LeishMANIAdb
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Asparagine--tRNA ligase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Asparagine--tRNA ligase
Gene product:
asparaginyl-tRNA synthetase - putative
Species:
Leishmania infantum
UniProt:
A4IA13_LEIIN
TriTrypDb:
LINF_340028800 *
Length:
890

Annotations

Annotations by Jardim et al.

tRNA synthetase, asparaginyl-tRNA synthetase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 12
GO:0110165 cellular anatomical entity 1 12

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IA13
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA13

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006399 tRNA metabolic process 7 12
GO:0006418 tRNA aminoacylation for protein translation 6 12
GO:0006421 asparaginyl-tRNA aminoacylation 7 10
GO:0006520 amino acid metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 12
GO:0043038 amino acid activation 4 12
GO:0043039 tRNA aminoacylation 5 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044281 small molecule metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003676 nucleic acid binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004812 aminoacyl-tRNA ligase activity 4 12
GO:0004816 asparagine-tRNA ligase activity 5 10
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140101 catalytic activity, acting on a tRNA 4 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 826 830 PF00656 0.544
CLV_C14_Caspase3-7 834 838 PF00656 0.451
CLV_C14_Caspase3-7 874 878 PF00656 0.468
CLV_MEL_PAP_1 692 698 PF00089 0.279
CLV_NRD_NRD_1 175 177 PF00675 0.703
CLV_NRD_NRD_1 380 382 PF00675 0.329
CLV_NRD_NRD_1 730 732 PF00675 0.253
CLV_NRD_NRD_1 848 850 PF00675 0.253
CLV_PCSK_FUR_1 173 177 PF00082 0.721
CLV_PCSK_KEX2_1 175 177 PF00082 0.703
CLV_PCSK_KEX2_1 380 382 PF00082 0.267
CLV_PCSK_KEX2_1 656 658 PF00082 0.242
CLV_PCSK_KEX2_1 726 728 PF00082 0.253
CLV_PCSK_KEX2_1 730 732 PF00082 0.232
CLV_PCSK_KEX2_1 832 834 PF00082 0.299
CLV_PCSK_KEX2_1 848 850 PF00082 0.232
CLV_PCSK_PC1ET2_1 656 658 PF00082 0.303
CLV_PCSK_PC1ET2_1 726 728 PF00082 0.328
CLV_PCSK_PC1ET2_1 832 834 PF00082 0.329
CLV_PCSK_PC7_1 652 658 PF00082 0.291
CLV_PCSK_SKI1_1 246 250 PF00082 0.267
CLV_PCSK_SKI1_1 279 283 PF00082 0.253
CLV_PCSK_SKI1_1 394 398 PF00082 0.390
CLV_PCSK_SKI1_1 92 96 PF00082 0.654
CLV_Separin_Metazoa 578 582 PF03568 0.483
DEG_APCC_DBOX_1 575 583 PF00400 0.491
DEG_SCF_FBW7_1 190 197 PF00400 0.640
DEG_SPOP_SBC_1 129 133 PF00917 0.607
DOC_CKS1_1 191 196 PF01111 0.644
DOC_CYCLIN_yCln2_LP_2 107 113 PF00134 0.495
DOC_CYCLIN_yCln2_LP_2 165 171 PF00134 0.618
DOC_CYCLIN_yCln2_LP_2 522 528 PF00134 0.453
DOC_CYCLIN_yCln2_LP_2 62 68 PF00134 0.575
