Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IA02_LEIIN

TriTrypDb:

LINF_340029800

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IA02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.565
CLV_NRD_NRD_1	180	182	PF00675	0.638
CLV_NRD_NRD_1	31	33	PF00675	0.488
CLV_PCSK_KEX2_1	182	184	PF00082	0.628
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.653
CLV_PCSK_SKI1_1	182	186	PF00082	0.612
CLV_PCSK_SKI1_1	33	37	PF00082	0.449
DEG_SPOP_SBC_1	115	119	PF00917	0.645
DOC_ANK_TNKS_1	145	152	PF00023	0.463
DOC_CKS1_1	15	20	PF01111	0.473
DOC_MAPK_MEF2A_6	80	89	PF00069	0.414
DOC_PP4_FxxP_1	100	103	PF00568	0.620
DOC_PP4_FxxP_1	147	150	PF00568	0.439
DOC_PP4_FxxP_1	15	18	PF00568	0.509
DOC_PP4_FxxP_1	91	94	PF00568	0.446
DOC_SPAK_OSR1_1	146	150	PF12202	0.464
DOC_USP7_MATH_1	115	119	PF00917	0.666
DOC_USP7_MATH_1	18	22	PF00917	0.449
DOC_WW_Pin1_4	14	19	PF00397	0.468
DOC_WW_Pin1_4	72	77	PF00397	0.466
LIG_14-3-3_CanoR_1	129	137	PF00244	0.641
LIG_14-3-3_CanoR_1	32	40	PF00244	0.503
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_eIF4E_1	59	65	PF01652	0.434
LIG_FHA_1	97	103	PF00498	0.608
LIG_FHA_2	15	21	PF00498	0.440
LIG_FHA_2	165	171	PF00498	0.572
LIG_LIR_Apic_2	90	94	PF02991	0.372
LIG_LIR_Apic_2	97	103	PF02991	0.525
LIG_LIR_Gen_1	20	29	PF02991	0.500
LIG_LIR_Nem_3	20	25	PF02991	0.373
LIG_SH2_CRK	79	83	PF00017	0.453
LIG_SH2_STAT5	22	25	PF00017	0.457
LIG_SH2_STAT5	59	62	PF00017	0.445
LIG_UBA3_1	152	160	PF00899	0.444
MOD_CK1_1	111	117	PF00069	0.652
MOD_CK1_1	119	125	PF00069	0.656
MOD_CK1_1	27	33	PF00069	0.507
MOD_CK2_1	121	127	PF00069	0.739
MOD_CK2_1	14	20	PF00069	0.475
MOD_GlcNHglycan	27	30	PF01048	0.464
MOD_GSK3_1	111	118	PF00069	0.610
MOD_GSK3_1	119	126	PF00069	0.678
MOD_GSK3_1	129	136	PF00069	0.632
MOD_GSK3_1	14	21	PF00069	0.454
MOD_LATS_1	121	127	PF00433	0.703
MOD_N-GLC_1	72	77	PF02516	0.591
MOD_NEK2_1	108	113	PF00069	0.575
MOD_NEK2_1	25	30	PF00069	0.457
MOD_NEK2_1	35	40	PF00069	0.398
MOD_NEK2_1	83	88	PF00069	0.447
MOD_NEK2_1	95	100	PF00069	0.476
MOD_PKA_2	122	128	PF00069	0.703
MOD_PKA_2	57	63	PF00069	0.426
MOD_Plk_1	96	102	PF00069	0.592
MOD_Plk_4	18	24	PF00069	0.523
MOD_Plk_4	35	41	PF00069	0.266
MOD_ProDKin_1	14	20	PF00069	0.462
MOD_ProDKin_1	72	78	PF00069	0.464
TRG_ENDOCYTIC_2	22	25	PF00928	0.382
TRG_ENDOCYTIC_2	81	84	PF00928	0.531
TRG_ER_diArg_1	180	183	PF00400	0.610
TRG_NLS_MonoExtC_3	180	185	PF00514	0.647
TRG_NLS_MonoExtN_4	179	186	PF00514	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I235	Leptomonas seymouri	71%	100%
A0A0S4INZ5	Bodo saltans	40%	94%
A0A1X0P9P7	Trypanosomatidae	58%	100%
A0A3R7KWP6	Trypanosoma rangeli	53%	100%
A0A3S7X7Y8	Leishmania donovani	98%	100%
A4HAV5	Leishmania braziliensis	87%	100%
C9ZMK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B530	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2V6	Leishmania major	96%	100%