DNAj-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNAj-like protein

Gene product:

DNAj-like protein

Species:

Leishmania infantum

UniProt:

A4IA01_LEIIN

TriTrypDb:

LINF_340029700

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IA01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA01

Function

Biological processes
Term	Name	Level	Count
GO:0007154	cell communication	2	1
GO:0007267	cell-cell signaling	2	1
GO:0007268	chemical synaptic transmission	6	1
GO:0009987	cellular process	1	1
GO:0023052	signaling	1	1
GO:0098916	anterograde trans-synaptic signaling	5	1
GO:0099536	synaptic signaling	3	1
GO:0099537	trans-synaptic signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0005102	signaling receptor binding	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0033130	acetylcholine receptor binding	4	1
GO:0043495	protein-membrane adaptor activity	3	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.663
CLV_C14_Caspase3-7	756	760	PF00656	0.440
CLV_NRD_NRD_1	108	110	PF00675	0.729
CLV_NRD_NRD_1	201	203	PF00675	0.460
CLV_NRD_NRD_1	243	245	PF00675	0.630
CLV_NRD_NRD_1	322	324	PF00675	0.561
CLV_NRD_NRD_1	353	355	PF00675	0.543
CLV_NRD_NRD_1	548	550	PF00675	0.534
CLV_NRD_NRD_1	649	651	PF00675	0.335
CLV_NRD_NRD_1	763	765	PF00675	0.436
CLV_PCSK_FUR_1	247	251	PF00082	0.619
CLV_PCSK_KEX2_1	108	110	PF00082	0.729
CLV_PCSK_KEX2_1	201	203	PF00082	0.479
CLV_PCSK_KEX2_1	243	245	PF00082	0.631
CLV_PCSK_KEX2_1	249	251	PF00082	0.626
CLV_PCSK_KEX2_1	322	324	PF00082	0.650
CLV_PCSK_KEX2_1	435	437	PF00082	0.573
CLV_PCSK_KEX2_1	649	651	PF00082	0.335
CLV_PCSK_KEX2_1	762	764	PF00082	0.351
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.631
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.568
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.354
CLV_PCSK_SKI1_1	178	182	PF00082	0.490
CLV_PCSK_SKI1_1	202	206	PF00082	0.448
CLV_PCSK_SKI1_1	220	224	PF00082	0.655
CLV_PCSK_SKI1_1	243	247	PF00082	0.721
CLV_PCSK_SKI1_1	370	374	PF00082	0.568
CLV_PCSK_SKI1_1	665	669	PF00082	0.337
CLV_PCSK_SKI1_1	709	713	PF00082	0.349
CLV_PCSK_SKI1_1	714	718	PF00082	0.319
CLV_Separin_Metazoa	214	218	PF03568	0.643
CLV_Separin_Metazoa	221	225	PF03568	0.531
CLV_Separin_Metazoa	409	413	PF03568	0.523
DEG_APCC_DBOX_1	219	227	PF00400	0.560
DEG_SPOP_SBC_1	11	15	PF00917	0.773
DEG_SPOP_SBC_1	16	20	PF00917	0.699
DEG_SPOP_SBC_1	283	287	PF00917	0.666
DOC_CKS1_1	474	479	PF01111	0.480
DOC_MAPK_gen_1	201	207	PF00069	0.604
DOC_MAPK_gen_1	717	725	PF00069	0.335
DOC_MAPK_MEF2A_6	184	191	PF00069	0.576
DOC_MAPK_RevD_3	187	202	PF00069	0.501
DOC_MAPK_RevD_3	230	244	PF00069	0.603
DOC_PP2B_LxvP_1	205	208	PF13499	0.632
DOC_PP4_FxxP_1	474	477	PF00568	0.488
DOC_PP4_FxxP_1	94	97	PF00568	0.743
DOC_USP7_MATH_1	133	137	PF00917	0.718
DOC_USP7_MATH_1	146	150	PF00917	0.728
DOC_USP7_MATH_1	151	155	PF00917	0.681
DOC_USP7_MATH_1	16	20	PF00917	0.731
DOC_USP7_MATH_1	194	198	PF00917	0.577
DOC_USP7_MATH_1	283	287	PF00917	0.638
DOC_USP7_MATH_1	311	315	PF00917	0.578
DOC_USP7_MATH_1	424	428	PF00917	0.508
DOC_USP7_MATH_1	48	52	PF00917	0.730
DOC_USP7_UBL2_3	641	645	PF12436	0.447
DOC_USP7_UBL2_3	693	697	PF12436	0.514
DOC_WW_Pin1_4	123	128	PF00397	0.668
DOC_WW_Pin1_4	272	277	PF00397	0.761
DOC_WW_Pin1_4	37	42	PF00397	0.789
DOC_WW_Pin1_4	441	446	PF00397	0.548
DOC_WW_Pin1_4	473	478	PF00397	0.485
DOC_WW_Pin1_4	523	528	PF00397	0.428
LIG_14-3-3_CanoR_1	322	326	PF00244	0.652
LIG_14-3-3_CanoR_1	423	431	PF00244	0.519
LIG_14-3-3_CanoR_1	448	457	PF00244	0.597
LIG_14-3-3_CanoR_1	497	504	PF00244	0.510
LIG_14-3-3_CanoR_1	531	539	PF00244	0.466
LIG_14-3-3_CanoR_1	709	718	PF00244	0.354
LIG_14-3-3_CanoR_1	93	97	PF00244	0.790
LIG_Actin_WH2_2	165	180	PF00022	0.628
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_FHA_1	126	132	PF00498	0.679
LIG_FHA_1	268	274	PF00498	0.750
LIG_FHA_1	367	373	PF00498	0.441
LIG_FHA_1	594	600	PF00498	0.406
LIG_FHA_1	632	638	PF00498	0.335
LIG_FHA_1	72	78	PF00498	0.777
LIG_FHA_2	155	161	PF00498	0.663
LIG_FHA_2	263	269	PF00498	0.690
LIG_FHA_2	296	302	PF00498	0.570
LIG_FHA_2	442	448	PF00498	0.561
LIG_FHA_2	674	680	PF00498	0.568
LIG_FHA_2	708	714	PF00498	0.415
LIG_FHA_2	754	760	PF00498	0.335
LIG_LIR_Apic_2	471	477	PF02991	0.487
LIG_LIR_Apic_2	91	97	PF02991	0.745
LIG_LIR_Gen_1	100	110	PF02991	0.698
LIG_LIR_Gen_1	540	548	PF02991	0.404
LIG_LIR_Gen_1	659	667	PF02991	0.447
LIG_LIR_Gen_1	751	761	PF02991	0.396
LIG_LIR_Nem_3	100	106	PF02991	0.750
LIG_LIR_Nem_3	480	486	PF02991	0.430
LIG_LIR_Nem_3	540	545	PF02991	0.400
LIG_LIR_Nem_3	593	597	PF02991	0.561
LIG_LIR_Nem_3	642	647	PF02991	0.447
LIG_LIR_Nem_3	659	664	PF02991	0.447
LIG_LIR_Nem_3	700	705	PF02991	0.342
LIG_LIR_Nem_3	744	750	PF02991	0.335
LIG_LIR_Nem_3	751	757	PF02991	0.335
LIG_PCNA_yPIPBox_3	605	616	PF02747	0.487
LIG_PTB_Apo_2	355	362	PF02174	0.577