DOC_MAPK_gen_1 254 264 PF00069 0.452
DOC_MAPK_gen_1 367 376 PF00069 0.529
DOC_MAPK_gen_1 470 479 PF00069 0.450
DOC_MAPK_gen_1 574 582 PF00069 0.560
DOC_MAPK_gen_1 730 740 PF00069 0.442
DOC_MAPK_RevD_3 163 176 PF00069 0.686
DOC_PP1_RVXF_1 862 869 PF00149 0.442
DOC_PP2B_LxvP_1 107 110 PF13499 0.700
DOC_PP2B_LxvP_1 165 168 PF13499 0.663
DOC_PP2B_LxvP_1 34 37 PF13499 0.425
DOC_PP2B_LxvP_1 522 525 PF13499 0.453
DOC_USP7_MATH_1 112 116 PF00917 0.569
DOC_USP7_MATH_1 129 133 PF00917 0.478
DOC_USP7_MATH_1 139 143 PF00917 0.687
DOC_USP7_MATH_1 210 214 PF00917 0.714
DOC_USP7_MATH_1 266 270 PF00917 0.401
DOC_USP7_MATH_1 322 326 PF00917 0.541
DOC_USP7_MATH_1 549 553 PF00917 0.503
DOC_USP7_MATH_1 650 654 PF00917 0.451
DOC_USP7_UBL2_3 722 726 PF12436 0.451
DOC_WW_Pin1_4 183 188 PF00397 0.672
DOC_WW_Pin1_4 190 195 PF00397 0.663
DOC_WW_Pin1_4 271 276 PF00397 0.447
DOC_WW_Pin1_4 445 450 PF00397 0.516
DOC_WW_Pin1_4 593 598 PF00397 0.453
DOC_WW_Pin1_4 61 66 PF00397 0.569
DOC_WW_Pin1_4 721 726 PF00397 0.520
DOC_WW_Pin1_4 82 87 PF00397 0.719
LIG_14-3-3_CanoR_1 148 157 PF00244 0.661
LIG_14-3-3_CanoR_1 173 179 PF00244 0.635
LIG_14-3-3_CanoR_1 18 23 PF00244 0.600
LIG_14-3-3_CanoR_1 476 480 PF00244 0.453
LIG_14-3-3_CanoR_1 657 665 PF00244 0.444
LIG_14-3-3_CanoR_1 92 101 PF00244 0.644
LIG_Actin_WH2_2 372 388 PF00022 0.503
LIG_APCC_ABBA_1 580 585 PF00400 0.491
LIG_BRCT_BRCA1_1 608 612 PF00533 0.442
LIG_eIF4E_1 822 828 PF01652 0.529
LIG_FHA_1 195 201 PF00498 0.598
LIG_FHA_1 229 235 PF00498 0.505
LIG_FHA_1 297 303 PF00498 0.481
LIG_FHA_1 308 314 PF00498 0.408
LIG_FHA_1 45 51 PF00498 0.666
LIG_FHA_1 484 490 PF00498 0.520
LIG_FHA_1 633 639 PF00498 0.463
LIG_FHA_1 799 805 PF00498 0.442
LIG_FHA_2 33 39 PF00498 0.634
LIG_FHA_2 364 370 PF00498 0.545
LIG_FHA_2 601 607 PF00498 0.450
LIG_FHA_2 608 614 PF00498 0.432
LIG_FHA_2 661 667 PF00498 0.453
LIG_FHA_2 689 695 PF00498 0.541
LIG_FHA_2 797 803 PF00498 0.454
LIG_GBD_Chelix_1 198 206 PF00786 0.495
LIG_LIR_Gen_1 478 484 PF02991 0.446
LIG_LIR_Gen_1 532 540 PF02991 0.507
LIG_LIR_Gen_1 609 617 PF02991 0.434
LIG_LIR_Gen_1 660 669 PF02991 0.544
LIG_LIR_Gen_1 673 681 PF02991 0.442
LIG_LIR_Gen_1 682 693 PF02991 0.435
LIG_LIR_Gen_1 775 784 PF02991 0.529
LIG_LIR_Nem_3 436 441 PF02991 0.426
LIG_LIR_Nem_3 478 482 PF02991 0.446
LIG_LIR_Nem_3 532 536 PF02991 0.497
LIG_LIR_Nem_3 589 595 PF02991 0.535
LIG_LIR_Nem_3 609 615 PF02991 0.312
LIG_LIR_Nem_3 660 665 PF02991 0.546
LIG_LIR_Nem_3 673 677 PF02991 0.378
LIG_LIR_Nem_3 682 688 PF02991 0.432
LIG_LIR_Nem_3 839 844 PF02991 0.461
LIG_MYND_1 86 90 PF01753 0.631
LIG_Pex14_1 588 592 PF04695 0.529
LIG_Pex14_2 583 587 PF04695 0.453
LIG_Pex14_2 778 782 PF04695 0.483
