Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IA08_LEIIN

TriTrypDb:

LINF_340028200

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.589
CLV_C14_Caspase3-7	206	210	PF00656	0.532
CLV_C14_Caspase3-7	283	287	PF00656	0.671
CLV_C14_Caspase3-7	60	64	PF00656	0.708
CLV_C14_Caspase3-7	690	694	PF00656	0.729
CLV_C14_Caspase3-7	73	77	PF00656	0.612
CLV_NRD_NRD_1	182	184	PF00675	0.545
CLV_NRD_NRD_1	215	217	PF00675	0.644
CLV_NRD_NRD_1	249	251	PF00675	0.695
CLV_NRD_NRD_1	258	260	PF00675	0.723
CLV_NRD_NRD_1	511	513	PF00675	0.756
CLV_NRD_NRD_1	514	516	PF00675	0.707
CLV_NRD_NRD_1	673	675	PF00675	0.718
CLV_PCSK_FUR_1	512	516	PF00082	0.751
CLV_PCSK_KEX2_1	182	184	PF00082	0.545
CLV_PCSK_KEX2_1	258	260	PF00082	0.705
CLV_PCSK_KEX2_1	301	303	PF00082	0.667
CLV_PCSK_KEX2_1	511	513	PF00082	0.756
CLV_PCSK_KEX2_1	514	516	PF00082	0.707
CLV_PCSK_KEX2_1	673	675	PF00082	0.745
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.650
CLV_PCSK_PC7_1	297	303	PF00082	0.639
CLV_PCSK_PC7_1	669	675	PF00082	0.723
CLV_PCSK_SKI1_1	168	172	PF00082	0.529
CLV_PCSK_SKI1_1	201	205	PF00082	0.590
CLV_PCSK_SKI1_1	276	280	PF00082	0.610
CLV_PCSK_SKI1_1	402	406	PF00082	0.401
CLV_PCSK_SKI1_1	502	506	PF00082	0.542
CLV_PCSK_SKI1_1	620	624	PF00082	0.441
CLV_PCSK_SKI1_1	669	673	PF00082	0.719
CLV_Separin_Metazoa	106	110	PF03568	0.513
CLV_Separin_Metazoa	491	495	PF03568	0.507
DEG_COP1_1	7	16	PF00400	0.587
DEG_SPOP_SBC_1	475	479	PF00917	0.603
DEG_SPOP_SBC_1	590	594	PF00917	0.756
DEG_SPOP_SBC_1	655	659	PF00917	0.710
DOC_CKS1_1	613	618	PF01111	0.475
DOC_CYCLIN_RxL_1	398	407	PF00134	0.435
DOC_CYCLIN_RxL_1	497	507	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	672	678	PF00134	0.626
DOC_MAPK_MEF2A_6	109	118	PF00069	0.479
DOC_MAPK_MEF2A_6	355	362	PF00069	0.439
DOC_PP1_RVXF_1	400	406	PF00149	0.411
DOC_PP4_FxxP_1	606	609	PF00568	0.674
DOC_PP4_FxxP_1	613	616	PF00568	0.497
DOC_USP7_MATH_1	291	295	PF00917	0.694
DOC_USP7_MATH_1	335	339	PF00917	0.598
DOC_USP7_MATH_1	38	42	PF00917	0.767
DOC_USP7_MATH_1	384	388	PF00917	0.593
DOC_USP7_MATH_1	549	553	PF00917	0.538
DOC_USP7_MATH_1	569	573	PF00917	0.640
DOC_USP7_MATH_1	70	74	PF00917	0.773
DOC_USP7_MATH_1	718	722	PF00917	0.749
DOC_WW_Pin1_4	232	237	PF00397	0.685
DOC_WW_Pin1_4	265	270	PF00397	0.584
DOC_WW_Pin1_4	295	300	PF00397	0.752
DOC_WW_Pin1_4	313	318	PF00397	0.249
DOC_WW_Pin1_4	41	46	PF00397	0.695
DOC_WW_Pin1_4	576	581	PF00397	0.740
DOC_WW_Pin1_4	595	600	PF00397	0.452
DOC_WW_Pin1_4	612	617	PF00397	0.581
DOC_WW_Pin1_4	66	71	PF00397	0.785
DOC_WW_Pin1_4	694	699	PF00397	0.666
DOC_WW_Pin1_4	707	712	PF00397	0.542
DOC_WW_Pin1_4	78	83	PF00397	0.741
LIG_14-3-3_CanoR_1	201	211	PF00244	0.575
LIG_14-3-3_CanoR_1	216	222	PF00244	0.456
LIG_14-3-3_CanoR_1	258	267	PF00244	0.674
LIG_14-3-3_CanoR_1	355	359	PF00244	0.431
LIG_14-3-3_CanoR_1	402	410	PF00244	0.465
LIG_14-3-3_CanoR_1	47	57	PF00244	0.597
LIG_Actin_WH2_2	93	111	PF00022	0.516
LIG_BIR_III_2	52	56	PF00653	0.643
LIG_BRCT_BRCA1_1	478	482	PF00533	0.662
LIG_BRCT_BRCA1_1	591	595	PF00533	0.748
LIG_deltaCOP1_diTrp_1	197	202	PF00928	0.376
LIG_FHA_1	155	161	PF00498	0.673
LIG_FHA_1	164	170	PF00498	0.478
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	34	40	PF00498	0.570
LIG_FHA_1	404	410	PF00498	0.486
LIG_FHA_1	499	505	PF00498	0.522
LIG_FHA_1	8	14	PF00498	0.566
LIG_FHA_2	56	62	PF00498	0.719
LIG_FHA_2	677	683	PF00498	0.779
LIG_FHA_2	79	85	PF00498	0.736
LIG_Integrin_RGD_1	582	584	PF01839	0.716
LIG_IRF3_LxIS_1	310	316	PF10401	0.573
LIG_LIR_Apic_2	612	616	PF02991	0.547
LIG_LIR_Apic_2	627	632	PF02991	0.429
LIG_LIR_Apic_2	9	14	PF02991	0.601
LIG_LIR_Gen_1	244	253	PF02991	0.680
LIG_LIR_Nem_3	197	203	PF02991	0.529
LIG_LIR_Nem_3	244	249	PF02991	0.687
LIG_LIR_Nem_3	390	395	PF02991	0.510
LIG_LIR_Nem_3	7	11	PF02991	0.552
LIG_NRBOX	143	149	PF00104	0.541
LIG_NRBOX	93	99	PF00104	0.574
LIG_PCNA_yPIPBox_3	137	148	PF02747	0.566
LIG_PCNA_yPIPBox_3	391	404	PF02747	0.568
LIG_PDZ_Class_3	745	750	PF00595	0.664
LIG_Pex14_2	118	122	PF04695	0.409
LIG_SH2_SRC	662	665	PF00017	0.573
LIG_SH2_STAP1	442	446	PF00017	0.507
LIG_SH2_STAT3	548	551	PF00017	0.701
LIG_SH2_STAT5	11	14	PF00017	0.666
LIG_SH2_STAT5	462	465	PF00017	0.512
LIG_SH2_STAT5	629	632	PF00017	0.587
LIG_SH3_1	629	635	PF00018	0.476
LIG_SH3_2	266	271	PF14604	0.607
LIG_SH3_3	263	269	PF00018	0.606
LIG_SH3_3	596	602	PF00018	0.655
LIG_SH3_3	629	635	PF00018	0.586
LIG_Sin3_3	430	437	PF02671	0.468
LIG_SUMO_SIM_anti_2	450	455	PF11976	0.434
LIG_SUMO_SIM_par_1	145	152	PF11976	0.604
LIG_SUMO_SIM_par_1	309	314	PF11976	0.462
LIG_SUMO_SIM_par_1	586	594	PF11976	0.749
LIG_SUMO_SIM_par_1	96	102	PF11976	0.508
LIG_TRAF2_1	343	346	PF00917	0.521
LIG_TRAF2_1	553	556	PF00917	0.760
MOD_CDC14_SPxK_1	235	238	PF00782	0.672
MOD_CDC14_SPxK_1	268	271	PF00782	0.604
MOD_CDC14_SPxK_1	298	301	PF00782	0.741
MOD_CDC14_SPxK_1	44	47	PF00782	0.654
MOD_CDC14_SPxK_1	579	582	PF00782	0.770
MOD_CDK_SPxK_1	232	238	PF00069	0.681
MOD_CDK_SPxK_1	265	271	PF00069	0.608
MOD_CDK_SPxK_1	295	301	PF00069	0.756
MOD_CDK_SPxK_1	41	47	PF00069	0.668
MOD_CDK_SPxK_1	576	582	PF00069	0.770
MOD_CDK_SPxxK_3	295	302	PF00069	0.751
MOD_CK1_1	163	169	PF00069	0.484
MOD_CK1_1	285	291	PF00069	0.591
MOD_CK1_1	300	306	PF00069	0.648
MOD_CK1_1	316	322	PF00069	0.315
MOD_CK1_1	338	344	PF00069	0.493
MOD_CK1_1	41	47	PF00069	0.746
MOD_CK1_1	476	482	PF00069	0.654
MOD_CK1_1	586	592	PF00069	0.722
MOD_CK1_1	598	604	PF00069	0.622
MOD_CK1_1	657	663	PF00069	0.751
MOD_CK1_1	687	693	PF00069	0.733
MOD_CK1_1	69	75	PF00069	0.818
MOD_CK1_1	697	703	PF00069	0.719
MOD_CK1_1	7	13	PF00069	0.557
MOD_CK1_1	90	96	PF00069	0.559
MOD_CK2_1	143	149	PF00069	0.554
MOD_CK2_1	339	345	PF00069	0.515
MOD_CK2_1	55	61	PF00069	0.713
MOD_CK2_1	676	682	PF00069	0.747
MOD_CK2_1	718	724	PF00069	0.788
MOD_GlcNHglycan	14	17	PF01048	0.550
MOD_GlcNHglycan	162	165	PF01048	0.555
MOD_GlcNHglycan	205	208	PF01048	0.486
MOD_GlcNHglycan	24	27	PF01048	0.528
MOD_GlcNHglycan	286	290	PF01048	0.642
MOD_GlcNHglycan	305	308	PF01048	0.592
MOD_GlcNHglycan	318	321	PF01048	0.413
MOD_GlcNHglycan	328	331	PF01048	0.548
MOD_GlcNHglycan	341	344	PF01048	0.541
MOD_GlcNHglycan	365	368	PF01048	0.472
MOD_GlcNHglycan	468	471	PF01048	0.712
MOD_GlcNHglycan	478	481	PF01048	0.591
MOD_GlcNHglycan	551	554	PF01048	0.743
MOD_GlcNHglycan	676	679	PF01048	0.715
MOD_GlcNHglycan	701	704	PF01048	0.769
MOD_GlcNHglycan	718	721	PF01048	0.723
MOD_GlcNHglycan	72	75	PF01048	0.830
MOD_GlcNHglycan	76	79	PF01048	0.766
MOD_GSK3_1	18	25	PF00069	0.687
MOD_GSK3_1	274	281	PF00069	0.503
MOD_GSK3_1	291	298	PF00069	0.572
MOD_GSK3_1	33	40	PF00069	0.570
MOD_GSK3_1	335	342	PF00069	0.577
MOD_GSK3_1	466	473	PF00069	0.668
MOD_GSK3_1	482	489	PF00069	0.304
MOD_GSK3_1	527	534	PF00069	0.568
MOD_GSK3_1	564	571	PF00069	0.765
MOD_GSK3_1	57	64	PF00069	0.725
MOD_GSK3_1	586	593	PF00069	0.750
MOD_GSK3_1	650	657	PF00069	0.792
MOD_GSK3_1	66	73	PF00069	0.762
MOD_GSK3_1	674	681	PF00069	0.698
MOD_GSK3_1	697	704	PF00069	0.765
MOD_GSK3_1	74	81	PF00069	0.639
MOD_GSK3_1	85	92	PF00069	0.609
MOD_NEK2_1	125	130	PF00069	0.511
MOD_NEK2_1	18	23	PF00069	0.706
MOD_NEK2_1	195	200	PF00069	0.451
MOD_NEK2_1	202	207	PF00069	0.437
MOD_NEK2_1	351	356	PF00069	0.454
MOD_NEK2_1	404	409	PF00069	0.407
MOD_NEK2_1	482	487	PF00069	0.567
MOD_NEK2_1	504	509	PF00069	0.578
MOD_NEK2_1	547	552	PF00069	0.693
MOD_NEK2_1	701	706	PF00069	0.755
MOD_NEK2_1	89	94	PF00069	0.554
MOD_NEK2_2	274	279	PF00069	0.561
MOD_NEK2_2	384	389	PF00069	0.592
MOD_NEK2_2	569	574	PF00069	0.581
MOD_PIKK_1	300	306	PF00454	0.595
MOD_PIKK_1	328	334	PF00454	0.633
MOD_PIKK_1	482	488	PF00454	0.556
MOD_PIKK_1	547	553	PF00454	0.702
MOD_PKA_2	354	360	PF00069	0.435
MOD_PKA_2	638	644	PF00069	0.714
MOD_PKA_2	716	722	PF00069	0.738
MOD_Plk_1	241	247	PF00069	0.668
MOD_Plk_1	422	428	PF00069	0.439
MOD_Plk_1	583	589	PF00069	0.757
MOD_Plk_1	684	690	PF00069	0.735
MOD_Plk_1	731	737	PF00069	0.597
MOD_Plk_4	143	149	PF00069	0.550
MOD_Plk_4	195	201	PF00069	0.493
MOD_Plk_4	354	360	PF00069	0.452
MOD_Plk_4	458	464	PF00069	0.557
MOD_Plk_4	518	524	PF00069	0.751
MOD_Plk_4	583	589	PF00069	0.757
MOD_Plk_4	591	597	PF00069	0.763
MOD_Plk_4	657	663	PF00069	0.751
MOD_Plk_4	7	13	PF00069	0.591
MOD_Plk_4	734	740	PF00069	0.577
MOD_Plk_4	90	96	PF00069	0.492
MOD_ProDKin_1	232	238	PF00069	0.681
MOD_ProDKin_1	265	271	PF00069	0.584
MOD_ProDKin_1	295	301	PF00069	0.749
MOD_ProDKin_1	313	319	PF00069	0.255
MOD_ProDKin_1	41	47	PF00069	0.692
MOD_ProDKin_1	576	582	PF00069	0.744
MOD_ProDKin_1	595	601	PF00069	0.451
MOD_ProDKin_1	612	618	PF00069	0.573
MOD_ProDKin_1	66	72	PF00069	0.785
MOD_ProDKin_1	694	700	PF00069	0.667
MOD_ProDKin_1	707	713	PF00069	0.544
MOD_ProDKin_1	78	84	PF00069	0.738
TRG_DiLeu_BaEn_1	633	638	PF01217	0.688
TRG_ER_diArg_1	136	139	PF00400	0.478
TRG_ER_diArg_1	257	259	PF00400	0.601
TRG_ER_diArg_1	511	514	PF00400	0.752
TRG_ER_diArg_1	672	674	PF00400	0.788
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8V5	Leptomonas seymouri	59%	99%
A0A1X0PAK4	Trypanosomatidae	31%	100%
A0A3R7N1B1	Trypanosoma rangeli	33%	100%
A0A3S7X7X6	Leishmania donovani	100%	100%
A4HAU0	Leishmania braziliensis	73%	100%
E9B514	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q2X2	Leishmania major	92%	100%