LIG_PTB_Phospho_1	355	361	PF10480	0.576
LIG_RPA_C_Fungi	318	330	PF08784	0.524
LIG_SH2_CRK	483	487	PF00017	0.525
LIG_SH2_CRK	754	758	PF00017	0.396
LIG_SH2_GRB2like	356	359	PF00017	0.588
LIG_SH2_NCK_1	356	360	PF00017	0.484
LIG_SH2_SRC	356	359	PF00017	0.556
LIG_SH2_STAP1	368	372	PF00017	0.419
LIG_SH2_STAP1	595	599	PF00017	0.393
LIG_SH2_STAP1	647	651	PF00017	0.335
LIG_SH2_STAP1	754	758	PF00017	0.412
LIG_SH2_STAT3	395	398	PF00017	0.568
LIG_SH2_STAT5	361	364	PF00017	0.404
LIG_SH2_STAT5	368	371	PF00017	0.390
LIG_SH2_STAT5	538	541	PF00017	0.371
LIG_SH2_STAT5	544	547	PF00017	0.399
LIG_SH2_STAT5	595	598	PF00017	0.409
LIG_SH2_STAT5	613	616	PF00017	0.335
LIG_SH2_STAT5	702	705	PF00017	0.358
LIG_SH3_3	270	276	PF00018	0.779
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.561
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.517
LIG_TYR_ITIM	718	723	PF00017	0.354
MOD_CDK_SPK_2	441	446	PF00069	0.609
MOD_CDK_SPxxK_3	441	448	PF00069	0.536
MOD_CK1_1	126	132	PF00069	0.630
MOD_CK1_1	136	142	PF00069	0.595
MOD_CK1_1	14	20	PF00069	0.710
MOD_CK1_1	154	160	PF00069	0.690
MOD_CK1_1	275	281	PF00069	0.702
MOD_CK1_1	427	433	PF00069	0.545
MOD_CK1_1	44	50	PF00069	0.798
MOD_CK1_1	500	506	PF00069	0.518
MOD_CK1_1	521	527	PF00069	0.462
MOD_CK1_1	785	791	PF00069	0.578
MOD_CK2_1	15	21	PF00069	0.650
MOD_CK2_1	262	268	PF00069	0.665
MOD_CK2_1	295	301	PF00069	0.560
MOD_CK2_1	312	318	PF00069	0.553
MOD_CK2_1	448	454	PF00069	0.538
MOD_CK2_1	459	465	PF00069	0.391
MOD_CK2_1	500	506	PF00069	0.550
MOD_CK2_1	537	543	PF00069	0.383
MOD_CK2_1	673	679	PF00069	0.507
MOD_CK2_1	707	713	PF00069	0.361
MOD_GlcNHglycan	138	141	PF01048	0.783
MOD_GlcNHglycan	14	17	PF01048	0.732
MOD_GlcNHglycan	142	145	PF01048	0.750
MOD_GlcNHglycan	149	152	PF01048	0.750
MOD_GlcNHglycan	153	156	PF01048	0.708
MOD_GlcNHglycan	254	257	PF01048	0.749
MOD_GlcNHglycan	309	312	PF01048	0.567
MOD_GlcNHglycan	390	393	PF01048	0.398
MOD_GlcNHglycan	426	429	PF01048	0.495
MOD_GlcNHglycan	461	464	PF01048	0.419
MOD_GlcNHglycan	499	502	PF01048	0.517
MOD_GlcNHglycan	50	53	PF01048	0.784
MOD_GlcNHglycan	539	542	PF01048	0.409
MOD_GlcNHglycan	66	69	PF01048	0.655
MOD_GlcNHglycan	787	790	PF01048	0.605
MOD_GlcNHglycan	81	84	PF01048	0.798
MOD_GSK3_1	10	17	PF00069	0.704
MOD_GSK3_1	104	111	PF00069	0.702
MOD_GSK3_1	118	125	PF00069	0.593
MOD_GSK3_1	136	143	PF00069	0.696
MOD_GSK3_1	147	154	PF00069	0.728
MOD_GSK3_1	307	314	PF00069	0.582
MOD_GSK3_1	317	324	PF00069	0.594
MOD_GSK3_1	37	44	PF00069	0.796
MOD_GSK3_1	46	53	PF00069	0.789
MOD_GSK3_1	705	712	PF00069	0.354
MOD_GSK3_1	781	788	PF00069	0.693
MOD_GSK3_1	88	95	PF00069	0.801
MOD_N-GLC_1	133	138	PF02516	0.728
MOD_N-GLC_1	151	156	PF02516	0.769
MOD_N-GLC_1	170	175	PF02516	0.503
MOD_N-GLC_1	259	264	PF02516	0.791
MOD_N-GLC_1	37	42	PF02516	0.752
MOD_N-GLC_1	388	393	PF02516	0.387
MOD_N-GLC_1	781	786	PF02516	0.660
MOD_N-GLC_2	401	403	PF02516	0.503
MOD_NEK2_1	147	152	PF00069	0.767
MOD_NEK2_1	490	495	PF00069	0.432
MOD_NEK2_1	520	525	PF00069	0.530
MOD_NEK2_1	537	542	PF00069	0.251
MOD_NEK2_1	705	710	PF00069	0.335
MOD_NEK2_1	781	786	PF00069	0.662
MOD_PIKK_1	118	124	PF00454	0.784
MOD_PIKK_1	254	260	PF00454	0.765
MOD_PKA_1	108	114	PF00069	0.686
MOD_PKA_2	108	114	PF00069	0.559
MOD_PKA_2	147	153	PF00069	0.735
MOD_PKA_2	321	327	PF00069	0.640
MOD_PKA_2	447	453	PF00069	0.587
MOD_PKA_2	773	779	PF00069	0.530
MOD_PKA_2	92	98	PF00069	0.712
MOD_Plk_1	41	47	PF00069	0.791
MOD_Plk_1	721	727	PF00069	0.327
MOD_Plk_2-3	23	29	PF00069	0.667
MOD_Plk_4	753	759	PF00069	0.323
MOD_ProDKin_1	123	129	PF00069	0.669
MOD_ProDKin_1	272	278	PF00069	0.761
MOD_ProDKin_1	37	43	PF00069	0.789
MOD_ProDKin_1	441	447	PF00069	0.556
MOD_ProDKin_1	473	479	PF00069	0.477
MOD_ProDKin_1	523	529	PF00069	0.419
MOD_SUMO_for_1	266	269	PF00179	0.787
MOD_SUMO_for_1	97	100	PF00179	0.738
MOD_SUMO_rev_2	713	718	PF00179	0.341
MOD_SUMO_rev_2	739	747	PF00179	0.357
TRG_ENDOCYTIC_2	483	486	PF00928	0.511
TRG_ENDOCYTIC_2	594	597	PF00928	0.554
TRG_ENDOCYTIC_2	620	623	PF00928	0.387
TRG_ENDOCYTIC_2	702	705	PF00928	0.338
TRG_ENDOCYTIC_2	720	723	PF00928	0.378
TRG_ENDOCYTIC_2	754	757	PF00928	0.396
TRG_ER_diArg_1	108	110	PF00400	0.778
TRG_ER_diArg_1	243	245	PF00400	0.650
TRG_ER_diArg_1	496	499	PF00400	0.402
TRG_ER_diArg_1	649	652	PF00400	0.335
TRG_ER_diArg_1	796	799	PF00400	0.720
TRG_NES_CRM1_1	402	414	PF08389	0.473
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	678	683	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH1	Leptomonas seymouri	62%	100%
A0A1X0P9Z7	Trypanosomatidae	51%	100%
A0A3S7X821	Leishmania donovani	100%	100%
A0A422P0G2	Trypanosoma rangeli	50%	100%
A4HAV4	Leishmania braziliensis	81%	100%
C9ZML0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B529	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q2V7	Leishmania major	95%	100%
V5BKG1	Trypanosoma cruzi	48%	100%