LIG_Rb_pABgroove_1 551 559 PF01858 0.415
LIG_RPA_C_Fungi 340 352 PF08784 0.362
LIG_SH2_CRK 533 537 PF00017 0.375
LIG_SH2_NCK_1 533 537 PF00017 0.375
LIG_SH2_SRC 630 633 PF00017 0.404
LIG_SH2_SRC 734 737 PF00017 0.352
LIG_SH2_STAP1 734 738 PF00017 0.329
LIG_SH2_STAP1 824 828 PF00017 0.315
LIG_SH2_STAT3 622 625 PF00017 0.329
LIG_SH2_STAT3 844 847 PF00017 0.294
LIG_SH2_STAT5 463 466 PF00017 0.380
LIG_SH2_STAT5 622 625 PF00017 0.296
LIG_SH2_STAT5 630 633 PF00017 0.271
LIG_SH2_STAT5 642 645 PF00017 0.112
LIG_SH2_STAT5 844 847 PF00017 0.294
LIG_SH3_1 722 728 PF00018 0.302
LIG_SH3_2 725 730 PF14604 0.294
LIG_SH3_2 87 92 PF14604 0.700
LIG_SH3_3 106 112 PF00018 0.513
LIG_SH3_3 184 190 PF00018 0.722
LIG_SH3_3 286 292 PF00018 0.383
LIG_SH3_3 443 449 PF00018 0.524
LIG_SH3_3 592 598 PF00018 0.294
LIG_SH3_3 712 718 PF00018 0.283
LIG_SH3_3 722 728 PF00018 0.312
LIG_SH3_3 792 798 PF00018 0.332
LIG_SH3_3 803 809 PF00018 0.279
LIG_SH3_3 84 90 PF00018 0.710
LIG_SH3_3 98 104 PF00018 0.407
LIG_SUMO_SIM_anti_2 801 808 PF11976 0.294
LIG_SUMO_SIM_par_1 103 108 PF11976 0.585
LIG_TRAF2_2 705 710 PF00917 0.362
LIG_UBA3_1 611 620 PF00899 0.256
LIG_UBA3_1 869 876 PF00899 0.415
LIG_WRC_WIRS_1 671 676 PF05994 0.415
LIG_WRC_WIRS_1 786 791 PF05994 0.294
LIG_WW_2 109 112 PF00397 0.495
MOD_CDK_SPK_2 183 188 PF00069 0.731
MOD_CDK_SPK_2 271 276 PF00069 0.294
MOD_CDK_SPK_2 721 726 PF00069 0.362
MOD_CDK_SPxK_1 190 196 PF00069 0.687
MOD_CDK_SPxK_1 721 727 PF00069 0.415
MOD_CK1_1 130 136 PF00069 0.702
MOD_CK1_1 142 148 PF00069 0.682
MOD_CK1_1 152 158 PF00069 0.611
MOD_CK1_1 220 226 PF00069 0.665
MOD_CK1_1 475 481 PF00069 0.310
MOD_CK1_1 539 545 PF00069 0.437
MOD_CK1_1 660 666 PF00069 0.294
MOD_CK1_1 785 791 PF00069 0.362
MOD_CK1_1 80 86 PF00069 0.707
MOD_CK2_1 250 256 PF00069 0.287
MOD_CK2_1 266 272 PF00069 0.287
MOD_CK2_1 32 38 PF00069 0.625
MOD_CK2_1 452 458 PF00069 0.448
MOD_CK2_1 600 606 PF00069 0.329
MOD_CK2_1 607 613 PF00069 0.329
MOD_CK2_1 660 666 PF00069 0.294
MOD_CK2_1 688 694 PF00069 0.362
MOD_CK2_1 796 802 PF00069 0.300
MOD_GlcNHglycan 132 135 PF01048 0.715
MOD_GlcNHglycan 210 213 PF01048 0.710
MOD_GSK3_1 124 131 PF00069 0.729
MOD_GSK3_1 135 142 PF00069 0.679
MOD_GSK3_1 149 156 PF00069 0.616
MOD_GSK3_1 190 197 PF00069 0.613
MOD_GSK3_1 545 552 PF00069 0.414
MOD_GSK3_1 564 571 PF00069 0.195
MOD_GSK3_1 596 603 PF00069 0.340
MOD_GSK3_1 630 637 PF00069 0.347
MOD_GSK3_1 684 691 PF00069 0.380
MOD_GSK3_1 77 84 PF00069 0.747
MOD_GSK3_1 796 803 PF00069 0.331
MOD_NEK2_1 135 140 PF00069 0.733
MOD_NEK2_1 208 213 PF00069 0.648
MOD_NEK2_1 307 312 PF00069 0.310
MOD_NEK2_1 568 573 PF00069 0.348
MOD_NEK2_1 600 605 PF00069 0.316
MOD_NEK2_1 623 628 PF00069 0.294
MOD_NEK2_1 66 71 PF00069 0.694
MOD_NEK2_1 684 689 PF00069 0.362
MOD_NEK2_1 81 86 PF00069 0.593
MOD_NEK2_1 815 820 PF00069 0.459
MOD_NEK2_1 836 841 PF00069 0.420
MOD_NEK2_1 97 102 PF00069 0.607
MOD_NEK2_2 607 612 PF00069 0.294
MOD_PIKK_1 307 313 PF00454 0.294
MOD_PIKK_1 600 606 PF00454 0.329
MOD_PIKK_1 621 627 PF00454 0.294
MOD_PIKK_1 703 709 PF00454 0.437
MOD_PK_1 18 24 PF00069 0.533
MOD_PKA_2 174 180 PF00069 0.587
MOD_PKA_2 475 481 PF00069 0.310
MOD_PKA_2 501 507 PF00069 0.294
MOD_PKA_2 508 514 PF00069 0.294
MOD_PKA_2 564 570 PF00069 0.282
MOD_PKB_1 16 24 PF00069 0.670
MOD_PKB_1 470 478 PF00069 0.294
MOD_Plk_1 220 226 PF00069 0.630
MOD_Plk_1 549 555 PF00069 0.529
MOD_Plk_1 660 666 PF00069 0.294
MOD_Plk_1 836 842 PF00069 0.437
MOD_Plk_2-3 670 676 PF00069 0.389
MOD_Plk_2-3 796 802 PF00069 0.331
MOD_Plk_4 201 207 PF00069 0.608
MOD_Plk_4 475 481 PF00069 0.409
MOD_Plk_4 542 548 PF00069 0.510
MOD_Plk_4 568 574 PF00069 0.380
MOD_Plk_4 596 602 PF00069 0.294
MOD_Plk_4 607 613 PF00069 0.294
MOD_Plk_4 684 690 PF00069 0.366
MOD_Plk_4 785 791 PF00069 0.294
MOD_Plk_4 837 843 PF00069 0.312
MOD_Plk_4 97 103 PF00069 0.641
MOD_ProDKin_1 183 189 PF00069 0.671
MOD_ProDKin_1 190 196 PF00069 0.662
MOD_ProDKin_1 271 277 PF00069 0.301
MOD_ProDKin_1 445 451 PF00069 0.520
MOD_ProDKin_1 593 599 PF00069 0.310
MOD_ProDKin_1 61 67 PF00069 0.571
MOD_ProDKin_1 721 727 PF00069 0.404
MOD_ProDKin_1 82 88 PF00069 0.720
MOD_SUMO_for_1 417 420 PF00179 0.694
MOD_SUMO_for_1 425 428 PF00179 0.701
MOD_SUMO_for_1 518 521 PF00179 0.340
MOD_SUMO_rev_2 271 281 PF00179 0.302
MOD_SUMO_rev_2 407 415 PF00179 0.591
TRG_DiLeu_BaLyEn_6 861 866 PF01217 0.352
TRG_ENDOCYTIC_2 533 536 PF00928 0.370
TRG_ENDOCYTIC_2 592 595 PF00928 0.395
TRG_ENDOCYTIC_2 642 645 PF00928 0.294
TRG_ENDOCYTIC_2 824 827 PF00928 0.315
TRG_ER_diArg_1 16 19 PF00400 0.593
TRG_ER_diArg_1 172 175 PF00400 0.709
TRG_ER_diArg_1 379 381 PF00400 0.415
TRG_ER_diArg_1 729 731 PF00400 0.296
TRG_ER_diArg_1 8 11 PF00400 0.667
TRG_ER_diArg_1 848 850 PF00400 0.409
TRG_Pf-PMV_PEXEL_1 657 661 PF00026 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMR3 Leptomonas seymouri 77% 100%
A0A0S4JDH2 Bodo saltans 60% 100%
A0A1X0P9Y4 Trypanosomatidae 62% 100%
A0A3R7P1H1 Trypanosoma rangeli 63% 100%
A0A3S7X7X7 Leishmania donovani 100% 100%
A4HAU6 Leishmania braziliensis 76% 100%
C9ZMM2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AV72 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B520 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 99%
Q4Q2W6 Leishmania major 94% 100%
Q554D9 Dictyostelium discoideum 39% 100%
V5DGS5 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS