LeishMANIAdb
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Alpha-1,3/1,6-mannosyltransferase ALG2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Alpha-1,3/1,6-mannosyltransferase ALG2
Gene product:
dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1 -3-mannosyltransferase - putative
Species:
Leishmania infantum
UniProt:
A4IA00_LEIIN
TriTrypDb:
LINF_340029600
Length:
550

Annotations

Annotations by Jardim et al.

Glycosylation, dolichyl-P-Man:GDP-Man1GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4IA00
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IA00

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0019538 protein metabolic process 3 11
GO:0036211 protein modification process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0043412 macromolecule modification 4 11
GO:0043413 macromolecule glycosylation 3 11
GO:0044238 primary metabolic process 2 11
GO:0070085 glycosylation 2 11
GO:0071704 organic substance metabolic process 2 11
GO:1901564 organonitrogen compound metabolic process 3 11
GO:0006490 oligosaccharide-lipid intermediate biosynthetic process 4 1
GO:0006629 lipid metabolic process 3 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 1
GO:0044237 cellular metabolic process 2 1
GO:0044255 cellular lipid metabolic process 3 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901137 carbohydrate derivative biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0000030 mannosyltransferase activity 5 11
GO:0003824 catalytic activity 1 11
GO:0004376 glycolipid mannosyltransferase activity 6 11
GO:0004378 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity 7 11
GO:0016740 transferase activity 2 11
GO:0016757 glycosyltransferase activity 3 11
GO:0016758 hexosyltransferase activity 4 11
GO:0102704 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity 5 11
GO:0000033 alpha-1,3-mannosyltransferase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.473
CLV_NRD_NRD_1 325 327 PF00675 0.218
CLV_NRD_NRD_1 36 38 PF00675 0.317
CLV_PCSK_FUR_1 36 40 PF00082 0.330
CLV_PCSK_KEX2_1 107 109 PF00082 0.266
CLV_PCSK_KEX2_1 36 38 PF00082 0.289
CLV_PCSK_PC1ET2_1 107 109 PF00082 0.266
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.351
CLV_PCSK_SKI1_1 220 224 PF00082 0.328
CLV_PCSK_SKI1_1 237 241 PF00082 0.283
CLV_PCSK_SKI1_1 249 253 PF00082 0.278
CLV_PCSK_SKI1_1 292 296 PF00082 0.386
CLV_PCSK_SKI1_1 306 310 PF00082 0.375
CLV_PCSK_SKI1_1 393 397 PF00082 0.263
CLV_PCSK_SKI1_1 403 407 PF00082 0.180
CLV_PCSK_SKI1_1 522 526 PF00082 0.397
CLV_PCSK_SKI1_1 81 85 PF00082 0.260
CLV_Separin_Metazoa 78 82 PF03568 0.530
DEG_Nend_UBRbox_2 1 3 PF02207 0.304
DEG_SCF_FBW7_2 413 420 PF00400 0.408
DOC_CKS1_1 414 419 PF01111 0.444
DOC_MAPK_gen_1 107 113 PF00069 0.561
DOC_MAPK_gen_1 26 34 PF00069 0.448
DOC_MAPK_gen_1 323 332 PF00069 0.414
DOC_MAPK_gen_1 352 359 PF00069 0.503
DOC_MAPK_JIP1_4 353 359 PF00069 0.452
DOC_MAPK_MEF2A_6 326 334 PF00069 0.408
DOC_MAPK_MEF2A_6 352 359 PF00069 0.503
DOC_MAPK_MEF2A_6 77 84 PF00069 0.444
DOC_MAPK_NFAT4_5 327 335 PF00069 0.408
DOC_MAPK_RevD_3 23 38 PF00069 0.319
DOC_PIKK_1 369 377 PF02985 0.497
DOC_PP1_RVXF_1 79 85 PF00149 0.481
DOC_PP2B_LxvP_1 385 388 PF13499 0.503
DOC_PP4_FxxP_1 283 286 PF00568 0.441
DOC_PP4_FxxP_1 84 87 PF00568 0.453
DOC_USP7_MATH_1 444 448 PF00917 0.408
DOC_USP7_MATH_1 540 544 PF00917 0.675
DOC_USP7_UBL2_3 542 546 PF12436 0.691
DOC_WW_Pin1_4 196 201 PF00397 0.320
DOC_WW_Pin1_4 413 418 PF00397 0.444
DOC_WW_Pin1_4 462 467 PF00397 0.467
LIG_14-3-3_CanoR_1 220 229 PF00244 0.634
LIG_14-3-3_CanoR_1 26 34 PF00244 0.535
LIG_14-3-3_CanoR_1 386 395 PF00244 0.462
LIG_14-3-3_CanoR_1 515 524 PF00244 0.540
LIG_BRCT_BRCA1_1 125 129 PF00533 0.585
LIG_BRCT_BRCA1_1 246 250 PF00533 0.545
LIG_CaM_IQ_9 504 519 PF13499 0.493
LIG_CtBP_PxDLS_1 528 533 PF00389 0.482
LIG_FHA_1 134 140 PF00498 0.473
LIG_FHA_1 197 203 PF00498 0.401
LIG_FHA_1 250 256 PF00498 0.508
LIG_FHA_1 380 386 PF00498 0.490
LIG_FHA_1 509 515 PF00498 0.500
LIG_FHA_2 269 275 PF00498 0.546
LIG_LIR_Apic_2 170 175 PF02991 0.294
LIG_LIR_Apic_2 280 286 PF02991 0.447
LIG_LIR_Gen_1 317 324 PF02991 0.488
LIG_LIR_Gen_1 335 341 PF02991 0.335
LIG_LIR_Gen_1 42 51 PF02991 0.525
LIG_LIR_Nem_3 234 239 PF02991 0.472
LIG_LIR_Nem_3 267 272 PF02991 0.492
LIG_LIR_Nem_3 281 287 PF02991 0.399
LIG_LIR_Nem_3 317 321 PF02991 0.488
LIG_LIR_Nem_3 335 340 PF02991 0.335
LIG_LIR_Nem_3 42 47 PF02991 0.515
LIG_LIR_Nem_3 420 425 PF02991 0.409
LIG_LYPXL_S_1 283 287 PF13949 0.242
LIG_LYPXL_yS_3 284 287 PF13949 0.445
LIG_Pex14_1 232 236 PF04695 0.623
LIG_Pex14_2 168 172 PF04695 0.320
LIG_Pex14_2 203 207 PF04695 0.432
LIG_Pex14_2 8 12 PF04695 0.304
LIG_PTB_Apo_2 254 261 PF02174 0.441
LIG_REV1ctd_RIR_1 192 199 PF16727 0.214
LIG_SH2_CRK 432 436 PF00017 0.488
LIG_SH2_CRK 48 52 PF00017 0.494
LIG_SH2_STAP1 373 377 PF00017 0.430
LIG_SH2_STAP1 44 48 PF00017 0.443
LIG_SH2_STAP1 484 488 PF00017 0.503
LIG_SH2_STAT5 20 23 PF00017 0.378
LIG_SH2_STAT5 33 36 PF00017 0.548
LIG_SH2_STAT5 394 397 PF00017 0.507
LIG_SH2_STAT5 415 418 PF00017 0.444
LIG_SH3_3 411 417 PF00018 0.457
LIG_SUMO_SIM_anti_2 115 120 PF11976 0.493
LIG_SUMO_SIM_anti_2 2 7 PF11976 0.301
LIG_SUMO_SIM_par_1 115 120 PF11976 0.482
LIG_SUMO_SIM_par_1 435 441 PF11976 0.523
LIG_TRAF2_1 128 131 PF00917 0.524
LIG_TRAF2_1 55 58 PF00917 0.669
LIG_TRAF2_2 208 213 PF00917 0.450
LIG_TYR_ITIM 282 287 PF00017 0.441
MOD_CDK_SPxK_1 413 419 PF00069 0.452
MOD_CK1_1 224 230 PF00069 0.560
MOD_CK1_1 258 264 PF00069 0.479
MOD_CK1_1 447 453 PF00069 0.404
MOD_CK2_1 339 345 PF00069 0.526
MOD_CK2_1 396 402 PF00069 0.503
MOD_CK2_1 461 467 PF00069 0.503
MOD_Cter_Amidation 350 353 PF01082 0.220
MOD_GlcNHglycan 143 146 PF01048 0.322
MOD_GlcNHglycan 223 226 PF01048 0.366
MOD_GlcNHglycan 301 304 PF01048 0.375
MOD_GlcNHglycan 312 315 PF01048 0.346
MOD_GlcNHglycan 69 73 PF01048 0.414
MOD_GSK3_1 129 136 PF00069 0.501
MOD_GSK3_1 170 177 PF00069 0.431
MOD_GSK3_1 310 317 PF00069 0.469
MOD_N-GLC_1 396 401 PF02516 0.264
MOD_NEK2_1 157 162 PF00069 0.296
MOD_NEK2_1 202 207 PF00069 0.349
MOD_NEK2_1 299 304 PF00069 0.580
MOD_NEK2_1 339 344 PF00069 0.428
MOD_NEK2_1 380 385 PF00069 0.417
MOD_NEK2_1 430 435 PF00069 0.452
MOD_NEK2_2 218 223 PF00069 0.569
MOD_PIKK_1 297 303 PF00454 0.446
MOD_PIKK_1 387 393 PF00454 0.503
MOD_PIKK_1 541 547 PF00454 0.643
MOD_PK_1 107 113 PF00069 0.507
MOD_PKA_1 107 113 PF00069 0.474
MOD_PKA_2 107 113 PF00069 0.521
MOD_PKA_2 141 147 PF00069 0.548
MOD_PKA_2 27 33 PF00069 0.544
MOD_Plk_1 218 224 PF00069 0.489
MOD_Plk_1 243 249 PF00069 0.598
MOD_Plk_2-3 498 504 PF00069 0.511
MOD_Plk_4 146 152 PF00069 0.496
MOD_Plk_4 314 320 PF00069 0.452
MOD_ProDKin_1 196 202 PF00069 0.320
MOD_ProDKin_1 413 419 PF00069 0.444
MOD_ProDKin_1 462 468 PF00069 0.467
MOD_SUMO_for_1 532 535 PF00179 0.664
MOD_SUMO_rev_2 302 311 PF00179 0.511
MOD_SUMO_rev_2 342 349 PF00179 0.509
MOD_SUMO_rev_2 399 405 PF00179 0.506
MOD_SUMO_rev_2 518 525 PF00179 0.539
TRG_DiLeu_BaEn_1 335 340 PF01217 0.503
TRG_DiLeu_BaEn_1 402 407 PF01217 0.464
TRG_DiLeu_BaEn_1 409 414 PF01217 0.464
TRG_DiLeu_BaLyEn_6 93 98 PF01217 0.471
TRG_ENDOCYTIC_2 20 23 PF00928 0.305
TRG_ENDOCYTIC_2 204 207 PF00928 0.436
TRG_ENDOCYTIC_2 236 239 PF00928 0.462
TRG_ENDOCYTIC_2 284 287 PF00928 0.445
TRG_ENDOCYTIC_2 44 47 PF00928 0.521
TRG_ENDOCYTIC_2 48 51 PF00928 0.512
TRG_ER_diArg_1 153 156 PF00400 0.429
TRG_ER_diArg_1 25 28 PF00400 0.523
TRG_ER_diArg_1 36 39 PF00400 0.567
TRG_ER_diArg_1 493 496 PF00400 0.502
TRG_ER_diArg_1 514 517 PF00400 0.533
TRG_ER_diLys_1 546 550 PF00400 0.670
TRG_NLS_MonoExtC_3 36 42 PF00514 0.464
TRG_NLS_MonoExtN_4 36 41 PF00514 0.461
TRG_Pf-PMV_PEXEL_1 306 310 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 523 527 PF00026 0.318
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.259

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8W1 Leptomonas seymouri 64% 97%
A0A0S4INF7 Bodo saltans 46% 100%
A0A1X0P9N2 Trypanosomatidae 47% 100%
A0A3Q8IEF0 Leishmania donovani 99% 100%
A0A3R7N194 Trypanosoma rangeli 44% 100%
A4HAV3 Leishmania braziliensis 83% 100%
C9ZML3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 100%
E9B528 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
O94738 Rhizomucor pusillus 38% 100%
P43636 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 100%
Q08B22 Xenopus laevis 27% 100%
Q3TZM9 Mus musculus 27% 100%
Q4Q2V8 Leishmania major 93% 100%
Q59LF2 Candida albicans (strain SC5314 / ATCC MYA-2876) 36% 100%
Q6BVA4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 34% 100%
Q6C3V7 Yarrowia lipolytica (strain CLIB 122 / E 150) 37% 100%
Q6CWQ0 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 39% 100%
Q6FJJ9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 35% 100%
Q6P312 Xenopus tropicalis 26% 100%
Q755C1 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 36% 100%
Q7KWM5 Dictyostelium discoideum 34% 100%
Q8X0H8 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 37% 100%
Q96WW6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 100%
Q9DBE8 Mus musculus 37% 100%
Q9H553 Homo sapiens 37% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS