 0.360
MOD_NEK2_1 323 328 PF00069 0.521
MOD_NEK2_1 384 389 PF00069 0.645
MOD_NEK2_1 390 395 PF00069 0.665
MOD_NEK2_1 397 402 PF00069 0.701
MOD_NEK2_1 4 9 PF00069 0.629
MOD_NEK2_1 417 422 PF00069 0.368
MOD_PIKK_1 107 113 PF00454 0.376
MOD_PIKK_1 180 186 PF00454 0.621
MOD_PIKK_1 231 237 PF00454 0.533
MOD_PK_1 52 58 PF00069 0.360
MOD_PKA_1 139 145 PF00069 0.360
MOD_PKA_2 278 284 PF00069 0.728
MOD_PKA_2 293 299 PF00069 0.530
MOD_PKA_2 324 330 PF00069 0.521
MOD_PKA_2 352 358 PF00069 0.658
MOD_PKA_2 366 372 PF00069 0.397
MOD_Plk_1 16 22 PF00069 0.511
MOD_Plk_1 175 181 PF00069 0.607
MOD_Plk_1 224 230 PF00069 0.550
MOD_Plk_1 344 350 PF00069 0.506
MOD_Plk_1 384 390 PF00069 0.685
MOD_Plk_1 39 45 PF00069 0.314
MOD_Plk_1 393 399 PF00069 0.581
MOD_Plk_1 52 58 PF00069 0.348
MOD_Plk_2-3 93 99 PF00069 0.360
MOD_Plk_4 224 230 PF00069 0.550
MOD_Plk_4 344 350 PF00069 0.456
MOD_Plk_4 385 391 PF00069 0.573
MOD_Plk_4 86 92 PF00069 0.315
MOD_ProDKin_1 183 189 PF00069 0.682
MOD_ProDKin_1 210 216 PF00069 0.646
MOD_ProDKin_1 248 254 PF00069 0.645
MOD_ProDKin_1 282 288 PF00069 0.626
MOD_ProDKin_1 289 295 PF00069 0.652
MOD_ProDKin_1 379 385 PF00069 0.573
MOD_ProDKin_1 8 14 PF00069 0.544
MOD_SUMO_for_1 357 360 PF00179 0.537
MOD_SUMO_for_1 64 67 PF00179 0.320
MOD_SUMO_for_1 91 94 PF00179 0.311
MOD_SUMO_rev_2 369 374 PF00179 0.547
TRG_DiLeu_BaEn_1 40 45 PF01217 0.376
TRG_DiLeu_BaLyEn_6 211 216 PF01217 0.603
TRG_ENDOCYTIC_2 125 128 PF00928 0.360
TRG_ENDOCYTIC_2 155 158 PF00928 0.414
TRG_ENDOCYTIC_2 27 30 PF00928 0.360
TRG_ENDOCYTIC_2 87 90 PF00928 0.360
TRG_ER_diArg_1 103 105 PF00400 0.267
TRG_ER_diArg_1 166 169 PF00400 0.546
TRG_ER_diArg_1 22 25 PF00400 0.364
TRG_ER_diArg_1 365 368 PF00400 0.482
TRG_ER_diArg_1 74 76 PF00400 0.360
TRG_Pf-PMV_PEXEL_1 103 107 PF00026 0.267
TRG_Pf-PMV_PEXEL_1 132 136 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 310 314 PF00026 0.537

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y4 Leptomonas seymouri 52% 98%
A0A0S4JG85 Bodo saltans 30% 83%
A0A3Q8IL47 Leishmania donovani 100% 100%
E9AI69 Leishmania braziliensis 78% 100%
E9B522 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4Q2W4 Leishmania major 93% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS