Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynamin family/50S ribosome-binding GTPase - putative

Species:

Leishmania infantum

UniProt:

A4IA07_LEIIN

TriTrypDb:

LINF_340028100

Length:

541

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 4
Forrest at al. (procyclic)	yes	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	22
GO:0016020	membrane	2	22
GO:0110165	cellular anatomical entity	1	22
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4IA07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA07

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0005525	GTP binding	5	22
GO:0017076	purine nucleotide binding	4	22
GO:0019001	guanyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032561	guanyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.443
CLV_C14_Caspase3-7	364	368	PF00656	0.448
CLV_C14_Caspase3-7	411	415	PF00656	0.498
CLV_NRD_NRD_1	165	167	PF00675	0.433
CLV_NRD_NRD_1	292	294	PF00675	0.366
CLV_NRD_NRD_1	299	301	PF00675	0.364
CLV_NRD_NRD_1	419	421	PF00675	0.541
CLV_PCSK_KEX2_1	165	167	PF00082	0.411
CLV_PCSK_KEX2_1	292	294	PF00082	0.375
CLV_PCSK_KEX2_1	299	301	PF00082	0.354
CLV_PCSK_KEX2_1	379	381	PF00082	0.384
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.384
CLV_PCSK_SKI1_1	199	203	PF00082	0.416
CLV_PCSK_SKI1_1	204	208	PF00082	0.406
CLV_PCSK_SKI1_1	292	296	PF00082	0.387
CLV_PCSK_SKI1_1	360	364	PF00082	0.371
CLV_PCSK_SKI1_1	384	388	PF00082	0.387
CLV_PCSK_SKI1_1	434	438	PF00082	0.807
CLV_Separin_Metazoa	227	231	PF03568	0.404
CLV_Separin_Metazoa	247	251	PF03568	0.232
DEG_APCC_DBOX_1	314	322	PF00400	0.385
DEG_APCC_DBOX_1	359	367	PF00400	0.422
DEG_SPOP_SBC_1	468	472	PF00917	0.589
DOC_CKS1_1	150	155	PF01111	0.364
DOC_CYCLIN_RxL_1	199	211	PF00134	0.360
DOC_MAPK_gen_1	165	172	PF00069	0.437
DOC_MAPK_gen_1	299	307	PF00069	0.365
DOC_MAPK_gen_1	376	385	PF00069	0.352
DOC_MAPK_gen_1	410	418	PF00069	0.598
DOC_MAPK_gen_1	55	63	PF00069	0.406
DOC_MAPK_MEF2A_6	387	394	PF00069	0.457
DOC_MAPK_MEF2A_6	55	63	PF00069	0.511
DOC_PP1_RVXF_1	143	150	PF00149	0.496
DOC_PP4_FxxP_1	63	66	PF00568	0.283
DOC_USP7_MATH_1	286	290	PF00917	0.436
DOC_USP7_MATH_1	464	468	PF00917	0.621
DOC_USP7_MATH_1	66	70	PF00917	0.296
DOC_USP7_UBL2_3	324	328	PF12436	0.370
DOC_USP7_UBL2_3	417	421	PF12436	0.624
DOC_WW_Pin1_4	149	154	PF00397	0.363
DOC_WW_Pin1_4	447	452	PF00397	0.773
DOC_WW_Pin1_4	453	458	PF00397	0.790
DOC_WW_Pin1_4	494	499	PF00397	0.677
DOC_WW_Pin1_4	501	506	PF00397	0.736
LIG_14-3-3_CanoR_1	121	130	PF00244	0.437
LIG_14-3-3_CanoR_1	145	150	PF00244	0.462
LIG_14-3-3_CanoR_1	250	260	PF00244	0.382
LIG_14-3-3_CanoR_1	292	298	PF00244	0.336
LIG_14-3-3_CanoR_1	299	307	PF00244	0.330
LIG_14-3-3_CanoR_1	345	354	PF00244	0.398
LIG_14-3-3_CanoR_1	426	432	PF00244	0.678
LIG_14-3-3_CanoR_1	434	439	PF00244	0.737
LIG_Actin_WH2_2	130	147	PF00022	0.428
LIG_AP2alpha_1	126	130	PF02296	0.459
LIG_APCC_ABBA_1	97	102	PF00400	0.309
LIG_APCC_ABBAyCdc20_2	204	210	PF00400	0.333
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_2	193	197	PF00653	0.528
LIG_BRCT_BRCA1_1	367	371	PF00533	0.424
LIG_CaM_NSCaTE_8	14	21	PF13499	0.429
LIG_CaM_NSCaTE_8	382	389	PF13499	0.290
LIG_FHA_1	150	156	PF00498	0.372
LIG_FHA_1	28	34	PF00498	0.474
LIG_FHA_1	282	288	PF00498	0.406
LIG_FHA_1	387	393	PF00498	0.417
LIG_FHA_1	478	484	PF00498	0.608
LIG_FHA_2	188	194	PF00498	0.409
LIG_FHA_2	353	359	PF00498	0.292
LIG_FHA_2	362	368	PF00498	0.303
LIG_LIR_Apic_2	254	260	PF02991	0.423
LIG_LIR_Apic_2	62	66	PF02991	0.283
LIG_LIR_Gen_1	102	112	PF02991	0.419
LIG_LIR_Gen_1	128	138	PF02991	0.409
LIG_LIR_Gen_1	164	172	PF02991	0.417
LIG_LIR_Gen_1	276	287	PF02991	0.468
LIG_LIR_Gen_1	333	343	PF02991	0.328
LIG_LIR_Gen_1	39	50	PF02991	0.484
LIG_LIR_Gen_1	92	100	PF02991	0.341
LIG_LIR_Nem_3	102	107	PF02991	0.338
LIG_LIR_Nem_3	128	133	PF02991	0.407
LIG_LIR_Nem_3	164	170	PF02991	0.425
LIG_LIR_Nem_3	181	187	PF02991	0.316
LIG_LIR_Nem_3	234	239	PF02991	0.444
LIG_LIR_Nem_3	276	282	PF02991	0.454
LIG_LIR_Nem_3	329	335	PF02991	0.358
LIG_LIR_Nem_3	368	374	PF02991	0.392
LIG_LIR_Nem_3	39	45	PF02991	0.493
LIG_LIR_Nem_3	72	77	PF02991	0.338
LIG_LIR_Nem_3	92	98	PF02991	0.164
LIG_NRBOX	74	80	PF00104	0.222
LIG_Pex14_1	257	261	PF04695	0.441
LIG_Pex14_2	126	130	PF04695	0.408
LIG_Pex14_2	45	49	PF04695	0.366
LIG_Pex14_2	63	67	PF04695	0.244
LIG_Rb_pABgroove_1	181	189	PF01858	0.299
LIG_SH2_CRK	120	124	PF00017	0.551
LIG_SH2_CRK	232	236	PF00017	0.386
LIG_SH2_GRB2like	236	239	PF00017	0.503
LIG_SH2_PTP2	169	172	PF00017	0.408
LIG_SH2_SRC	167	170	PF00017	0.437
LIG_SH2_STAP1	279	283	PF00017	0.521
LIG_SH2_STAP1	29	33	PF00017	0.474
LIG_SH2_STAP1	335	339	PF00017	0.409
LIG_SH2_STAT3	100	103	PF00017	0.290
LIG_SH2_STAT3	422	425	PF00017	0.586
LIG_SH2_STAT3	77	80	PF00017	0.369
LIG_SH2_STAT5	169	172	PF00017	0.387
LIG_SH2_STAT5	252	255	PF00017	0.388
LIG_SH2_STAT5	27	30	PF00017	0.415
LIG_SH2_STAT5	77	80	PF00017	0.349
LIG_SH2_STAT5	83	86	PF00017	0.331
LIG_SH3_3	134	140	PF00018	0.419
LIG_SH3_3	280	286	PF00018	0.516
LIG_SH3_3	389	395	PF00018	0.359
LIG_SH3_3	41	47	PF00018	0.409
LIG_SH3_3	451	457	PF00018	0.808
LIG_SUMO_SIM_par_1	388	393	PF11976	0.271
LIG_TRAF2_2	286	291	PF00917	0.410
LIG_TYR_ITIM	118	123	PF00017	0.348
LIG_TYR_ITIM	277	282	PF00017	0.509
LIG_UBA3_1	397	402	PF00899	0.516
LIG_WRC_WIRS_1	253	258	PF05994	0.402
LIG_WRC_WIRS_1	60	65	PF05994	0.283
LIG_WW_3	247	251	PF00397	0.409
MOD_CDK_SPK_2	447	452	PF00069	0.608
MOD_CK1_1	313	319	PF00069	0.448
MOD_CK1_1	349	355	PF00069	0.290
MOD_CK1_1	467	473	PF00069	0.639
MOD_CK1_1	496	502	PF00069	0.669
MOD_CK1_1	69	75	PF00069	0.370
MOD_CK2_1	28	34	PF00069	0.467
MOD_GlcNHglycan	157	161	PF01048	0.619
MOD_GlcNHglycan	427	430	PF01048	0.696
MOD_GlcNHglycan	447	450	PF01048	0.692
MOD_GlcNHglycan	68	71	PF01048	0.342
MOD_GSK3_1	145	152	PF00069	0.392
MOD_GSK3_1	23	30	PF00069	0.542
MOD_GSK3_1	341	348	PF00069	0.379
MOD_GSK3_1	361	368	PF00069	0.346
MOD_GSK3_1	464	471	PF00069	0.757
MOD_GSK3_1	493	500	PF00069	0.781
MOD_GSK3_1	65	72	PF00069	0.339
MOD_GSK3_1	89	96	PF00069	0.337
MOD_N-GLC_1	237	242	PF02516	0.408
MOD_NEK2_1	113	118	PF00069	0.486
MOD_NEK2_1	18	23	PF00069	0.397
MOD_NEK2_1	251	256	PF00069	0.447
MOD_NEK2_1	28	33	PF00069	0.284
MOD_NEK2_1	281	286	PF00069	0.448
MOD_NEK2_1	385	390	PF00069	0.413
MOD_NEK2_1	50	55	PF00069	0.309
MOD_NEK2_1	516	521	PF00069	0.533
MOD_PIKK_1	121	127	PF00454	0.440
MOD_PIKK_1	471	477	PF00454	0.612
MOD_PIKK_1	533	539	PF00454	0.654
MOD_PK_1	219	225	PF00069	0.374
MOD_PKA_1	292	298	PF00069	0.461
MOD_PKA_1	299	305	PF00069	0.461
MOD_PKA_2	292	298	PF00069	0.356
MOD_PKA_2	299	305	PF00069	0.341
MOD_PKA_2	425	431	PF00069	0.680
MOD_PKA_2	45	51	PF00069	0.359
MOD_Plk_1	18	24	PF00069	0.499
MOD_Plk_1	349	355	PF00069	0.290
MOD_Plk_1	36	42	PF00069	0.359
MOD_Plk_1	402	408	PF00069	0.668
MOD_Plk_1	516	522	PF00069	0.641
MOD_Plk_4	145	151	PF00069	0.371
MOD_Plk_4	18	24	PF00069	0.493
MOD_Plk_4	231	237	PF00069	0.430
MOD_Plk_4	252	258	PF00069	0.411
MOD_Plk_4	293	299	PF00069	0.355
MOD_Plk_4	334	340	PF00069	0.496
MOD_Plk_4	45	51	PF00069	0.355
MOD_Plk_4	477	483	PF00069	0.591
MOD_Plk_4	519	525	PF00069	0.603
MOD_Plk_4	59	65	PF00069	0.324
MOD_Plk_4	70	76	PF00069	0.350
MOD_ProDKin_1	149	155	PF00069	0.365
MOD_ProDKin_1	447	453	PF00069	0.776
MOD_ProDKin_1	494	500	PF00069	0.683
MOD_ProDKin_1	501	507	PF00069	0.735
MOD_SUMO_rev_2	209	213	PF00179	0.455
TRG_DiLeu_BaEn_1	178	183	PF01217	0.369
TRG_DiLeu_BaEn_1	273	278	PF01217	0.384
TRG_DiLeu_BaEn_3	333	339	PF01217	0.329
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.491
TRG_ENDOCYTIC_2	120	123	PF00928	0.375
TRG_ENDOCYTIC_2	167	170	PF00928	0.389
TRG_ENDOCYTIC_2	232	235	PF00928	0.386
TRG_ENDOCYTIC_2	236	239	PF00928	0.396
TRG_ENDOCYTIC_2	279	282	PF00928	0.509
TRG_ENDOCYTIC_2	335	338	PF00928	0.387
TRG_ENDOCYTIC_2	42	45	PF00928	0.309
TRG_ER_diArg_1	165	167	PF00400	0.385
TRG_ER_diArg_1	292	294	PF00400	0.393
TRG_ER_diArg_1	298	300	PF00400	0.382
TRG_ER_diArg_1	314	317	PF00400	0.353
TRG_NES_CRM1_1	514	530	PF08389	0.659
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	47%	91%
A0A0N0P9A4	Leptomonas seymouri	74%	98%
A0A0S4KGM0	Bodo saltans	48%	89%
A0A1X0P6D7	Trypanosomatidae	50%	99%
A0A1X0P9Q8	Trypanosomatidae	62%	97%
A0A3R7LDF3	Trypanosoma rangeli	48%	100%
A0A3S7WV81	Leishmania donovani	46%	86%
A0A3S7X801	Leishmania donovani	100%	100%
A0A422P0G8	Trypanosoma rangeli	60%	99%
A4H9Y5	Leishmania braziliensis	46%	86%
A4HAT9	Leishmania braziliensis	78%	100%
A4HY50	Leishmania infantum	46%	86%
B3LF48	Arabidopsis thaliana	35%	99%
C9ZMM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	87%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	86%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2X3	Leishmania major	94%	100%
Q4QDJ3	Leishmania major	45%	85%
Q4V8H8	Rattus norvegicus	34%	100%
Q5E9R3	Bos taurus	34%	100%
Q5RBP4	Pongo abelii	34%	100%
Q641Z6	Rattus norvegicus	34%	100%
Q94CF0	Arabidopsis thaliana	36%	99%
Q9H223	Homo sapiens	34%	100%
Q9H4M9	Homo sapiens	34%	100%
Q9NZN4	Homo sapiens	33%	100%
Q9WVK4	Mus musculus	34%	100%
V5BSA9	Trypanosoma cruzi	46%	100%
V5DGT0	Trypanosoma cruzi	61%	99%
V5DMH3	Trypanosoma cruzi	26%	100%